Comparing 5209661 FitnessBrowser__PV4:5209661 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8ewoA Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
48% identity, 100% coverage: 1:259/260 of query aligns to 2:259/259 of 8ewoA
2qedA Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
43% identity, 97% coverage: 7:259/260 of query aligns to 7:252/252 of 2qedA
Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
38% identity, 97% coverage: 7:259/260 of query aligns to 76:324/324 of Q9SID3
Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
43% identity, 97% coverage: 7:259/260 of query aligns to 6:251/251 of Q8ZRM2
2q42A Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
38% identity, 97% coverage: 7:259/260 of query aligns to 6:254/254 of 2q42A
6rz0A Crystal structure of escherichia coli glyoxalase ii
42% identity, 97% coverage: 7:259/260 of query aligns to 6:251/251 of 6rz0A
O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
39% identity, 88% coverage: 7:236/260 of query aligns to 6:239/258 of O24496
Sites not aligning to the query:
Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see paper)
34% identity, 98% coverage: 4:259/260 of query aligns to 51:303/308 of Q16775
1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione (see paper)
34% identity, 98% coverage: 4:259/260 of query aligns to 3:255/260 of 1qh5B
1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione (see paper)
34% identity, 98% coverage: 4:259/260 of query aligns to 3:255/260 of 1qh5A
1qh3A Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
34% identity, 98% coverage: 4:259/260 of query aligns to 3:255/260 of 1qh3A
2p18A Crystal structure of the leishmania infantum glyoxalase ii (see paper)
32% identity, 85% coverage: 3:224/260 of query aligns to 14:258/283 of 2p18A
7l0bA Crystal structure of hydroxyacyl glutathione hydrolase (glob) from staphylococcus aureus, apoenzyme (see paper)
28% identity, 55% coverage: 28:171/260 of query aligns to 27:185/202 of 7l0bA
2zwrB Crystal structure of ttha1623 from thermus thermophilus hb8 (see paper)
30% identity, 57% coverage: 25:171/260 of query aligns to 23:184/207 of 2zwrB
2zziA Crystal structure of ttha1623 in a di-iron-bound form (see paper)
30% identity, 57% coverage: 25:171/260 of query aligns to 21:182/198 of 2zziA
2xf4A Crystal structure of salmonella enterica serovar typhimurium ycbl (see paper)
29% identity, 54% coverage: 2:142/260 of query aligns to 3:160/210 of 2xf4A
Sites not aligning to the query:
4ysbA Crystal structure of ethe1 from myxococcus xanthus (see paper)
28% identity, 62% coverage: 14:173/260 of query aligns to 14:172/225 of 4ysbA
7ev5A Crystal structure of bleg-1 b3 metallo-beta-lactamase (see paper)
28% identity, 44% coverage: 28:142/260 of query aligns to 26:159/209 of 7ev5A
Sites not aligning to the query:
3r2uB 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
24% identity, 80% coverage: 16:222/260 of query aligns to 20:245/336 of 3r2uB
Sites not aligning to the query:
4chlB Human ethylmalonic encephalopathy protein 1 (hethe1) (see paper)
25% identity, 75% coverage: 13:207/260 of query aligns to 19:216/237 of 4chlB
>5209661 FitnessBrowser__PV4:5209661
MHTVTPIPAFNDNYIWLIHAKDSGGHYVVDPGDAKAVLDYLEQHQIVLDGILITHHHSDH
TGGIAELQASHDHKLTVYGPDNENIKGINHPISGQTESVKPEKLDSDAAVFHLPGHTLGH
IAYLIDDHLFCGDTLFSAGCGRLFEGTPAQMHHSLQTLAQLDETTLVYPAHEYTQANLAF
ALTVENDNEALIAHAAKVKQLRDQNLPSLPSSIGLEKQINPFLRPEQASIKQNLSCHFAQ
DVTDDGTSFTLLRQWKDNFL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory