SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 6938540 FitnessBrowser__SB2B:6938540 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
64% identity, 98% coverage: 4:455/460 of query aligns to 2:449/450 of 6gwiB

query
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6gwiB

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active site: F18 (= F24), Y149 (= Y155), D255 (= D261), K284 (= K290)
binding pyridoxal-5'-phosphate: S115 (= S121), G116 (= G122), S117 (= S123), Y149 (= Y155), H150 (= H156), G151 (= G157), E222 (= E228), D255 (= D261), V257 (= V263), I258 (= I264), K284 (= K290)

7qx0B Transaminase structure of plurienzyme (tr2e2) in complex with plp (see paper)
62% identity, 96% coverage: 13:455/460 of query aligns to 6:442/443 of 7qx0B

query
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7qx0B

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binding pyridoxal-5'-phosphate: S114 (= S121), G115 (= G122), S116 (= S123), Y148 (= Y155), H149 (= H156), E221 (= E228), D254 (= D261), V256 (= V263), I257 (= I264), K283 (= K290)

7qx3A Structure of the transaminase tr2e2 with eos (see paper)
63% identity, 92% coverage: 35:455/460 of query aligns to 1:421/422 of 7qx3A

query
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I

V

E

K

S

N

G

G

L

L

V

V

M

M

R

R

A

A

V

V

G

G

D

G

T

T

M

M

I

I

I

I

S

S

P

P

P

P

L

L

C

V

I

L

T

S

R

R

D

E

E

Q

I

V

D

D

E

E

L

L

I

I

F

D

K

K

A

A

S

R

Q

R

A

T

L

L

S

D

L

E

T

T

L

H

E

K

K

A

I

I

binding 2-azanylethyl hydrogen sulfate: Y121 (= Y155), A199 (= A233), K256 (= K290)

6s4gA Crystal structure of the omega transaminase from chromobacterium violaceum in complex with pmp (see paper)
55% identity, 98% coverage: 8:459/460 of query aligns to 1:452/453 of 6s4gA

query
sites
6s4gA

T

T

I

T

S

S

A

Q

L

W

Q

R

A

E

M

L

D

D

A

A

A

A

H

H

H

H

L

L

H

H

P

P

F
|
F

T

T

D

D

S

T

A

A

D

S

L

L

A

N

K

Q

R

A

G

G

T

A

R

R

V

V

I

M

E

T

R

R

A

G

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

D

I

F

A

A

D

E

A

A

A

A

Y

R

A

R

Q

Q

L

M

Q

E

T

E

L

L

P

P

F

F

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

T

H

H

E

P

P

A

A

V

I

V

R

E

L

L

A

S

S

S

K

L

I

L

A

A

S

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

N

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

D

D

L

V

K

Q

G

G

M

K

P

P

S

E

K

K

K

K

T

T

I

L

I

I

S

G

R

R

K

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

G

K

F

Y

M

M

H

H

Q

E

Q

Q

G

G

D

D

L

L

P

P

I

I

P

P

G

G

I

M

V

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

S

T

P

P

E

D

A

E

F

F

G

G

I

V

K

V

T

A

A

A

Q

R

A

W

L

L

E

E

A

E

K

K

I

I

L

L

E

E

L

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

F

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

D

A

S

T

Y

Y

W

W

N

P

E

E

I

I

K

E

R

R

I

I

L

C

E

R

K

K

Y

Y

N

D

I

V

L

L

F

L

I

V

L

A

D
|
D

E

E

V
|
V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

T

G

G

N

E

W

W

F

F

A

G

A

H

Q

Q

T

H

L

F

G

G

L

F

K

Q

P

P

D

D

L

L

I

F

T

T

I

A

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

S

G

D

K

R

R

V

V

A

A

D

E

V

G

L

L

I

I

S

A

D

-

G

G

G

G

E

D

F

F

A

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

E

R

E

D

E

E

R

G

L

I

V

V

D

Q

K

R

V

V

R

K

T

D

D

D

T

I

G

G

P

P

Y

Y

L

M

Q

Q

D

K

R

R

L

W

-

R

Q

E

T

T

L

F

S

S

A

R

H

F

P

E

L

H

V

V

G

D

E

D

V

V

R

R

G

G

M

V

G

G

M

M

V

V

G

Q

A

A

I

F

E

T

L

L

V

V

A

K

D

N

K

K

H

A

S

K

M

R

V

E

R

L

F

F

G

P

S

D

E

F

I

G

S

E

A

I

G

G

M

T

L

L

C

C

R

R

E

D

A

I

C

F

I

F

E

R

S

N

G

N

L

L

V

I

M

M

R

R

A

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

C

V

I

M

T

T

R

R

D

A

E

E

I

V

D

D

E

E

L

M

I

L

F

A

K

V

A

A

S

E

Q

R

A

C

L

L

S

E

L

E

T

F

L

E

E

Q

K

T

I

L

A

K

A

A

R

R

G

G

active site: F17 (= F24), Y148 (= Y155), D254 (= D261), K283 (= K290)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S114 (= S121), G115 (= G122), S116 (= S123), Y148 (= Y155), H149 (= H156), G150 (= G157), E221 (= E228), D254 (= D261), V256 (= V263), I257 (= I264), K283 (= K290), F315 (= F323), T316 (= T324)

7q9xAAA Probable aminotransferase
55% identity, 98% coverage: 8:459/460 of query aligns to 2:453/455 of 7q9xAAA

query
sites
7q9xAAA

T

T

I

T

S

S

A

Q

L

W

Q

R

A

E

M

L

D

D

A

A

A

A

H

H

H

H

L

L

H

H

P

P

F

F

T

T

D

D

S

T

A

A

D

S

L

L

A

N

K

Q

R

A

G

G

T

A

R

R

V

V

I

M

E

T

R

R

A

G

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

I

D

D

A

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

D

I

F

A

A

D

E

A

A

A

A

Y

R

A

R

Q

Q

L

M

Q

E

T

E

L

L

P

P

F

F

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

T

H

H

E

P

P

A

A

V

I

V

R

E

L

L

A

S

S

S

K

L

I

L

A

A

S

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

N

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

D

D

L

V

K

Q

G

G

M

K

P

P

S

E

K

K

K

K

T

T

I

L

I

I

S

G

R

R

K

W

N

N

A

G

Y
|
Y

H

H

G
|
G

S

S

T

T

V

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

G

K

F

Y

M

M

H

H

Q

E

Q

Q

G

G

D

D

L

L

P

P

I

I

P

P

G

G

I

M

V

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

S

T

P

P

E

D

A

E

F

F

G

G

I

V

K

V

T

A

A

A

Q

R

A

W

L

L

E

E

A

E

K

K

I

I

L

L

E

E

L

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

F

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

D

A

S

T

Y

Y

W

W

N

P

E

E

I

I

K

E

R

R

I

I

L

C

E

R

K

K

Y

Y

N

D

I

V

L

L

F

L

I

V

L

A

D
|
D

E

E

V
|
V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

T

G

G

N

E

W

W

F

F

A

G

A

H

Q

Q

T

H

L

F

G

G

L

F

K

Q

P

P

D

D

L

L

I

F

T

T

I

A

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

S

G

D

K

R

R

V

V

A

A

D

E

V

G

L

L

I

I

S

A

D

-

G

G

G

G

E

D

F

F

A

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

E

R

E

D

E

E

R

G

L

I

V

V

D

Q

K

R

V

V

R

K

T

D

D

D

T

I

G

G

P

P

Y

Y

L

M

Q

Q

D

K

R

R

L

W

-

R

Q

E

T

T

L

F

S

S

A

R

H

F

P

E

L

H

V

V

G

D

E

D

V

V

R

R

G

G

M

V

G

G

M

M

V

V

G

Q

A

A

I

F

E

T

L

L

V

V

A

K

D

N

K

K

H

A

S

K

M

R

V

E

R

L

F

F

G

P

S

D

E

F

I

G

S

E

A

I

G

G

M

T

L

L

C

C

R

R

E

D

A

I

C

F

I

F

E

R

S

N

G

N

L

L

V

I

M

M

R
|
R

A

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

C

V

I

M

T

T

R

R

D

A

E

E

I

V

D

D

E

E

L

M

I

L

F

A

K

V

A

A

S

E

Q

R

A

C

L

L

S

E

L

E

T

F

L

E

E

Q

K

T

I

L

A

K

A

A

R

R

G

G

binding (3E)-4-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}-2-oxobut-3-enoic acid: L55 (= L61), W56 (= W62), S115 (= S121), G116 (= G122), S117 (= S123), Y149 (= Y155), G151 (= G157), E222 (= E228), D255 (= D261), V257 (= V263), I258 (= I264), K284 (= K290), F316 (= F323), T317 (= T324), R412 (= R418)
binding pyridoxal-5'-phosphate: F316 (= F323), T317 (= T324)

4a6tC Crystal structure of the omega transaminase from chromobacterium violaceum in complex with plp (see paper)
55% identity, 98% coverage: 8:459/460 of query aligns to 2:453/455 of 4a6tC

query
sites
4a6tC

T

T

I

T

S

S

A

Q

L

W

Q

R

A

E

M

L

D

D

A

A

A

A

H

H

H

H

L

L

H

H

P

P

F
|
F

T

T

D

D

S

T

A

A

D

S

L

L

A

N

K

Q

R

A

G

G

T

A

R

R

V

V

I

M

E

T

R

R

A

G

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

D

I

F

A

A

D

E

A

A

A

A

Y

R

A

R

Q

Q

L

M

Q

E

T

E

L

L

P

P

F

F

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

T

H

H

E

P

P

A

A

V

I

V

R

E

L

L

A

S

S

S

K

L

I

L

A

A

S

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S

S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

N

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

D

D

L

V

K

Q

G

G

M

K

P

P

S

E

K

K

K

K

T

T

I

L

I

I

S

G

R

R

K

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

G

K

F

Y

M

M

H

H

Q

E

Q

Q

G

G

D

D

L

L

P

P

I

I

P

P

G

G

I

M

V

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

S

T

P

P

E

D

A

E

F

F

G

G

I

V

K

V

T

A

A

A

Q

R

A

W

L

L

E

E

A

E

K

K

I

I

L

L

E

E

L

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

F

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

D

A

S

T

Y

Y

W

W

N

P

E

E

I

I

K

E

R

R

I

I

L

C

E

R

K

K

Y

Y

N

D

I

V

L

L

F

L

I

V

L

A

D
|
D

E

E

V
|
V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

T

G

G

N

E

W

W

F

F

A

G

A

H

Q

Q

T

H

L

F

G

G

L

F

K

Q

P

P

D

D

L

L

I

F

T

T

I

A

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

S

G

D

K

R

R

V

V

A

A

D

E

V

G

L

L

I

I

S

A

D

-

G

G

G

G

E

D

F

F

A

N

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

E

R

E

D

E

E

R

G

L

I

V

V

D

Q

K

R

V

V

R

K

T

D

D

D

T

I

G

G

P

P

Y

Y

L

M

Q

Q

D

K

R

R

L

W

-

R

Q

E

T

T

L

F

S

S

A

R

H

F

P

E

L

H

V

V

G

D

E

D

V

V

R

R

G

G

M

V

G

G

M

M

V

V

G

Q

A

A

I

F

E

T

L

L

V

V

A

K

D

N

K

K

H

A

S

K

M

R

V

E

R

L

F

F

G

P

S

D

E

F

I

G

S

E

A

I

G

G

M

T

L

L

C

C

R

R

E

D

A

I

C

F

I

F

E

R

S

N

G

N

L

L

V

I

M

M

R

R

A

A

V

C

G

G

D

D

T

H

M

I

I
x
V

I

S

S

A

P

P

P

P

L

L

C

V

I

M

T

T

R

R

D

A

E

E

I

V

D

D

E

E

L

M

I

L

F

A

K

V

A

A

S

E

Q

R

A

C

L

L

S

E

L

E

T

F

L

E

E

Q

K

T

I

L

A

K

A

A

R

R

G

G

active site: F18 (= F24), Y149 (= Y155), E222 (= E228), D255 (= D261), I258 (= I264), K284 (= K290), V419 (≠ I425)
binding pyridoxal-5'-phosphate: G116 (= G122), S117 (= S123), Y149 (= Y155), H150 (= H156), G151 (= G157), E222 (= E228), D255 (= D261), V257 (= V263), I258 (= I264), K284 (= K290)

5ti8B Crystal structure of an aspartate aminotransferase from pseudomonas (see paper)
61% identity, 90% coverage: 36:451/460 of query aligns to 1:379/384 of 5ti8B

query
sites
5ti8B

R

R

V

I

I

I

E

T

R

K

A

A

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

L

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

M

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

E

I

L

A

A

D

E

A

V

A

A

Y

Y

A

K

Q

Q

L

M

Q

L

T

E

L

L

P

P

F

Y

Y

Y

N

N

N

L

F

F

F

F

Q

Q

C

T

T

A

H

H

E

P

P

P

A

A

I

L

R

E

L

L

A

A

S

K

K

A

I

I

A
|
A

S

D

L

I

A

A

P

P

G

E

H

G

M

M

N
|
N

R

H

V

V

F

F

F

F

T

T

G

G

S

S

G

G

S

S

E

E

A

S

N

N

D

D

T

T

N

V

L

L

R

R

M

M

V

V

R

R

R

H

Y

Y

W

W

D

S

L

I

K

K

G

G

M

K

P

P

S

Q

K

K

K

K

T

V

I

V

I

I

S

G

R

R

K

W

N

N

A

-

Y

-

H

-

G

-

S

-

T

-

V

-

A

-

G

-

A

-

S

-

L

-

G

-

G

-

M

-

G

-

F

-

M

-

H

-

Q

-

Q

-

G

-

D

-

L

-

P

-

I

-

P

P

G

G

I

I

V

V

H

H

I

I

D

A

Q

Q

P

P

Y

Y

W

W

F

Y

G

G

E

E

G

G

R

G

D

D

M

M

S

S

P

A

E

E

A

E

F

F

G

G

I

V

K

W

T

A

A

A

Q

E

A

Q

L

L

E

E

A

K

K

K

I

I

L

L

E

E

L

V

G

G

E

E

D

E

K

N

V

V

A

A

A

A

F

F

I

I

A

A

E
|
E

P

P

F

I

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

D

D

S

T

Y

Y

W

W

N

P

E

K

I

I

K

R

R

E

I

I

L

L

E

A

K

K

Y

Y

N

E

I

I

L

L

F

F

I

I

L

A

D
|
D

E

E

V

V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

T

G

G

N

E

W

W

F

F

A

G

A

S

Q

Q

T

Y

L

Y

G

G

L

N

K

A

P

P

D

D

L

L

I

M

T

P

I

I

A

A

K
|
K

G

G

M

L

T

T

S

S

G

G

Y

Y

I

I

P

P

M

M

G

G

G

G

V

V

I

I

V

V

S

R

D

D

R

E

V

I

A

V

D

D

V

T

L

L

I

N

S

E

D

-

G

-

G

-

E

-

F

-

A

-

H

-

G

-

F

-

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

A

A

A

A

A

V

V

A

A

L

L

E

E

N

N

I

I

R

R

I

I

L

L

E

R

E

E

E

E

R

K

L

I

V

V

D

E

K

T

V

V

R

K

T

A

D

E

T

T

G

A

P

P

Y

Y

L

L

Q

Q

D

K

R

R

L

W

Q

Q

T

E

L

L

S

A

A

D

H

H

P

P

L

L

V

V

G

G

E

E

V

A

R

R

G

G

M

V

G

G

M

M

V

V

G

G

A

A

I

L

E

E

L

L

V

V

A

K

D

N

K

K

H

K

S

T

M

R

V

E

R

R

F

F

G

-

S

-

E

E

I

N

S

G

A

V

G

G

M

M

L

L

C

C

R

R

E

E

A

H

C

C

I

F

E

R

S

N

G

G

L

L

V

I

M

M

R

R

A

A

V

V

G

G

D

D

T

T

M

M

I
|
I

I

I

S

S

P

P

P

P

L

L

C

V

I

I

T

T

R

K

D

P

E

E

I

I

D

D

E

E

L

L

I

I

F

T

K

L

A

A

S

R

Q

K

A

C

L

L

S

D

L

Q

T

T

active site: E167 (= E228), D200 (= D261), I203 (= I264), K229 (= K290), T254 (= T324), I353 (= I425)
binding calcium ion: A71 (= A106), N79 (= N114)

7ypmA Crystal structure of transaminase cc1012 complexed with plp and l- alanine (see paper)
56% identity, 94% coverage: 9:441/460 of query aligns to 3:437/454 of 7ypmA

query
sites
7ypmA

I

I

S

A

A

E

L

L

Q

K

A

R

M

L

D

D

A

L

A

A

H

H

H

H

L

L

H

P

P

A

F

Q

T

A

D

D

S

H

A

K

D

V

L

I

A

A

K

E

R

Q

G

G

-

G

T

S

R

R

V

I

I

I

E

T

R

R

A

A

E

E

G

G

V

V

Y

Y

I

I

W

H

D

D

A

G

K

E

G

G

N

H

K

Q

L

I

L

L

D

D

A

G

M

M

A

A

G

G

L

L

W
|
W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

E

S

E

I

L

A

A

D

K

A

A

A

A

Y

Y

A

D

Q

Q

L

M

Q

L

T

E

L

L

P

P

F

Y

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

A

H

T

E

P

P

P

A

P

I

I

R

E

L

L

A

A

S

A

K

K

I

I

A

A

S

Q

L

K

A

M

P

G

G

G

H

H

M

L

N

S

R

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N

N

D

D

T

T

N

V

L

F

R

R

M

L

V

V

R

R

R

H

Y

F

W

W

D

K

L

L

K

K

G

G

M

E

P

P

S

S

K

R

K

T

T

V

I

F

I

I

S

S

R

R

K

W

N

N

A

A

Y
|
Y

H

H

G
|
G

S

S

T

T

V

V

A

A

G

G

A

V

S

S

L

L

G

G

G

G

M

M

G

K

F

H

M

M

H

H

Q

K

Q

Q

G

G

D

D

L

L

P

P

I

I

P

A

G

G

I

V

V

E

H

H

I

V

D

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

R

F

D

G

M

E

S

D

P

P

E

A

A

A

F

F

G

R

I

D

K

R

T

A

A

V

Q

Q

A

A

L

I

E

E

A

D

K

K

I

I

L

L

E

E

L

V

G

G

E

P

D

E

K

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

F

V

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

I

P

P

P

P

D

D

S

G

Y

Y

W

W

N

P

E

A

I

V

K

E

R

A

I

L

L

C

E

R

K

K

Y

Y

N

G

I

I

L

L

F

L

I

V

L

C

D
|
D

E

E

V
|
V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

L

G

G

N

Q

W

W

F

F

A

G

A

H

Q

Q

T

H

L

Y

G

G

L

I

K

K

P

P

D

D

L

L

I

I

T

A

I

M

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

S

G

A

V

V

I

G

V

V

S

A

D

D

R

H

V

I

A

V

D

A

V

E

L

L

I

R

S

E

D

K

G

G

G

G

E

D

F

F

A

I

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

T

A

A

A

A

A

A

V

V

A

A

L

L

E

K

N

N

I

I

R

E

I

I

L

M

E

E

E

R

E

E

R

G

L

L

V

V

D

E

K

R

V

T

R

R

T

D

D

E

T

T

G

G

P

P

Y

Y

L

L

Q

A

D

Q

R

A

L

L

Q

A

T

S

L

L

S

N

A

D

H

H

P

P

L

L

V

V

G

G

E

E

V

V

R

R

G

S

M

L

G

G

M

L

V

I

G

G

A

A

I

V

E

E

L

I

V

V

A

R

D

E

K

K

H

G

S

T

M

N

V

H

R

R

F

F

-

L

G

D

S

K

E

E

I

G

S

E

A

A

G

G

M

P

L

I

C

V

R

R

E

D

A

L

C

C

I

I

E

K

S

N

G

G

L

L

V

M

M

V

R

R

A

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

C

I

I

I

T

T

R

K

D

A

E

Q

I

I

D

D

E

E

L

L

I

V

binding alanine: W57 (= W62), Y150 (= Y155)
binding pyridoxal-5'-phosphate: S116 (= S121), G117 (= G122), S118 (= S123), Y150 (= Y155), G152 (= G157), E223 (= E228), D256 (= D261), V258 (= V263), I259 (= I264), K285 (= K290)

7ypnD Crystal structure of transaminase cc1012 mutant m9 complexed with plp (see paper)
55% identity, 94% coverage: 9:441/460 of query aligns to 3:437/455 of 7ypnD

query
sites
7ypnD

I

I

S

A

A

E

L

L

Q

K

A

R

M

L

D

D

A

L

A

A

H

H

H

H

L

L

H

P

P

A

F

F

T

A

D

D

S

H

A

K

D

V

L

I

A

A

K

E

R

Q

G

G

-

G

T

S

R

R

V

I

I

I

E

T

R

R

A

A

E

E

G

G

V

V

Y

Y

I

I

W

H

D

D

A

G

K

E

G

G

N

H

K

Q

L

I

L

L

D

D

A

G

M

W

A

A

G

G

L

L

W

F

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

E

S

E

I

L

A

A

D

K

A

A

A

A

Y

Y

A

D

Q

Q

L

M

Q

L

T

E

L

L

P

P

F

Y

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

A

H

T

E

P

P

P

A

P

I

I

R

E

L

L

A

A

S

A

K

K

I

I

A

A

S

Q

L

K

A

M

P

G

G

G

H

H

M

L

N

S

R

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N

N

D

D

T

T

N

V

L

F

R

R

M

L

V

V

R

R

R

H

Y

F

W

W

D

K

L

L

K

K

G

G

M

E

P

P

S

S

K

R

K

T

T

V

I

F

I

I

S

S

R

R

K

W

N

N

A

A

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

V

A

A

G

G

A

V

S

S

L

L

G

G

G

G

M

M

G

K

F

H

M

M

H

H

Q

K

Q

Q

G

G

D

D

L

L

P

P

I

I

P

A

G

G

I

V

V

E

H

H

I

V

D

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

R

F

D

G

M

E

S

D

P

P

E

A

A

A

F

F

G

R

I

D

K

R

T

A

A

V

Q

Q

A

A

L

I

E

E

A

D

K

K

I

I

L

L

E

E

L

V

G

G

E

P

D

E

K

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

F

V

Q

Q

G

G

A

A

G

G

G

G

V

V

I

I

I

I

P

P

P

P

D

D

S

G

Y

Y

W

W

N

P

E

A

I

V

K

E

R

A

I

L

L

C

E

R

K

K

Y

Y

N

G

I

I

L

L

F

L

I

V

L

C

D
|
D

E

E

V
|
V

I

A

S

C

G

G

F

F

G

G

R

R

T

L

G

G

N

Q

W

W

F

F

A

G

A

H

Q

Q

T

H

L

Y

G

G

L

I

K

K

P

P

D

D

L

L

I

I

T

A

I

M

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

S

G

A

V

V

I

G

V

V

S

A

D

D

R

H

V

I

A

V

D

A

V

E

L

L

I

R

S

E

D

K

G

G

G

G

E

D

F

F

A

I

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

T

A

A

A

A

A

A

V

V

A

A

L

L

E

K

N

N

I

I

R

E

I

I

L

M

E

E

E

R

E

E

R

G

L

L

V

V

D

E

K

R

V

T

R

R

T

D

D

E

T

T

G

G

P

P

Y

Y

L

L

Q

A

D

Q

R

A

L

L

Q

A

T

S

L

L

S

N

A

D

H

H

P

P

L

L

V

V

G

G

E

E

V

V

R

R

G

S

M

L

G

G

M

L

V

I

G

G

A

A

I

V

E

E

L

I

V

V

A

R

D

E

K

K

H

G

S

T

M

N

V

H

R

R

F

F

-

L

G

D

S

K

E

E

I

G

S

E

A

A

G

G

M

P

L

I

C

V

R

R

E

D

A

L

C

C

I

I

E

K

S

N

G

G

L

L

V

M

M

V

R

R

A

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

C

I

I

I

T

T

R

K

D

A

E

Q

I

I

D

D

E

E

L

L

I

V

binding pyridoxal-5'-phosphate: S116 (= S121), G117 (= G122), S118 (= S123), Y150 (= Y155), H151 (= H156), G152 (= G157), E223 (= E228), D256 (= D261), V258 (= V263), K285 (= K290), F318 (= F323), T319 (= T324)

4ba5A Crystal structure of omega-transaminase from chromobacterium violaceum (see paper)
55% identity, 92% coverage: 36:459/460 of query aligns to 2:425/427 of 4ba5A

query
sites
4ba5A

R

R

V

V

I

M

E

T

R

R

A

G

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

I

D

D

A

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

D

I

F

A

A

D

E

A

A

A

A

Y

R

A

R

Q

Q

L

M

Q

E

T

E

L

L

P

P

F

F

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

T

H

H

E

P

P

A

A

V

I

V

R

E

L

L

A

S

S

S

K

L

I

L

A

A

S

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S

S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

N

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

D

D

L

V

K

Q

G

G

M

K

P

P

S

E

K

K

K

K

T

T

I

L

I

I

S

G

R

R

K

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

G

K

F

Y

M

M

H

H

Q

E

Q

Q

G

G

D

D

L

L

P

P

I

I

P

P

G

G

I

M

V

A

H

H

I

I

D

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

S

T

P

P

E

D

A

E

F

F

G

G

I

V

K

V

T

A

A

A

Q

R

A

W

L

L

E

E

A

E

K

K

I

I

L

L

E

E

L

I

G

G

E

A

D

D

K

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

F

I

Q

Q

G

G

A
|
A

G

G

G

G

V

V

I

I

I

V

P

P

P

P

D

A

S

T

Y

Y

W

W

N

P

E

E

I

I

K

E

R

R

I

I

L

C

E

R

K

K

Y

Y

N

D

I

V

L

L

F

L

I

V

L

A

D
|
D

E

E

V
|
V

I
|
I

S

C

G

G

F

F

G

G

R

R

T

T

G

G

N

E

W

W

F

F

A

G

A

H

Q

Q

T

H

L

F

G

G

L

F

K

Q

P

P

D

D

L

L

I

F

T

T

I

A

A

A

K
|
K

G

G

M

L

T

S

S

S

G

G

Y

Y

I

L

P

P

M

I

G

G

G

A

V

V

I

F

V

V

S

G

D

K

R

R

V

V

A

A

D

E

V

G

L

L

I

I

S

A

D

-

G

G

G

G

E

D

F

F

A

N

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

V

A

C

A

A

A

A

V

V

A

A

L

H

E

A

N

N

I

V

R

A

I

A

L

L

E

R

E

D

E

E

R

G

L

I

V

V

D

Q

K

R

V

V

R

K

T

D

D

D

T

I

G

G

P

P

Y

Y

L

M

Q

Q

D

K

R

R

L

W

-

R

Q

E

T

T

L

F

S

S

A

R

H

F

P

E

L

H

V

V

G

D

E

D

V

V

R

R

G

G

M

V

G

G

M

M

V

V

G

Q

A

A

I

F

E

T

L

L

V

V

A

K

D

N

K

K

H

A

S

K

M

R

V

E

R

L

F

F

G

P

S

D

E

F

I

G

S

E

A

I

G

G

M

T

L

L

C

C

R

R

E

D

A

I

C

F

I

F

E

R

S

N

G

N

L

L

V

I

M

M

R
|
R

A

A

V

C

G

G

D

D

T

H

M

I

I
x
V

I

S

S

A

P

P

P

P

L

L

C

V

I

M

T

T

R

R

D

A

E

E

I

V

D

D

E

E

L

M

I

L

F

A

K

V

A

A

S

E

Q

R

A

C

L

L

S

E

L

E

T

F

L

E

E

Q

K

T

I

L

A

K

A

A

R

R

G

G

active site: Y121 (= Y155), E194 (= E228), D227 (= D261), I230 (= I264), K256 (= K290), V391 (≠ I425)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: L27 (= L61), W28 (= W62), G88 (= G122), S89 (= S123), Y121 (= Y155), H122 (= H156), G123 (= G157), E194 (= E228), A199 (= A233), D227 (= D261), V229 (= V263), R384 (= R418)

4a6rA Crystal structure of the omega transaminase from chromobacterium violaceum in the apo form, crystallised from polyacrylic acid (see paper)
55% identity, 92% coverage: 36:459/460 of query aligns to 1:421/423 of 4a6rA

query
sites
4a6rA

R

R

V

V

I

M

E

T

R

R

A

G

E

E

G

G

V

V

Y

Y

I

L

W

W

D

D

A

S

K

E

G

G

N

N

K

K

L

I

L

I

D

D

A

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

V

V

G

G

Y

Y

G

G

R

R

K

K

S

D

I

F

A

A

D

E

A

A

A

A

Y

R

A

R

Q

Q

L

M

Q

E

T

E

L

L

P

P

F

F

Y

Y

N

N

N

T

F

F

F

F

Q

K

C

T

T

T

H

H

E

P

P

A

A

V

I

V

R

E

L

L

A

S

S

S

K

L

I

L

A

A

S

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T
|
T

G
x
N

S
|
S

G

G

S
|
S

E
|
E

A

S

N

V

D

D

T
|
T

N

M

L

I

R
|
R

M

M

V

V

R

R

R

R

Y

Y

W

W

D

D

L

V

K

Q

G

G

M

K

P

P

S

E

K

K

K

K

T

T

I

L

I

I

S

G

R

R

K

W

N

N

A

G

Y
|
Y

H

H

G

G

S
|
S

T
|
T

V

I

A

G

G

G

A

A

S

S

L

L

G

G

G

G

M

M

G

K

F

Y

M

M

H

H