Comparing 5208303 FitnessBrowser__PV4:5208303 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
2bkxA Structure and kinetics of a monomeric glucosamine-6-phosphate deaminase: missing link of the nagb superfamily (see paper)
45% identity, 89% coverage: 1:239/268 of query aligns to 1:239/242 of 2bkxA
2bkvB Structure and kinetics of a monomeric glucosamine-6-phosphate deaminase: missing link of the nagb superfamily (see paper)
45% identity, 89% coverage: 1:239/268 of query aligns to 1:239/242 of 2bkvB
O35000 Glucosamine-6-phosphate deaminase 1; GlcN6P deaminase 1; GNPDA 1; Glucosamine-6-phosphate isomerase 1; EC 3.5.99.6 from Bacillus subtilis (strain 168) (see paper)
45% identity, 89% coverage: 1:239/268 of query aligns to 1:239/242 of O35000
5hj5B Crystal structure of tertiary complex of glucosamine-6-phosphate deaminase from vibrio cholerae with beta-d-glucose-6-phosphate and fructose-6-phosphate
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/267 of 5hj5B
2wu1A Glucosamine-6-phosphate deaminase complexed with the allosteric activator n-acetyl-glucoamine-6-phosphate both in the active and allosteric sites.
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/266 of 2wu1A
1horA Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from escherichia coli at 2.1 angstroms resolution (see paper)
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/266 of 1horA
1fqoA Glucosamine 6-phosphate deaminase complexed with the substrate of the reverse reaction fructose 6-phosphate (open form) (see paper)
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/266 of 1fqoA
1deaA Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from escherichia coli at 2.1 angstroms resolution (see paper)
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/266 of 1deaA
P0A759 Glucosamine-6-phosphate deaminase; GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase; EC 3.5.99.6 from Escherichia coli (strain K12) (see 3 papers)
43% identity, 95% coverage: 1:254/268 of query aligns to 1:262/266 of P0A759
P46926 Glucosamine-6-phosphate isomerase 1; Glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; Oscillin; EC 3.5.99.6 from Homo sapiens (Human) (see paper)
45% identity, 91% coverage: 1:244/268 of query aligns to 1:250/289 of P46926
Sites not aligning to the query:
1ne7A Human glucosamine-6-phosphate deaminase isomerase at 1.75 a resolution complexed with n-acetyl-glucosamine-6-phosphate and 2-deoxy-2-amino- glucitol-6-phosphate (see paper)
45% identity, 91% coverage: 1:244/268 of query aligns to 1:250/281 of 1ne7A
Sites not aligning to the query:
3hn6A Crystal structure of glucosamine-6-phosphate deaminase from borrelia burgdorferi
42% identity, 95% coverage: 1:254/268 of query aligns to 4:265/271 of 3hn6A
2ri1A Crystal structure of glucosamine 6-phosphate deaminase (nagb) with glcn6p from s. Mutans (see paper)
45% identity, 78% coverage: 31:239/268 of query aligns to 32:233/235 of 2ri1A
O95479 GDH/6PGL endoplasmic bifunctional protein; EC 1.1.1.47; EC 1.1.1.363; EC 3.1.1.31 from Homo sapiens (Human) (see 6 papers)
27% identity, 65% coverage: 32:204/268 of query aligns to 587:753/791 of O95479
Sites not aligning to the query:
4tm7A Crystal structure of 6-phosphogluconolactonase from mycobacterium smegmatis n131d mutant soaked with cuso4 (see paper)
31% identity, 65% coverage: 69:241/268 of query aligns to 68:243/243 of 4tm7A
Sites not aligning to the query:
P56201 GDH/6PGL endoplasmic bifunctional protein; EC 1.1.1.47; EC 1.1.1.363; EC 3.1.1.31 from Oryctolagus cuniculus (Rabbit) (see paper)
26% identity, 65% coverage: 32:204/268 of query aligns to 593:759/797 of P56201
Sites not aligning to the query:
Q84WW2 6-phosphogluconolactonase 3, chloroplastic; 6PGL3; Protein EMBRYO DEFECTIVE 2024; EC 3.1.1.31 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 86% coverage: 11:241/268 of query aligns to 95:325/325 of Q84WW2
>5208303 FitnessBrowser__PV4:5208303
MQIVILKDSAEVAEYGANLIINQLKRKPDSVLGLATGSTPVSLYQRLVAANQAGAVSFEG
VTSFNLDEYLGLEGSHPQSYRYFMDSQLFDAIDINKANTHVPPGDAEDPIAACEAYEAQI
QAAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTQATIEDNARFFAEGEYQPHLSI
TMGIGTILDAKKVLLLATGESKADAIRAAVEGALSAACPASALQLHRDAVLVIDEAAASK
LADKEFYRHIEAENQLLQARLAALKAGE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory