SitesBLAST
Comparing 6936188 FitnessBrowser__SB2B:6936188 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
88% identity, 100% coverage: 1:475/476 of query aligns to 1:474/474 of P0A9P0
- M1 (= M1) modified: Initiator methionine, Removed
- K220 (= K221) modified: N6-acetyllysine
4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
88% identity, 99% coverage: 2:473/476 of query aligns to 1:471/471 of 4jdrA
- active site: P15 (= P16), L40 (= L41), C44 (= C45), C49 (= C50), S52 (= S53), E77 (= E78), P78 (= P79), I184 (= I186), E188 (= E190), V324 (= V326), H442 (= H444), H444 (= H446), E449 (= E451), N467 (= N469), P468 (= P470)
- binding flavin-adenine dinucleotide: G12 (= G13), G14 (= G15), P15 (= P16), A16 (= A17), E35 (= E36), R36 (= R37), Y37 (≠ F38), V43 (= V44), C44 (= C45), G48 (= G49), C49 (= C50), K53 (= K54), L115 (= L116), G116 (= G117), A144 (= A146), G145 (= G147), I185 (= I187), G311 (= G313), D312 (= D314), M318 (= M320), L319 (= L321), A320 (= A322), H321 (= H323)
1bhyA Low temperature middle resolution structure of p64k from masc data (see paper)
63% identity, 95% coverage: 19:471/476 of query aligns to 19:481/482 of 1bhyA
- active site: L41 (= L41), C45 (= C45), C50 (= C50), S53 (= S53), I195 (= I186), E199 (= E190), H454 (= H444), H456 (= H446), E461 (= E451), P479 (≠ N469), Q480 (≠ P470)
- binding flavin-adenine dinucleotide: E36 (= E36), R37 (= R37), Y38 (≠ F38), G43 (= G43), V44 (= V44), C45 (= C45), G49 (= G49), C50 (= C50), K54 (= K54), D116 (≠ L116), G117 (= G117), Y135 (vs. gap), A156 (= A146), G157 (= G147), D324 (= D314), L331 (= L321), A332 (= A322)
Sites not aligning to the query:
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
46% identity, 94% coverage: 9:457/476 of query aligns to 9:459/470 of 6uziC
- active site: C45 (= C45), C50 (= C50), S53 (= S53), V187 (≠ I186), E191 (= E190), H448 (= H446), E453 (= E451)
- binding flavin-adenine dinucleotide: I12 (≠ L12), G13 (= G13), G15 (= G15), P16 (= P16), G17 (≠ A17), E36 (= E36), K37 (≠ R37), G43 (= G43), T44 (≠ V44), C45 (= C45), G49 (= G49), C50 (= C50), S53 (= S53), K54 (= K54), V117 (≠ L116), G118 (= G117), T147 (≠ A146), G148 (= G147), I188 (= I187), R276 (= R274), D316 (= D314), M322 (= M320), L323 (= L321), A324 (= A322)
- binding zinc ion: H448 (= H446), E453 (= E451)
1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
46% identity, 96% coverage: 5:459/476 of query aligns to 2:453/455 of 1ebdA
- active site: P13 (= P16), L37 (= L41), C41 (= C45), C46 (= C50), S49 (= S53), N74 (≠ E78), V75 (≠ P79), Y180 (≠ I186), E184 (= E190), S320 (≠ V326), H438 (= H444), H440 (= H446), E445 (= E451)
- binding flavin-adenine dinucleotide: G10 (= G13), G12 (= G15), P13 (= P16), V32 (≠ I35), E33 (= E36), K34 (≠ R37), G39 (= G43), V40 (= V44), C41 (= C45), G45 (= G49), C46 (= C50), K50 (= K54), E112 (≠ L116), A113 (≠ G117), T141 (≠ A146), G142 (= G147), Y180 (≠ I186), I181 (= I187), R268 (= R274), D308 (= D314), A314 (≠ M320), L315 (= L321), A316 (= A322)
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
45% identity, 96% coverage: 5:463/476 of query aligns to 8:463/470 of P11959
- 39:47 (vs. 36:45, 60% identical) binding FAD
- K56 (= K54) binding FAD
- D314 (= D314) binding FAD
- A322 (= A322) binding FAD
P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
42% identity, 98% coverage: 6:473/476 of query aligns to 4:478/478 of P14218
- 34:49 (vs. 36:45, 31% identical) binding FAD
- C49 (= C45) modified: Disulfide link with 54, Redox-active
- C54 (= C50) modified: Disulfide link with 49, Redox-active
- K58 (= K54) binding FAD
- G122 (= G117) binding FAD
- D319 (= D314) binding FAD
- A327 (= A322) binding FAD
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
42% identity, 97% coverage: 6:469/476 of query aligns to 3:473/473 of 5u8wA
- active site: P13 (= P16), L44 (= L41), C48 (= C45), C53 (= C50), S56 (= S53), G82 (≠ E78), V83 (≠ P79), V190 (≠ I186), E194 (= E190), S330 (≠ V326), F448 (≠ H444), H450 (= H446), E455 (= E451), N473 (= N469)
- binding flavin-adenine dinucleotide: I9 (≠ L12), G12 (= G15), P13 (= P16), G14 (≠ A17), E33 (= E36), K34 (≠ R37), G46 (= G43), T47 (≠ V44), C48 (= C45), G52 (= G49), C53 (= C50), K57 (= K54), H120 (≠ L116), G121 (= G117), A149 (= A145), S150 (≠ A146), G151 (= G147), S170 (= S166), G317 (= G313), D318 (= D314), M324 (= M320), L325 (= L321), A326 (= A322), H327 (= H323), Y357 (= Y353), H450 (= H446), P451 (= P447)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ M182), G189 (= G185), V190 (≠ I186), I191 (= I187), E194 (= E190), E210 (= E206), A211 (≠ M207), L212 (≠ F208), A275 (= A271), V276 (≠ I272), G277 (= G273), R278 (= R274), M324 (= M320), L325 (= L321), V355 (≠ I351), Y357 (= Y353)
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
42% identity, 97% coverage: 6:469/476 of query aligns to 2:472/472 of 5u8vA
- active site: P12 (= P16), L43 (= L41), C47 (= C45), C52 (= C50), S55 (= S53), G81 (≠ E78), V82 (≠ P79), V189 (≠ I186), E193 (= E190), S329 (≠ V326), F447 (≠ H444), H449 (= H446), E454 (= E451), N472 (= N469)
- binding flavin-adenine dinucleotide: I8 (≠ L12), G11 (= G15), P12 (= P16), G13 (≠ A17), E32 (= E36), G45 (= G43), T46 (≠ V44), C47 (= C45), G51 (= G49), C52 (= C50), K56 (= K54), H119 (≠ L116), G120 (= G117), A148 (= A145), S149 (≠ A146), G150 (= G147), S169 (= S166), I190 (= I187), R277 (= R274), G316 (= G313), D317 (= D314), M323 (= M320), L324 (= L321), A325 (= A322), H326 (= H323), H449 (= H446), P450 (= P447)
- binding nicotinamide-adenine-dinucleotide: I185 (≠ M182), G186 (= G183), G188 (= G185), V189 (≠ I186), I190 (= I187), L208 (≠ V205), E209 (= E206), A210 (≠ M207), V243 (= V239), V275 (≠ I272), G276 (= G273)
5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
42% identity, 97% coverage: 6:469/476 of query aligns to 6:476/477 of 5u8uD