Comparing 6937362 FitnessBrowser__SB2B:6937362 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
6r77A Crystal structure of trans-3-hydroxy-l-proline dehydratase in complex with substrate - closed conformation (see paper)
52% identity, 95% coverage: 17:346/346 of query aligns to 20:348/348 of 6r77A
Q96EM0 Trans-3-hydroxy-L-proline dehydratase; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Homo sapiens (Human) (see paper)
44% identity, 95% coverage: 17:346/346 of query aligns to 20:354/354 of Q96EM0
8a3fAAA Proline racemase A (AsProR)
36% identity, 96% coverage: 15:345/346 of query aligns to 5:335/335 of 8a3fAAA
6hjgB Trypanosoma cruzi proline racemase in complex with inhibitor oxopa (see paper)
35% identity, 99% coverage: 5:346/346 of query aligns to 14:372/376 of 6hjgB
6hjeA Trypanosoma cruzi proline racemase in complex with inhibitor ng-p27 (see paper)
35% identity, 98% coverage: 9:346/346 of query aligns to 1:355/357 of 6hjeA
Q4DA80 Proline racemase A; TcPA45-A; TcPRACA; rTcPA45; EC 5.1.1.4 from Trypanosoma cruzi (strain CL Brener) (see 2 papers)
35% identity, 99% coverage: 5:346/346 of query aligns to 64:422/423 of Q4DA80
1w61A Proline racemase in complex with 2 molecules of pyrrole-2- carboxylic acid (holo form) (see paper)
35% identity, 96% coverage: 15:346/346 of query aligns to 3:351/353 of 1w61A
Q2YLF3 4-hydroxyproline epimerase; Hydroxyproline-2-epimerase; HyPRE; EC 5.1.1.8 from Brucella abortus (strain 2308) (see paper)
33% identity, 94% coverage: 20:345/346 of query aligns to 9:332/333 of Q2YLF3
6j7cA Crystal structure of proline racemase-like protein from thermococcus litoralis in complex with proline (see paper)
32% identity, 95% coverage: 20:346/346 of query aligns to 10:331/331 of 6j7cA
4lb0B Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline
30% identity, 96% coverage: 15:345/346 of query aligns to 6:335/347 of 4lb0B
B9JQV3 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
30% identity, 96% coverage: 15:345/346 of query aligns to 5:334/347 of B9JQV3
4q2hA Crystal structure of probable proline racemase from agrobacterium radiobacter k84, target efi-506561, with bound carbonate
31% identity, 96% coverage: 15:345/346 of query aligns to 6:335/346 of 4q2hA
Q9I476 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; Hydroxyproline-2-epimerase; PaHyPRE; EC 5.1.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
32% identity, 95% coverage: 14:343/346 of query aligns to 1:312/314 of Q9I476
4k7gD Crystal structure of a 3-hydroxyproline dehydratse from agrobacterium vitis, target efi-506470, with bound pyrrole 2-carboxylate, ordered active site
28% identity, 96% coverage: 15:345/346 of query aligns to 15:345/352 of 4k7gD
B9K4G4 Trans-3-hydroxy-L-proline dehydratase; T3LHyp dehydratase; t3HypD; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
28% identity, 96% coverage: 15:345/346 of query aligns to 5:335/342 of B9K4G4
4j9xA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with trans-4-hydroxy-l- proline
31% identity, 95% coverage: 14:343/346 of query aligns to 1:308/310 of 4j9xA
4j9wA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with the inhibitor pyrrole- 2-carboxylate
31% identity, 95% coverage: 14:343/346 of query aligns to 1:308/310 of 4j9wA
Q4KGU2 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
31% identity, 95% coverage: 14:343/346 of query aligns to 1:308/310 of Q4KGU2
4q60A Crystal structure of a 4-hydroxyproline epimerase from burkholderia multivorans atcc 17616, target efi-506586, open form, with bound pyrrole-2-carboxylate
30% identity, 96% coverage: 13:344/346 of query aligns to 5:311/311 of 4q60A
>6937362 FitnessBrowser__SB2B:6937362
MGPVQLSPELLGQFRRITTLDAHTEGEPLRIITSGYPAIPGNTMLDKRKFLAEHLDEYRQ
LLMFEPRGHADMYGVLLTEPVSKGADFGVLFLHNEGYSSMCGHAVLALATVLCQTGAIDF
DGCSAEIGIDAPAGFIRAFAEKDTTGRIQASFLNVPSWAEALDLSIEVPGIGEVPFDIGF
GGAYYAYVDADALGLDCSADNVSQLIDWGRRIKQAVMASYPIKHPLDEDLSFLYGTIFTS
RHTAVPGAHSRHVCVFADGEVDRSPTGTGVAGRIALLHARGKVELAQALTIESIVGGKMT
VEARERVDFHGRDALIPRVSGRAFITGEHTFLLHPDDIFQTGFLLR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory