Comparing 6936711 FitnessBrowser__SB2B:6936711 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12)
55% identity, 58% coverage: 1:383/659 of query aligns to 1:382/386 of P0A9J8
2qmxA The crystal structure of l-phe inhibited prephenate dehydratase from chlorobium tepidum tls (see paper)
32% identity, 41% coverage: 104:376/659 of query aligns to 1:273/278 of 2qmxA
7am0B Gqqa- a novel type of quorum quenching acylases (see paper)
31% identity, 41% coverage: 107:377/659 of query aligns to 4:270/278 of 7am0B
6vh5D Crystal structure of prephenate dehydratase from brucella melitensis biovar abortus 2308 in complex with phenylalanine
31% identity, 41% coverage: 107:376/659 of query aligns to 9:276/282 of 6vh5D
4grsA Crystal structure of a chimeric dah7ps (see paper)
31% identity, 32% coverage: 431:639/659 of query aligns to 83:299/333 of 4grsA
Sites not aligning to the query:
1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
36% identity, 23% coverage: 486:639/659 of query aligns to 74:228/262 of 1zcoB
Sites not aligning to the query:
1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
36% identity, 23% coverage: 486:639/659 of query aligns to 74:228/262 of 1zcoA
Sites not aligning to the query:
4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
36% identity, 23% coverage: 486:639/659 of query aligns to 74:228/262 of 4c1kA
Sites not aligning to the query:
3pg9A Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
30% identity, 32% coverage: 431:639/659 of query aligns to 83:299/338 of 3pg9A
Sites not aligning to the query:
1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p (see paper)
30% identity, 32% coverage: 431:639/659 of query aligns to 83:299/338 of 1rzmA
P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168) (see paper)
33% identity, 24% coverage: 486:646/659 of query aligns to 169:330/358 of P39912
Sites not aligning to the query:
1ecmB Atomic structure of the buried catalytic pocket of escherichia coli chorismate mutase
51% identity, 14% coverage: 6:97/659 of query aligns to 1:92/95 of 1ecmB
5j6fA Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
32% identity, 24% coverage: 486:646/659 of query aligns to 167:328/352 of 5j6fA
Sites not aligning to the query:
3mwbB The crystal structure of prephenate dehydratase in complex with l-phe from arthrobacter aurescens to 2.0a
28% identity, 41% coverage: 109:376/659 of query aligns to 5:271/303 of 3mwbB
3mwbA The crystal structure of prephenate dehydratase in complex with l-phe from arthrobacter aurescens to 2.0a
28% identity, 41% coverage: 109:376/659 of query aligns to 5:274/306 of 3mwbA
3nvtA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
27% identity, 33% coverage: 431:646/659 of query aligns to 95:318/345 of 3nvtA
Sites not aligning to the query:
3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate (see paper)
27% identity, 33% coverage: 431:646/659 of query aligns to 94:317/343 of 3tfcA
Sites not aligning to the query:
1vs1D Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
33% identity, 29% coverage: 425:613/659 of query aligns to 18:211/271 of 1vs1D
Sites not aligning to the query:
3luyA Putative chorismate mutase from bifidobacterium adolescentis
26% identity, 41% coverage: 109:377/659 of query aligns to 8:284/326 of 3luyA
7alzA Gqqa- a novel type of quorum quenching acylases (see paper)
32% identity, 16% coverage: 274:377/659 of query aligns to 81:186/194 of 7alzA
>6936711 FitnessBrowser__SB2B:6936711
MEKPQPLSETREQITDIDNTVLQLLARRRELSLEVARSKEVDVRPVRDTQRERELLSRLV
QKGREQGLDPHFVMQLYQSIIEDSVLNQQAYLHGRANPETQKQQYCIAYLGARGSYSYLA
ANRYCQRRQVDMVDLGCQSFDEIVHAVESGHADYGFLPIENTSSGSINEVYDVLQHTSLA
IVGETTIEVGHCLLAKPGTKASDIKTLYAHPQPISQCSRYLARHPGLRLEYCASSAEAME
KVQAADSKDVAAIGSAEGGGLYQLEAIEKGLANQKVNQSRFIVVARKAVAVPEQLPAKCT
LIMATGQKPGALVEALLVLKANNLNMSKLESRPIPGTPWEEMFYLDIDANLASVPMQLAL
KELERITRFIKVLGCYPCETVAPTQLSNAQLLIEPEHFRTDAPEPAAAQARDGDSVPARH
SLGYKETVSEVQAGALLIGNGHSGALAMLSLPDTLEGFEPFLKQLKAAGFAGLVLDNLSE
RPDPAKALDACTKAAEKFGLITAAAVNREDELEHAISRVELILIRGKQMFNQPLLERLGK
LHLPVVLERNTMADIDELLAAADTILAEGNQQLMLCESGVSSFKSSTLATLDLAGLVELK
ARSHLPVLVNPSYAVTPEACPRQAKAVKRLGADGLLLEVSLDTSMADSYLGETLRQFFV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory