Comparing 5208972 FitnessBrowser__PV4:5208972 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
27% identity, 94% coverage: 15:395/407 of query aligns to 15:410/425 of O59010
2nwwA Crystal structure of gltph in complex with tboa (see paper)
27% identity, 94% coverage: 15:395/407 of query aligns to 6:401/407 of 2nwwA
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
27% identity, 94% coverage: 15:395/407 of query aligns to 7:402/408 of 6bauA
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
27% identity, 94% coverage: 15:395/407 of query aligns to 7:402/409 of 6bavA
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
26% identity, 94% coverage: 15:395/407 of query aligns to 15:410/419 of 6x15A
Sites not aligning to the query:
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
26% identity, 94% coverage: 15:395/407 of query aligns to 12:407/413 of 6x14A
Sites not aligning to the query:
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
29% identity, 79% coverage: 15:334/407 of query aligns to 7:346/396 of 6bmiA
Sites not aligning to the query:
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
27% identity, 96% coverage: 16:406/407 of query aligns to 11:410/416 of 6r7rA
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
28% identity, 96% coverage: 16:406/407 of query aligns to 16:419/425 of 6zgbA
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
28% identity, 96% coverage: 16:406/407 of query aligns to 18:421/427 of 5e9sA
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
28% identity, 96% coverage: 16:406/407 of query aligns to 15:418/424 of 6zl4A
Sites not aligning to the query:
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
28% identity, 96% coverage: 16:406/407 of query aligns to 18:421/426 of 6xwnB
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
23% identity, 94% coverage: 23:406/407 of query aligns to 33:407/412 of 7awmA
Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans (see paper)
25% identity, 64% coverage: 146:405/407 of query aligns to 204:471/503 of Q10901
Sites not aligning to the query:
7nsgA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with hip-b
23% identity, 75% coverage: 103:406/407 of query aligns to 127:425/430 of 7nsgA
6s3qA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with tfb-tboa
23% identity, 75% coverage: 103:406/407 of query aligns to 127:425/430 of 6s3qA
Sites not aligning to the query:
7bcsA Asct2 in the presence of the inhibitor lc-bpe (position "down") in the outward-open conformation. (see paper)
28% identity, 63% coverage: 135:392/407 of query aligns to 172:431/442 of 7bcsA
7bcqA Asct2 in the presence of the inhibitor lc-bpe (position "up") in the outward-open conformation. (see paper)
28% identity, 63% coverage: 135:392/407 of query aligns to 172:431/442 of 7bcqA
Sites not aligning to the query:
6mpbB Cryo-em structure of the human neutral amino acid transporter asct2 (see paper)
27% identity, 63% coverage: 135:392/407 of query aligns to 176:435/446 of 6mpbB
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
23% identity, 94% coverage: 23:406/407 of query aligns to 25:393/397 of 5mjuA
>5208972 FitnessBrowser__PV4:5208972
MNQNRSLFAKLADGSLVLQIILGIIAGVALASFSPSSAESVAFLGDLFVGALKAIAPILV
FILVAASIANQKKNTKTNMRPIIVLYLFGTFAAAITAVTMSFLFPTSLVLVSGAQGATPP
EGIGEVLNTLLFKVVDNPVNALMTGNYIGILAWGVGLGIALHHASENTKTVFADVSHGVS
QMVRFVIRLAPIGIFGLVANTFAATGFEAIAGYAQLLAVLLGSMLIIALIINPLIVWFKI
RRNPYPLVFTCLRESGVTAFFTRSSAANIPVNMALCEKLDLHEDTFSVSIPLGATINMAG
AAITITVLTLAAVHTEGIQVDILTAILLSVVAAVSACGASGVAGGSLLLIPLACSLFGIS
NDVAMQVVAVGFIIGVIQDSAETALNSSTDVLFTAAACEAAERQAEI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory