Comparing 6937476 FitnessBrowser__SB2B:6937476 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 11 hits to proteins with known functional sites (download)
6uekA Structure of urocanate hydratase from trypanosoma cruzi in complex with NAD+ (see paper)
59% identity, 97% coverage: 14:665/670 of query aligns to 12:660/660 of 6uekA
6uekD Structure of urocanate hydratase from trypanosoma cruzi in complex with NAD+ (see paper)
56% identity, 94% coverage: 34:660/670 of query aligns to 18:585/585 of 6uekD
2fknB Crystal structure of urocanase from bacillus subtilis
36% identity, 82% coverage: 105:653/670 of query aligns to 19:546/546 of 2fknB
P25503 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Bacillus subtilis (strain 168)
36% identity, 82% coverage: 105:653/670 of query aligns to 25:552/552 of P25503
Q5L084 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Geobacillus kaustophilus (strain HTA426)
36% identity, 84% coverage: 94:653/670 of query aligns to 13:551/551 of Q5L084
P25080 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 4 papers)
35% identity, 80% coverage: 98:631/670 of query aligns to 22:534/557 of P25080
Sites not aligning to the query:
1uwkA The high resolution structure of urocanate hydratase from pseudomonas putida in complex with urocanate (see paper)
34% identity, 83% coverage: 98:656/670 of query aligns to 19:551/554 of 1uwkA
7jfzA Structure of urocanate hydratase from legionella pneumophila bound to NAD
34% identity, 83% coverage: 94:652/670 of query aligns to 9:541/547 of 7jfzA
1x87A 2.4a x-ray structure of urocanase protein complexed with NAD
31% identity, 84% coverage: 94:653/670 of query aligns to 7:495/495 of 1x87A
8q9vA S-methylthiourocanate hydratase from variovorax sp. Ra8 in complex with NAD+ and imidazolone propionate (see paper)
32% identity, 82% coverage: 99:645/670 of query aligns to 14:529/543 of 8q9vA
7nedA Thiourocanate hydratase from paenibacillus sp. Soil724d2 in complex with cofactor NAD+ and urocanate (see paper)
29% identity, 81% coverage: 95:638/670 of query aligns to 10:530/545 of 7nedA
>6937476 FitnessBrowser__SB2B:6937476
METNMTFAEQIKQGIPAELPSPKPYPADANRAPKRKDILTAAEKQLAVRNALRYFPAEWH
QELAAEFAKELNDFGRIYMYRFKPEYAMKARAISEYPAKCEQAAAIMLMVDNNLDPAVAQ
HPEELITYGGNGAVFQNWAQYRLTMKYLSEMEADQTLHLYSGHPMGLFPSSVDAPRVVVT
NGMMIPNYSKPDDWERFNALGVTQYGQMTAGSFMYIGPQGIVHGTTITVMNGFRKVLEKG
DSPKGKIFLTAGLGGMSGAQPKAGNIAGCITVCAEVNPKAATKRHAQGWVDELIDNMDAL
VARVKQAQANEEVVSIAFIGNVVNVWEAFDEHDIFVHLGSDQTSLHNPWSGGYYPVDISY
DESNRLIREEPELFKTKVQATLKRHADAINRHTAKGTYFFDYGNAFLLEASRAGGDVMAE
NGIDFKYPSYVQDILGPMCFDYGFGPFRWVCTSGNSADLDRTDAIAAEVLARIMAEAPAE
IQQQMQDNITWIKDAKQNKLVVGSQARILYADAEGRMEIAKAFNDAISRGEIGPVVLGRD
HHDVSGTDSPFRETSNIYDGSRFTADMAIHNVIGDSFRGATWVSIHNGGGVGWGEVINGG
FGMLLDGTEAAERRLKSMLLFDVNNGIARRSWARNEEANFAIKREMARTPKLKVTLANSV
DDDIINGLEF
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory