Comparing 6938100 FitnessBrowser__SB2B:6938100 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
Q02I31 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
69% identity, 98% coverage: 1:110/112 of query aligns to 1:110/118 of Q02I31
2v6tB Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from toxoplasma gondii with 7,8-dihydrobiopterin (see paper)
30% identity, 78% coverage: 22:108/112 of query aligns to 9:93/100 of 2v6tB
P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat) (see 2 papers)
32% identity, 67% coverage: 36:110/112 of query aligns to 28:99/104 of P61459
Sites not aligning to the query:
P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human) (see 6 papers)
32% identity, 67% coverage: 36:110/112 of query aligns to 28:99/104 of P61457
Sites not aligning to the query:
1dcpA Dcoh, a bifunctional protein-binding transcriptional coactivator, complexed with biopterin (see paper)
32% identity, 67% coverage: 36:110/112 of query aligns to 23:94/99 of 1dcpA
1f93A Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh (see paper)
32% identity, 67% coverage: 36:110/112 of query aligns to 27:98/103 of 1f93A
>6938100 FitnessBrowser__SB2B:6938100
MSELASMKCEACQADAPKVTDAELAELIRMIPDWSVQVRDGIMQLERVYKFKNFKLAMAF
SNKLAELAEEEFHHPGIFTEWGKVTVTWWSHSIKGLHRNDFIMAAKTDQLLD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory