Comparing 6938359 FitnessBrowser__SB2B:6938359 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3triA Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
42% identity, 97% coverage: 6:269/271 of query aligns to 5:269/272 of 3triA
2ag8A NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
34% identity, 98% coverage: 6:271/271 of query aligns to 3:262/263 of 2ag8A
5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline (see paper)
35% identity, 97% coverage: 6:268/271 of query aligns to 11:272/272 of 5bshA
5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+ (see paper)
35% identity, 97% coverage: 6:268/271 of query aligns to 11:272/272 of 5bsgA
5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+ (see paper)
35% identity, 97% coverage: 6:268/271 of query aligns to 11:272/272 of 5bsfA
5bseA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
35% identity, 97% coverage: 6:268/271 of query aligns to 11:272/272 of 5bseA
Q96C36 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC 1.5.1.2 from Homo sapiens (Human) (see paper)
35% identity, 95% coverage: 8:265/271 of query aligns to 5:267/320 of Q96C36
Sites not aligning to the query:
6xp0A Structure of human pycr1 complexed with n-formyl l-proline (see paper)
34% identity, 97% coverage: 2:265/271 of query aligns to 1:266/272 of 6xp0A
5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid (see paper)
33% identity, 98% coverage: 1:265/271 of query aligns to 2:271/278 of 5uavA
6xp1B Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate (see paper)
33% identity, 98% coverage: 1:265/271 of query aligns to 4:273/281 of 6xp1B
6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid (see paper)
33% identity, 98% coverage: 1:265/271 of query aligns to 1:270/276 of 6xp3A
5uatC Structure of human pycr-1 complexed with NADPH (see paper)
33% identity, 98% coverage: 1:265/271 of query aligns to 2:271/277 of 5uatC
2izzA Crystal structure of human pyrroline-5-carboxylate reductase
34% identity, 95% coverage: 8:265/271 of query aligns to 6:268/272 of 2izzA
2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP (see paper)
33% identity, 96% coverage: 6:265/271 of query aligns to 5:269/277 of 2graA
2gr9A Crystal structure of p5cr complexed with nadh (see paper)
33% identity, 96% coverage: 6:265/271 of query aligns to 5:269/277 of 2gr9A
5uauA Structure of human pycr-1 complexed with proline (see paper)
33% identity, 96% coverage: 6:265/271 of query aligns to 3:267/274 of 5uauA
P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 4 papers)
33% identity, 96% coverage: 6:265/271 of query aligns to 3:267/319 of P32322
Sites not aligning to the query:
2rcyA Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
29% identity, 99% coverage: 1:267/271 of query aligns to 2:260/262 of 2rcyA
2ahrE Crystal structures of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
31% identity, 97% coverage: 5:267/271 of query aligns to 5:259/259 of 2ahrE
2amfA Crystal structure of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
31% identity, 97% coverage: 5:267/271 of query aligns to 3:257/257 of 2amfA
>6938359 FitnessBrowser__SB2B:6938359
MQNKKICFIGAGNMSRAIIGGLIKSGYSASLITATNPSLPKLDALAADYGINTSQDNVPS
ASAADVIVLSVKPQLMQAVCESLAGVVDDKLLITIAAGIPENRYHDYFGKQVKLIRTMPN
TPMQLGLGMTGLYAPAGMPDEDKAFAESLMRACGDIVWVNEESGIDKVIALAGSSPAYFF
LFIEAMIEAGVEMGLPEADARTLAQQAAVGAAAMVKQNPGLTPAELRANVTSKGGTTAEA
IATFEAGGLRTLVKDAMGNCIKRAEEMARNF
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory