SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 5209866 FitnessBrowser__PV4:5209866 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7bw9A Crystal structure of serine acetyltransferase isoform 3 in complex with cysteine from entamoeba histolytica
42% identity, 64% coverage: 7:181/273 of query aligns to 103:272/280 of 7bw9A

query
sites
7bw9A

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binding cysteine: D114 (= D18), P115 (= P19), D179 (= D83), H180 (= H84), A206 (≠ G110), R214 (= R118), H215 (= H119)

6wyeA Crystal structure of neisseria gonorrhoeae serine acetyltransferase (cyse) (see paper)
42% identity, 64% coverage: 7:182/273 of query aligns to 82:261/261 of 6wyeA

query
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6wyeA

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binding (2S)-2-hydroxybutanedioic acid: D93 (= D18), P94 (= P19), D158 (= D83), H159 (= H84), G185 (= G110), R193 (= R118), H194 (= H119)

7ra4A Crystal structure of neisseria gonorrhoeae serine acetyltransferase (cyse) in complex with serine (see paper)
43% identity, 60% coverage: 7:170/273 of query aligns to 80:243/243 of 7ra4A

query
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7ra4A

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binding serine: D91 (= D18), P92 (= P19), D156 (= D83), H157 (= H84), R191 (= R118), H192 (= H119)

4n69A Soybean serine acetyltransferase complexed with serine (see paper)
46% identity, 59% coverage: 10:170/273 of query aligns to 83:243/243 of 4n69A

query
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4n69A

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binding serine: G183 (= G110), R191 (= R118), H192 (= H119)

3gvdI Crystal structure of serine acetyltransferase cyse from yersinia pestis
43% identity, 61% coverage: 10:176/273 of query aligns to 87:253/272 of 3gvdI

query
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3gvdI

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binding cysteine: D95 (= D18), P96 (= P19), D160 (= D83), G186 (= G109), G187 (= G110), R195 (= R118)

4hzdA Crystal structure of serine acetyltransferase in complex with coenzyme a from brucella abortus strain s19 (see paper)
41% identity, 59% coverage: 7:168/273 of query aligns to 81:242/250 of 4hzdA

query
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4hzdA

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binding coenzyme a: H158 (= H84), G203 (= G129), A204 (= A130), A221 (≠ G147), A222 (≠ S148), T235 (= T161), A237 (≠ V163)
binding magnesium ion: S224 (= S150), A237 (≠ V163), G238 (= G164)

Sites not aligning to the query:

binding coenzyme a: 244

4h7oA Crystal structure of serine acetyltransferase from vibrio cholerae o1 biovar el tor n16961
43% identity, 61% coverage: 10:176/273 of query aligns to 80:246/258 of 4h7oA

query
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4h7oA

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E

D

binding arginine: Y127 (≠ M57), Q131 (≠ F61)
binding cysteine: D88 (= D18), P89 (= P19), D153 (= D83), H154 (= H84), G180 (= G110), R188 (= R118), H189 (= H119)

Sites not aligning to the query:

binding arginine: 51, 53

1ssqD Serine acetyltransferase- complex with cysteine (see paper)
42% identity, 60% coverage: 10:172/273 of query aligns to 80:242/257 of 1ssqD

query
sites
1ssqD

D

D

I

I

A

Q

S

A

I

V

Y

R

H

H

R

R

D
|
D

P

P

A

A

A

V

N

E

G

L

T

W

L

S

E

T

I

P

L

L

L

L

N

Y

Y

L

P

K

G

G

M

F

Q

H

A

A

I

I

W

Q

I

S

H

Y

R

R

V

I

S

T

H

H

K

Y

L

L

W

W

K

N

A

Q

K

N

W

R

C

K

L

S

T

L

A

A

R

L

M

Y

I

L

S

Q

T

N

F

Q

S

I

R

S

W

V

L

A

T

F

G

D

V

V

E

D

I

I

H

H

P

P

G

A

A

A

T

K

I

I

G

G

D

H

R

G

F

I

F

M

I

F

D
|
D

H
|
H

G

A

M

T

G

G

V

I

V

V

I

V

G

G

E

E

T

T

A

S

E

V

I

I

G

E

N

N

D

D

C

V

T

S

L

I

Y

L

H

Q

G

G

V

V

T

T

L

L

G

G

G

G

T

T

T

G

W

K

Q

E

A

S

G

G

K

D

R

R

H

H

P

P

T

K

L

V

G

R

N

E

N

G

V

V

V

M

V

I

G

G

A

A

G

G

A

A

K

K

I

I

L

L

G

G

P

N

I

I

T

E

M

V

H

G

D

K

G

Y

A

A

R

K

V

I

G

G

S

A

N

N

S

S

V

V

V

V

V

L

K

N

E

P

V

V

P

P

K

E

D

Y

T

A

T

T

V

A

V

A

G

G

I

V

P

P

A

A

R

R

E

I

V

V

A

S

R

Q

binding cysteine: D88 (= D18), D153 (= D83), H154 (= H84)

1t3dA Crystal structure of serine acetyltransferase from e.Coli at 2.2a (see paper)
41% identity, 61% coverage: 10:176/273 of query aligns to 84:250/262 of 1t3dA

query
sites
1t3dA

D

D

I

I

A

Q

S

A

I

V

Y

R

H

T

R

R

D
|
D

P
|
P

A

A

A

V

N

D

G

K

T

Y

L

S

E

T

I

P

L

L

L

L

N

Y

Y

L

P

K

G

G

M

F

Q

H

A

A

I

L

W

Q

I

A

H

Y

R

R

V

I

S

G

H

H

K

W

L

L

W

W

K

N

A

Q

K

G

W

R

C

R

L

A

T

L

A

A

R

I

M

F

I

L

S

Q

T

N

F

Q

S

V

R

S

W

V

L

T

T

F

G

Q

V

V

E

D

I

I

H

H

P

P

G

A

A

A

T

K

I

I

G

G

D

R

R

G

F

I

F

M

I

L

D
|
D

H

H

G

A

M

T

G

G

V

I

V

V

I

V

G

G

E

E

T

T

A

A

E

V

I

I

G

E

N

N

D

D

C

V

T

S

L

I

Y

L

H

Q

G

S

V

V

T

T

L

L

G

G

G
|
G

T

T

T

G

W

K

Q

S

A

G

G

G

K

D

R
|
R

H
|
H

P

P

T

K

L

I

G

R

N

E

N

G

V

V

V

M

V

I

G

G

A

A

G

G

A

A

K

K

I

I

L

L

G

G

P

N

I

I

T

E

M

V

H

G

D

R

G

G

A

A

R

K

V

I

G

G

S

A

N

G

S

S

V

V

V

V

V

L

K

Q

E

P

V

V

P

P

K

P

D

H

T

T

T

T

V

A

V

A

G

G

I

V

P

P

A

A

R

R

E

I

V

V

A

G

R

K

P

P

S

D

E

S

E

D

binding cysteine: D92 (= D18), P93 (= P19), D157 (= D83), G184 (= G110), R192 (= R118), H193 (= H119)

4n6bA Soybean serine acetyltransferase complexed with coa (see paper)
49% identity, 52% coverage: 28:170/273 of query aligns to 94:233/233 of 4n6bA

query
sites
4n6bA

L

L

L

L

N

N

Y

Y

P

K

G

G

M

F

Q

L

A

A

I

C

W

Q

I

A

H

H

R

R

V

V

S

A

H

H

K

L

L

L

W

W

K

R

A

Q

K

S

-

R

-

R

-

P

-

L

-

A

W

L

C

A

L

L

T

H

A

S

R

R

M

I

I

A

S

N

T

V

F

F

S

A

R

-

W

-

L

-

T

-

G

-

V

V

E

D

I

I

H

H

P

P

G

A

A

A

T

R

I

I

G

G

D

K

R

G

F

I

F

L

I

F

D

D

H
|
H

G

A

M

T

G

G

V

V

V

V

I

V

G

G

E

E

T

T

A

A

E

V

I

I

G

G

N

N

D

N

C

V

T

S

L

I

Y
x
L

H

H

G

H

V

V

T

T

L

L

G

G

G
|
G

T

T

T

-

W

-

Q

-

A

G

G

G

K

D

R

R

H

H

P

P

T

K

L

I

G

G

N

D

N

G

V

V

V

L

V

I

G

G

A

A

G

G

A

A

K

T

I

I

L

L

G

G

P

N

I

I

T

K

M

I

H

G

D

E

G

G

A

A

R
x
K

V

V

G
|
G

S
x
A

N

G

S

S

V

V

V

V

V
x
L

K

I

E

D

V

V

P

P

K

P

D

R

T

T

T

T

V

A

V
|
V

G

G

I

N

P

P

A

A

R

R

E

L

V

V

binding coenzyme a: H150 (= H84), L169 (≠ Y103), G176 (= G110), K208 (≠ R145), G210 (= G147), A211 (≠ S148), L216 (≠ V153), V226 (= V163)

3p47A Crystal structure of entamoeba histolytica serine acetyltransferase 1 in complex with l-cysteine (see paper)
41% identity, 57% coverage: 7:162/273 of query aligns to 105:268/270 of 3p47A

query
sites
3p47A

I

L

K

K

D

T

D

D

I

L

A

I

S

A

I

A

Y

Y

H

A

R

G

D

D

P

P

A

A

A

A

N

P

G

G

T

L

L

S

E

L

I

I

L

I

L

R

N

C

Y

Y

P

P

G

G

M

F

Q

Q

A

A

I

V

W

I

I

V

H

Y

R

R

V

I

S

A

H

H

K

V

L

L

W

Y

K

E

A

C

K

G

W

E

C

R

L

Y

T

Y

A

C

R

R

M

E

I

M

S

M

T

E

F

S

S

V

R

H

W

S

L

Y

T

T

G

S

V

I

E

D

I

I

H

H

P

P

G

G

A

A

T

S

I

I

G

K

D

G

R

H

F

F

F

F

I

I

D

D

H

H

G

G

M

V

G

G

V

V

V

V

I

I

G

G

E

E

T

T

A

A

E

I

I

I

G

G

N

E

D

W

C

C

T

R

L

I

Y

Y

H

Q

G

S

V

V

T

T

L

L

G

G

G
x
A

T

M

T
x
H

W

F

Q

Q

-

E

-

E

-

G

-

G

-

V

-

I

-

K

-

R

A

G

G

T

K

K

R
|
R

H
|
H

P

P

T

T

L

V

G

G

N

D

N

Y

V

V

V

T

V

I

G

G

A

T

G

G

A

A

K

K

I

V

L

L

G

G

P

N

I

I

T

I

M

V

H

G

D

S

G

H

A

V

R

R

V

I

G

G

S

A

N

N

S

C

V

W

V

I

V

D

K

R

E

D

V

V

P

D

K

S

D

N

T

Q

T

T

V

V

binding cysteine: A208 (≠ G110), H210 (≠ T112), R224 (= R118), H225 (= H119)

3q1xA Crystal structure of entamoeba histolytica serine acetyltransferase 1 in complex with l-serine (see paper)
41% identity, 57% coverage: 7:162/273 of query aligns to 103:266/267 of 3q1xA

query
sites
3q1xA

I

L

K

K

D

T

D

D

I

L

A

I

S

A

I

A

Y

Y

H

A

R

G

D

D

P

P

A

A

A

A

N

P

G

G

T

L

L

S

E

L

I

I

L

I

L

R

N

C

Y

Y

P

P

G

G

M

F

Q

Q

A

A

I

V

W

I

I

V

H

Y

R

R

V

I

S

A

H

H

K

V

L

L

W

Y

K

E

A

C

K

G

W

E

C

R

L

Y

T

Y

A

C

R

R

M

E

I

M

S

M

T

E

F

S

S

V

R

H

W

S

L

Y

T

T

G

S

V

I

E

D

I

I

H

H

P

P

G

G

A

A

T

S

I

I

G

K

D

G

R

H

F

F

F

F

I

I

D

D

H

H

G

G

M

V

G

G

V

V

V

V

I

I

G

G

E

E

T

T

A

A

E

I

I

I

G

G

N

E

D

W

C

C

T

R

L

I

Y

Y

H

Q

G

S

V

V

T

T

L

L

G

G

G

A

T

M

T
x
H

W

F

Q

Q

-

E

-

E

-

G

-

G

-

V

-

I

-

K

-

R

A

G

G

T

K

K

R
|
R

H
|
H

P

P

T

T

L

V

G

G

N

D

N

Y

V

V

V

T

V

I

G

G

A

T

G

G

A

A

K

K

I

V

L

L

G

G

P

N

I

I

T

I

M

V

H

G

D

S

G

H

A

V

R

R

V

I

G

G

S

A

N

N

S

C

V

W

V

I

V

D

K

R

E

D

V

V

P

D

K

S

D

N

T

Q

T

T

V

V

binding serine: H208 (≠ T112), R222 (= R118), H223 (= H119)

8i04A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with serine (see paper)
42% identity, 61% coverage: 10:176/273 of query aligns to 80:246/258 of 8i04A

query
sites
8i04A

D

D

I

I

A

Q

S

A

I

V

Y

R

H

T

R

R

D
|
D

P
|
P

A

A

A

V

N

D

G

K

T

Y

L

S

E

T

I

P

L

L

L

L

N

Y

Y

L

P

K

G

G

M

F

Q

H

A

A

I

L

W

Q

I

A

H

Y

R

R

V

I

S

G

H

H

K

W

L

L

W

W

-

N

K

K

A

G

K

R

W

R

C

A

L

L

T

A

A

I

R

F

M

L

I

Q

S

N

T

Q

F

V

S

S

R

V

W

S

L

F

T

Q

G

-

V

V

E

D

I

I

H

H

P

P

G

A

A

A

T

K

I

I

G

G

D

R

R

G

F

I

F

M

I

L

D
|
D

H
|
H

G

A

M

T

G

G

V

I

V

V

I

V

G

G

E

E

T

T

A

A

E

V

I

I

G

E

N

D

D

D

C

V

T

S

L

I

Y

L

H

Q

G

S

V

V

T

T

L

L

G

G

G
|
G

T

T

T

G

W

K

Q

T

A

S

G

G

K

D

R
|
R

H
|
H

P

P

T

K

L

I

G

R

N

E

N

G

V

V

V

M

V

I

G

G

A

A

G

G

A

A

K

K

I

I

L

L

G

G

P

N

I

I

T

E

M

V

H

G

D

R

G

G

A

A

R

K

V

I

G

G

S

A

N

G

S

S

V

V

V

V

V

L

K

Q

E

P

V

V

P

P

K

P

D

H

T

T

T

T

V

A

V

A

G

G

I

V

P

P

A

A

R

R

E

I

V

V

A

G

R

K

P

P

S

G

E

S

E

D

binding serine: D88 (= D18), P89 (= P19), D153 (= D83), H154 (= H84), G180 (= G110), R188 (= R118), H189 (= H119)

8i09A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with butyl gallate (see paper)
41% identity, 63% coverage: 3:173/273 of query aligns to 76:246/246 of 8i09A

query
sites
8i09A

V

M

I

I

S

A

R

S

I

A

K

A

D

C

D

D

I

I

A

Q

S

A

I

V

Y

R

H

T

R

R

D
|
D

P

P

A

A

A

V

N

D

G

K

T

Y

L

S

E

T

I

P

L

L

L

L

N

Y

Y

L

P

K

G

G

M

F

Q

H

A

A

I

L

W

Q

I

A

H

Y

R

R

V

I

S

G

H

H

K

W

L

L

W

W

-

N

K

K

A

G

K

R

W

R

C

A

L

L

T

A

A

I

R

F

M

L

I

Q

S

N

T

Q

F

V

S

S

R

V

W

S

L

F

T

Q

G

-

V

V

E

D

I

I

H

H

P

P

G

A

A

A

T

K

I

I

G

G

D

R

R

G

F

I

F

M

I

L

D
|
D

H
|
H

G

A

M

T

G

G

V

I

V

V

I

V

G
|
G

E

E

T

T

A

A

E

V

I

I

G

E

N

D

D

D

C

V

T

S

L

I

Y

L

H

Q

G

S

V

V

T

T

L

L

G

G

G
|
G

T
|
T

T

G

W

K

Q

T

A

S

G

G

K

D

R
|
R

H
|
H

P

P

T

K

L

I

G

R

N

E

N

G

V

V

V

M

V

I

G
|
G

A

A

G

G

A

A

K

K

I

I

L

L

G

G

P

N

I

I

T

E

M

V

H

G

D

R

G

G

A

A

R
x
K

V
x
I

G
|
G

S

A

N

G

S

S

V

V

V

V

V
x
L

K

Q

E

P

V

V

P

P

K

P

D

H

T

T

T

T

V

A

V
x
A

G

G

I

V

P

P

A

A

R

R

E

I

V

V

A

G

R

K

P

P

binding cysteine: D91 (= D18), D156 (= D83), H157 (= H84), G164 (= G91), R191 (= R118), H192 (= H119)
binding butyl 3,4,5-tris(oxidanyl)benzoate: G183 (= G110), T184 (= T111), G202 (= G129), K218 (≠ R145), I219 (≠ V146), G220 (= G147), L226 (≠ V153), A236 (≠ V163)

8i06A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with coa (see paper)
41% identity, 62% coverage: 3:170/273 of query aligns to 77:244/244 of 8i06A

query
sites
8i06A

V

M

I

I

S

A

R

S

I

A

K

A

D

C

D

D

I

I

A

Q

S

A

I

V

Y

R

H

T

R

R

D

D

P
|
P

A

A

A

V

N

D

G

K

T

Y

L

S

E

T

I

P

L

L

L

L

N

Y

Y

L

P

K

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G

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F

Q

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A

A

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W

Q

I

A

H

Y

R

R

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I

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H

H

K

W

L

L

W

W

-

N

K

K

A

G

K

R

W

R

C

A

L

L

T

A

A

I

R

F

M

L

I

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N

T

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R

V

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S

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-

V

V

E

D

I

I

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P

G

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A

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K

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I

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H
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H

G

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M

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G

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I

V

V

I

V

G

G

E

E

T

T

A

A

E

V

I

I

G

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N

D

D

D

C

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T

S

L

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Y
x
L

H
x
Q

G

S

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V

T

T

L

L

G

G

G

G

T

T

T

G

W

K

Q

T

A

S

G

G

K

D

R

R

H

H

P

P

T

K

L

I

G

R

N

E

N

G

V

V

V

M

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I

G
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G

A
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A

G

G

A

A

K

K

I

I

L

L

G

G

P

N

I

I

T

E

M

V

H

G

D

R

G

G

A

A

R

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G

S
x
A

N

G

S

S

V

V

V

V

V

L

K

Q

E

P

V

V

P

P

K

P

D

H

T

T

T
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T

V

A

V
x
A

G

G

I

V

P

P

A

A

R

R

E

I

V

V

binding coenzyme a: H158 (= H84), L177 (≠ Y103), Q178 (≠ H104), G203 (= G129), A204 (= A130), G221 (= G147), A222 (≠ S148), T235 (= T161), A237 (≠ V163)
binding cysteine: P93 (= P19), H158 (= H84)

1sstA Serine acetyltransferase- complex with coa (see paper)
42% identity, 59% coverage: 10:170/273 of query aligns to 80:233/233 of 1sstA

query
sites
1sstA

D

D

I

I

A

Q

S

A

I

V

Y

R

H

H

R

R

D

D

P

P

A

A

A

V

N

E

G

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T

W

L

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N

Y

Y

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A

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K

N

W

R

C

K

L

S

T

L

A

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Y

I

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N

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V

E

D

I

I

H

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G

A

A

A

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K

I

I

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G

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H

R

G

F

I

F

M

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F

D

D

H
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H

G

A

M

T

G

G

V

I

V

V

I

V

G

G

E

E

T

T

A

S

E

V

I

I

G

E

N

N

D

D

C

V

T

S

L

I

Y
x
L

H

Q

G

G

V

V

T

T

L

L

G

G

G
|
G

T
|
T

T

-

W

-

Q

-

A

-

G

-

K

-

R

-

H

H

P

P

T

K

L

V

G

R

N

E

N

G

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V

V

M

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I

G

G

A
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A

G

G

A

A

K

K

I

I

L
|
L

G

G

P

N

I

I

T

E

M

V

H

G

D

K

G

Y

A

A

R
x
K

V

I

G
|
G

S
x
A

N

N

S

S

V
|
V

V

V

V
x
L

K

N

E

P

V

V

P

P

K

E

D

Y

T

A

T
|
T

V

A

V
x
A

G

G

I
x
V

P
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P

A

A

R

R

E

I

V
|
V

binding coenzyme a: H154 (= H84), L173 (≠ Y103), G180 (= G110), T181 (= T111), A193 (= A130), L198 (= L135), K208 (≠ R145), G210 (= G147), A211 (≠ S148), V214 (= V151), L216 (≠ V153), T224 (= T161), A226 (≠ V163), V228 (≠ I165), P229 (= P166), V233 (= V170)

7txsA X-ray structure of the viob n-aetyltransferase from acinetobacter baumannii in the presence of a reaction intermediate (see paper)
34% identity, 36% coverage: 70:168/273 of query aligns to 91:203/209 of 7txsA

query
sites
7txsA

I

I

H

D

P

P

G

T

A

A

T

T

I

I

G

G

D

E

R

N

F

I

F

H

I

I

D

E

H

E

G

G

-

T

-

M

-

I

-

C

-

A

-

G

-

G

-

I

-

L

-

T

M

V

G

D

V

V

V

K

I

L

G

G

E

K

T

H

A

C

E

I

I

V

G

N

N

T

D

N

C

A

T

V

L

L

Y

S

H

H

G

G

V

V

T

I

L

L

G

G

G

D

T

Y

T

V

W

T

Q

V

A

A

G
x
P

K

N

R

A

H

S

-

I

-

S

-

G

-

D

P

V

T

S

L

L

G

G

N

N

N

I

V

V

V

E

V

I

G
|
G

A
|
A

G

N

A

A

K

T

I

I

L

R

G

E

P

K

I

V

T

S

M

V

H

Q

D

D

G

G

A

A

R
x
M

V

V

G
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G

S
x
M

N

G

S

S

V

V

V

V

V

I

K

R

E

N

V

I

P

L

K

S

D

N

T

Q

T

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V

V

V
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V

G

G

I

N

P

P

A

A

R

K

binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-4-({3-[(2-{[(1S)-1-{[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-{[(R)-hydroxy{[(R)-hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methoxy}phosphoryl]oxy}phosphoryl]oxy}-2-methyloxan-3-yl]amino}ethyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (non-preferred name): P147 (≠ G116), G164 (= G129), A165 (= A130), M180 (≠ R145), G182 (= G147), M183 (≠ S148), V198 (= V163)

Sites not aligning to the query:

binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-4-({3-[(2-{[(1S)-1-{[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-{[(R)-hydroxy{[(R)-hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methoxy}phosphoryl]oxy}phosphoryl]oxy}-2-methyloxan-3-yl]amino}ethyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (non-preferred name): 10, 11, 12, 32, 33, 34, 37, 66, 67, 74, 75, 205

7txqA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in the present of tdp and acetyl-coenzymea (see paper)
34% identity, 36% coverage: 70:168/273 of query aligns to 91:203/209 of 7txqA

query
sites
7txqA

I

I

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M

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A

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G

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N

N

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x
P

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R

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H

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I

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S

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D

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L

L

G

G

N

N

N

I

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I

G
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G

A
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A

G

N

A

A

K

T

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G

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M

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G

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N

V

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V

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binding acetyl coenzyme *a: P147 (≠ G116), G164 (= G129), A165 (= A130), G182 (= G147), M183 (≠ S148), V198 (= V163)

Sites not aligning to the query:

binding acetyl coenzyme *a: 205
binding thymidine-5'-diphosphate: 10, 11, 12, 32, 33, 34, 37, 66, 67

7txpA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in complex with tdp-4-amino-4,6-dideoxy-d-glucose (see paper)
34% identity, 36% coverage: 70:168/273 of query aligns to 91:203/209 of 7txpA

query
sites
7txpA

I

I

H

D

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P

G

T

A

A

T

T

I

I

G

G

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R

N

F

I

F

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E

H

E

G

G

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T

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M

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I

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C

-

A

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G

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I

I

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N

N

T

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N

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L

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H

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G

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T

I

L

L

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T

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T

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A

A

G

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K

N

R

A

H

S

-

I

-

S

-

G

-

D

P

V

T

S

L

L

G

G

N

N

N

I

V

V

V

E

V

I

G

G

A

A

G

N

A

A

K

T

I

I

L

R

G

E

P

K

I

V

T

S

M

V

H

Q

D

D

G

G

A

A

R

M

V

V

G

G

S

M

N

G

S

S

V

V

V

V

V

I

K

R

E

N

V

I

P

L

K

S

D

N

T

Q

T

V

V

V

V

V

G

G

I

N

P

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A

A

R

K

Sites not aligning to the query:

binding dTDP-4-amino-4,6-dideoxyglucose: 10, 11, 12, 32, 33, 34, 37, 66, 67, 75

G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase; UDP-D-GlcNAc3NA N-acetyltransferase; UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid 3-N-acetyltransferase; EC 2.3.1.201 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
26% identity, 44% coverage: 61:179/273 of query aligns to 26:161/191 of G3XD01

query
sites
G3XD01

F

F

S

V

R

H

W

I

L

C

T

A

G

G

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A

E

R

I

I

H

G

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A

G

G

A

V

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S

I

L

G

G

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Q

R

N

F

V

F

F

I

V

D

-

H

-

G

G

M

N

G

K

V

V

V

V

I

I

G

G

E

D

T

R

A

C

E

K

I

I

G

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N

N

D

N

C

V

T

S

L

V

Y

Y

H

D

G

N

V

V

T

T

L

L

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E

G

E

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G

T

V

W

F

-

C

-

G

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P

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M

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V

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N

-

V

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N

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-

L

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I

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E

-

R

Q

K

A

D

G

Q

K

Y

R

R

H

N

P

T

T

L

L

V

G

K

N

K

N

G

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A

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G

G

A

A

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A

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M

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G

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A

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F

V

V

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G

S

A

N

G

S

A

V

V

V

I

V

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K
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K

E

N

V

V

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P

K

S

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Y

T

A

T

L

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M

V

V

G

G

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A

A

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A

G

R

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M

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S

E

E

E

F

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G

K

E

E

Q

K136 (= K154) mutation to A: Reduction in catalytic activity.; mutation to R: No effect on catalytic activity.

Query Sequence

>5209866 FitnessBrowser__PV4:5209866
MGVISRIKDDIASIYHRDPAANGTLEILLNYPGMQAIWIHRVSHKLWKAKWCLTARMIST
FSRWLTGVEIHPGATIGDRFFIDHGMGVVIGETAEIGNDCTLYHGVTLGGTTWQAGKRHP
TLGNNVVVGAGAKILGPITMHDGARVGSNSVVVKEVPKDTTVVGIPAREVARPSEEAKEH
VQRRTEMAKKYGFDAYAVSPDNPDPVANAIGKMLDHMHLMDSKVQEVCQAVQSMGGSVCT
ERLPELEVGEFSDAEQAAAEKRQQAIDEFDPII

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory