Comparing 6937918 FitnessBrowser__SB2B:6937918 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 11 hits to proteins with known functional sites (download)
1itwA Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn (see paper)
71% identity, 99% coverage: 4:740/741 of query aligns to 1:737/740 of 1itwA
1j1wA Crystal structure of the monomeric isocitrate dehydrogenase in complex with NADP+ (see paper)
71% identity, 99% coverage: 5:740/741 of query aligns to 1:736/738 of 1j1wA
P16100 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Azotobacter vinelandii (see 2 papers)
71% identity, 99% coverage: 4:740/741 of query aligns to 2:738/741 of P16100
Sites not aligning to the query:
6g3uA Structure of pseudomonas aeruginosa isocitrate dehydrogenase, idh (see paper)
64% identity, 98% coverage: 8:736/741 of query aligns to 3:730/737 of 6g3uA
4zdaA Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
63% identity, 99% coverage: 6:736/741 of query aligns to 1:732/735 of 4zdaA
5z16B A novel dimeric isocitrate dehydrogenase from acinetobacter baumannii
62% identity, 99% coverage: 7:740/741 of query aligns to 2:736/739 of 5z16B
5kvuA Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from mycobacterium tuberculosis
61% identity, 99% coverage: 6:739/741 of query aligns to 2:735/738 of 5kvuA
3mbcA Crystal structure of monomeric isocitrate dehydrogenase from corynebacterium glutamicum in complex with NADP (see paper)
62% identity, 99% coverage: 8:739/741 of query aligns to 3:732/735 of 3mbcA
2b0tA Structure of monomeric NADP isocitrate dehydrogenase (see paper)
62% identity, 99% coverage: 8:739/741 of query aligns to 3:732/735 of 2b0tA
P50216 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
62% identity, 99% coverage: 8:739/741 of query aligns to 4:733/738 of P50216
7y1uA Crystal structure of isocitrate dehydrogenase from campylobacter corcagiensis
55% identity, 99% coverage: 8:740/741 of query aligns to 2:723/723 of 7y1uA
>6937918 FitnessBrowser__SB2B:6937918
MKDNSPTIIYTETDEAPALATLSLLPILQTFAEPAGVKIETRDISLSGRVIATFPEKLTD
AQRIGDHLAELGELATKPEANIIKLPNISASIPQLKACIKELQAQGYDIPNYPEEPKTDE
EKSIKARYDKIKGSAVNPVLREGNSDRRAPLSVKNYARKNPHSMGKWASDSKSHVSHMEA
GDFYGSEQSVTLADADSVSIVHTSKAGVETVLKSGLKLQAGEIIDSAVMSKNALVAFFER
EIEAAKAEDVLLSLHLKATMMKVSDPIMFGHAVKVFFKPLFAKHAETFERLGVDVNNGFG
DVVAKIQSLPEAERAAIEADIQAVYAERPAMAMVNSDKGITNLHVPSDIIIDASMPAAIR
SSGQMWGPDGQLKDTKFMIPDRCYAGVYDATINFCKAHGAFDPRTMGTIPNVGLMAQKAE
EYGSHDKTFEIAEDGVVTVVNAAGSVLMSHTVEAGDIFRMCQVKDAPIQDWVKLAVRRAR
LSETPAVFWLDKNRAHDAELIKKVEAYLPQHDTSGLEIHIMSPVEATQFSLARMKDGKDT
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVEQVQSENY
LRWDSLGEFLALAASFEHLAQTAGVAKAQVLADTLDTAIGKFLDENKSPARRVGQIDNRG
SHFYLAMYWAQALAAQTADAELAAHFGQLADKLAANEETILAELIGVQGHSVDLGGYYRP
DFAKASAVMRPSATLNGLMSH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory