Comparing 6936141 FitnessBrowser__SB2B:6936141 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
45% identity, 95% coverage: 4:194/201 of query aligns to 540:725/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
39% identity, 100% coverage: 1:200/201 of query aligns to 1:191/198 of P9WK95
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
34% identity, 78% coverage: 18:174/201 of query aligns to 13:157/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
34% identity, 78% coverage: 18:174/201 of query aligns to 13:157/167 of 2pkpA
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
43% identity, 28% coverage: 72:127/201 of query aligns to 658:713/780 of P20004
Sites not aligning to the query:
5acnA Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 631:686/754 of 5acnA
Sites not aligning to the query:
P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 3 papers)
41% identity, 28% coverage: 72:127/201 of query aligns to 658:713/781 of P16276
Sites not aligning to the query:
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 630:685/753 of 8acnA
Sites not aligning to the query:
1fghA Complex with 4-hydroxy-trans-aconitate (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 630:685/753 of 1fghA
Sites not aligning to the query:
1amjA Steric and conformational features of the aconitase mechanism (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 630:685/753 of 1amjA
Sites not aligning to the query:
1amiA Steric and conformational features of the aconitase mechanism (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 630:685/753 of 1amiA
Sites not aligning to the query:
1acoA Crystal structure of aconitase with transaconitate bound (see paper)
41% identity, 28% coverage: 72:127/201 of query aligns to 630:685/753 of 1acoA
Sites not aligning to the query:
>6936141 FitnessBrowser__SB2B:6936141
MQAFTTHTGLAVAIDSANIDTDQIIPKQFLSKVTKDGFGIHLFHDWRYLDDAGDIPNPEF
NLNKPRYKGATILLAQENFGCGSSREHAPWALADFGLRAIIAPTFADIFYGNAINNGLLP
VRLPEAAVRQLMDEVEANEGAEVTVDLENLKVVSPSGAEFSFTLAESARQNLLKGLDAIG
LTLAHEAAISEYESRIPAWRR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory