SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 5209393 Shew_1864 glucose-specific PTS system component (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

P69783 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12) (see 6 papers)
60% identity, 99% coverage: 1:168/169 of query aligns to 1:168/169 of P69783

query
sites
P69783
M
|
M
G
 
G
F
 
L
L
x
F
S
 
D
R
 
K
I
 
L
R
 
K
R
 
S
L
 
L
I
 
V
S
 
S
G
 
D
Q
 
D
P
 
K
P
 
K
I
 
D
T
 
T
G
 
G
G
 
T
I
 
I
D
 
E
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I
Y
 
I
A
 
A
P
 
P
V
 
L
S
 
S
G
 
G
E
 
E
I
 
I
V
 
V
A
 
N
I
 
I
E
 
E
K
 
D
V
 
V
P
 
P
D
 
D
V
 
V
V
 
V
F
 
F
A
 
A
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E
K
 
K
I
 
I
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V
G
 
G
D
 
D
G
 
G
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I
A
 
A
I
 
I
A
 
K
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P
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T
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G
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N
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K
I
 
M
V
 
V
A
 
A
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P
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V
D
 
D
G
 
G
T
 
T
I
 
I
G
 
G
K
 
K
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I
F
 
F
E
 
E
T
 
T
N
 
N
H
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H
A
 
A
F
 
F
S
 
S
I
 
I
E
 
E
S
 
S
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D
Q
 
S
G
 
G
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V
E
 
E
L
 
L
F
 
F
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V
H
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H
F
 
F
G
 
G
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I
G
 
D
T
 
T
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V
E
 
E
L
 
L
R
 
K
G
 
G
N
 
E
G
 
G
F
 
F
T
 
K
R
 
R
L
 
I
A
 
A
E
 
E
E
 
E
G
 
G
Q
 
Q
Q
 
R
V
 
V
K
 
K
A
 
V
G
 
G
D
 
D
P
 
T
I
 
V
L
 
I
E
 
E
F
 
F
D
 
D
L
 
L
D
 
P
Y
 
L
L
 
L
K
 
E
A
 
E
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K
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A
E
 
K
S
 
S
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T
L
 
L
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T
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P
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V
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V
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I
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S
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N
M
 
M
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D
D
 
E
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I
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K
G
 
E
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L
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I
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K
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L
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S
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G
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S
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V
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G
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E
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I
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K

1glcF Cation promoted association (cpa) of a regulatory and target protein is controlled by phosphorylation (see paper)
59% identity, 99% coverage: 2:168/169 of query aligns to 1:160/161 of 1glcF

query
sites
1glcF
G
 
G
F
 
L
L
 
F
S
 
D
R
 
K
I
 
L
R
 
K
R
 
S
L
 
L
I
 
V
S
 
S
G
 
T
Q
 
-
P
 
-
P
 
-
I
 
-
T
 
-
G
 
-
G
 
-
I
 
I
D
 
E
V
 
I
Y
 
I
A
 
A
P
 
P
V
 
L
S
 
S
G
 
G
E
 
E
I
 
I
V
 
V
A
 
N
I
 
I
E
 
E
K
 
D
V
 
V
P
 
P
D
 
D
V
 
V
V
 
V
F
 
F
A
 
A
E
 
E
K
 
K
I
 
I
V
 
V
G
 
G
D
 
D
G
 
G
I
 
I
A
 
A
I
 
I
A
 
K
P
 
P
K
 
T
G
 
G
K
 
N
Q
 
K
I
 
M
V
 
V
A
 
A
P
 
P
V
 
V
D
 
D
G
 
G
T
 
T
I
 
I
G
 
G
K
 
K
I
 
I
F
 
F
E
 
E
T
 
T
N
 
N
H
|
H
A
 
A
F
 
F
S
 
S
I
 
I
E
 
E
S
 
S
P
 
D
Q
 
S
G
 
G
L
 
V
E
 
E
L
 
L
F
 
F
V
 
V
H
|
H
F
 
F
G
 
G
V
 
I
G
 
D
T
 
T
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V
E
 
E
L
 
L
R
 
K
G
 
G
N
 
E
G
 
G
F
 
F
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K
R
 
R
L
 
I
A
 
A
E
 
E
E
 
E
G
 
G
Q
 
Q
Q
 
R
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V
K
 
K
A
 
V
G
 
G
D
 
D
P
 
T
I
 
V
L
 
I
E
 
E
F
 
F
D
 
D
L
 
L
D
 
P
Y
 
L
L
 
L
K
 
E
A
 
E
H
 
K
V
 
A
E
 
K
S
 
S
L
 
T
L
 
L
T
 
T
P
 
P
V
 
V
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V
L
 
I
A
 
S
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N
M
 
M
E
 
D
D
 
E
I
 
I
Q
 
K
G
 
E
L
 
L
D
 
I
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K
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L
H
 
S
G
 
G
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S
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E
 
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A
 
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E
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K

1o2fA Complex of enzyme iiaglc and iibglc phosphocarrier protein hpr from escherichia coli nmr, restrained regularized mean structure (see paper)
64% identity, 88% coverage: 21:168/169 of query aligns to 2:149/150 of 1o2fA

query
sites
1o2fA
I
 
I
D
 
E
V
 
I
Y
 
I
A
 
A
P
 
P
V
 
L
S
 
S
G
 
G
E
 
E
I
 
I
V
 
V
A
 
N
I
 
I
E
 
E
K
 
D
V
 
V
P
 
P
D
 
D
V
 
V
V
 
V
F
 
F
A
 
A
E
 
E
K
 
K
I
 
I
V
 
V
G
 
G
D
 
D
G
 
G
I
 
I
A
 
A
I
 
I
A
 
K
P
 
P
K
 
T
G
 
G
K
 
N
Q
 
K
I
 
M
V
 
V
A
 
A
P
 
P
V
 
V
D
 
D
G
 
G
T
 
T
I
 
I
G
 
G
K
 
K
I
 
I
F
 
F
E
 
E
T
|
T
N
 
N
H
|
H
A
 
A
F
 
F
S
 
S
I
 
I
E
 
E
S
 
S
P
 
D
Q
 
S
G
 
G
L
 
V
E
 
E
L
 
L
F
 
F
V
 
V
H
|
H
F
 
F
G
 
G
V
 
I
G
x
D
T
 
T
V
 
V
E
 
E
L
 
L
R
 
K
G
 
G
N
 
E
G
 
G
F
 
F
T
 
K
R
 
R
L
 
I
A
 
A
E
 
E
E
 
E
G
 
G
Q
 
Q
Q
 
R
V
 
V
K
 
K
A
 
V
G
 
G
D
 
D
P
 
T
I
 
V
L
 
I
E
 
E
F
 
F
D
 
D
L
 
L
D
 
P
Y
 
L
L
 
L
K
 
E
A
 
E
H
 
K
V
 
A
E
 
K
S
 
S
L
 
T
L
 
L
T
 
T
P
 
P
V
 
V
V
 
V
L
 
I
A
 
S
N
 
N
M
 
M
E
 
D
D
 
E
I
 
I
Q
 
K
G
 
E
L
 
L
D
 
I
K
 
K
R
 
L
H
 
S
G
 
G
S
 
S
I
 
V
E
 
T
A
 
V
G
 
G
K
 
E
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T
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P
I
 
V
F
 
I
S
 
R
V
 
I
Q
 
K

P09323 PTS system N-acetylglucosamine-specific EIICBA component; EIICBA-Nag; EII-Nag; EC 2.7.1.193 from Escherichia coli (strain K12) (see paper)
50% identity, 87% coverage: 22:168/169 of query aligns to 500:647/648 of P09323

query
sites
P09323
D
 
E
V
 
L
Y
 
V
A
 
S
P
 
P
V
 
I
S
 
T
G
 
G
E
 
D
I
 
V
V
 
V
A
 
A
I
 
L
E
 
D
K
 
Q
V
 
V
P
 
P
D
 
D
V
 
E
V
 
A
F
 
F
A
 
A
E
 
S
K
 
K
I
 
A
V
 
V
G
 
G
D
 
D
G
 
G
I
 
V
A
 
A
I
 
V
A
 
K
P
 
P
K
 
T
G
 
D
K
 
K
Q
 
I
I
 
V
V
 
V
A
 
S
P
 
P
V
 
A
D
 
A
G
 
G
T
 
T
I
 
I
G
 
V
K
 
K
I
 
I
F
 
F
E
 
N
T
 
T
N
 
N
H
 
H
A
 
A
F
 
F
S
 
C
I
 
L
E
 
E
S
 
T
P
 
E
Q
 
K
G
 
G
L
 
A
E
 
E
L
 
I
F
 
V
V
 
V
H
 
H
F
 
M
G
 
G
V
 
I
G
 
D
T
 
T
V
 
V
E
 
A
L
 
L
R
 
E
G
 
G
N
 
K
G
 
G
F
 
F
T
 
K
R
 
R
L
 
L
A
 
V
E
 
E
E
 
E
G
 
G
Q
 
A
Q
 
Q
V
 
V
K
 
S
A
 
A
G
 
G
D
 
Q
P
 
P
I
 
I
L
 
L
E
 
E
F
 
M
D
 
D
L
 
L
D
 
D
Y
 
Y
L
 
L
K
 
N
A
 
A
H
 
N
V
 
A
E
 
R
S
 
S
L
 
M
L
 
I
T
 
S
P
 
P
V
 
V
V
 
V
L
 
C
A
 
S
N
 
N
M
 
I
E
 
D
D
 
D
I
 
F
Q
 
S
G
 
G
L
 
L
-
 
I
D
 
I
K
 
K
R
 
A
H
 
Q
G
 
G
S
 
H
I
 
I
E
 
V
A
 
A
G
 
G
K
 
Q
D
 
T
V
 
P
I
 
L
F
 
Y
S
 
E
V
 
I
Q
 
K

Sites not aligning to the query:

Query Sequence

>5209393 Shew_1864 glucose-specific PTS system component (RefSeq)
MGFLSRIRRLISGQPPITGGIDVYAPVSGEIVAIEKVPDVVFAEKIVGDGIAIAPKGKQI
VAPVDGTIGKIFETNHAFSIESPQGLELFVHFGVGTVELRGNGFTRLAEEGQQVKAGDPI
LEFDLDYLKAHVESLLTPVVLANMEDIQGLDKRHGSIEAGKDVIFSVQL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory