Comparing 370251 FitnessBrowser__MR1:370251 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
Q12640 Chorismate synthase aro-2; 5-enolpyruvylshikimate-3-phosphate phospholyase; EC 1.5.1.38; EC 4.2.3.5 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 3 papers)
46% identity, 95% coverage: 4:250/261 of query aligns to 2:271/432 of Q12640
Sites not aligning to the query:
1um0A Crystal structure of chorismate synthase complexed with fmn (see paper)
47% identity, 94% coverage: 4:248/261 of query aligns to 2:251/365 of 1um0A
Sites not aligning to the query:
P56122 Chorismate synthase; CS; 5-enolpyruvylshikimate-3-phosphate phospholyase; EC 4.2.3.5 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
47% identity, 94% coverage: 4:248/261 of query aligns to 2:251/365 of P56122
Sites not aligning to the query:
P9WPY1 Chorismate synthase; CS; 5-enolpyruvylshikimate-3-phosphate phospholyase; EC 4.2.3.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
37% identity, 94% coverage: 14:258/261 of query aligns to 6:276/401 of P9WPY1
Sites not aligning to the query:
2qhfA Mycobacterium tuberculosis chorismate synthase in complex with nca
37% identity, 94% coverage: 14:258/261 of query aligns to 6:276/392 of 2qhfA
Sites not aligning to the query:
2o12A Mycobacterium tuberculosis chorismate synthase in complex with fmn
37% identity, 94% coverage: 14:258/261 of query aligns to 6:270/386 of 2o12A
Sites not aligning to the query:
1qxoA Crystal structure of chorismate synthase complexed with oxidized fmn and epsp (see paper)
40% identity, 90% coverage: 14:249/261 of query aligns to 5:262/388 of 1qxoA
Sites not aligning to the query:
P0A2Y6 Chorismate synthase; CS; 5-enolpyruvylshikimate-3-phosphate phospholyase; EC 4.2.3.5 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
40% identity, 90% coverage: 14:249/261 of query aligns to 5:262/388 of P0A2Y6
Sites not aligning to the query:
>370251 FitnessBrowser__MR1:370251
MSGNSIGQNFVVTTFGESHGVALGCIIDGCPPGLELTEADMQHDLDRRRPGTSRYTTARR
EPDEVRILSGVFEGKTTGTSIGLLIENTDQRSQDYSNIKDLFRPGHADYTYQQKYGLRDY
RGGGRSSARETAMRVAAGAVAKKYLKQVHGISIQGYMSQLGPICAETLDFSQIEQNAFFF
PDASKLEALDEYMRELKKSGDSIGAKISVVATNVPVGLGEPVFDRLDADIAHALMGINAV
KGVEIGDGFGVVTQRAQKGAI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory