Comparing 5208528 FitnessBrowser__PV4:5208528 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P23533 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Staphylococcus carnosus (strain TM300) (see paper)
36% identity, 76% coverage: 172:735/743 of query aligns to 7:571/573 of P23533
2wqdA Crystal structure of enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state (see paper)
35% identity, 76% coverage: 172:734/743 of query aligns to 6:570/570 of 2wqdA
P08839 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Escherichia coli (strain K12) (see 2 papers)
36% identity, 62% coverage: 281:739/743 of query aligns to 115:574/575 of P08839
2hwgA Structure of phosphorylated enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system (see paper)
36% identity, 62% coverage: 281:738/743 of query aligns to 114:572/572 of 2hwgA
Sites not aligning to the query:
2xz9A Crystal structure from the phosphoenolpyruvate-binding domain of enzyme i in complex with pyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
41% identity, 42% coverage: 425:736/743 of query aligns to 5:316/317 of 2xz9A
2xz7A Crystal structure of the phosphoenolpyruvate-binding domain of enzyme i in complex with phosphoenolpyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
41% identity, 42% coverage: 425:736/743 of query aligns to 12:323/324 of 2xz7A
1vbgA Pyruvate phosphate dikinase from maize (see paper)
26% identity, 47% coverage: 339:689/743 of query aligns to 441:856/874 of 1vbgA
Sites not aligning to the query:
5lu4A C4-type pyruvate phosphate dikinase: conformational intermediate of central domain in the swiveling mechanism (see paper)
27% identity, 47% coverage: 339:689/743 of query aligns to 441:834/850 of 5lu4A
Sites not aligning to the query:
P11155 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Zea mays (Maize) (see 7 papers)
26% identity, 47% coverage: 339:684/743 of query aligns to 514:924/947 of P11155
Sites not aligning to the query:
5jvjB C4-type pyruvate phosphate dikinase: different conformational states of the nucleotide binding domain in the dimer (see paper)
26% identity, 47% coverage: 339:689/743 of query aligns to 368:779/797 of 5jvjB
Sites not aligning to the query:
5jvlA C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
26% identity, 47% coverage: 339:689/743 of query aligns to 441:856/874 of 5jvlA
Sites not aligning to the query:
Q39735 Pyruvate, phosphate dikinase, chloroplastic; Cold-sensitive pyruvate, orthophosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Flaveria bidentis (Coastal plain yellowtops) (Ethulia bidentis) (see 2 papers)
25% identity, 47% coverage: 339:689/743 of query aligns to 520:935/953 of Q39735
Sites not aligning to the query:
1vbhA Pyruvate phosphate dikinase with bound mg-pep from maize (see paper)
26% identity, 47% coverage: 339:689/743 of query aligns to 432:844/862 of 1vbhA
Sites not aligning to the query:
O23404 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 50% coverage: 321:689/743 of query aligns to 514:944/963 of O23404
1kc7A Pyruvate phosphate dikinase with bound mg-phosphonopyruvate (see paper)
24% identity, 47% coverage: 339:689/743 of query aligns to 439:852/872 of 1kc7A
Sites not aligning to the query:
P22983 Pyruvate, phosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Clostridium symbiosum (Bacteroides symbiosus) (see 4 papers)
24% identity, 47% coverage: 339:689/743 of query aligns to 440:853/874 of P22983
Sites not aligning to the query:
5jvlB C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
24% identity, 46% coverage: 351:689/743 of query aligns to 122:502/520 of 5jvlB
Sites not aligning to the query:
Q02KR1 Phosphoenolpyruvate synthase; PEP synthase; Pyruvate, water dikinase; EC 2.7.9.2 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
25% identity, 48% coverage: 344:702/743 of query aligns to 408:784/791 of Q02KR1
P37349 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM; Dihydroxyacetone kinase subunit M; EC 2.7.1.121 from Escherichia coli (strain K12) (see paper)
28% identity, 23% coverage: 196:364/743 of query aligns to 271:440/472 of P37349
Sites not aligning to the query:
5fbuA Crystal structure of rifampin phosphotransferase rph-lm from listeria monocytogenes in complex with rifampin-phosphate (see paper)
40% identity, 10% coverage: 322:394/743 of query aligns to 661:731/733 of 5fbuA
Sites not aligning to the query:
>5208528 FitnessBrowser__PV4:5208528
MLKTLRDITQAVAAADDLQSALSLLVRQTKSAMETQCCSIYILEEQELVLSATDGLDPRA
VGKVKMPMSQGLVGLVAEREEPVNLADAQQHPRFKLFTEVDEEDFRAFLAVPIIYQKLIL
GVLVVQQADARQFSEAEEAFLMTLAAQLAVAVREQRKKAEVKSAPDKCVYTGTSAASGVV
IAHAMVLGGEIPLEQQGRRTKQVDEELLALSQALDACRNTLSALSQRFDGENEKEVQSIF
SALQLLLDDTSLGGEYGREIQAGWTAISAVSRVSLRYIDHFQQMQDPYMQERATDIRDLG
QRVLRELIEPQKMQLELDVPVILVTKEATATMLAEFPQHKLVGIVTELGGVNSHAAILAR
AFGVPAVIGVEGILNAGIDGKQLILNANRGQVLISPTPTLIGEYRSLISAEKALQKRYAE
ELSKPAMTLDERRIHLYLNAGLLSSLASEIAEGADGVGLYRTEIPFMLQTRFPSEAEQVE
VYRQVLNAALGRPVVMRTLDVGGDKPLSYLPIIEENPFLGWRGIRLTLDHPELFLVQLRA
MLNASGGGEQLHILLPMVCCLDEIDQAIAYLEQAYLEVKQDVHPDLQRPKIGIMLEVPAL
LFQLEEVAKRVDFISVGSNDLTQYLLAVDRNNPRVSTLYDSYHPGILRALTQARLACREY
RLPISVCGELAGEPMGVLLLVAMGYTQLSMNQGSLAKINYLIRRVSYQDLSELLAQALSL
TNGFEVRELLTLYLKEKCLDEFL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory