Comparing 5209347 Shew_1821 2-methylcitrate synthase/citrate synthase II (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6s87D Crystal structure of 2-methylcitrate synthase (prpc) from pseudomonas aeruginosa in complex with oxaloacetate.
72% identity, 98% coverage: 10:374/374 of query aligns to 1:365/365 of 6s87D
P39120 Citrate synthase 2; Citrate synthase II; EC 2.3.3.16 from Bacillus subtilis (strain 168) (see paper)
43% identity, 98% coverage: 10:374/374 of query aligns to 6:371/372 of P39120
1aj8A Citrate synthase from pyrococcus furiosus (see paper)
39% identity, 98% coverage: 10:374/374 of query aligns to 4:370/371 of 1aj8A
1iomA Crystal structure of citrate synthase from thermus thermophilus hb8 (see paper)
38% identity, 98% coverage: 10:374/374 of query aligns to 4:374/374 of 1iomA
1a59A Cold-active citrate synthase (see paper)
39% identity, 96% coverage: 10:368/374 of query aligns to 7:376/377 of 1a59A
O34002 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Antarctic bacterium DS2-3R (see 2 papers)
39% identity, 96% coverage: 10:368/374 of query aligns to 9:378/379 of O34002
Sites not aligning to the query:
I6Y9Q3 2-methylcitrate synthase; 2-MCS; MCS; Citrate synthase; EC 2.3.3.5; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
40% identity, 97% coverage: 10:370/374 of query aligns to 31:390/393 of I6Y9Q3
1ixeA Crystal structure of citrate synthase from thermus thermophilus hb8 (see paper)
38% identity, 98% coverage: 10:374/374 of query aligns to 4:371/371 of 1ixeA
P39119 Citrate synthase 1; Citrate synthase I; EC 2.3.3.16 from Bacillus subtilis (strain 168) (see paper)
35% identity, 96% coverage: 10:369/374 of query aligns to 5:365/366 of P39119
2c6xA Structure of bacillus subtilis citrate synthase
35% identity, 96% coverage: 10:368/374 of query aligns to 4:363/363 of 2c6xA
6abxA Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with citrate (see paper)
36% identity, 98% coverage: 10:374/374 of query aligns to 6:370/370 of 6abxA
6abyA Crystal structure of citrate synthase (msed_1522) from metallosphaera sedula in complex with oxaloacetate (see paper)
36% identity, 98% coverage: 10:374/374 of query aligns to 6:370/372 of 6abyA
6abwA Crystal structure of citrate synthase (msed_0281) from metallosphaera sedula in complex with acetyl-coa (see paper)
35% identity, 95% coverage: 19:374/374 of query aligns to 8:369/369 of 6abwA
2h12B Structure of acetobacter aceti citrate synthase complexed with oxaloacetate and carboxymethyldethia coenzyme a (cmx) (see paper)
34% identity, 96% coverage: 17:374/374 of query aligns to 45:426/426 of 2h12B
P9WPD5 Citrate synthase 1; EC 2.3.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
34% identity, 98% coverage: 9:374/374 of query aligns to 47:431/431 of P9WPD5
2ifcC The structure of the binary complex of oxalateacetate with citrate synthase from the thermophilic archaeon thermolasma acidophilum
33% identity, 98% coverage: 10:374/374 of query aligns to 7:381/382 of 2ifcC
2r9eA The structure of the binary complex of citryl dethia coa and citrate synthase from the thermophilic archaeonthermoplasma acidophilum
33% identity, 98% coverage: 10:374/374 of query aligns to 7:381/381 of 2r9eA
2r26A The structure of the ternary complex of carboxymethyl coenzyme a and oxalateacetate with citrate synthase from the thermophilic archaeonthermoplasma acidophilum
33% identity, 98% coverage: 10:374/374 of query aligns to 7:381/381 of 2r26A
4yboB Structure of citrate synthase from the thermoacidophilic euryarchaeon thermolasma acidophilum (see paper)
33% identity, 98% coverage: 10:374/374 of query aligns to 6:380/381 of 4yboB
4jagA Structural determination of the a50t:s279g:s280k:v281k:k282e:h283n variant of citrate synthase from e. Coli complexed with oxaloacetate (see paper)
31% identity, 95% coverage: 10:366/374 of query aligns to 45:418/426 of 4jagA
>5209347 Shew_1821 2-methylcitrate synthase/citrate synthase II (RefSeq)
MVDKKLGGAGLRGQSAGETALCTVGKSGSGLTYCGYDVSDLADNATFEEVAYLLFNGELP
NAAQLDAYKSELMSMRDLPQTLKEVLQRIPADAHPMDVMRTGCSFLGNLEPETDFSQQNK
AANRLLAAFPAIMCYWYRFSHDGVEIDCVTDEDSLGGHFLKLLNGKTPSDQHRRVMDVSL
ILYAEHEFNASTFTARVCASTLSDMFSCITGAIGSLRGPLHGGANEAAMEMIQKFSSPED
AKVQMAGMLERKEKIMGFGHAIYRESDPRNVIIKAWSEKLAKEFGDTSLYDISVACEEYM
WDTKKLFCNADFFHASAYHFMGIPTKLFTPIFVCSRLTGWAAHVMEQRANNRIIRPSADY
IGSAPRKVVPISER
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory