SitesBLAST
Comparing 6938693 FitnessBrowser__SB2B:6938693 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
69% identity, 99% coverage: 5:390/391 of query aligns to 1:388/390 of 2r0nA
- active site: L133 (= L138), T134 (= T139), A247 (= A249), E368 (= E370), R380 (= R382)
- binding flavin-adenine dinucleotide: F131 (= F136), L133 (= L138), T134 (= T139), G139 (= G144), S140 (= S145), W166 (= W169), I167 (= I170), T168 (= T171), Y367 (= Y369), T370 (= T372), D372 (= D374)
- binding 3-thiaglutaryl-CoA: R92 (= R97), S93 (= S98), V97 (= V102), P142 (= P147), G238 (≠ K240), F241 (= F243), L244 (= L246), N245 (= N247), P318 (≠ V320), Y367 (= Y369), E368 (= E370), I377 (= I379)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
69% identity, 99% coverage: 5:390/391 of query aligns to 1:388/390 of 1sirA
- active site: L133 (= L138), T134 (= T139), A247 (= A249), E368 (= E370), R380 (= R382)
- binding flavin-adenine dinucleotide: F131 (= F136), L133 (= L138), T134 (= T139), G139 (= G144), S140 (= S145), W166 (= W169), I167 (= I170), T168 (= T171), Y367 (= Y369), T370 (= T372)
- binding s-4-nitrobutyryl-coa: S93 (= S98), S140 (= S145), F241 (= F243), G242 (= G244), L244 (= L246), N245 (= N247), R248 (= R250), P318 (≠ V320), Y367 (= Y369), E368 (= E370), R380 (= R382)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
69% identity, 99% coverage: 5:390/391 of query aligns to 1:388/390 of 2r0mA
- active site: L133 (= L138), T134 (= T139), A247 (= A249), D368 (≠ E370), R380 (= R382)
- binding 4-nitrobutanoic acid: L101 (= L106), Y367 (= Y369), D368 (≠ E370)
- binding flavin-adenine dinucleotide: F131 (= F136), L133 (= L138), T134 (= T139), G139 (= G144), S140 (= S145), W166 (= W169), I167 (= I170), T168 (= T171), L210 (= L212), Y367 (= Y369), T370 (= T372)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
68% identity, 98% coverage: 6:390/391 of query aligns to 3:385/385 of 3gqtC
- active site: L135 (= L138), T136 (= T139), A250 (= A249), E365 (= E370), R377 (= R382)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W169), K210 (= K209), L213 (= L212), T218 (= T217), Y364 (= Y369)
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
68% identity, 98% coverage: 6:389/391 of query aligns to 3:382/382 of 3eonC
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
68% identity, 98% coverage: 6:389/391 of query aligns to 4:380/380 of 3gncA
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
66% identity, 98% coverage: 6:389/391 of query aligns to 3:377/377 of 3d6bC
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
48% identity, 97% coverage: 10:390/391 of query aligns to 6:386/387 of 3sf6A
- active site: L134 (= L138), T135 (= T139), A245 (= A249), E366 (= E370), Q378 (≠ R382)
- binding dihydroflavine-adenine dinucleotide: F132 (= F136), L134 (= L138), T135 (= T139), G140 (= G144), S141 (= S145), W165 (= W169), I166 (= I170), T167 (= T171), S361 (≠ A365), T364 (= T368), Y365 (= Y369), T368 (= T372), E370 (≠ D374), M371 (≠ I375)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
48% identity, 96% coverage: 14:390/391 of query aligns to 7:380/380 of 2ebaA
- active site: L131 (= L138), T132 (= T139), A239 (= A249), E360 (= E370), R372 (= R382)
- binding flavin-adenine dinucleotide: L131 (= L138), T132 (= T139), G136 (≠ V143), G137 (= G144), S138 (= S145), W161 (= W169), T163 (= T171), R265 (= R275), L272 (= L282), K275 (≠ N285), D333 (= D343), I334 (≠ M344), G337 (= G347), T355 (≠ A365), T358 (= T368), Y359 (= Y369), T362 (= T372)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
46% identity, 97% coverage: 12:390/391 of query aligns to 10:387/388 of 3swoA
- active site: L135 (= L138), T136 (= T139), A246 (= A249), E367 (= E370), K379 (≠ R382)
- binding dihydroflavine-adenine dinucleotide: F133 (= F136), L135 (= L138), T136 (= T139), G141 (= G144), S142 (= S145), W166 (= W169), I167 (= I170), T168 (= T171), R272 (= R275), V274 (≠ Q277), F275 (= F278), L279 (= L282), Y282 (≠ N285), T340 (≠ D343), L341 (≠ M344), G344 (= G347), I347 (= I350), T365 (= T368), Y366 (= Y369), T369 (= T372), E371 (≠ D374), M372 (≠ I375)
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
35% identity, 97% coverage: 10:390/391 of query aligns to 31:412/416 of 2ix6A
- active site: L158 (= L138), T159 (= T139), S271 (≠ A249), E392 (= E370), R404 (= R382)
- binding flavin-adenine dinucleotide: T159 (= T139), G164 (= G144), S165 (= S145), W189 (= W169), N239 (≠ T217), R297 (= R275), F300 (= F278), L304 (= L282), F307 (≠ N285), N310 (≠ Y288), E365 (≠ D343), L366 (≠ M344), G369 (= G347), I372 (= I350), Y391 (= Y369), T394 (= T372), D396 (= D374)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
35% identity, 97% coverage: 10:390/391 of query aligns to 31:412/415 of 2ix5A