SitesBLAST
Comparing 5209813 FitnessBrowser__PV4:5209813 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8gy3B Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
56% identity, 84% coverage: 8:148/168 of query aligns to 5:148/154 of 8gy3B
- binding fe2/s2 (inorganic) cluster: G38 (= G41), C39 (= C42), G40 (= G43), G42 (= G45), C44 (= C47), G45 (= G48), C47 (= C50), C59 (= C62), C97 (= C97), C100 (= C100), Q101 (= Q101), C132 (= C132), C134 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q96 (= Q96), C134 (= C134)
5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
45% identity, 88% coverage: 6:153/168 of query aligns to 5:157/157 of 5y6qA
- binding fe2/s2 (inorganic) cluster: G40 (= G41), C41 (= C42), D42 (≠ G43), G44 (= G45), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C101 (= C97), G102 (= G98), C104 (= C100), C136 (= C132), C138 (= C134)
- binding pterin cytosine dinucleotide: Q100 (= Q96), C138 (= C134)
1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
42% identity, 83% coverage: 5:144/168 of query aligns to 5:148/162 of 1t3qA
- binding fe2/s2 (inorganic) cluster: I40 (≠ Y40), C42 (= C42), E43 (≠ G43), G45 (= G45), C47 (= C47), G48 (= G48), C50 (= C50), R60 (= R60), C62 (= C62), C101 (= C97), G102 (= G98), C104 (= C100), C136 (= C132), C138 (= C134)
- binding pterin cytosine dinucleotide: Q100 (= Q96), C138 (= C134)
3hrdD Crystal structure of nicotinate dehydrogenase (see paper)
39% identity, 88% coverage: 1:147/168 of query aligns to 1:151/160 of 3hrdD
- binding flavin-adenine dinucleotide: E44 (≠ A44), G45 (= G45), E46 (≠ L46)
- binding fe2/s2 (inorganic) cluster: E40 (≠ Y40), C42 (= C42), S43 (≠ G43), G45 (= G45), C47 (= C47), G48 (= G48), C50 (= C50), C62 (= C62), Q100 (= Q96), C101 (= C97), G102 (= G98), C104 (= C100), C136 (= C132), C138 (= C134)
- binding pterin cytosine dinucleotide: Q100 (= Q96), C138 (= C134)
Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
39% identity, 88% coverage: 1:147/168 of query aligns to 1:151/157 of Q0QLF3
- C42 (= C42) binding
- C47 (= C47) binding
- C50 (= C50) binding
- C62 (= C62) binding
- C101 (= C97) binding
- C104 (= C100) binding
- C136 (= C132) binding
- C138 (= C134) binding
4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
39% identity, 87% coverage: 3:148/168 of query aligns to 9:157/161 of 4zohC
- binding fe2/s2 (inorganic) cluster: C47 (= C42), S50 (≠ G45), C52 (= C47), G53 (= G48), C55 (= C50), C67 (= C62), C106 (= C97), G107 (= G98), C109 (= C100), C141 (= C132), C143 (= C134)
- binding pterin cytosine dinucleotide: Q105 (= Q96), C143 (= C134)
1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
42% identity, 85% coverage: 6:148/168 of query aligns to 5:151/161 of 1sb3C
- binding fe2/s2 (inorganic) cluster: Q39 (≠ Y40), C41 (= C42), G44 (= G45), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C135 (= C132), C137 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q96), C137 (= C134)
P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
40% identity, 86% coverage: 6:149/168 of query aligns to 63:225/229 of P77165
- C99 (= C42) binding
- C104 (= C47) binding
- G105 (= G48) binding
- C107 (= C50) binding
- C119 (= C62) binding
- C158 (= C97) binding
- C161 (= C100) binding
- C208 (= C132) binding
- C210 (= C134) binding
5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
40% identity, 86% coverage: 6:149/168 of query aligns to 12:174/175 of 5g5gA
- binding fe2/s2 (inorganic) cluster: G47 (= G41), C48 (= C42), D49 (≠ G43), G51 (= G45), C53 (= C47), G54 (= G48), C56 (= C50), C68 (= C62), C107 (= C97), G108 (= G98), C110 (= C100), C157 (= C132), C159 (= C134)
P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
38% identity, 88% coverage: 1:148/168 of query aligns to 1:153/166 of P19921
- C42 (= C42) binding
- C47 (= C47) binding
- C50 (= C50) binding
- C62 (= C62) binding
- C102 (= C97) binding
- C105 (= C100) binding
- C137 (= C132) binding
- C139 (= C134) binding
1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
36% identity, 85% coverage: 6:148/168 of query aligns to 5:151/156 of 1ffuD
- binding fe2/s2 (inorganic) cluster: C41 (= C42), S44 (≠ G45), H45 (≠ L46), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C135 (= C132), C137 (= C134)
1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
36% identity, 85% coverage: 6:148/168 of query aligns to 4:150/155 of 1ffvA
- binding fe2/s2 (inorganic) cluster: I38 (≠ Y40), C40 (= C42), S43 (≠ G45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C99 (= C97), G100 (= G98), C102 (= C100), C134 (= C132), C136 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q96), C136 (= C134)
1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
38% identity, 87% coverage: 3:148/168 of query aligns to 1:151/161 of 1n5wA
- binding flavin-adenine dinucleotide: S43 (≠ G45), H44 (≠ L46)
- binding fe2/s2 (inorganic) cluster: I38 (≠ Y40), G39 (= G41), C40 (= C42), S43 (≠ G45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C135 (= C132), C137 (= C134)
1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
38% identity, 87% coverage: 3:148/168 of query aligns to 1:151/158 of 1n5wD
- binding flavin-adenine dinucleotide: S43 (≠ G45), H44 (≠ L46)
- binding fe2/s2 (inorganic) cluster: C40 (= C42), S43 (≠ G45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C135 (= C132), C137 (= C134)
- binding pterin cytosine dinucleotide: Q99 (= Q96), C137 (= C134)
7dqxC Crystal structure of xanthine dehydrogenase family protein
35% identity, 88% coverage: 1:147/168 of query aligns to 1:152/160 of 7dqxC
- binding fe2/s2 (inorganic) cluster: C42 (= C42), G45 (= G45), V46 (≠ L46), C47 (= C47), C50 (= C50), R60 (= R60), C62 (= C62), Q100 (= Q96), C101 (= C97), C104 (= C100), C137 (= C132), C139 (= C134)
- binding pterin cytosine dinucleotide: Q100 (= Q96), C139 (= C134)
1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
36% identity, 84% coverage: 8:148/168 of query aligns to 6:153/906 of 1dgjA
- binding fe2/s2 (inorganic) cluster: V38 (≠ Y40), G39 (= G41), C40 (= C42), G41 (= G43), G43 (= G45), Q44 (≠ L46), C45 (= C47), G46 (= G48), C48 (= C50), R58 (= R60), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C137 (= C132), C139 (= C134)
- binding pterin cytosine dinucleotide: Q99 (= Q96), C139 (= C134)
Sites not aligning to the query:
- active site: 391, 427, 503, 507, 535, 869, 870
- binding molybdenum (iv)oxide: 424, 535, 698, 869
- binding pterin cytosine dinucleotide: 423, 424, 535, 652, 655, 656, 657, 658, 697, 698, 700, 702, 703, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869
4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
34% identity, 90% coverage: 8:159/168 of query aligns to 6:168/907 of 4usaA
- binding fe2/s2 (inorganic) cluster: V38 (≠ Y40), C40 (= C42), E41 (≠ G43), G43 (= G45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (= R60), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C137 (= C132), C139 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q96), C139 (= C134)
Sites not aligning to the query:
- active site: 390, 425, 501, 505, 533, 869, 870
- binding bicarbonate ion: 460, 531, 532, 535, 539
- binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
- binding magnesium ion: 899, 903
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
34% identity, 90% coverage: 8:159/168 of query aligns to 6:168/907 of 4us9A
- binding fe2/s2 (inorganic) cluster: V38 (≠ Y40), C40 (= C42), E41 (≠ G43), G43 (= G45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (= R60), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C137 (= C132), C139 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q96), C139 (= C134)
Sites not aligning to the query:
- active site: 390, 425, 501, 505, 533, 869, 870
- binding 3-phenylpropanal: 255, 257, 258, 752
- binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
- binding magnesium ion: 899, 903
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
34% identity, 90% coverage: 8:159/168 of query aligns to 6:168/907 of 4us8A
- binding fe2/s2 (inorganic) cluster: V38 (≠ Y40), C40 (= C42), E41 (≠ G43), G43 (= G45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (= R60), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C137 (= C132), C139 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q96), C139 (= C134)
Sites not aligning to the query:
- active site: 390, 425, 501, 505, 533, 869, 870
- binding bicarbonate ion: 460, 498, 531, 532, 535, 539
- binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
34% identity, 90% coverage: 8:159/168 of query aligns to 6:168/907 of 4c7yA
- binding fe2/s2 (inorganic) cluster: C40 (= C42), E41 (≠ G43), G43 (= G45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (= R60), C60 (= C62), C100 (= C97), G101 (= G98), C103 (= C100), C137 (= C132), C139 (= C134)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q96), C139 (= C134)
Sites not aligning to the query:
- active site: 390, 425, 501, 505, 533, 869, 870
- binding bicarbonate ion: 460, 498, 531, 535, 539
- binding magnesium ion: 899, 903
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
- binding hydrogen peroxide: 696, 697, 869
Query Sequence
>5209813 FitnessBrowser__PV4:5209813
MSQSKLGLKINGKDYTLDADPNMPVLWAIRDLLGLTGTKYGCGAGLCGACTIHVDGEPAR
ACLTSLKQVQGKQVTTIEGLAADGLKQAWRDNNVPQCGYCQAGQLMSAAALLSQYPQPND
AQIEEAMVGNLCRCGTYTRIKAAIKQASGTSAQLDLNEREQSLREIEA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory