Comparing 5209242 FitnessBrowser__PV4:5209242 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1djeA Crystal structure of the plp-bound form of 8-amino-7-oxonanoate synthase (see paper)
42% identity, 97% coverage: 5:376/382 of query aligns to 3:379/383 of 1djeA
1dj9A Crystal structure of 8-amino-7-oxonanoate synthase (or 7-keto- 8aminipelargonate or kapa synthase) complexed with plp and the product 8(s)-amino-7-oxonanonoate (or kapa). The enzyme of biotin biosynthetic pathway. (see paper)
42% identity, 97% coverage: 5:376/382 of query aligns to 3:379/383 of 1dj9A
2g6wA Suicide inhibition of a-oxamine synthase: structures of the covalent adducts of 8-amino-7-oxonanoate synthase with trifluoroalanine (see paper)
44% identity, 87% coverage: 46:376/382 of query aligns to 42:379/383 of 2g6wA
P12998 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; EC 2.3.1.47 from Escherichia coli (strain K12) (see 2 papers)
44% identity, 87% coverage: 46:376/382 of query aligns to 43:380/384 of P12998
Sites not aligning to the query:
1fc4A 2-amino-3-ketobutyrate coa ligase (see paper)
33% identity, 98% coverage: 4:378/382 of query aligns to 8:392/401 of 1fc4A
P0AB77 2-amino-3-ketobutyrate coenzyme A ligase; AKB ligase; Glycine acetyltransferase; EC 2.3.1.29 from Escherichia coli (strain K12) (see paper)
33% identity, 98% coverage: 4:378/382 of query aligns to 5:389/398 of P0AB77
7poaA An irreversible, promiscuous and highly thermostable claisen- condensation biocatalyst drives the synthesis of substituted pyrroles
34% identity, 96% coverage: 4:370/382 of query aligns to 8:381/398 of 7poaA
7v58B Structural insights into the substrate selectivity of acyl-coa transferase (see paper)
31% identity, 95% coverage: 19:382/382 of query aligns to 22:395/400 of 7v58B
3tqxA Structure of the 2-amino-3-ketobutyrate coenzyme a ligase (kbl) from coxiella burnetii (see paper)
29% identity, 97% coverage: 1:370/382 of query aligns to 1:380/396 of 3tqxA
Q8GW43 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Biotin synthase 4; Biotin synthase F; AtbioF; EC 2.3.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 87% coverage: 47:380/382 of query aligns to 107:459/476 of Q8GW43
Sites not aligning to the query:
3a2bA Crystal structure of serine palmitoyltransferase from sphingobacterium multivorum with substrate l-serine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/392 of 3a2bA
8h29A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-threonine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8h29A
8h21A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-alanine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8h21A
8h20A Serine palmitoyltransferase from sphingobacterium multivorum complexed with glycine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8h20A
8h1yA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-homoserine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8h1yA
8h1qA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-serine (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8h1qA
8guhA Serine palmitoyltransferase from sphingobacterium multivorum complexed with tris (see paper)
30% identity, 88% coverage: 47:381/382 of query aligns to 48:390/394 of 8guhA
Q0P5L8 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; Aminoacetone synthase; Glycine acetyltransferase; EC 2.3.1.29 from Bos taurus (Bovine) (see paper)
29% identity, 97% coverage: 1:370/382 of query aligns to 24:402/419 of Q0P5L8
Sites not aligning to the query:
P18079 5-aminolevulinate synthase; 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase; EC 2.3.1.37 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
33% identity, 85% coverage: 47:372/382 of query aligns to 51:389/409 of P18079
Sites not aligning to the query:
6hrhA Structure of human erythroid-specific 5'-aminolevulinate synthase, alas2
31% identity, 98% coverage: 1:376/382 of query aligns to 6:394/429 of 6hrhA
>5209242 FitnessBrowser__PV4:5209242
MSRLQQKIDDKMQRAEQSGLLRRRQLLTQSVGSANRLVHQGSIKHNFASNDYLGLSQSPE
LIEALGEGARLYGVGSGASPLVTGYSDAHAALEQALCEATGHEAALLFSSGFSANSALMK
TLLDKESVVVADKLIHASLIDGLLESGAQLKRFAHNDLGAAKRLVDKHQPLTVVTESVFS
MDGDLAPIDELYELTQANDAWLIVDDAHGFGVLPLGGHNKVDASCCDIQIVTFGKALGCQ
GAAILGSNTCIDFLVAHARDYIYSTALSPASAHVALKAVNLIKNGECRDRLAQVIEAFKL
AAKARGLRLLGSHTPIQPLVVGDIDKLAKVNRELKTAGFWVGAIRPPTVPQGSARLRITL
NVNHTQAELEALADQLQRALQD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory