Comparing 5208005 FitnessBrowser__PV4:5208005 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 98% coverage: 6:790/797 of query aligns to 91:908/916 of O81852
P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
32% identity, 42% coverage: 438:770/797 of query aligns to 4:335/359 of P31116
1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol (see paper)
32% identity, 42% coverage: 438:770/797 of query aligns to 3:334/358 of 1tveA
1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline (see paper)
32% identity, 42% coverage: 438:770/797 of query aligns to 3:334/358 of 1q7gA
Sites not aligning to the query:
1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine (see paper)
32% identity, 42% coverage: 438:770/797 of query aligns to 3:334/358 of 1ebuD
Sites not aligning to the query:
1ebfA Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
32% identity, 42% coverage: 438:770/797 of query aligns to 3:334/358 of 1ebfA
O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
31% identity, 42% coverage: 437:767/797 of query aligns to 5:341/376 of O94671
3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine (see paper)
29% identity, 39% coverage: 6:313/797 of query aligns to 3:318/458 of 3c1nA
Sites not aligning to the query:
3c1mC Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
28% identity, 39% coverage: 6:313/797 of query aligns to 3:322/468 of 3c1mC
2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate (see paper)
28% identity, 39% coverage: 6:313/797 of query aligns to 3:322/464 of 2hmfA
P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12) (see paper)
33% identity, 37% coverage: 1:296/797 of query aligns to 1:295/449 of P08660
2j0xA Crystal structure of e. Coli aspartokinase iii in complex with lysine and aspartate (t-state) (see paper)
33% identity, 37% coverage: 6:296/797 of query aligns to 4:293/447 of 2j0xA
Sites not aligning to the query:
2j0wA Crystal structure of e. Coli aspartokinase iii in complex with aspartate and adp (r-state) (see paper)
33% identity, 37% coverage: 6:296/797 of query aligns to 4:293/447 of 2j0wA
2cdqA Crystal structure of arabidopsis thaliana aspartate kinase complexed with lysine and s-adenosylmethionine (see paper)
29% identity, 38% coverage: 6:305/797 of query aligns to 6:311/470 of 2cdqA
Sites not aligning to the query:
3tviE Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
23% identity, 48% coverage: 6:384/797 of query aligns to 5:379/439 of 3tviE
3tviA Crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production (see paper)
23% identity, 48% coverage: 6:384/797 of query aligns to 3:371/429 of 3tviA
O60163 Probable aspartokinase; Aspartate kinase; EC 2.7.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
28% identity, 25% coverage: 100:300/797 of query aligns to 124:330/519 of O60163
3ingA Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
28% identity, 30% coverage: 438:679/797 of query aligns to 1:236/319 of 3ingA
Sites not aligning to the query:
3l76A Crystal structure of aspartate kinase from synechocystis (see paper)
28% identity, 36% coverage: 6:292/797 of query aligns to 4:233/585 of 3l76A
Sites not aligning to the query:
P61489 Aspartokinase; Aspartate kinase; AK; ASK; Threonine-sensitive AK; ThrA; EC 2.7.2.4 from Thermus thermophilus (see paper)
26% identity, 44% coverage: 36:385/797 of query aligns to 3:346/405 of P61489
>5208005 FitnessBrowser__PV4:5208005
MTRCHLHKFGGSSLADADCYRRVAHILLTHGHSDDLIVVSAAGKSTNFLYRLLELCDTDQ
LWQEELQVLVSYQQNLIEQLLSNEQARSLRERLATDKSQLTSLLSLDELNDYQRNQVVSF
GERWSSCLLAALLRESGVAATDVDARTLLVADEGAVPQIRLGESRQKVQALLEAHPQERL
VITGFICANEQGDTLLLGRNGSDFSATLLASLADIERVTIWTDVEGVFNADPNRINDAKL
LKSMSLTEANRLAHLGSPVLHNRTLQPLFDTEVSLAVRSSYAPHTDFTLIAPKSSSASAP
VVTSLSSVSLFSLTISVELPQLLACFAQAGLTPLAYWSLAHGRAELAFTHENQKQAQAIF
EAKRSELGIDELQLRDDLGLVALVSADASLYRRGFSRLLSREAHPLCNDGLSLVTLVPKA
QVNLLTQKVHRRCAGPRKRIGVLLLGIGNIGEAWIDLFKRARPVLNKELEVSVELVGLLS
SKKALLSETDIDLSSWQQAFEERGTGWQYTHLFEQLQALNCDELIALDISASADLTLQYP
EFFARGIHIVSANKLAGSGPLAFYQELKQQLGNRRLFWRYNASCGAGLPVQHALNDLHNS
GDSIEAVGGIFSGTLCWLFEHYDAKKPFSELVLEAKGLGITEPDPRDDLSGRDMQRKLLI
LAREIGYDIELDDIELESLVPTKLAEIPLDDFIKRMAELDGEMLQQYQAAAEQNKVLRYV
ASLDSEQGQLKAKVGIQWVDRSHPYANLTPGDNVFVIRSDFYQDNPLIIRGPGAGREVTA
AAVQSDLAQICRDLLQE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory