SitesBLAST
Comparing 6938321 FitnessBrowser__SB2B:6938321 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
24% identity, 51% coverage: 42:514/935 of query aligns to 45:460/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ F70), G75 (≠ A72), S76 (≠ A73), G77 (= G74), T78 (= T75), G79 (≠ S76), L80 (= L77), A83 (≠ Q80), C84 (≠ A81), P137 (= P133), G138 (≠ A134), E139 (≠ T135), A142 (= A139), T143 (≠ M140), G146 (= G143), N147 (≠ I144), S149 (≠ N146), T150 (≠ N147), A152 (= A149), G153 (≠ S150), E203 (= E251), G204 (= G252), I209 (≠ V257), E422 (= E476), H423 (= H477)
- binding fe (iii) ion: H377 (= H431), H384 (= H438), E422 (= E476)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
25% identity, 50% coverage: 52:520/935 of query aligns to 50:458/459 of P9WIT1
- K354 (≠ I396) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
25% identity, 40% coverage: 137:514/935 of query aligns to 196:513/521 of Q8N465
- A205 (≠ N146) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
- A231 (= A172) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
- G233 (= G174) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734
- D375 (= D367) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
- R386 (= R378) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- T390 (≠ F382) binding ; binding ; mutation to A: Significantly reduced catalytic activity.
- V399 (= V395) to M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
- K401 (≠ I397) binding ; binding ; mutation to A: Loss of catalytic activity.
- R419 (≠ T415) to H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
- A426 (≠ G422) to T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
- H434 (= H431) binding ; mutation to A: Loss of catalytic activity.
- G436 (≠ L433) to V: slight reduction in catalytic activity
- N439 (= N436) to D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
- H441 (= H438) binding ; mutation to A: Loss of catalytic activity.
- N443 (≠ I440) binding ; mutation to A: Significantly reduced catalytic activity.
- V444 (≠ I441) to A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
- A446 (≠ I451) to V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
- E475 (= E476) binding ; mutation to A: Loss of catalytic activity.
- H476 (= H477) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- G477 (= G478) to R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640
Sites not aligning to the query:
- 15 R → G: in dbSNP:rs4675887
- 109 S → W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
- 127 N → K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
- 131 G → V: in D2HGA1; uncertain significance; complete loss of catalytic activity
- 147 I → S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
- 153 M → T: in D2HGA1; uncertain significance; significant loss of catalytic activity; M → V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
- 169:521 natural variant: Missing (in D2HGA1; uncertain significance)
- 172 C → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
- 189 P → L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
- 400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
25% identity, 41% coverage: 132:514/935 of query aligns to 139:461/467 of 6lpnB
- binding flavin-adenine dinucleotide: L140 (≠ P133), A142 (≠ T135), C146 (≠ A139), H147 (≠ M140), G150 (= G143), N151 (≠ I144), A153 (≠ N146), T154 (≠ N147), G208 (= G252), I212 (≠ F256), I213 (≠ V257), E423 (= E476), N460 (= N513)
Sites not aligning to the query:
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
25% identity, 41% coverage: 132:514/935 of query aligns to 138:460/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R378), T337 (≠ F382), K348 (≠ I397), Y379 (= Y429), H381 (= H431), H388 (= H438), H423 (= H477)
- binding flavin-adenine dinucleotide: L139 (≠ P133), G140 (≠ A134), A141 (≠ T135), C145 (≠ A139), G149 (= G143), N150 (≠ I144), A152 (≠ N146), T153 (≠ N147), G157 (= G151), G207 (= G252), I212 (≠ V257), E422 (= E476), N459 (= N513)
- binding zinc ion: H381 (= H431), H388 (= H438), E422 (= E476)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 39, 75, 76, 77, 78, 79, 80, 81, 82, 85, 86
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
25% identity, 41% coverage: 132:514/935 of query aligns to 138:460/466 of 6lpuA
- binding flavin-adenine dinucleotide: L139 (≠ P133), G140 (≠ A134), A141 (≠ T135), C145 (≠ A139), H146 (≠ M140), G148 (= G142), G149 (= G143), N150 (≠ I144), A152 (≠ N146), T153 (≠ N147), A155 (= A149), E206 (= E251), G207 (= G252), I211 (≠ F256), I212 (≠ V257), E422 (= E476), N459 (= N513)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R378), T337 (≠ F382), K348 (≠ I397), Y379 (= Y429), H381 (= H431), H388 (= H438), H423 (= H477)
- binding zinc ion: H381 (= H431), H388 (= H438), E422 (= E476)
Sites not aligning to the query:
6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
25% identity, 41% coverage: 132:514/935 of query aligns to 138:460/466 of 6lpqA
- binding flavin-adenine dinucleotide: L139 (≠ P133), G140 (≠ A134), A141 (≠ T135), C145 (≠ A139), H146 (≠ M140), G149 (= G143), N150 (≠ I144), A152 (≠ N146), T153 (≠ N147), A155 (= A149), G157 (= G151), E206 (= E251), G207 (= G252), I211 (≠ F256), I212 (≠ V257), E422 (= E476), N459 (= N513)
- binding d-malate: R333 (= R378), T337 (≠ F382), K348 (≠ I397), Y379 (= Y429), H381 (= H431), H388 (= H438), E422 (= E476), H423 (= H477)
- binding zinc ion: H381 (= H431), H388 (= H438), E422 (= E476)
Sites not aligning to the query:
6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
25% identity, 41% coverage: 132:514/935 of query aligns to 138:460/466 of 6lppA
- binding (2R)-2-hydroxypentanedioic acid: R333 (= R378), T337 (≠ F382), K348 (≠ I397), Y379 (= Y429), H381 (= H431), H388 (= H438), N390 (≠ I440), H423 (= H477)
- binding flavin-adenine dinucleotide: L139 (≠ P133), G140 (≠ A134), A141 (≠ T135), C145 (≠ A139), G149 (= G143), N150 (≠ I144), A152 (≠ N146), T153 (≠ N147), A155 (= A149), G157 (= G151), G207 (= G252), I212 (≠ V257), E422 (= E476), H423 (= H477)
- binding zinc ion: H381 (= H431), H388 (= H438), E422 (= E476)
Sites not aligning to the query:
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
24% identity, 53% coverage: 24:518/935 of query aligns to 22:465/465 of 3pm9A
- active site: A149 (= A149), L159 (≠ N159)
- binding flavin-adenine dinucleotide: P69 (≠ F70), Q70 (≠ R71), G71 (≠ A72), G72 (≠ A73), N73 (≠ G74), T74 (= T75), G75 (≠ S76), L76 (= L77), G79 (≠ Q80), Q80 (≠ A81), L91 (≠ M89), L133 (≠ P133), G134 (≠ A134), A135 (≠ T135), C139 (≠ A139), T140 (≠ M140), G142 (= G142), G143 (= G143), S146 (≠ N146), T147 (≠ N147), A149 (= A149), G150 (≠ S150), E200 (= E251), G201 (= G252), I205 (≠ F256), I206 (≠ V257), E423 (= E476)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ T75), R317 (= R378), W321 (≠ F382), H368 (= H431), H375 (= H438), H413 (= H477)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W321 (≠ F382), Y322 (≠ P383), E412 (= E476), H413 (= H477), N449 (= N513)
- binding manganese (ii) ion: H368 (= H431), H375 (= H438), E412 (= E476)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R378), W322 (≠ F382), H369 (= H431), H376 (= H438), H414 (= H477)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W322 (≠ F382), E413 (= E476), N450 (= N513)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E413 (= E476)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ A35), P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W323 (≠ F382), E414 (= E476), H415 (= H477), N451 (= N513)
- binding manganese (ii) ion: H370 (= H431), H377 (= H438), E414 (= E476)
- binding pyruvic acid: R319 (= R378), H370 (= H431), H377 (= H438), H415 (= H477)
P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 51% coverage: 38:514/935 of query aligns to 64:492/496 of P39976
Sites not aligning to the query:
- 17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
22% identity, 55% coverage: 1:518/935 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W322 (≠ F382), E413 (= E476), H414 (= H477), N450 (= N513)
- binding lactic acid: R318 (= R378), H369 (= H431), H376 (= H438), H414 (= H477)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E413 (= E476)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R378), H369 (= H431), H376 (= H438), H414 (= H477)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W322 (≠ F382), E413 (= E476), H414 (= H477), N450 (= N513)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E413 (= E476)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ A35), P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W322 (≠ F382), E413 (= E476), H414 (= H477), N450 (= N513)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R378), H369 (= H431), H376 (= H438), H414 (= H477)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E413 (= E476)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R378), W322 (≠ F382), H369 (= H431), H376 (= H438), H413 (= H477)
- binding flavin-adenine dinucleotide: E32 (≠ A35), P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), W322 (≠ F382), E412 (= E476), H413 (= H477), N449 (= N513)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E412 (= E476)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R378), W322 (≠ F382), S336 (≠ I397), H369 (= H431), H376 (= H438), H413 (= H477)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), E412 (= E476), N449 (= N513)
- binding manganese (ii) ion: H369 (= H431), H376 (= H438), E412 (= E476)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), Y324 (≠ P383), H370 (= H431), E414 (= E476), N451 (= N513)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R378), W323 (≠ F382), H415 (= H477)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
23% identity, 55% coverage: 1:518/935 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R378), W323 (≠ F382), H370 (= H431), H415 (= H477)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (≠ F70), T71 (≠ R71), G72 (≠ A72), T73 (≠ A73), G74 (= G74), G78 (≠ S78), V79 (≠ G79), L90 (= L90), P132 (= P133), G133 (≠ A134), A134 (= A137), G140 (= G143), M141 (≠ I144), A143 (≠ N146), T144 (≠ N147), A146 (= A149), S147 (= S150), E200 (= E251), G201 (= G252), I206 (≠ V257), H370 (= H431), E414 (= E476), N451 (= N513)
Query Sequence
>6938321 FitnessBrowser__SB2B:6938321
MSVDYKAVIEALKSRLGPQAVSDDPVRRFAWSTDASYFRIVPEVVVHADSLDEVQQTLAI
AREHGAPVTFRAAGTSLSGQAIGPGILLMLGHDGFRQLKVSSDGTKVSLGAAVIGADANA
ALKALDKKIGPDPATLASAMIGGIVNNNASGMCCGTAQNSYQTIDSLRMVLADGTVLDTG
SEASRQAFEQSHGALLNDLSNLAAMVKANHGLAARIRKKYAIKNTTGYSLNALVDFSCPF
DIINHLMVGSEGTLGFVEQVTYHTVDEARFKASAMAVFFSMEEAASAIPFLIGKSVAAAE
LLDWASIRAVTGKKGMPDWLSSLPEGAAILLIESRAADADTLQAYTEEVIGKIAHIPTER
PIVFSTDPAVYSKYWAMRSGLFPIIGGERPKGSSVIIEDVAFEVQHLAAAAKDLTALFHE
HGYPEGVIYGHALAGNFHFIITPTFASQGDIDRFHGFMQAVAEMVINKYDGSMKAEHGTG
RAVAPFVEMEWGSEAYTLMKSIKSLFDPSGLLNPGVILNDDATVHVKNIKPCPVVDDLVD
KCIECGFCEKTCPTSALNLTPRQRIATLREISRLEASGDEEAASRMRDAAKYDVVDTCAA
CQLCTIACPVDNSMGQLVRKLRTPYISTTEQKVLDFQAKHFGAVNQVISTGFDTLGVIHK
LTGDTVTSALMKVGRMVSKEVPYWDPSFPKGGALPKLPPHKVGQETLVYFPACGGRTFGP
TPLDKDKRPLPEVVVQVLERAGYNVVIPEHTRSLCCGQMWESKGDFKNADGKRRELIEAL
KAKSENGKLKVVVDALSCTKRTLGGDPDVEILDLVEFLHDDVLSRLSIRQKPLVTLHLGC
SARHLKVEAKMQAIADTCAKEVHKPAGIECCGYAGEKGLYKPEINASALRNIKKLLPAAA
TEGYYANRMCEVGLSKHSGISYRHLVYLLEECSRG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory