Comparing 6938397 FitnessBrowser__SB2B:6938397 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see paper)
63% identity, 95% coverage: 11:371/379 of query aligns to 7:366/367 of P0A7B5
2j5tD Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
63% identity, 95% coverage: 11:371/379 of query aligns to 5:364/365 of 2j5tD
2j5vB Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
56% identity, 95% coverage: 11:371/379 of query aligns to 5:324/325 of 2j5vB
2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
56% identity, 95% coverage: 11:370/379 of query aligns to 5:321/323 of 2j5vA
2akoA Crystal structure of glutamate 5-kinase from campylobacter jejuni
38% identity, 63% coverage: 9:247/379 of query aligns to 1:226/241 of 2akoA
7wx3B Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
35% identity, 68% coverage: 3:259/379 of query aligns to 7:256/258 of 7wx3B
7f5xA Gk domain of drosophila p5cs filament with glutamate (see paper)
34% identity, 68% coverage: 3:259/379 of query aligns to 7:234/236 of 7f5xA
3c1mC Cyrstal structure of threonine-sensitive aspartokinase from methanococcus jannaschii with mgamp-pnp and l-aspartate (see paper)
32% identity, 22% coverage: 115:199/379 of query aligns to 167:255/468 of 3c1mC
Sites not aligning to the query:
3c1nA Crystal structure of allosteric inhibition threonine-sensitive aspartokinase from methanococcus jannaschii with l-threonine (see paper)
32% identity, 22% coverage: 115:199/379 of query aligns to 166:254/458 of 3c1nA
Sites not aligning to the query:
2hmfA Structure of a threonine sensitive aspartokinase from methanococcus jannaschii complexed with mg-adp and aspartate (see paper)
32% identity, 22% coverage: 115:199/379 of query aligns to 167:255/464 of 2hmfA
Sites not aligning to the query:
8u0mA Isopentenyl phosphate kinase (see paper)
27% identity, 40% coverage: 112:263/379 of query aligns to 107:247/247 of 8u0mA
Sites not aligning to the query:
Q8U122 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
31% identity, 22% coverage: 153:237/379 of query aligns to 120:201/225 of Q8U122
Sites not aligning to the query:
2bmuB Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp (see paper)
31% identity, 22% coverage: 153:237/379 of query aligns to 121:202/226 of 2bmuB
Sites not aligning to the query:
>6938397 FitnessBrowser__SB2B:6938397
MNSSVQGYRRVVVKLGTSVLTSGSKSLDKAHMVELARQMAGLMKSGVEVVLVTSGAIAAG
REHLGYPVLPDTMANKQLLAAVGQSQLILAWSQLFSIYGLHVGQLLLTRADLHDRERYLN
ARDTLNALLAQGIVPIINENDAVATTEIKVGDNDNLSARAALLCDADLLMLLTDQKGLFD
ADPRKEPNARLIPEVEHIDDSLRLLAGGSVSGLGTGGMATKLQAADIARRAGVEVIIASG
HHPEVIKKAVHREAVGTRFLAIESPLESRKQWILAGPKAKGRLLLDIGAVAAVTCRGRSL
LSKGITGVEGQFERGDTLELVSPDGRVVARGMARYQSQALNLIAGKHSDEIEPLLGYDYG
DAVVHRNDMVVLEMIGEAK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory