Comparing 5209702 FitnessBrowser__PV4:5209702 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
44% identity, 99% coverage: 5:346/346 of query aligns to 2:351/352 of 1cjxA
7xntA Crystal structure of pfhppd-y13161 complex
44% identity, 97% coverage: 5:340/346 of query aligns to 5:341/341 of 7xntA
7x8eA Crystal structure of pfhppd-y13287 complex
43% identity, 98% coverage: 5:344/346 of query aligns to 4:341/341 of 7x8eA
7xntC Crystal structure of pfhppd-y13161 complex
40% identity, 96% coverage: 5:335/346 of query aligns to 4:320/320 of 7xntC
1t47A Structure of fe2-hppd bound to ntbc (see paper)
36% identity, 80% coverage: 65:340/346 of query aligns to 73:360/362 of 1t47A
7yvvA Acmp1, r-4-hydroxymandelate synthase
31% identity, 84% coverage: 52:340/346 of query aligns to 47:334/335 of 7yvvA
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
30% identity, 86% coverage: 50:346/346 of query aligns to 63:381/393 of P32755
Sites not aligning to the query:
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
30% identity, 86% coverage: 50:346/346 of query aligns to 63:381/393 of Q02110
Sites not aligning to the query:
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
30% identity, 86% coverage: 50:346/346 of query aligns to 55:373/376 of 5ec3A
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
30% identity, 85% coverage: 50:344/346 of query aligns to 57:373/374 of 8im2A
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
28% identity, 95% coverage: 12:338/346 of query aligns to 295:624/635 of Q88JU3
Sites not aligning to the query:
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
29% identity, 84% coverage: 50:340/346 of query aligns to 57:369/371 of 8im3A
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
28% identity, 95% coverage: 12:338/346 of query aligns to 297:621/624 of 5hmqD
Sites not aligning to the query:
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
30% identity, 79% coverage: 67:340/346 of query aligns to 69:342/343 of 3zgjB
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
30% identity, 82% coverage: 50:331/346 of query aligns to 56:343/343 of 1sqiA
2r5vA Hydroxymandelate synthase crystal structure (see paper)
26% identity, 95% coverage: 13:341/346 of query aligns to 5:345/346 of 2r5vA
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
26% identity, 95% coverage: 13:341/346 of query aligns to 6:347/357 of O52791
P93836 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
31% identity, 79% coverage: 64:337/346 of query aligns to 126:432/445 of P93836
5ywkA Crystal structure of arabidopsis thaliana hppd complexed with benquitrione-methyl (see paper)
32% identity, 79% coverage: 64:337/346 of query aligns to 91:370/372 of 5ywkA
1tg5A Crystal structures of plant 4-hydroxyphenylpyruvate dioxygenases complexed with das645 (see paper)
33% identity, 79% coverage: 64:336/346 of query aligns to 92:371/371 of 1tg5A
>5209702 FitnessBrowser__PV4:5209702
MASEQNPLGLLGIEFTEFCTPDLDFMHKVFIDFGFSKLKKHKQKDIVYYKQNDINFLLNN
EKSGFSAEFAKKHGAAISSMGWRVEDAKFAFEGAVARGAKPAGDEVKDLPYPAIYGIGDS
LIYFIDTFGADNNIYATDFVDLENPEIVQEKGFIEVDHLTNNVYKGTMEHWSNFYKDIFG
FTEVRYFDIKGSQTALISYALRSPDGSFCIPINEGKGDDRNQIDEYLREYDGPGVQHLAF
RSRDIVASLDAMEGSSIQTLDIIPEYYDTIFDKLPQVTEDRERIKHHQILVDGDEDGYLL
QIFTKNLFGPIFIEIIQRKNNLGFGEGNFKALFESIERDQVRRGVL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory