SitesBLAST
Comparing 6937877 FitnessBrowser__SB2B:6937877 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
41% identity, 100% coverage: 2:573/573 of query aligns to 92:665/667 of P09342
- C161 (≠ V71) modified: Disulfide link with 307
- P194 (= P104) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A217) modified: Disulfide link with 161
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 12:583/597 of 6demA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q225), M264 (= M260), V291 (≠ T287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (= D449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (≠ I508), N523 (≠ G513), V524 (≠ H514)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), W496 (= W485), A567 (≠ R558)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ I219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (≠ V281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ T287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ S323), V337 (≠ A324), M412 (= M401), G430 (= G419)
- binding magnesium ion: D460 (= D449), N487 (= N476), E489 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (= D449), A461 (≠ G450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 12:583/597 of 6delA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q225), M264 (= M260), V291 (≠ T287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (= D449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (≠ I508), N523 (≠ G513), V524 (≠ H514)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ I219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (≠ V281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ T287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ S323), V337 (≠ A324), M412 (= M401), G430 (= G419)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (= D449), A461 (≠ G450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
- binding magnesium ion: D460 (= D449), N487 (= N476), E489 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (= D449), A461 (≠ G450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 14:585/599 of 6denA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K230 (≠ Q225), M266 (= M260), V293 (≠ T287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (= D449), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (≠ I508), N525 (≠ G513), V526 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R153), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ I219), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G286 (= G280), A287 (≠ V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), E319 (≠ D304), I320 (= I305), N324 (≠ S309), D338 (≠ S323), V339 (≠ A324), M414 (= M401), G432 (= G419)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W485)
- binding magnesium ion: D462 (= D449), N489 (= N476), E491 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (= D449), A463 (≠ G450), S464 (= S451), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), G493 (= G480), M494 (= M481), V495 (= V482)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
41% identity, 100% coverage: 2:573/573 of query aligns to 89:662/664 of P09114
- P191 (= P104) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W485) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 10:579/593 of 6deoA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (≠ S29), I36 (≠ V30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), K224 (≠ Q225), M260 (= M260), V287 (≠ T287), V403 (= V396), L428 (= L421), G429 (= G422), M431 (= M424), D456 (= D449), N483 (= N476), E485 (≠ F478), Q486 (≠ L479), M488 (= M481), V489 (= V482), W492 (= W485), L514 (≠ I508), N519 (≠ G513), V520 (≠ H514)
- binding flavin-adenine dinucleotide: R159 (= R153), G213 (= G214), A214 (≠ G215), G215 (= G216), N218 (≠ I219), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (= L258), G280 (= G280), A281 (≠ V281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (≠ T287), E313 (≠ D304), I314 (= I305), N318 (≠ S309), D332 (≠ S323), V333 (≠ A324), M408 (= M401), G426 (= G419)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M481), W492 (= W485)
- binding magnesium ion: D456 (= D449), N483 (= N476), E485 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V396), G404 (= G397), Q405 (= Q398), H406 (= H399), G429 (= G422), M431 (= M424), G455 (= G448), D456 (= D449), A457 (≠ G450), S458 (= S451), M461 (= M454), N483 (= N476), E485 (≠ F478), Q486 (≠ L479), G487 (= G480), M488 (= M481), V489 (= V482)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 14:586/600 of 6derA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K231 (≠ Q225), M267 (= M260), V294 (≠ T287), V410 (= V396), L435 (= L421), G436 (= G422), M438 (= M424), D463 (= D449), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), M495 (= M481), V496 (= V482), W499 (= W485), L521 (≠ I508), N526 (≠ G513), V527 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R153), G220 (= G214), A221 (≠ G215), G222 (= G216), N225 (≠ I219), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (= L258), H268 (= H261), G287 (= G280), A288 (≠ V281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (≠ T287), E320 (≠ D304), I321 (= I305), N325 (≠ S309), G338 (= G322), D339 (≠ S323), V340 (≠ A324), Q414 (= Q400), M415 (= M401), G433 (= G419)
- binding Metosulam: R293 (= R286), M495 (= M481), W499 (= W485), A570 (≠ R558)
- binding magnesium ion: D463 (= D449), N490 (= N476), E492 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (= D449), A464 (≠ G450), S465 (= S451), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), G494 (= G480), M495 (= M481), V496 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (= D449), A464 (≠ G450), S465 (= S451), M468 (= M454), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), G494 (= G480), V496 (= V482)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 12:584/598 of 6desA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q225), M265 (= M260), V292 (≠ T287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (= D449), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (≠ I508), N524 (≠ G513), V525 (≠ H514)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ I219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G285 (= G280), A286 (≠ V281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ T287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ S323), V338 (≠ A324), Q412 (= Q400), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (= D449), N488 (= N476), E490 (≠ F478)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (= D449), A462 (≠ G450), S463 (= S451), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 12:584/598 of 6depA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q225), M265 (= M260), V292 (≠ T287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (= D449), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (≠ I508), N524 (≠ G513), V525 (≠ H514)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M481), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ I219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G264 (= G259), G285 (= G280), A286 (≠ V281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ T287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ S323), V338 (≠ A324), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (= D449), N488 (= N476), E490 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (= D449), A462 (≠ G450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (= D449), A462 (≠ G450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
42% identity, 99% coverage: 4:572/573 of query aligns to 14:587/601 of 6deqA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K232 (≠ Q225), M268 (= M260), V295 (≠ T287), V411 (= V396), L436 (= L421), G437 (= G422), M439 (= M424), D464 (= D449), N491 (= N476), E493 (≠ F478), Q494 (≠ L479), M496 (= M481), V497 (= V482), W500 (= W485), L522 (≠ I508), N527 (≠ G513), V528 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R153), G221 (= G214), A222 (≠ G215), G223 (= G216), N226 (≠ I219), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (= L258), G288 (= G280), A289 (≠ V281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (≠ T287), E321 (≠ D304), I322 (= I305), D340 (≠ S323), V341 (≠ A324), M416 (= M401), G434 (= G419)
- binding magnesium ion: D464 (= D449), N491 (= N476), E493 (≠ F478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M481), V497 (= V482), W500 (= W485), A571 (≠ R558)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V396), G412 (= G397), Q413 (= Q398), H414 (= H399), M439 (= M424), G463 (= G448), D464 (= D449), A465 (≠ G450), S466 (= S451), N491 (= N476), E493 (≠ F478), Q494 (≠ L479), G495 (= G480), M496 (= M481), V497 (= V482)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 8:572/595 of 1t9bB
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (≠ S29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R226 (≠ K224), M262 (= M260), V289 (≠ T287), V405 (= V396), L430 (= L421), G431 (= G422), M433 (= M424), D458 (= D449), N485 (= N476), E487 (≠ F478), Q488 (≠ L479), M490 (= M481), V491 (= V482), W494 (= W485), L516 (≠ I508), G521 (= G513), L522 (≠ H514), K555 (≠ E548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V103), P108 (= P104), D287 (= D285), R288 (= R286), M490 (= M481), W494 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R153), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ S220), T242 (= T240), L243 (= L241), Q244 (≠ M242), M259 (= M257), L260 (= L258), M262 (= M260), H263 (= H261), G282 (= G280), A283 (≠ V281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (≠ T287), E315 (≠ D304), V316 (≠ I305), N320 (≠ S309), G333 (= G322), D334 (≠ S323), A335 (= A324), Q409 (= Q400), M410 (= M401), G428 (= G419), G429 (= G420)
- binding magnesium ion: D458 (= D449), N485 (= N476), E487 (≠ F478)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
42% identity, 98% coverage: 4:565/573 of query aligns to 8:573/596 of 1t9cA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (≠ S29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (≠ Q225), M263 (= M260), V290 (≠ T287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (= D449), N486 (= N476), E488 (≠ F478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (≠ I508), G522 (= G513), L523 (≠ H514), K556 (≠ E548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ I219), T243 (= T240), L244 (= L241), Q245 (≠ M242), L261 (= L258), M263 (= M260), H264 (= H261), G283 (= G280), A284 (≠ V281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (≠ T287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (≠ S323), A336 (= A324), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (= D449), N486 (= N476), E488 (≠ F478)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
42% identity, 98% coverage: 4:565/573 of query aligns to 8:573/596 of 1t9dA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (≠ S29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (≠ K224), M263 (= M260), V290 (≠ T287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (= D449), N486 (= N476), E488 (≠ F478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (≠ I508), G522 (= G513), L523 (≠ H514), K556 (≠ E548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), A33 (≠ S29), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), M263 (= M260), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ S220), T243 (= T240), L244 (= L241), Q245 (≠ M242), M260 (= M257), L261 (= L258), H264 (= H261), G283 (= G280), A284 (≠ V281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (≠ T287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (≠ S323), A336 (= A324), Q410 (= Q400), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (= D449), N486 (= N476), E488 (≠ F478)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E51), P81 (= P77), Q118 (= Q114), G432 (= G422), M434 (= M424), M464 (= M454)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
42% identity, 98% coverage: 4:565/573 of query aligns to 9:574/597 of 1t9aA
- active site: Y30 (= Y25), G32 (= G27), G33 (= G28), A34 (≠ S29), I35 (≠ V30), E56 (= E51), T79 (= T74), F118 (= F113), Q119 (= Q114), E120 (= E115), K168 (= K163), R228 (≠ Q225), M264 (= M260), V291 (≠ T287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (= D449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (≠ I508), G523 (= G513), L524 (≠ H514), K557 (≠ E548)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G28), V108 (= V103), P109 (= P104), F118 (= F113), K168 (= K163), M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), V493 (= V482), W496 (= W485)
- binding flavin-adenine dinucleotide: R158 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ I219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), M264 (= M260), H265 (= H261), G284 (= G280), A285 (≠ V281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ T287), E317 (≠ D304), V318 (≠ I305), N322 (≠ S309), G335 (= G322), D336 (≠ S323), A337 (= A324), Q411 (= Q400), M412 (= M401), G430 (= G419), G431 (= G420)
- binding magnesium ion: D460 (= D449), N487 (= N476), E489 (≠ F478)
- binding propyl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (= D449), A461 (≠ G450), S462 (= S451), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G422), M435 (= M424), M465 (= M454)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 92:664/687 of P07342
- R241 (= R153) binding
- 355:376 (vs. 261:282, 45% identical) binding
- 407:426 (vs. 304:323, 35% identical) binding
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 8:568/591 of 5wkcA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (≠ S29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R222 (≠ K224), M258 (= M260), V285 (≠ T287), V401 (= V396), L426 (= L421), G427 (= G422), M429 (= M424), D454 (= D449), N481 (= N476), E483 (≠ F478), Q484 (≠ L479), M486 (= M481), V487 (= V482), W490 (= W485), L512 (≠ I508), G517 (= G513), L518 (≠ H514), K551 (≠ E548)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V396), G402 (= G397), Q403 (= Q398), H404 (= H399), G427 (= G422), M429 (= M424), G453 (= G448), D454 (= D449), A455 (≠ G450), S456 (= S451), M459 (= M454), N481 (= N476), E483 (≠ F478), Q484 (≠ L479), G485 (= G480), M486 (= M481), V487 (= V482)
- binding ethaneperoxoic acid: G32 (= G28), Q118 (= Q114)
- binding flavin-adenine dinucleotide: R157 (= R153), G211 (= G214), A212 (≠ G215), G213 (= G216), N216 (≠ S220), T238 (= T240), L239 (= L241), Q240 (≠ M242), L256 (= L258), M258 (= M260), G278 (= G280), A279 (≠ V281), R280 (= R282), R284 (= R286), V285 (≠ T287), E311 (≠ D304), V312 (≠ I305), N316 (≠ S309), D330 (≠ S323), A331 (= A324), M406 (= M401), G424 (= G419)
- binding magnesium ion: D454 (= D449), N481 (= N476), E483 (≠ F478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G28), A33 (≠ S29), V107 (= V103), F117 (= F113), K167 (= K163), M258 (= M260), R284 (= R286), M486 (= M481), W490 (= W485)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P26), E55 (= E51)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 7:559/582 of 1t9dB
- active site: Y28 (= Y25), G30 (= G27), G31 (= G28), A32 (≠ S29), I33 (≠ V30), E54 (= E51), T77 (= T74), F116 (= F113), Q117 (= Q114), E118 (= E115), K166 (= K163), R213 (≠ Q225), M249 (= M260), V276 (≠ T287), V392 (= V396), L417 (= L421), G418 (= G422), M420 (= M424), D445 (= D449), N472 (= N476), E474 (≠ F478), Q475 (≠ L479), M477 (= M481), V478 (= V482), W481 (= W485), L503 (≠ I508), G508 (= G513), L509 (≠ H514), K542 (≠ E548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G28), A32 (≠ S29), V106 (= V103), P107 (= P104), F116 (= F113), K166 (= K163), M249 (= M260), D274 (= D285), R275 (= R286), W481 (= W485)
- binding flavin-adenine dinucleotide: R156 (= R153), G202 (= G214), A203 (≠ G215), G204 (= G216), N207 (≠ I219), T229 (= T240), L230 (= L241), Q231 (≠ M242), L247 (= L258), M249 (= M260), H250 (= H261), G269 (= G280), A270 (≠ V281), R271 (= R282), D273 (= D284), R275 (= R286), V276 (≠ T287), E302 (≠ D304), V303 (≠ I305), N307 (≠ S309), G320 (= G322), D321 (≠ S323), A322 (= A324), Q396 (= Q400), M397 (= M401), G415 (= G419), G416 (= G420)
- binding magnesium ion: D445 (= D449), N472 (= N476), E474 (≠ F478)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E51), P80 (= P77), G418 (= G422), M420 (= M424), M450 (= M454)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
42% identity, 98% coverage: 4:565/573 of query aligns to 12:584/607 of 6u9dB
