SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 6936188 FitnessBrowser__SB2B:6936188 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
88% identity, 100% coverage: 1:475/476 of query aligns to 1:474/474 of P0A9P0

query
sites
P0A9P0

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M1 (= M1) modified: Initiator methionine, Removed
K220 (= K221) modified: N6-acetyllysine

4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
88% identity, 99% coverage: 2:473/476 of query aligns to 1:471/471 of 4jdrA

query
sites
4jdrA

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active site: P15 (= P16), L40 (= L41), C44 (= C45), C49 (= C50), S52 (= S53), E77 (= E78), P78 (= P79), I184 (= I186), E188 (= E190), V324 (= V326), H442 (= H444), H444 (= H446), E449 (= E451), N467 (= N469), P468 (= P470)
binding flavin-adenine dinucleotide: L11 (= L12), G12 (= G13), A13 (= A14), G14 (= G15), P15 (= P16), A16 (= A17), V34 (≠ I35), E35 (= E36), R36 (= R37), Y37 (≠ F38), G42 (= G43), V43 (= V44), C44 (= C45), V47 (= V48), G48 (= G49), C49 (= C50), S52 (= S53), K53 (= K54), G114 (= G115), L115 (= L116), G116 (= G117), A143 (= A145), A144 (= A146), G145 (= G147), S146 (= S148), S164 (= S166), I185 (= I187), R272 (= R274), G311 (= G313), D312 (= D314), M318 (= M320), L319 (= L321), A320 (= A322), H321 (= H323), Y351 (= Y353), H444 (= H446), P445 (= P447)

1bhyA Low temperature middle resolution structure of p64k from masc data (see paper)
63% identity, 95% coverage: 19:471/476 of query aligns to 19:481/482 of 1bhyA

query
sites
1bhyA

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G

G

H

H

V

V

A

A

E

E

V

N

I

C

S

A

G

G

L

H

K

K

H

A

F

Y

F

F

D

D

P

A

K

R

V

V

I

I

P

P

S

G

I

V

A

A

Y
|
Y

T

T

D

S

P

P

E

E

V

V

A

A

W

W

V

V

G

G

L

E

T

T

E

E

K

L

E

S

A

A

K

K

E

A

K

S

G

A

I

R

A

K

Y

I

E

T

T

K

A

A

T

N

F

F

P

P

W

W

A

A

S

S

G

G

R

R

A

A

I

I

A

A

S

N

D

G

A

C

S

D

D

K

G

P

M

F

T

T

K

K

L

L

I

I

F

F

D

D

K

A

E

E

T

T

H

G

R

R

V

I

I

I

G

G

A

G

I

I

V

V

G

G

V

P

N

N

G

G

E

D

L

M

L

I

G

G

E

E

I

V

G

Y

L

L

A

A

I

I

E

E

M

M

G

G

C

C

D

D

A

A

E

A

D

D

I

I

A

G

L

K

T

T

I

I

H
|
H

A

P

H
|
H

P

P

T

T

L

L

H

G

E
|
E

S

S

V

I

G

G

L

M

A

A

E

E

V

V

Y

A

E

L

G

G

S

T

I

C

T

T

D

D

L

L

P

P

N
x
P

P
x
Q

K

K

active site: L41 (= L41), C45 (= C45), C50 (= C50), S53 (= S53), I195 (= I186), E199 (= E190), H454 (= H444), H456 (= H446), E461 (= E451), P479 (≠ N469), Q480 (≠ P470)
binding flavin-adenine dinucleotide: V35 (≠ I35), E36 (= E36), R37 (= R37), Y38 (≠ F38), G43 (= G43), V44 (= V44), C45 (= C45), V48 (= V48), G49 (= G49), C50 (= C50), S53 (= S53), K54 (= K54), G115 (= G115), D116 (≠ L116), G117 (= G117), Y135 (vs. gap), A155 (= A145), A156 (= A146), G157 (= G147), S175 (= S166), I196 (= I187), R284 (= R274), G323 (= G313), D324 (= D314), M330 (= M320), L331 (= L321), A332 (= A322), H333 (= H323), A335 (≠ G325), Y363 (= Y353)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 12, 13, 14, 15, 16, 17

6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
46% identity, 94% coverage: 9:457/476 of query aligns to 9:459/470 of 6uziC

query
sites
6uziC

V

V

V

A

V

V

L
x
I

G
|
G

A
x
S

G
|
G

P
|
P

A
x
G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

C

A

A

D

Q

L

L

G

G

L

F

E

K

T

T

V

V

I

I

I
|
I

E
|
E

R
x
K

F

Y

S

S

T

T

L

L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V
|
V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

H

D

I

S

A

S

K

E

V

H

I

F

E

E

E

N

A

A

K

K

-

H

T

T

A

F

A

A

E

T

H

H

G

G

V

I

V

L

F

I

G

D

E

E

P

P

S

K

I

V

D

D

I

I

D

A

K

Q

L

M

R

I

G

S

Y

R

K

K

E

N

K

D

V

V

I

V

G

D

Q

Q

L

T

T

T

G

K

G

G

L

I

G

N

G

F

M

L

A

M

K

D

M

K

R

N

K

K

V

I

Q

T

V

V

V

L

N

Q

G
|
G

L
x
V

G
|
G

K

S

F

F

T

E

G

S

P

A

N

T

S

Q

I

I

E

K

V

V

T

T

G

K

A

A

D

D

G

G

A

S

T

E

V

V

I

I

N

E

F

A

D

K

N

N

A

T

I

I

A
|
A

A
x
T

G
|
G

S
|
S

R

K

P

P

I

S

Q

S

L

L

P

P

F

F

I

I

P

T

H

L

E

D

D

K

P

E

R

R

I

V

W

I

D

T

S
|
S

T

T

D

E

A

A

L

L

E

N

L

L

K

K

E

E

V

V

P

P

K

K

K

H

L

L

L

I

V

V

M

I

G

G

I
x
V

I
|
I

G

G

L

L

E
|
E

M

L

G

G

T

S

V

V

Y

Y

H

L

A

R

L

L

G

G

S

S

D

D

I

V

D

T

V

V

E

E

M

Y

F

L

D

D

Q

K

V

I

I

I

P

P

A

G

A

M

D

D

K

G

D

T

V

L

V

S

K

K

V

E

Y

L

T

Q

R

K

K

T

I

L

S

K

K

K

K

Q

-

G

F

M

N

K

L

F

M

M

L

L

E

S

T

T

K

A

V

V

T

S

A

G

V

V

E

E

A

R

K

N

E

G

D

D

G

T

I

V

Y

K

V

V

S

T

M

A

E

K

G

D

K

K

A

G

P

E

T

D

E

V

P

V

V

V

R

E

Y

G

D

D

A

Y

V

C

L

L

V

V

A

S

I

V

G

G

R
|
R

T

R

P

P

N
x
Y

G

T

K

D

L

G

I

L

D

G

A

L

D

E

K

K

A

A

G

G

I

V

N

E

V

L

D

D

E

E

R

R

G

G

F

R

I

V

K

K

V

T

D

N

K

D

Q

H

L

L

R

Q

T

T

N

N

V

V

P

P

H

N

I

I

F

Y

A

A

V

I

G
|
G

D
|
D

I

V

V

V

G

K

Q

G

P

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

G
x
A

V

E

H

E

E

E

G

G

H

V

V

F

A

V

A

A

E

E

V

T

I

L

S

A

G

G

L

E

K

K

H

P

F

H

F

V

D

N

P

Y

K

N

V

L

I

I

P

P

S

G

I

V

A

V

Y
|
Y

T

T

D

W

P

P

E

E

V

V

A

A

W

G

V

V

G

G

L

K

T

T

E

E

K

E

E

Q

A

L

K

K

E

E

K

A

G

G

I

V

A

A

Y

Y

E

K

T

T

A

G

T

S

F

F

P

P

W

M

A

R

A

A

S

L

G

G

R

R

A

S

I

R

A

A

S

S

D

M

A

D

S

T

D

D

G

G

M

V

T

I

K

K

L

I

I

L

F

A

D

D

K

E

E

K

T

T

H

D

R

E

V

I

I

L

G

G

G

V

A

H

I

M

V

I

G

G

V

A

N

R

G

A

E

D

L

M

L

I

G

A

E

E

I

A

G

V

L

V

A

A

I

M

E

E

M

F

G

R

C

A

D

S

A

A

E

E

D

D

I

I

A

A

L

R

T

I

I

S

H

H

A

A

H
|
H

P
|
P

T

T

L

Y

H

T

E
|
E

S

A

V

I

G

K

L

E

A

A

active site: C45 (= C45), C50 (= C50), S53 (= S53), V187 (≠ I186), E191 (= E190), H448 (= H446), E453 (= E451)
binding flavin-adenine dinucleotide: I12 (≠ L12), G13 (= G13), S14 (≠ A14), G15 (= G15), P16 (= P16), G17 (≠ A17), I35 (= I35), E36 (= E36), K37 (≠ R37), G43 (= G43), T44 (≠ V44), C45 (= C45), V48 (= V48), G49 (= G49), C50 (= C50), S53 (= S53), K54 (= K54), G116 (= G115), V117 (≠ L116), G118 (= G117), A146 (= A145), T147 (≠ A146), G148 (= G147), S149 (= S148), S167 (= S166), I188 (= I187), R276 (= R274), Y279 (≠ N277), G315 (= G313), D316 (= D314), M322 (= M320), L323 (= L321), A324 (= A322), H325 (= H323), A327 (≠ G325), Y355 (= Y353), H448 (= H446), P449 (= P447)
binding zinc ion: H448 (= H446), E453 (= E451)

1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
46% identity, 96% coverage: 5:459/476 of query aligns to 2:453/455 of 1ebdA

query
sites
1ebdA

I

I

K

E

T

T

Q

E

V

T

V

L

V

V

L
x
V

G
|
G

A

A

G
|
G

P
|
P

A
x
G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

A

D

Q

L

L

G

G

L

Q

E

K

T

V

V

T

I

I

I
x
V

E
|
E

R
x
K

F

-

S

G

T

N

L
|
L

G

G

G
|
G

V
|
V

C
|
C

L

L

N

N

V
|
V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

I

H

S

I

A

A

S

K

H

V

R

I

Y

E

E

E

Q

A

A

K

K

T

H

A

S

A

E

E

E

H

M

G

G

V

I

V

K

F

A

G

E

E
x
N

P
x
V

S

T

I

I

D

D

I

F

D

A

K

K

L

V

R

Q

G

E

Y

W

K

K

E

A

K

S

V

V

I

V

G

K

Q

K

L

L

T

T

G

G

L

V

G

E

G

G

M

L

A

L

K

K

M

G

R

N

K

K

V

V

Q

E

V

I

V

V

N

K

G
|
G

L
x
E

G
x
A

K

Y

F

F

T

V

G

D

P

A

N

N

S

T

I

V

E

R

V

V

T

V

G

N

A

G

D

D

G

S

A

A

A

Q

T

T

V

Y

I

-

N

T

F

F

D

K

N

N

A

A

I

I

A
|
A

A
x
T

G
|
G

S

S

R

R

P

P

I

I

Q

E

L

L

P

P

F

N

I

F

P

K

H

F

E

S

D

N

P

-

R

R

I

I

W

L

D

D

S
|
S

T

T

D

G

A

A

L

L

E

N

L

L

K

G

E

E

V

V

P

P

K

K

K

S

L

L

L

V

V

V

M

I

G

G

I
x
Y

I
|
I

G

G

L

I

E
|
E

M

L

G

G

T

T

V

A

Y

Y

H

A

A

N

L

F

G

G

S

T

D

K

I

V

D

T

V

I

V

L

E

E

M

G

F

A

D

G

Q

E

V

I

I

L

P

S

A

G

A

F

D

E

K

K

D

Q

V

M

V

A

K

A

V

I

Y

I

T

K

R

K

K

R

I

L

S

K

K

K

-

G

F

V

N

E

L

V

M

V

L

T

E

N

T

A

K

L

V

A

T

K

A

G

V

A

E

E

A

E

K

R

E

E

D

D

G

G

I

V

Y

T

V

V

S

T

M

Y

E

E

G

A

K

N

K

-

A

G

P

E

T

T

E

K

P

T

V

I

R

D

Y

A

D

D

A

Y

V

V

L

L

V

V

A

T

I

V

G

G

R
|
R

T

R

P

P

N

N

G

T

K

D

L

E

I

L

D

G

A

L

D

E

K

Q

A

I

G

G

I

I

N

K

V

M

D

T

E

N

R

R

G

G

F

L

I

I

K

E

V

V

D

D

K

Q

Q

Q

L

C

R

R

T

T

N

S

V

V

P

P

H

N

I

I

F

F

A

A

V

I

G
|
G

D
|
D

I

I

V

V

G

P

Q

G

P

P

M
x
A

L
|
L

A
|
A

H

H

K

K

G
x
A

V
x
S

H

Y

E

E

G

G

H

K

V

V

A

A

E

E

V

A

I

I

S

A

G

G

L

H

K

P

H

S

F

A

F

V

D

D

P

Y

K

V

V

A

I

I

P

P

S

A

I

V

A

V

Y

F

T

S

D

D

P

P

E

E

V

C

A

A

W

S

V

V

G

G

L

Y

T

F

E

E

K

Q

E

Q

A

A

K

K

E

D

K

E

G

G

I

I

A

D

Y

V

E

I

T

A

A

A

T

K

F

F

P

P

W

F

A

A

S

N

G

G

R

R

A

A

I

L

A

A

S

L

D

N

A

D

S

T

D

D

G

G

M

F

T

L

K

K

L

L

I

V

F

V

D

R

K

K

E

E

T

D

H

G

R

V

V

I

I

I

G

G

G

A

A

Q

I

I

V

I

G

G

V

P

N

N

G

A

G

S

E

D

L

M

L

I

G

A

E

E

I

L

G

G

L

L

A

A

I

I

E

E

M

A

G

G

C

M

D

T

A

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H
|
H

A

A

H
|
H

P
|
P

T

T

L

L

H

G

E
|
E

S

I

V

A

G

M

L

E

A

A

E

E

V

V

active site: P13 (= P16), L37 (= L41), C41 (= C45), C46 (= C50), S49 (= S53), N74 (≠ E78), V75 (≠ P79), Y180 (≠ I186), E184 (= E190), S320 (≠ V326), H438 (= H444), H440 (= H446), E445 (= E451)
binding flavin-adenine dinucleotide: V9 (≠ L12), G10 (= G13), G12 (= G15), P13 (= P16), G14 (≠ A17), V32 (≠ I35), E33 (= E36), K34 (≠ R37), G39 (= G43), V40 (= V44), C41 (= C45), V44 (= V48), G45 (= G49), C46 (= C50), K50 (= K54), G111 (= G115), E112 (≠ L116), A113 (≠ G117), A140 (= A145), T141 (≠ A146), G142 (= G147), S160 (= S166), Y180 (≠ I186), I181 (= I187), R268 (= R274), G307 (= G313), D308 (= D314), A314 (≠ M320), L315 (= L321), A316 (= A322), A319 (≠ G325), H440 (= H446), P441 (= P447)

P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
45% identity, 96% coverage: 5:463/476 of query aligns to 8:463/470 of P11959

query
sites
P11959

I

I

K

E

T

T

Q

E

V

T

V

L

V

V

L

V

G

G

A

A

G

G

P

P

A

G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

A

D

Q

L

L

G

G

L

Q

E

K

T

V

V

T

I

I

I

V

E
|
E

R
x
K

F

-

S
x
G

T
x
N

L
|
L

G
|
G

V
|
V

C
|
C

L

L

N

N

V

V

G

G

C

C

I

I

P

P

S

S

K
|
K

A

A

L

L

L

I

H

S

I

A

A

S

K

H

V

R

I

Y

E

E

E

Q

A

A

K

K

T

H

A

S

A

E

E

E

H

M

G

G

V

I

V

K

F

A

G

E

E

N

P

V

S

T

I

I

D

D

I

F

D

A

K

K

L

V

R

Q

G

E

Y

W

K

K

E

A

K

S

V

V

I

V

G

K

Q

K

L

L

T

T

G

G

L

V

G

E

G

G

M

L

A

L

K

K

M

G

R

N

K

K

V

V

Q

E

V

I

V

V

N

K

G

G

L

E

G

A

K

Y

F

F

T

V

G

D

P

A

N

N

S

T

I

V

E

R

V

V

T

V

G

N

A

G

D

D

G

S

A

A

A

Q

T

T

V

Y

I

-

N

T

F

F

D

K

N

N

A

A

I

I

A

A

A

T

G

G

S

S

R

R

P

P

I

I

Q

E

L

L

P

P

F

N

I

F

P

K

H

F

E

S

D

N

P

-

R

R

I

I

W

L

D

D

S

S

T

T

D

G

A

A

L

L

E

N

L

L

K

G

E

E

V

V

P

P

K

K

K

S

L

L

L

V

V

V

M

I

G

G

I

Y

I

I

G

G

L

I

E

E

M

L

G

G

T

T

V

A

Y

Y

H

A

A

N

L

F

G

G

S

T

D

K

I

V

D

T

V

I

V

L

E

E

M

G

F

A

D

G

Q

E

V

I

I

L

P

S

A

G

A

F

D

E

K

K

D

Q

V

M

V

A

K

A

V

I

Y

I

T

K

R

K

K

R

I

L

S

K

K

K

-

G

F

V

N

E

L

V

M

V

L

T

E

N

T

A

K

L

V

A

T

K

A

G

V

A

E

E

A

E

K

R

E

E

D

D

G

G

I

V

Y

T

V

V

S

T

M

Y

E

E

G

A

K

N

K

-

A

G

P

E

T

T

E

K

P

T

V

I

R

D

Y

A

D

D

A

Y

V

V

L

L

V

V

A

T

I

V

G

G

R

R

T

R

P

P

N

N

G

T

K

D

L

E

I

L

D

G

A

L

D

E

K

Q

A

I

G

G

I

I

N

K

V

M

D

T

E

N

R

R

G

G

F

L

I

I

K

E

V

V

D

D

K

Q

Q

Q

L

C

R

R

T

T

N

S

V

V

P

P

H

N

I

I

F

F

A

A

V

I

G

G

D
|
D

I

I

V

V

G

P

Q

G

P

P

M

A

L

L

A
|
A

H

H

K

K

G

A

V

S

H

Y

E

E

G

G

H

K

V

V

A

A

E

E

V

A

I

I

S

A

G

G

L

H

K

P

H

S

F

A

F

V

D

D

P

Y

K

V

V

A

I

I

P

P

S

A

I

V

A

V

Y

F

T

S

D

D

P

P

E

E

V

C

A

A

W

S

V

V

G

G

L

Y

T

F

E

E

K

Q

E

Q

A

A

K

K

E

D

K

E

G

G

I

I

A

D

Y

V

E

I

T

A

A

A

T

K

F

F

P

P

W

F

A

A

S

N

G

G

R

R

A

A

I

L

A

A

S

L

D

N

A

D

S

T

D

D

G

G

M

F

T

L

K

K

L

L

I

V

F

V

D

R

K

K

E

E

T

D

H

G

R

V

V

I

I

I

G

G

G

A

A

Q

I

I

V

I

G

G

V

P

N

N

G

A

G

S

E

D

L

M

L

I

G

A

E

E

I

L

G

G

L

L

A

A

I

I

E

E

M

A

G

G

C

M

D

T

A

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H

H

A

A

H

H

P

P

T

T

L

L

H

G

E

E

S

I

V

A

G

M

L

E

A

A

E

E

V

V

Y

A

E

L

G

G

S

T

39:47 (vs. 36:45, 60% identical) binding
K56 (= K54) binding
D314 (= D314) binding
A322 (= A322) binding

P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
42% identity, 98% coverage: 6:473/476 of query aligns to 4:478/478 of P14218

query
sites
P14218

K

K

T

F

Q

D

V

V

L

I

G

G

A

A

G

G

P

P

A

G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

A

D

Q

L

L

G

G

L

L

E

K

T

T

V

A

I

C

I

I

E
|
E

R
x
K

F
x
Y

-
x
I

-
x
G

-
x
K

-
x
E

-
x
G

-
x
K

S
x
V

T
x
A

L
|
L

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G

G

C
|
C

I

I

P

P

S

S

K
|
K

A

A

L

L

H

D

I

S

A

S

K

Y

V

K

I

Y

E

H

E

E

A

A

K

K

T

E

A

A

A

F

E

K

-

V

H

H

G

G

V

I

V

E

F

A

G

K

E

G

P

V

S

T

I

I

D

D

I

V

D

P

K

A

L

M

R

V

G

A

Y

R

K

K

E

A

K

N

V

I

I

V

G

K

Q

N

L

L

T

T

G

G

L

I

G

A

G

T

M

L

A

F

K

K

M

A

R

N

K

G

V

V

Q

T

V

S

V

F

N

E

G

G

L

H

G
|
G

K

K

F

L

T

L

G

A

P

N

N

K

S

Q

I

V

E

E

V

V

T

T

G

G

A

L

D

D

G

G

A

K

A

T

T

Q

V

V

I

L

N

E

F

A

D

E

N

N

A

V

I

I

A

A

A

S

G

G

S

S

R

R

P

P

I

V

Q

E

L

I

P

P

F

P

I

A

P

P

H

L

E

S

D

D

P

D

R

I

I

I

W

V

D

D

S

S

T

T

D

G

A

A

L

L

E

E

L

F

K

Q

E

A

V

V

P

P

K

K

L

L

L

G

V

V

M

I

G

G

G

A

G

G

I

V

I

I

G

G

L

L

E

E

M

L

G

G

T

S

V

V

Y

W

H

A

A

R

L

L

G

G

S

A

D

E

I

V

D

T

V

V

V

L

E

E

M

A

F

L

D

D

Q

K

V

F

I

L

P

P

A

A

D

D

K

E

D

Q

V

I

V

A

K

K

V

E

Y

A

T

L

R

K

K

V

I

L

S

T

K

K

K

Q

-

G

F

L

N

N

L

I

M

R

L

L

E

G

T

A

K

R

V

V

T

T

A

A

V

S

E

E

A

V

K

K

E

K

D

K

G

Q

I

V

Y

T

V

V

S

T

M

F

E

T

G

D

K

A

K

N

A

G

P

E

T

Q

E

K

P

E

V

T

R

-

Y

F

D

D

A

K

V

L

L

I

V

V

A

A

I

V

G

G

R

R

T

R

P

P

N

V

G

T

K

T

L

D

I

L

D

L

A

A

D

A

K

D

A

S

G

G

I

V

N

T

V

L

D

D

E

E

R

R

G

G

F

F

I

I

K

Y

V

V

D

D

K

D

Q

H

L

C

R

K

T

T

N

S

V

V

P

P

H

G

I

V

F

F

A

A

V

I

G

G

D
|
D

I

V

V

V

G

R

Q

G

P

A

M

M

L

L

A
|
A

H

H

K

K

G

A

V

S

H

E

E

E

G

G

H

V

V

M

A

V

A

A

E

E

V

R

I

I

S

A

G

G

L

H

K

K

H

A

F

Q

F

M

D

N

P

Y

K

D

V

L

I

I

P

P

S

S

I

V

A

I

Y

Y

T

T

D

H

P

P

E

E

V

I

A

A

W

W

V

V

G

G

L

K

T

T

E

E

K

Q

E

T

A

L

K

K

E

A

K

E

G

G

I

V

A

E

Y

V

E

N

T

V

A

G

T

T

F

F

P

P

W

F

A

A

S

S

G

G

R

R

A

A

I

M

A

A

S

A

D

N

A

D

S

T

D

T

G

G

M

L

T

V

K

K

L

V

I

I

F

A

D

D

K

A

E

K

T

T

H

D

R

R

V

V

I

L

G

G

G

V

A

H

I

V

V

I

G

G

V

P

N

S

G

A

E

E

L

L

L

V

G

Q

E

Q

I

G

G

A

L

I

A

G

I

M

E

E

M

F

G

G

C

T

D

S

A

A

E

E

D

D

I

L

A

G

L

M

T

M

I

V

H

F

A

S

H

H

P

P

T

T

L

L

H

S

E

E

S

A

V

L

G

H

L

E

A

A

E

L

V

A

Y

V

E

N

G

G

S

H

I

A

T

I

D

H

L

I

P

A

N

N

P

R

K

K

A

K

K

R

34:49 (vs. 36:45, 31% identical) binding
C49 (= C45) modified: Disulfide link with 54, Redox-active
C54 (= C50) modified: Disulfide link with 49, Redox-active
K58 (= K54) binding
G122 (= G117) binding
D319 (= D314) binding
A327 (= A322) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
42% identity, 97% coverage: 6:469/476 of query aligns to 3:473/473 of 5u8wA

query
sites
5u8wA

K

K

T

F

Q

D

V

V

L
x
I

G
|
G

A
|
A

G
|
G

P
|
P

A
x
G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

A

D

Q

L

L

G

G

L

L

E

K

T

T

V

A

I

C

I
|
I

E
|
E

R
x
K

F
x
Y

-

I

-

G

-

K

-

E

-

G

-

K

S

V

T

A

L
|
L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V
|
V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

H

D

I

S

A

S

K

Y

V

K

I

Y

E

H

E

E

A

A

K

K

T

E

A

A

A

F

E

K

-

V

H

H

G

G

V

I

V

E

F

A

G

K

E
x
G

P
x
V

S

T

I

I

D

D

I

V

D

P

K

A

L

M

R

V

G

A

Y

R

K

K

E

A

K

N

V

I

I

V

G

K

Q

N

L

L

T

T

G

G

L

I

G

A

G

T

M

L

A

F

K

K

M

A

R

N

K

G

V

V

Q

T

V

S

V

F

N

E

G
|
G

L
x
H

G
|
G

K

K

F

L

T

L

G

A

P

N

N

K

S

Q

I

V

E

E

V

V

T

T

G

G

A

L

D

D

G

G

A

K

A

T

T

Q

V

V

I

L

N

E

F

A

D

E

N

N

A

V

I

I

A
|
A

A
x
S

G
|
G

S

S

R

R

P

P

I

V

Q

E

L

I

P

P

F

P

I

A

P

P

H

L

E

T

D

D

P

D

R

I

I

I

W

V

D

D

S
|
S

T

T

D

G

A

A

L

L

E

E

L

F

K

Q

E

A

V

V

P

P

K

K

L

L

L

G

V

V

M
x
I

G
|
G

G

A

G
|
G

I
x
V

I
|
I

G

G

L

L

E
|
E

M

L

G

G

T

S

V

V

Y

W

H

A

A

R

L

L

G

G

S

A

D

E

I

V

D

T

V

V

V
x
L

E
|
E

M
x
A

F
x
L

D

D

Q

K

V

F

I

L

P

P

A

A

D

D

K

E

D

Q

V

I

V

A

K

K

V

E

Y

A

T

L

R

K

K

V

I

L

S

T

K

K

K

Q

-

G

F

L

N

N

L

I

M

R

L

L

E

G

T

A

K

R

V

V

T

T

A

A

V

S

E

E

A

V

K

K

E

K

D

K

G

Q

I

V

Y

T

V

V

S

T

M

F

E

T

G

D

K

A

K

N

A

G

P

E

T

Q

E

K

P

E

V

T

R

-

Y

F

D

D

A

K

V

L

L

I

V

V

A
|
A

I
x
V

G
|
G

R
|
R

T

R

P

P

N

V

G

T

K

T

L

D

I

L

D

L

A

A

D

A

K

D

A

S

G

G

I

V

N

T

V

L

D

D

E

E

R

R

G

G

F

F

I

I

K

Y

V

V

D

D

K

D

Q

H

L

C

R

K

T

T

N

S

V

V

P

P

H

G

I

V

F

F

A

A

V

I

G
|
G

D
|
D

I

V

V

V

G

R

Q

G

P

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

G
x
A

V
x
S

H

E

E

E

G

G

H

V

V

M

A

V

A

A

E

E

V

R

I

I

S

A

G

G

L

H

K

K

H

A

F

Q

F

M

D

N

P

Y

K

D

V

L

I

I

P

P

S

S

I
x
V

A

I

Y
|
Y

T

T

D

H

P

P

E

E

V

I

A

A

W

W

V

V

G

G

L

K

T

T

E

E

K

Q

E

T

A

L

K

K

E

A

K

E

G

G

I

V

A

E

Y

V

E

N

T

V

A

G

T

T

F

F

P

P

W

F

A

A

S

S

G

G

R

R

A

A

I

M

A

A

S

A

D

N

A

D

S

T

D

T

G

G

M

L

T

V

K

K

L

V

I

I

F

A

D

D

K

A

E

K

T

T

H

D

R

R

V

V

I

L

G

G

G

V

A

H

I

V

V

I

G

G

V

P

N

S

G

A

E

E

L

L

L

V

G

Q

E

Q

I

G

G

A

L

I

A

G

I

M

E

E

M

F

G

G

C

T

D

S

A

A

E

E

D

D

I

L

A

G

L

M

T

M

I

V

H
x
F

A

S

H
|
H

P
|
P

T

T

L

L

H

S

E
|
E

S

A

V

L

G

H

L

E

A

A

E

L

V

A

Y

V

E

N

G

G

S

H

I

A

T

I

D

H

L

I

P

A

N
|
N

active site: P13 (= P16), L44 (= L41), C48 (= C45), C53 (= C50), S56 (= S53), G82 (≠ E78), V83 (≠ P79), V190 (≠ I186), E194 (= E190), S330 (≠ V326), F448 (≠ H444), H450 (= H446), E455 (= E451), N473 (= N469)
binding flavin-adenine dinucleotide: I9 (≠ L12), G10 (= G13), A11 (= A14), G12 (= G15), P13 (= P16), G14 (≠ A17), I32 (= I35), E33 (= E36), K34 (≠ R37), Y35 (≠ F38), G46 (= G43), T47 (≠ V44), C48 (= C45), V51 (= V48), G52 (= G49), C53 (= C50), S56 (= S53), K57 (= K54), G119 (= G115), H120 (≠ L116), G121 (= G117), A149 (= A145), S150 (≠ A146), G151 (= G147), S170 (= S166), I191 (= I187), R278 (= R274), G317 (= G313), D318 (= D314), M324 (= M320), L325 (= L321), A326 (= A322), H327 (= H323), A329 (≠ G325), Y357 (= Y353), H450 (= H446), P451 (= P447)
binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ M182), G187 (= G183), G189 (= G185), V190 (≠ I186), I191 (= I187), E194 (= E190), L209 (≠ V205), E210 (= E206), A211 (≠ M207), L212 (≠ F208), A275 (= A271), V276 (≠ I272), G277 (= G273), R278 (= R274), M324 (= M320), L325 (= L321), V355 (≠ I351), Y357 (= Y353)

5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
42% identity, 97% coverage: 6:469/476 of query aligns to 2:472/472 of 5u8vA

query
sites
5u8vA

K

K

T

F

Q

D

V

V

L
x
I

G
|
G

A
|
A

G
|
G

P
|
P

A
x
G

G

G

Y

Y

S

V

A

A

F

I

R

R

A

A

D

Q

L

L

G

G

L

L

E

K

T

T

V

A

I

C

I
|
I

E
|
E

R
x
K

F
x
Y

-

I

-

G

-

K

-

E

-

G

-

K

S

V

T

A

L
|
L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V
|
V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

H

D

I

S

A

S

K

Y

V

K

I

Y

E

H

E

E

A

A

K

K

T

E

A

A

A

F

E

K

-

V

H

H

G

G

V

I

V

E

F

A

G

K

E
x
G

P
x
V

S

T

I

I

D

D

I

V

D

P

K

A

L

M

R

V

G

A

Y

R

K

K

E

A

K

N

V

I

I

V

G

K

Q

N

L

L

T

T

G

G

L

I

G

A

G

T

M

L

A

F

K

K

M

A

R

N

K

G

V

V

Q

T

V

S

V

F

N

E

G
|
G

L
x
H

G
|
G

K

K

F

L

T

L

G

A

P

N

N

K

S

Q

I

V

E

E

V

V

T

T

G

G

A

L

D

D

G

G

A

K

A

T

T

Q

V

V

I

L

N

E

F

A

D

E

N

N

A

V

I

I

A
|
A

A
x
S

G
|
G

S
|
S

R

R

P

P

I

V

Q

E

L

I

P

P

F

P

I

A

P

P

H

L

E

T

D

D

P

D

R

I

I

I

W

V

D

D

S
|
S

T

T

D

G

A

A

L

L

E

E

L

F

K

Q

E

A

V

V

P

P

K

K

L

L

L

G

V

V

M
x
I

G
|
G

G

A

G
|
G

I
x
V

I
|
I

G

G

L

L

E
|
E

M

L

G

G

T

S

V

V

Y

W

H

A

A

R

L

L

G

G

S

A

D

E

I

V

D

T

V

V

V
x
L

E
|
E

M
x
A

F
x
L

D

D

Q

K

V

F

I

L

P

P

A

A

D

D

K

E

D

Q

V

I

V

A

K

K

V

E

Y

A

T

L

R

K

K

V

I

L

S

T

K

K

K

Q

-

G

F

L

N

N

L

I

M

R

L

L

E

G

T
x
A

K
x
R

V
|
V

T

T

A

A

V

S

E

E

A

V

K

K

E

K

D

K

G

Q

I

V

Y

T

V

V

S

T

M

F

E

T

G

D

K

A

K

N

A

G

P

E

T

Q

E

K

P

E

V

T

R

-

Y

F

D

D

A

K

V

L

L

I

V

V

A
|
A

I
x
V

G
|
G

R
|
R

T

R

P

P

N

V

G

T

K

T

L

D

I

L

D

L

A

A

D

A

K

D

A

S

G

G

I

V

N

T

V

L

D

D

E

E

R

R

G

G

F

F

I

I

K

Y

V

V

D

D

K

D

Q

H

L

C

R

K

T

T

N

S

V

V

P

P

H

G

I

V

F

F

A

A

V

I

G
|
G

D
|
D

I

V

V

V

G

R

Q

G

P

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

G
x
A

V
x
S

H

E

E

E

G

G

H

V

V

M

A

V

A

A

E

E

V

R

I

I

S

A

G

G

L

H

K

K

H

A

F

Q

F

M

D

N

P

Y

K

D

V

L

I

I

P

P

S

S

I

V

A

I

Y
|
Y

T

T

D

H

P

P

E

E

V

I

A

A

W

W

V

V

G

G

L

K

T

T

E

E

K

Q

E

T

A

L

K

K

E

A

K

E

G

G

I

V

A

E

Y

V

E

N

T

V

A

G

T

T

F

F

P

P

W

F

A

A

S

S

G

G

R

R

A

A