SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 6935814 Sama_0032 multifunctional fatty acid oxidation complex subunit alpha (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
61% identity, 100% coverage: 1:714/716 of query aligns to 1:715/719 of 6tnmA

query
sites
6tnmA

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active site: A68 (= A67), F73 (= F72), G116 (= G115), E119 (= E118), P138 (= P137), E139 (= E138), G147 (= G146), N271 (≠ V270), S429 (= S428), H450 (= H449), E462 (= E461), N500 (= N499)
binding adenosine-5'-triphosphate: D343 (= D342), I344 (= I343), V400 (= V399), V401 (= V400), V406 (= V405), K584 (= K583)

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
61% identity, 100% coverage: 1:714/716 of query aligns to 1:715/729 of P21177

query
sites
P21177

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D

V

A

M

L

Y

F

E

D

A

A

G

N

R

R

L

F

G

G

Q

Q

K

K

N

N

G

G

K

L

G

G

F

F

Y

W

Q

R

Y

Y

S

K

I

E

D

D

K

S

R

K

G

G

K

K

P

P

K

K

K

K

D

E

V

E

D

D

P

A

A

A

S

V

Y

E

T

D

M

L

L

L

A

A

E

E

A

V

F

S

G

Q

A

P

Q

K

K

R

A

D

F

F

E

S

A

E

D

E

E

E

I

I

I

I

A

A

R

R

T

M

M

M

I

I

P

P

M

M

I

V

I

N

E

E

T

V

V

V

R

R

C

C

L

L

E

E

E

E

G

G

I

I

V

I

A

A

S

T

P

P

A

A

E

E

A

A

D

D

M

M

G

A

L

L

V

V

Y

Y

G

G

L

L

G

G

F

F

P

P

P

P

F

F

R

H

G

G

G

G

V

A

F

F

R

R

Y

W

L

L

D

D

T

T

M

L

G

G

V

S

A

A

N

K

F

Y

V

L

A

D

L

M

A

A

D

Q

K

Q

Y

Y

A

Q

H

H

L

L

G

G

G

P

L

L

Y

Y

Q

E

V

V

T

P

D

E

A

G

M

L

R

R

E

N

L

K

A

A

S

R

N

H

N

N

G

E

S

P

Y

Y

Y

Y

P

P

G116 (= G115) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
G322 (= G321) mutation to A: 10-fold increase in KM for NADH.
H450 (= H449) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
61% identity, 100% coverage: 1:713/716 of query aligns to 1:714/715 of 1wdlA

query
sites
1wdlA

M

M

I

I

Y

Y

Q

E

S

G

P

K

T

A

I

I

Q

T

V

V

E

T

L

A

T

L

A

E

D

S

K

G

I

I

A

V

R

E

L

L

C

K

F

F

N

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

F

F

D

N

R

R

E

L

T

T

L

L

A

N

S

E

L

L

N

R

A

Q

A

A

L

V

D

D

V

A

L

I

K

K

-

A

D

D

S

A

D

S

A

V

K

K

A

G

A

V

V

I

L

V

T

S

S

S

G

G

K

K

D

D

T

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

A

E

L

N

F

F

A

K

E

L

E

P

D

D

A

A

K

E

L

L

M

I

E

A

W

G

I
x
N

A

L

Q

E

A

A

N
|
N

V

K

V

I

F

F

N

S

K

D

L

F

E

E

D

D

L

L

P

N

F

V

P

P

T

T

V

V

S

A

A

A

I

I

K

N

G

G

F

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

A

M

I

C

L

L

A

A

T

A

D

D

F

F

R

R

V

V

A

M

D

A

T

D

S

S

A

A

K

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K

K

L

L

G

G

L

I

I

Y

P
|
P

G
|
G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

D

N

N

A

A

L

V

E

E

W

W

I

I

T

A

T

S

G

G

K

K

D

E

Q

N

R

R

P

A

E

E

D

D

A

A

L

L

K

K

V

V

G

S

A

A

I

V

D

D

A

A

V

V

V

V

A

T

P

A

E

D

N

K

L

L

E

G

A

A

A

A

A

A

I

L

Q

D

M

L

L

I

N

K

D

R

A

A

L

I

A

S

G

G

K

E

L

L

D

D

W

Y

Q

K

A

A

R

K

R

R

A

Q

R

P

K

K

Q

L

A

E

P

K

L

L

T

K

L

L

P

N

K

A

L

I

E

E

A

Q

M

M

M

M

S

A

F

F

T

E

T

T

A

A

K

K

G

G

M

F

V

V

Y

A

A

G

V

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

M

V

A

E

A

A

V

I

S

K

V

T

V

I

E

Q

Q

K

A

A

A

A

G

N

M

F

S

G

R

R

A

D

E

K

A

A

L

L

V

E

V

V

E

E

H

A

N

A

A

G

F

F

I

A

K

K

L

L

A

A

K

K

T

T

D

S

V

A

A

S

T

N

A

C

L

L

I

I

G

G

I

L

F

F

L

L

N

N

D

D

Q

Q

L

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

A

Y

S

D

K

K

L

I

A

A

K

K

D

D

I

V

K

K

H

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

S

K

K

G

G

T

T

P

P

I

I

V

L

M

M

K

K

D
|
D

I
|
I

N

N

Q

E

A

H

A

G

L

I

D

E

L

Q

G

G

V

L

N

A

E

E

A

A

A

A

K

K

L

L

L

L

S

V

A

G

Q

R

V

V

A

D

R

K

G

G

R

R

S

M

T

T

P

P

D

A

K

K

M

M

A

A

K

E

V

V

L

L

N

N

N

G

I

I

T

R

P

P

A

T

L

L

D

S

Y

Y

A

G

P

D

L

F

K

G

D

N

V

V

N

D

V

L

V

V

V

V

E

E

A
|
A

V
|
V

V
|
V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

A

Q

M

A

V
|
V

L

L

A

A

D

E

V

V

E

E

N

N

V

H

V

V

A

R

D

E

D

D

A

A

I

I

I

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

S

S

I

I

D

S

L

L

L

L

A

A

K

K

S

A

L

L

K

K

N

R

P

P

A

E

R

N

F

F

C

V

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

H

H

K

M

M

M

P

P

L

L

V

V

E
|
E

V

V

I

I

R

R

G

G

K

E

D

K

T

S

S

S

E

D

E

L

T

A

V

V

A

A

S

T

V

T

V

V

A

A

Y

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

N

A

G

K

L

L

L

V

A

S

D

A

G

G

G

V

D

D

F

F

A

V

A

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V

V

G

G

L

I

D

D

T

T

G

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

D

E

G

G

F

F

P

P

D

D

R

R

M

M

G

K

K

D

S

D

D

R

K

R

D

S

A

A

I

I

D

D

V

A

M

L

Y

Y

E

E

A

A

G

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

Q

A

Y

Y

S

E

I

A

D

D

K

K

R

K

G

G

K

K

P

Q

K

K

K

K

D

L

V

V

D

D

P

S

A

S

S

V

Y

L

T

E

M

V

L

L

A

K

E

P

A

I

F

V

G

Y

A

E

Q

Q

K

R

A

D

F

V

E

T

A

D

D

E

E

D

I

I

I

I

A

N

R

W

T

M

M

M

I

I

P

P

M

L

I

C

I

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

V

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V

V

Y

Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

V

A

F

L

R

R

Y

Y

L

I

D

D

T

S

M

I

G

G

V

V

A

A

N

E

F

F

V

V

A

A

L

L

A

A

D

D

K

Q

Y

Y

A

A

H

E

L

L

G

G

G

A

L

L

Y

Y

Q

H

V

P

T

T

D

A

A

K

M

L

R

R

E

E

L

M

A

A

S

K

N

N

N

G

G

Q

S

S

Y

F

Y

F

active site: A69 (= A67), N89 (≠ I87), N93 (= N91), G117 (= G115), E120 (= E118), P139 (= P137), E140 (= E138), P147 (= P145), G148 (= G146), S430 (= S428), H451 (= H449), E463 (= E461), N501 (= N499)
binding nicotinamide-adenine-dinucleotide: G321 (= G319), A322 (= A320), I324 (= I322), M325 (= M323), D344 (= D342), I345 (= I343), A400 (= A398), V401 (= V399), V402 (= V400), E403 (= E401), K408 (= K406), V411 (= V409), N428 (= N426), T429 (= T427), S430 (= S428)

P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
61% identity, 100% coverage: 1:713/716 of query aligns to 1:714/715 of P28793

query
sites
P28793

M

M

I

I

Y

Y

Q

E

S

G

P

K

T

A

I

I

Q

T

V

V

E

T

L

A

T

L

A

E

D

S

K

G

I

I

A

V

R

E

L

L

C

K

F

F

N

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

F

F

D

N

R

R

E

L

T

T

L

L

A

N

S

E

L

L

N

R

A

Q

A

A

L

V

D

D

V

A

L

I

K

K

-

A

D

D

S

A

D

S

A

V

K

K

A

G

A

V

V

I

L

V

T

S

S

S

G

G

K

K

D

D

T

V

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

L

V

A

E

L

N

F

F

A

K

E

L

E

P

D

D

A

A

K

E

L

L

M

I

E

A

W

G

I

N

A

L

Q

E

A

A

N

N

V

K

V

I

F

F

N

S

K

D

L

F

E

E

D

D

L

L

P

N

F

V

P

P

T

T

V

V

S

A

A

A

I

I

K

N

G

G

F

I

A

A

L

L

G

G

G

G

G

G

C

L

E

E

A

M

I

C

L

L

A

A

T

A

D

D

F

F

R

R

V

V

A

M

D

A

T

D

S

S

A

A

K

K

I

I

G

G

L

L

P

P

E

E

T

V

K

K

L

L

G

G

L

I

I

Y

P

P

G

G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

D

N

N

A

A

L

V

E

E

W

W

I

I

T

A

T

S

G

G

K

K

D

E

Q

N

R

R

P

A

E

E

D

D

A

A

L

L

K

K

V

V

G

S

A

A

I

V

D

D

A

A

V

V

V

V

A

T

P

A

E

D

N

K

L

L

E

G

A

A

A

A

A

A

I

L

Q

D

M

L

L

I

N

K

D

R

A

A

L

I

A

S

G

G

K

E

L

L

D

D

W

Y

Q

K

A

A

R

K

R

R

A

Q

R

P

K

K

Q

L

A

E

P

K

L

L

T

K

L

L

P

N

K

A

L

I

E

E

A

Q

M

M

M

M

S

A

F

F

T

E

T

T

A

A

K

K

G

G

M

F

V

V

Y

A

A

G

V

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

M

V

A

E

A

A

V

I

S

K

V

T

V

I

E

Q

Q

K

A

A

A

A

G

N

M

F

S

G

R

R

A

D

E

K

A

A

L

L

V

E

V

V

E

E

H

A

N

A

A

G

F

F

I

A

K

K

L

L

A

A

K

K

T

T

D

S

V

A

A

S

T

N

A

C

L

L

I

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

L

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

A

Y

S

D

K

K

L

I

A

A

K

K

D

D

I

V

K

K

H

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

S

K

K

G

G

T

T

P

P

I

I

V

L

M

M

K

K

D
|
D

I

I

N

N

Q

E

A

H

A

G

L

I

D

E

L

Q

G

G

V

L

N

A

E

E

A

A

A

A

K

K

L

L

L

L

S

V

A

G

Q

R

V

V

A

D

R

K

G

G

R

R

S

M

T

T

P

P

D

A

K

K

M

M

A

A

K

E

V

V

L

L

N

N

N

G

I

I

T

R

P

P

A

T

L

L

D

S

Y

Y

A

G

P

D

L

F

K

G

D

N

V

V

N

D

V

L

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

A

Q

M

A

V

V

L

L

A

A

D

E

V

V

E

E

N

N

V

H

V

V

A

R

D

E

D

D

A

A

I

I

I

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

S

S

I

I

D

S

L

L

L

L

A

A

K

K

S

A

L

L

K

K

N

R

P

P

A

E

R

N

F

F

C

V

G

G

M

M

H

H

F

F

F

F

N
|
N

P

P

V

V

H

H

K

M

M

M

P

P

L

L

V

V

E

E

V

V

I

I

R

R

G

G

K

E

D

K

T

S

S

S

E

D

E

L

T

A

V

V

A

A

S

T

V

T

V

V

A

A

Y

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

N

A

G

K

L

L

L

V

A

S

D

A

G

G

G

V

D

D

F

F

A

V

A

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V

V

G

G

L

I

D

D

T

T

G

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

D

E

G

G

F

F

P

P

D

D

R

R

M

M

G

K

K

D

S

D

D

R

K

R

D

S

A

A

I

I

D

D

V

A

M

L

Y

Y

E

E

A

A

G

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

Q

A

Y

Y

S

E

I

A

D

D

K

K

R

K

G

G

K

K

P

Q

K

K

K

K

D

L

V

V

D

D

P

S

A

S

S

V

Y

L

T

E

M

V

L

L

A

K

E

P

A

I

F

V

G

Y

A

E

Q

Q

K

R

A

D

F

V

E

T

A

D

D

E

E

D

I

I

I

I

A

N

R

W

T

M

M

M

I

I

P

P

M

L

I

C

I

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

V

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V

V

Y
|
Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

V

A

F

L

R

R

Y

Y

L

I

D

D

T

S

M

I

G

G

V

V

A

A

N

E

F

F

V

V

A

A

L

L

A

A

D

D

K

Q

Y

Y

A

A

H

E

L

L

G

G

G

A

L

L

Y

Y

Q

H

V

P

T

T

D

A

A

K

M

L

R

R

E

E

L

M

A

A

S

K

N

N

N

G

G

Q

S

S

Y

F

Y

F

D297 (= D295) binding
M325 (= M323) binding
D344 (= D342) binding
VVE 401:403 (= VVE 399:401) binding
K408 (= K406) binding
S430 (= S428) binding
N454 (= N452) binding
N501 (= N499) binding
Y660 (= Y659) binding

1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
60% identity, 100% coverage: 1:713/716 of query aligns to 1:706/707 of 1wdmA

query
sites
1wdmA

M

M

I

I

Y

Y

Q

E

S

G

P

K

T

A

I

I

Q

T

V

V

E

T

L

A

T

L

A

E

D

S

K

G

I

I

A

V

R

E

L

L

C

K

F

F

N

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

F

F

D

N

R

R

E

L

T

T

L

L

A

N

S

E

L

L

N

R

A

Q

A

A

L

V

D

D

V

A

L

I

K

K

-

A

D

D

S

A

D

S

A

V

K

K

A

G

A

V

V

I

L

V

T

S

S

S

G

G

K

K

D

D

T

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

A

E

L

N

F

F

A

K

E

L

E

P

D

D

A

A

K

E

L

L

M

I

E

A

W

G

I
x
N

A

L

Q

E

A

A

N
|
N

V

K

V

I

F

F

N

S

K

D

L

F

E

E

D

D

L

L

P

N

F

V

P

P

T

T

V

V

S

A

A

A

I

I

K

N

G

G

F

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

A

M

I

C

L

L

A

A

T

A

D

D

F

F

R

R

V

V

A

M

D

A

T

D

S

S

A

A

K

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K
|
K

L

L

G

G

L

I

I

Y

P
|
P

G
|
G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

D

N

N

A

A

L

V

E

E

W

W

I

I

T

A

T

S

G

G

K

K

D

E

Q

N

R

R

P

A

E

E

D

D

A

A

L

L

K

K

V

V

G

S

A

A

I

V

D

D

A

A

V

V

V

V

A

T

P

A

E

D

N

K

L

L

E

G

A

A

A

A

A

A

I

L

Q

D

M

L

L

I

N

K

D

R

A

A

L

I

A

S

G

G

K

E

L

L

D

D

W

Y

Q

K

A

A

R

K

R

R

A

Q

R

P

K

K

Q

L

A

E

P

K

L

L

T

K

L

L

P

N

K

A

L

I

E

E

A

Q

M

M

M

M

S

A

F

F

T

E

T

T

A

A

K

K

G

G

M

F

V

V

Y

A

A

G

V

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

M

V

A

E

A

A

V

I

S

K

V

T

V

I

E

Q

Q

K

A

A

A

A

G

N

M

F

S

G

R

R

A

D

E

K

A

A

L

L

V

E

V

V

E

E

H

A

N

A

A

G

F

F

I

A

K

K

L

L

A

A

K

K

T

T

D

S

V

A

A

S

T

N

A

C

L

L

I

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

L

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

A

Y

S

D

K

K

L

I

A

A

K

K

D

D

I

V

K

K

H

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

S

K

K

G

G

T

T

P

P

I

I

V

L

M

M

K
|
K

D
|
D

I
|
I

N

N

Q

E

A

H

A

G

L

I

D

E

L

Q

G

G

V

L

N

A

E

E

A

A

A

A

K

K

L

L

L

L

S

V

A

G

Q

R

V

V

A

D

R

K

G

G

R

R

S

M

T

T

P

P

D

A

K

K

M

M

A

A

K

E

V

V

L

L

N

N

N

G

I

I

T

R

P

P

A

T

L

L

D

S

Y

Y

A

G

P

D

L

F

K

G

D

N

V

V

N

D

V

L

V

V

V

V

E

E

A
|
A

V
|
V

V

V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

A

Q

M

A

V

V

L

L

A

A

D

E

V

V

E

E

N

N

V

H

V

V

A

R

D

E

D

D

A

A

I

I

I

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

S

S

I

I

D

S

L

L

L

L

A

A

K

K

S

A

L

L

K

K

N

R

P

P

A

E

R

N

F

F

C

V

G

G

M

M

H
|
H

F
|
F

F

F

N
|
N

P

P

V

V

H

H

K

M

M
|
M

P

P

L

L

V

V

E
|
E

V

V

I

I

R

R

G

G

K

E

D

K

T

S

S

S

E

D

E

L

T

A

V

V

A

A

S

T

V

T

V

V

A

A

Y

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

N

A

G

K

L

L

L

V

A

S

D

A

G

G

G

V

D

D

F

F

A

V

A

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P
|
P

M
|
M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V
|
V

G

G

L

I

D

D

T

T

G

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

D

E

G

G

F

F

P

P

D

D

R

R

M

M

G

K

K

D

S

D

D

R

K

R

D

S

A

A

I

I

D

D

V

A

M

L

Y

Y

E

E

A

A

G

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

Q

A

Y

Y

S

-

I

-

D

-

K

-

R

-

G

-

K

-

P

-

K

K

K

K

D

L

V

V

D

D

P

S

A

S

S

V

Y

L

T

E

M

V

L

L

A

K

E

P

A

I

F

V

G

Y

A

E

Q

Q

K

R

A

D

F

V

E

T

A

D

D

E

E

D

I

I

I

I

A

N

R

W

T

M

M

M

I

I

P

P

M

L

I

C

I

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

V

V

A

E

S

T

P

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V
|
V

Y
|
Y

G

G

L

I

G
|
G

F

F

P

P

P
x
L

F

F

R

R

G

G

G

G

V

A

F

L

R

R

Y

Y

L

I

D

D

T

S

M

I

G

G

V

V

A

A

N

E

F

F

V

V

A

A

L

L

A

A

D

D

K

Q

Y

Y

A

A

H

E

L

L

G

G

G

A

L

L

Y

Y

Q

H

V

P

T

T

D

A

A

K

M

L

R

R

E

E

L

M

A

A

S

K

N

N

N

G

G

Q

S

S

Y

F

Y

F

active site: A69 (= A67), N89 (≠ I87), N93 (= N91), G117 (= G115), E120 (= E118), P139 (= P137), E140 (= E138), P147 (= P145), G148 (= G146), S430 (= S428), H451 (= H449), E463 (= E461), N501 (= N499)
binding acetyl coenzyme *a: K142 (= K140), D297 (= D295), M459 (= M457), N501 (= N499), P534 (= P533), M535 (= M534), V544 (= V543), V651 (= V658), Y652 (= Y659), G655 (= G662), L658 (≠ P665)
binding nicotinamide-adenine-dinucleotide: G321 (= G319), A322 (= A320), I324 (= I322), M325 (= M323), K343 (= K341), D344 (= D342), I345 (= I343), A400 (= A398), V401 (= V399), E403 (= E401), K408 (= K406), N428 (= N426), T429 (= T427), S430 (= S428), F452 (= F450), N454 (= N452)

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
35% identity, 94% coverage: 17:689/716 of query aligns to 49:736/763 of P40939

query
sites
P40939

I

V

A

A

R

V

L

V

C

R

F

I

N

N

A

S

P

P

G

N

S

S

-

K

V

V

N

N

K

T

F

L

D

S

R

K

E

E

T

L

L

H

A

S

S

E

L

F

N

S

A

E

A

V

L

M

D

N

V

E

L

I

K

W

D

A

S

S

D

D

A

Q

-

I

K

R

A

S

A

A

V

V

L

L

T

I

S

S

G

S

K

K

-

P

D

G

T

C

F

F

I

I

V

A

G

G

A

A

D

D

I

I

T

N

E

M

F

L

L

A

A

A

L

C

F

K

A

T

E

L

E

Q

D

E

A

V

K

T

L

Q

M

L

E

S

W

Q

I

E

A

A

Q

Q

A

R

N

-

V

-

V

I

F

V

N

E

K

K

L

L

E

E

D

K

L

S

P

T

F

K

P

P

T

I

V

V

S

A

A

A

I

I

K

N

G

G

F

S

A

C

L

L

G

G

G

G

G

G

C

L

E

E

A

V

I

A

L

I

A

S

T

C

D

Q

F

Y

R

R

V

I

A

A

-

T

-

K

D

D

T

R

S

K

A

T

K

V

I

L

G

G

L

T

P

P

E

E

T

V

K

L

L

L

G

G

L

A

I

L

P

P

G

G

F

A

G

G

G

G

T

T

V

Q

R

R

L

L

P

P

R

K

L

M

I

V

G

G

A

V

D

P

N

A

A

A

L

L

E

D

W

M

I

M

T

L

T

T

G

G

K

R

D

S

Q

I

R

R

P

A

E

D

D

R

A

A

L

K

K

K

V

M

G

G

A

L

I

V

D

D

A

Q

V

L

V

V

A

E

P

P

-

L

-

G

-

P

-

G

-

L

-

K

-

P

-

P

-

E

-

E

-

R

-

T

-

I

E

E

N

Y

L

L

E

E

A

E

A

V

A

A

I

I

Q

T

-

F

-

A

-

K

-

G

M

L

L

A

N

D

D

K

A

K

L

I

A

S

G

P

K

K

L

R

D

D

W

K

Q

G

A

L

R

V

R

E

A

K

R

L

K

T

Q

A

A

Y

P

A

L

M

T

T

L

I

P

P

K

F

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V282 (≠ M230) to D: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
I305 (≠ V254) to N: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
L342 (≠ I291) to P: in LCHAD deficiency; dbSNP:rs137852772
E510 (= E461) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769

6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
35% identity, 99% coverage: 7:713/716 of query aligns to 5:703/707 of 6yswA

query
sites
6yswA

T

T

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