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M274 (= M260), V301 (≠ T287), V417 (= V396), G443 (= G422), M445 (= M424), D470 (= D449), N497 (= N476), E499 (≠ F478), Q500 (≠ L479), M502 (= M481), V503 (= V482), W506 (= W485)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G28), V111 (= V103), P112 (= P104), F121 (= F113), K171 (= K163), D299 (= D285), R300 (= R286), M502 (= M481), W506 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R153), A228 (≠ G215), G229 (= G216), N232 (≠ I219), T254 (= T240), L255 (= L241), Q256 (≠ M242), L272 (= L258), M274 (= M260), G294 (= G280), R296 (= R282), D298 (= D284), R300 (= R286), V301 (≠ T287), E327 (≠ D304), V328 (≠ I305), N332 (≠ S309), D346 (≠ S323), A347 (= A324), M422 (= M401), G440 (= G419), G441 (= G420)
- binding magnesium ion: D470 (= D449), N497 (= N476)
- binding thiamine diphosphate: E59 (= E51), P85 (= P77), V417 (= V396), G418 (= G397), Q419 (= Q398), H420 (= H399), G443 (= G422), M445 (= M424), A471 (≠ G450), S472 (= S451), N497 (= N476), E499 (≠ F478), Q500 (≠ L479), G501 (= G480), M502 (= M481), V503 (= V482)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 10:576/599 of 1n0hA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (≠ S29), I36 (≠ V30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), R230 (≠ Q225), M266 (= M260), V293 (≠ T287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (= D449), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (≠ I508), G525 (= G513), L526 (≠ H514), K559 (≠ E548)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (= D449), A463 (≠ G450), S464 (= S451), M467 (= M454), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), G493 (= G480), V495 (= V482)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G28), A35 (≠ S29), V109 (= V103), P110 (= P104), F119 (= F113), K169 (= K163), M266 (= M260), D291 (= D285), R292 (= R286), V495 (= V482), W498 (= W485)
- binding flavin-adenine dinucleotide: R159 (= R153), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ I219), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), A287 (≠ V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), E319 (≠ D304), V320 (≠ I305), N324 (≠ S309), G337 (= G322), D338 (≠ S323), A339 (= A324), M414 (= M401), G432 (= G419), G433 (= G420)
- binding magnesium ion: D462 (= D449), N489 (= N476), E491 (≠ F478)
- binding thiamine diphosphate: Y31 (= Y25), E57 (= E51), P83 (= P77)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
43% identity, 98% coverage: 4:565/573 of query aligns to 8:560/583 of 1t9bA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (≠ S29), I34 (≠ V30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R214 (≠ Q225), M250 (= M260), V277 (≠ T287), V393 (= V396), L418 (= L421), G419 (= G422), M421 (= M424), D446 (= D449), N473 (= N476), E475 (≠ F478), Q476 (≠ L479), M478 (= M481), V479 (= V482), W482 (= W485), L504 (≠ I508), G509 (= G513), L510 (≠ H514), K543 (≠ E548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V103), P108 (= P104), F117 (= F113), D275 (= D285), R276 (= R286), M478 (= M481), W482 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R153), G203 (= G214), A204 (≠ G215), G205 (= G216), N208 (≠ I219), T230 (= T240), L231 (= L241), Q232 (≠ M242), M247 (= M257), L248 (= L258), M250 (= M260), H251 (= H261), G270 (= G280), A271 (≠ V281), R272 (= R282), D274 (= D284), R276 (= R286), V277 (≠ T287), E303 (≠ D304), V304 (≠ I305), N308 (≠ S309), D322 (≠ S323), A323 (= A324), Q397 (= Q400), M398 (= M401), G416 (= G419), G417 (= G420)
- binding magnesium ion: D446 (= D449), N473 (= N476), E475 (≠ F478)
Query Sequence
>6937877 FitnessBrowser__SB2B:6937877
MEKLSGASMIVRSLIDEGVKHIFGYPGGSVLDIYDALHESSNIEHILVRHEQAAVHMADG
YARATGDVGVVLVTSGPGATNAITGIATAYMDSVPLVILSGQVPSSLIGNDAFQECDMIG
ISRPIVKHSFLVKDPTEIPETIKKAFYIAATGRPGPVVVDLPKDTLNPALKFDYEYPSEV
KMRSYNPTVTGHKGQIRRGLQALLNAKKPVLYVGGGAIISSCDKQILALSERLNIPVVNT
LMGLGAFPGTHPNNIGMLGMHGTYEANMTMHNSDLIFGIGVRFDDRTTNNVQKYCPNATV
LHIDIDPSSISKTVQAHIPIVGSADKVLDEMLSLLDGDTEMRNDEGAIDCWWNDINQWRS
RKCLAYETNSEKIKPQQVIETLYRLTKGDAYVSSDVGQHQMFAALYYPFDKPRRWINSGG
LGTMGFGLPAAMGVKMAMPDETVVCVTGDGSIQMNIQELSTALQYDVPVKIINLNNRFLG
MVKQWQDMIYSGRHSHSYMDSVPDFAKIAEAYGHVGITISRPEELEPKLAEALSMTDRLV
FVDINVDETEHVYPMQIRGGAMNDMWLSKTERS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory