SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 7023203 FitnessBrowser__ANA3:7023203 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

A0A140FAN3 11-beta-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase; Steroleosin; EC 1.1.1.146; EC 1.1.1.62 from Pinus massoniana (Chinese red pine) (see paper)
35% identity, 97% coverage: 2:260/267 of query aligns to 43:307/356 of A0A140FAN3

query
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A0A140FAN3

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Sites not aligning to the query:

206:356 mutation Missing: Loss of binding to plant derived cholesterol, cholest-5-en-3beta-ol.

1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
34% identity, 76% coverage: 8:209/267 of query aligns to 3:206/244 of 1edoA

query
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1edoA

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active site: G12 (= G17), S138 (= S142), Y151 (= Y155), K155 (= K159)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), S10 (= S15), R11 (≠ E16), I13 (= I18), N31 (≠ S36), Y32 (vs. gap), A33 (= A37), R34 (= R38), S35 (≠ N39), D59 (= D63), V60 (= V64), N86 (= N90), A87 (= A91), S138 (= S142), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (≠ D186), I184 (≠ V188), S186 (= S190), M188 (≠ I192)

2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
32% identity, 91% coverage: 4:247/267 of query aligns to 2:253/255 of 2q2qD

query
sites
2q2qD

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active site: G15 (= G17), S138 (= S142), Y151 (= Y155), K155 (= K159), R196 (= R195)
binding nicotinamide-adenine-dinucleotide: G11 (= G13), T13 (≠ S15), S14 (≠ E16), G15 (= G17), I16 (= I18), F36 (≠ R38), D59 (= D63), L60 (≠ V64), N86 (= N90), G88 (= G92), L109 (≠ V114), I136 (≠ V140), S138 (= S142), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (≠ D186), W183 (≠ F187), V184 (= V188), T186 (≠ S190), L188 (vs. gap), V189 (vs. gap)

5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
31% identity, 83% coverage: 4:225/267 of query aligns to 2:231/255 of 5yssB

query
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5yssB

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binding nicotinamide-adenine-dinucleotide: G11 (= G13), T13 (≠ S15), S14 (≠ E16), G15 (= G17), I16 (= I18), G35 (≠ A37), F36 (≠ R38), L60 (≠ V64), N86 (= N90), G88 (= G92), I89 (≠ M93), A137 (= A141), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (≠ D186), V184 (= V188), T186 (≠ S190)

3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
37% identity, 74% coverage: 4:200/267 of query aligns to 6:198/247 of 3op4A

query
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3op4A

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G

G

L

T

T

M

G

G

V

N

P

A

T

G

R

Q

S

A

G

N

Y
|
Y

A

A

S

A

K
|
K

H

A

A

G

V

V

I

I

G

G

F

F

F

T

D

K

S

S

L

M

R

A

I

R

E

E

L

V

A

A

D

S

D

R

N

G

V

V

A

T

V

V

T

N

V

T

I

V

C

A

P
|
P

D
x
G

F

F

V
x
I

V

E

S
x
T

Q

D

I
x
M

H

T

K

K

R

-

A

A

L

L

N

N

G

D

E

E

binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (= S15), R18 (≠ E16), I20 (= I18), T40 (≠ R38), N62 (≠ D63), V63 (= V64), N89 (= N90), A90 (= A91), I92 (≠ M93), V139 (= V140), S141 (= S142), Y154 (= Y155), K158 (= K159), P184 (= P185), G185 (≠ D186), I187 (≠ V188), T189 (≠ S190), M191 (≠ I192)

6d9yB Crystal structure of a short chain dehydrogenase/reductase sdr from burkholderia phymatum with partially occupied NAD
36% identity, 71% coverage: 4:192/267 of query aligns to 7:195/251 of 6d9yB

query
sites
6d9yB

L

L

T

E

G

G

K

R

V

V

I

V

I

I

T

T

G
|
G

A

G

S

A

E
x
R

G
|
G

I

I

G

G

R

Y

A

A

L

V

A

A

I

Q

A

R

M

A

A

L

R

R

V

S

G

G

C

A

Q

A

L

V

V

A

L

L

S

W

A
x
D

R
x
L

N

D

E

A

T

E

R

R

L

L

A

A

S

R

L

S

A

E

L

R

E

E

I

L

A

A

N

E

Y

L

G

G

P

K

T

V

P

C

F

A

V

V

F

-

A

T

A
x
V

D
|
D

V
x
Q

S

T

S

K

A

E

S

A

Q

Q

C

I

E

E

A

A

L

A

I

V

Q

G

A

K

T

T

I

L

A

A

H

A

Y

F

G

G

R

A

L

I

D

D

I

V

L

L

V

I

N

N

N

C

A
|
A

G

G

M

I

T

T

M

G

W

G

S

N

R

G

F

T

D

T

E

W

L

E

N

L

Q

E

L

P

S

D

V

V

L

W

E

R

D

Q

I

V

M

I

R

D

V

V

N

N

Y

L

L

I

G

G

P

P

A

Y

Y

L

L

V

T

C

H

R

A

A

A

V

L

V

P

P

-

Q

Y

M

L

L

K

K

S

Q

S

G

Q

Y

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S
|
S

V

V

A

A

G

G

L

K

T

E

G

G

V

N

P

P

T

N

R

A

S

S

G

H

Y
|
Y

A

S

A

A

S

S

K
|
K

H

A

A

G

V

L

I

I

G

G

F

L

F

T

D

K

S

S

L

L

R

G

I

K

E

E

L

L

A

A

D

T

D

K

N

N

V

I

A

L

V

V

T

N

V

A

I

V

C

T

P
|
P

D
x
A

F
x
A

V
x
A

V

K

S
x
T

Q

E

I

I

active site: G20 (= G17), S145 (= S142), Y158 (= Y155)
binding nicotinamide-adenine-dinucleotide: G16 (= G13), R19 (≠ E16), G20 (= G17), D40 (≠ A37), L41 (≠ R38), V64 (≠ A62), D65 (= D63), Q66 (≠ V64), A93 (= A91), S145 (= S142), Y158 (= Y155), K162 (= K159), P188 (= P185), A189 (≠ D186), A190 (≠ F187), A191 (≠ V188), T193 (≠ S190)

6ci9D Rmm microcompartment-associated aminopropanol dehydrogenase NADP + aminoacetone holo-structure (see paper)
32% identity, 70% coverage: 4:191/267 of query aligns to 7:195/259 of 6ci9D

query
sites
6ci9D

L

L

T

E

G

G

K

R

V

S

V

A

I

I

I

V

T

T

G
|
G

A

G

S
|
S

E

K

G
|
G

I
|
I

G

G

R

R

A

G

L

I

A

A

I

E

A

T

M

F

A

A

R

N

V

A

G

G

C

V

Q

D

L

V

V

V

L

I

S

T

A
x
G

R
|
R

N
|
N

E

Q

T

D

R

D

L

L

A

D

S

R

L

T

A

V

L

A

E

D

I

L

A

S

N

G

Y

T

G

R

P

G

T

K

P

V

F

T

V

A

F

V

A

R

A

A

D
|
D

V
|
V

S

T

S

D

A

P

S

E

Q

D

C

A

E

R

A

R

L

T

I

V

Q

A

A

E

T

T

I

V

A

S

H

R

Y

H

G

G

R

G

L

L

D

D

I

I

L

V

V

C

N

A

N
|
N

A

A

G
|
G

M

I

T
x
F

M

P

W

S

S

G

R

R

F

L

D

E

E

D

L

L

N

T

Q

P

L

D

S

D

V

I

L

-

E

E

D

Q

I

V

M

L

R

G

V

V

N

N

Y

F

L

K

G

G

P

T

A

V

Y

Y

L

I

T

V

H

Q

A

A

L

L

P

Q

Y

A

L

L

K

T

S

A

S

S

-

G

Q

H

G

G

Q

R

V

V

V
x
T

A

S

S
|
S

V

I

A
x
T

G

G

-

P

L

I

T

T

G

G

V

Y

P

P

T

G

R
x
W

S

S

G

H

Y
|
Y

A

G

A

A

S

S

K
|
K

H

A

A

A

V

Q

I

L

G

G

F

F

F

L

D

R

S

T

L

A

R

A

I

M

E

E

L

L

A

A

D

P

D

K

N

K

V

I

A

T

V

I

T

N

V

A

I

V

C

L

P
|
P

D
x
G

F
x
N

V
x
I

V

M

S
x
T

Q

E

active site: G20 (= G17), S145 (= S142), Y159 (= Y155)
binding 1-aminopropan-2-one: F97 (≠ T94), S145 (= S142), T147 (≠ A144), W156 (≠ R152), Y159 (= Y155), G190 (≠ D186)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G16 (= G13), S18 (= S15), G20 (= G17), I21 (= I18), G40 (≠ A37), R41 (= R38), N42 (= N39), D66 (= D63), V67 (= V64), N93 (= N90), G95 (= G92), T143 (≠ V140), S145 (= S142), Y159 (= Y155), K163 (= K159), P189 (= P185), N191 (≠ F187), I192 (≠ V188), T194 (≠ S190)

Sites not aligning to the query:

binding nadp nicotinamide-adenine-dinucleotide phosphate: 196, 197

4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
36% identity, 71% coverage: 4:193/267 of query aligns to 6:192/243 of 4i08A

query
sites
4i08A

L

L

T

E

G

G

K

K

V

V

V

A

I

L

I

V

T

T

G
|
G

A

A

S
|
S

E
x
R

G
|
G

I
|
I

G

G

R

K

A

A

L

I

A

A

I

E

A

L

M

L

A

A

R

E

V

R

G

G

C

A

Q

K

L

V

V

I

L

G

S

T

A

A

R
x
T

N

S

E

E

T

-

R

-

L

-

A

-

S

S

L

G

A

A

L

Q

E

A

I

I

A

S

N

D

Y

Y

-

L

G

G

P

D

T

N

P

G

F

K

V

G

F

M

A

A

A

L

D
x
N

V
|
V

S

T

S

N

A

P

S

E

Q

S

C

I

E

E

A

A

L

V

I

L

Q

K

A

A

T

I

I

T

A

D

H

E

Y

F

G

G

R

G

L

V

D

D

I

I

L

L

V

V

N

N

N
|
N

A
|
A

G

G

M

I

T

T

M

-

W

-

S

-

R

R

F

D

D

N

E

L

L

L

N

M

Q

R

L

M

S

K

V

E

L

E

E

E

-

W

-

S

D

D

I

I

M

M

R

E

V

T

N
|
N

Y

L

L

T

G

S

P

I

A

F

Y

R

L

L

T

S

H

K

A

A

A

V

L

L

-

R

P

G

Y

M

L

M

K

K

S

K

S

R

Q

Q

G

G

Q

R

V

I

V

N

V

V

A
x
G

S
|
S

V

V

A

V

G

G

L

T

T

M

G

G

V

N

P

A

T

G

R
x
Q

S

A

G

N

Y
|
Y

A

A

S

A

K
|
K

H

A

A

G

V

V

I

I

G

G

F

F

F

T

D

K

S

S

L

M

R

A

I

R

E

E

L

V

A

A

D

S

D

R

N

G

V

V

A

T

V

V

T

N

V

T

I

V

C

A

P
|
P

D
x
G

F

F

V

I

V

E

S
x
T

Q

D

I

M

H

N

active site: G19 (= G17), N113 (= N115), S141 (= S142), Q151 (≠ R152), Y154 (= Y155), K158 (= K159)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (= S15), R18 (≠ E16), I20 (= I18), T40 (≠ R38), N62 (≠ D63), V63 (= V64), N89 (= N90), A90 (= A91), G140 (≠ A141), S141 (= S142), Y154 (= Y155), K158 (= K159), P184 (= P185), G185 (≠ D186), T189 (≠ S190)

P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
35% identity, 75% coverage: 1:200/267 of query aligns to 1:200/247 of P73574

query
sites
P73574

M

M

D

T

G

A

L

L

T

T

G

A

K

Q

V

V

V

A

I

L

I

V

T

T

G

G

A
|
A

S

S

E

R

G

G

I

I

G

G

R

K

A

A

L

T

A

A

I

L

A

A

M

L

A

A

R

A

V

T

G

G

C

M

Q

K

L

V

V

V

L

V

S

N

-

Y

A

A

R

Q

N

S

E

S

T

T

R

A

L

A

A

D

S

A

L

V

A

V

L

A

E

E

I

I

A

I

N

A

Y

N

G

G

P

G

T

E

P

A

F

I

V

A

F

V

A

Q

A

A

D

N

V

V

S

A

S

N

A

A

S

D

Q

E

C

V

E

D

A

Q

L

L

I

I

Q

K

A

T

T

T

I

L

A

D

H

K

Y

F

G

S

R

R

L

I

D

D

I

V

L

L

V

V

N

N

A

A

G

G

M

I

T

T

M

R

W

-

S

-

R

-

F

-

D

D

E

T

L

L

N

L

Q

L

L

R

S

M

V

K

L

L

E

E

D

D

-

W

-

Q

-

A

I

V

M

I

R

D

V

L

N

N

Y

L

L

T

G

G

P

V

A

F

Y

L

L

C

T

T

H

K

A

A

A

V

L

S

P

K

-

L

Y

M

L

L

K

K

S

Q

S

K

Q

S

G

G

Q

R

V

I

V

N

V

I

A

T

S

S

V

V

A

A

G

G

L

M

T

M

G

G

V

N

P
|
P

T

G

R

Q

S

A

G

N

Y

Y

A

S

A

A

S

A

K
|
K

H

A

A

G

V

V

I

I

G

G

F

F

F

T

D

K

S

T

L

V

R

A

I

K

E

E

L

L

A

A

D

S

D

R

N

G

V

V

A

T

V

V

T

N

V

A

I

V

C

A

P

P

D

G

F
|
F

V

I

V

A

S

T

Q

D

I

M

H

T

K

E

R

N

A

-

L

L

N
|
N

G

A

E

E

A14 (= A14) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
P151 (= P150) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
K160 (= K159) mutation to A: Almost no activity on acetoacetyl-CoA.
F188 (= F187) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
N198 (= N198) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.

3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
31% identity, 70% coverage: 7:192/267 of query aligns to 5:191/246 of 3osuA

query
sites
3osuA

K

K

V

S

V

A

I

L

I

V

T

T

G

G

A

A

S

S

E

R

G
|
G

I

I

G

G

R

R

A

S

L

I

A

A

I

L

A

Q

M

L

A

A

R

E

V

E

G

G

C

Y

Q

N

L

V

V

A

L

V

S

N

-

Y

A

A

R

G

N

S

E

K

T

E

R

K

L

A

A

E

S

A

L

V

A

V

L

E

E

E

I

I

A

K

N

A

Y

K

G

G

P

V

T

D

P

S

F

F

V

A

F

I

A

Q

A

A

D

N

V

V

S

A

S

D

A

A

S

D

Q

E

C

V

E

K

A

A

L

M

I

I

Q

K

A

E

T

V

I

V

A

S

H

Q

Y

F

G

G

R

S

L

L

D

D

I

V

L

L

V

V

N

N

N
|
N

A

A

G

G

M

I

T

T

M

R

W

D

S

N

R

L

F

L

D

M

E

R

L

M

N

K

Q

E

L

Q

S

E

V

-

L

W

E

D

D

D

I

V

M

I

R

D

V

T

N

N

Y

L

L

K

G

G

P

V

A

F

Y

N

L

C

T

I

H

Q

A

K

A

A

L

T

P

P

-

Q

Y

M

L

L

K

R

S

Q

S

R

Q

S

G

G

Q

A

V

I

V

N

V

L

A

S

S
|
S

V

V

A

V

G

G

L

A

T

V

G

G

V

N

P

P

T

G

R
x
Q

S

A

G

N

Y
|
Y

A

V

A

A

S

T

K
|
K

H

A

A

G

V

V

I

I

G

G

F

L

F

T

D

K

S

S

L

A

R

A

I

R

E

E

L

L

A

A

D

S

D

R

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

A

P

P

D

G

F

F

V

I

V

V

S

S

Q

D

I

M

active site: G15 (= G17), S141 (= S142), Q151 (≠ R152), Y154 (= Y155), K158 (= K159)
binding magnesium ion: N89 (= N90), K158 (= K159)

3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
31% identity, 70% coverage: 7:192/267 of query aligns to 2:188/239 of 3sj7A

query
sites
3sj7A

K

K

V

S

V

A

I

L

I

V

T

T

G
|
G

A

A

S
|
S

E
x
R

G
|
G

I
|
I

G

G

R

R

A

S

L

I

A

A

I

L

A

Q

M

L

A

A

R

E

V

E

G

G

C

Y

Q

N

L

V

V

A

L

V

S
x
N

-
x
Y

A
|
A

R
x
G

N
x
S

E

K

T

E

R

K

L

A

A

E

S

A

L

V

A

V

L

E

E

E

I

I

A

K

N

A

Y

K

G

G

P

V

T

D

P

S

F

F

V

A

F

I

A

Q

A
|
A

D
x
N

V
|
V

S

A

S

D

A

A

S

D

Q

E

C

V

E

K

A

A

L

M

I

I

Q

K

A

E

T

V

I

V

A

S

H

Q

Y

F

G

G

R

S

L

L

D

D

I

V

L

L

V

V

N

N

N
|
N

A
|
A

G

G

M

I

T

T

M

R

W

D

S

N

R

L

F

L

D

M

E

R

L

M

N

K

Q

E

L

Q

S

E

V

-

L

W

E

D

D

D

I

V

M

I

R

D

V
x
T

N

N

Y

L

L

K

G

G

P

V

A

F

Y

N

L

C

T

I

H

Q

A

K

A

A

L

T

P

P

-

Q

Y

M

L

L

K

R

S

Q

S

R

Q

S

G

G

Q

A

V

I

V

N

V

L

A

S

S
|
S

V

V

A

V

G

G

L

A

T

V

G

G

V

N

P

P

T

G

R
x
Q

S

A

G

N

Y
|
Y

A

V

A

A

S

T

K
|
K

H

A

A

G

V

V

I

I

G

G

F

L

F

T

D

K

S

S

L

A

R

A

I

R

E

E

L

L

A

A

D

S

D

R

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

A

P
|
P

D
x
G

F

F

V

I

V

V

S

S

Q

D

I

M

active site: G12 (= G17), S138 (= S142), Q148 (≠ R152), Y151 (= Y155), K155 (= K159)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), S10 (= S15), R11 (≠ E16), I13 (= I18), N31 (≠ S36), Y32 (vs. gap), A33 (= A37), G34 (≠ R38), S35 (≠ N39), A58 (= A62), N59 (≠ D63), V60 (= V64), N86 (= N90), A87 (= A91), T109 (≠ V114), S138 (= S142), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (≠ D186)

3gmdA Structure-based design of 7-azaindole-pyrrolidines as inhibitors of 11beta-hydroxysteroid-dehydrogenase type i (see paper)
33% identity, 73% coverage: 4:199/267 of query aligns to 7:204/264 of 3gmdA

query
sites
3gmdA

L

L

T

Q

G

G

K

K

V

K

V

V

I

I

I

V

T

T

G
|
G

A

A

S

S

E
x
K

G
|
G

I
|
I

G

G

R

R

A

E

L

M

A

A

I

Y

A

H

M

L

A

S

R

K

V

M

G

G

C

A

Q

H

L

V

V

V

L

L

S

T

A

A

R
|
R

N
x
S

E

E

T

E

-

G

-

L

-

Q

R

K

L

V

A

V

S

S

L

R

A

C

L

L

E

E

I

L

A

G

N

-

Y

-

G

A

P

A

T

S

P

A

F

H

V

Y

F

I

A

A

A

G

D
x
T

V
x
M

S

E

S

D

A

M

S

T

Q

F

C

A

E

E

A

Q

L

F

I

I

Q

V

A

K

T

A

I

G

A

K

H

L

Y

M

G

G

R

G

L

L

D

D

I

M

L

L

V

I

-

L

N
|
N

N
x
H

A
x
I

G

T

M

Q

T
|
T

M

S

W

L

S

S

R

L

F

F

D

H

E

-

L

-

N

D

Q

D

L

I

S

H

V

S

L

V

E

R

D

R

I

V

M

M

R

E

V
|
V

N

N

Y

F

L

L

G

S

P

Y

A

V

Y

V

L

M

T

S

H

T

A

A

L

L

P

P

Y

M

L

L

K

K

S

Q

S

S

Q

N

G

G

Q

S

V

I

V

A

V

V

V
x
I

A

S

S
|
S

V

L

A

A

G

G

L

K

T

V

G

T

V
x
Y

P

P

T

M

R

V

S

A

G

P

Y
|
Y

A

S

A

A

S

S

K
|
K

H

F

A

A

V

L

I

D

G

G

F

F

D

S

S

T

L

I

R

R

I

T

E

E

L

L

-

Y

-

I

A

T

D

K

D

V

N

N

V

V

A

S

V

I

T

T

V

L

I

C

C

V

P
x
L

D
x
G

F
x
L

V
x
I

V

D

S
x
T

Q

E

I
x
T

H
x
A

K

M

R

K

A

A

L

V

N

S

G

G

active site: S145 (= S142), Y158 (= Y155), K162 (= K159)
binding 2-methyl-3-{(3S)-1-[(1-pyridin-2-ylcyclopropyl)carbonyl]pyrrolidin-3-yl}-1H-pyrrolo[2,3-b]pyridine: T99 (= T94), S145 (= S142), Y152 (≠ V149), Y158 (= Y155), G191 (≠ D186), L192 (≠ F187), T197 (≠ I192), A198 (≠ H193)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G16 (= G13), K19 (≠ E16), G20 (= G17), I21 (= I18), R41 (= R38), S42 (≠ N39), T67 (≠ D63), M68 (≠ V64), N94 (= N89), H95 (≠ N90), I96 (≠ A91), V117 (= V114), I143 (≠ V140), S145 (= S142), Y158 (= Y155), K162 (= K159), L190 (≠ P185), G191 (≠ D186), L192 (≠ F187), I193 (≠ V188), T195 (≠ S190), T197 (≠ I192)

2rh4B Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
35% identity, 68% coverage: 7:188/267 of query aligns to 14:197/268 of 2rh4B

query
sites
2rh4B

K

E

V

V

V

A

I

L

I

V

T

T

G
|
G

A

A

S
x
T

E
x
S

G
|
G

I
|
I

G

G

R

L

A

E

L

I

A

A

I

R

A

R

M

L

A

G

R

K

V

E

G

G

C

L

Q

R

L

V

V

F

L

V

S

C

A
|
A

R
|
R

N
x
G

E

E

T

E

R

G

L

L

A

R

S

T

L

T

A

L

L

K

E

E

I

L

A

R

N

E

Y

A

G

G

P

V

T

E

P

A

F

D

V

G

F

R

A

T

A
x
C

D
|
D

V
|
V

S

R

S

S

A

V

S

P

Q

E

C

I

E

E

A

A

L

L

I

V

Q

A

A

A

T

V

I

V

A

E

H

R

Y

Y

G

G

R

P

L

V

D

D

I

V

L

L

V

V

N

N

N
|
N

A

A

G

G

M

R

T

P

M

G

W

G

S

G

R

A

F

T

D

A

E

E

L

L

N

A

Q

D

L

E

S

L

V

W

L

L

E

-

D

D

I

V

M

V

R

E

V

T

N
|
N

Y

L

L

T

G

G

P

V

A

F

Y

R

L

V

T

T

H

K

A

Q

A

V

L

L

P

K

-

A

-

G

Y

M

L

L

K

E

S

R

S

G

Q

T

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S
|
S

V

T

A

G

G

G

L

K

T

Q

G

G

V

V

P

V

T

H

R

A

S

A

G

P

Y
|
Y

A

S

A

A

S

S

K
|
K

H

H

A

G

V

V

I

V

G

G

F

F

F

T

D

K

S

A

L

L

R

G

I

L

E

E

L

L

A

A

D

R

D

T

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

C

P

P

D
x
G

F

F

V
|
V

active site: G24 (= G17), N121 (= N115), S151 (= S142), Y164 (= Y155), K168 (= K159)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G20 (= G13), T22 (≠ S15), S23 (≠ E16), I25 (= I18), A44 (= A37), R45 (= R38), G46 (≠ N39), C69 (≠ A62), D70 (= D63), V71 (= V64), N97 (= N90), S151 (= S142), Y164 (= Y155), K168 (= K159), G195 (≠ D186), V197 (= V188)

Sites not aligning to the query:

active site: 209
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: 199, 201

1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound (see paper)
35% identity, 68% coverage: 7:188/267 of query aligns to 2:185/256 of 1xr3A

query
sites
1xr3A

K

E

V

V

V

A

I

L

I

V

T

T

G
|
G

A

A

S
x
T

E
x
S

G
|
G

I
|
I

G

G

R

L

A

E

L

I

A

A

I

R

A

R

M

L

A

G

R

K

V

E

G

G

C

L

Q

R

L

V

V

F

L

V

S

C

A
|
A

R
|
R

N
x
G

E

E

T

E

R

G

L

L

A

R

S

T

L

T

A

L

L

K

E

E

I

L

A

R

N

E

Y

A

G

G

P

V

T

E

P

A

F

D

V

G

F

R

A

T

A
x
C

D
|
D

V
|
V

S

R

S

S

A

V

S

P

Q

E

C

I

E

E

A

A

L

L

I

V

Q

A

A

A

T

V

I

V

A

E

H

R

Y

Y

G

G

R

P

L

V

D

D

I

V

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

M

R

T

P

M

G

W

G

S

G

R

A

F

T

D

A

E

E

L

L

N

A

Q

D

L

E

S

L

V

W

L

L

E

-

D

D

I

V

M

V

R

E

V

T

N
|
N

Y

L

L

T

G

G

P

V

A

F

Y

R

L

V

T

T

H

K

A

Q

A

V

L

L

P

K

-

A

-

G

Y

M

L

L

K

E

S

R

S

G

Q

T

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S
|
S

V
x
T

A
x
G

G

G

L

K

T

Q

G

G

V
|
V

P

V

T

H

R

A

S

A

G

P

Y
|
Y

A

S

A

A

S

S

K
|
K

H

H

A

G

V

V

I

V

G

G

F

F

F

T

D

K

S

A

L

L

R

G

I

L

E

E

L

L

A

A

D

R

D

T

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

C

P

P

D
x
G

F

F

V
|
V

active site: G12 (= G17), N109 (= N115), S139 (= S142), Y152 (= Y155), K156 (= K159)
binding 4-(diazenylcarbonyl)pyridine: T140 (≠ V143), G141 (≠ A144), V146 (= V149)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), T10 (≠ S15), S11 (≠ E16), G12 (= G17), I13 (= I18), A32 (= A37), R33 (= R38), G34 (≠ N39), C57 (≠ A62), D58 (= D63), V59 (= V64), N85 (= N90), A86 (= A91), G87 (= G92), S139 (= S142), Y152 (= Y155), K156 (= K159), G183 (≠ D186), V185 (= V188)

Sites not aligning to the query:

active site: 197
binding nadp nicotinamide-adenine-dinucleotide phosphate: 187, 188

P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
35% identity, 68% coverage: 7:188/267 of query aligns to 7:190/261 of P16544

query
sites
P16544

K

E

V

V

V

A

I

L

I
x
V

T
|
T

G
|
G

A
|
A

S
x
T

E
x
S

G
|
G

I
|
I

G
|
G

R
x
L

A
x
E

L
x
I

A
|
A

I
x
R

A
x
R

M
x
L

A
x
G

R
x
K

V
x
E

G
|
G

C
x
L

Q
x
R

L
x
V

V
x
F

L
x
V

S
x
C

A
|
A

R
|
R

N
x
G

E

E

T

E

R

G

L

L

A

R

S

T

L

T

A

L

L

K

E

E

I

L

A

R

N

E

Y

A

G

G

P

V

T

E

P

A

F

D

V

G

F

R

A

T

A

C

D
|
D

V

V

S

R

S

S

A

V

S

P

Q

E

C

I

E

E

A

A

L

L

I

V

Q

A

A

A

T

V

I

V

A

E

H

R

Y

Y

G

G

R

P

L

V

D

D

I

V

L

L

V

V

N

N

A

A

G

G

M

R

T

P

M

G

W

G

S

G

R

A

F

T

D

A

E

E

L

L

N

A

Q

D

L

E

S

L

V

W

L

L

E

-

D

D

I

V

M

V

R

E

V

T

N

N

Y

L

L

T

G

G

P

V

A

F

Y

R

L

V

T

T

H

K

A

Q

A

V

L

L

P

K

-

A

-

G

Y

M

L

L

K

E

S

R

S

G

Q

T

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S

S

V

T

A

G

G

G

L

K

T

Q

G

G

V

V

P

V

T

H

R

A

S

A

G

P

Y

Y

A

S

A

A

S

S

K
|
K

H

H

A

G

V

V

I

V

G

G

F

F

F

T

D

K

S

A

L

L

R

G

I

L

E

E

L

L

A

A

D

R

D

T

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

C

P

P

D

G

F

F

V

V

11:39 (vs. 11:39, 34% identical) binding
D63 (= D63) binding
K161 (= K159) binding

1w4zA Structure of actinorhodin polyketide (actiii) reductase (see paper)
35% identity, 68% coverage: 7:188/267 of query aligns to 5:188/259 of 1w4zA

query
sites
1w4zA

K

E

V

V

V

A

I

L

I

V

T

T

G
|
G

A

A

S
x
T

E
x
S

G
|
G

I
|
I

G

G

R

L

A

E

L

I

A

A

I

R

A

R

M

L

A

G

R

K

V

E

G

G

C

L

Q

R

L

V

V

F

L

V

S

C

A

A

R
|
R

N
x
G

E

E

T

E

R

G

L

L

A

R

S

T

L

T

A

L

L

K

E

E

I

L

A

R

N

E

Y

A

G

G

P

V

T

E

P

A

F

D

V

G

F

R

A

T

A

C

D
|
D

V
|
V

S

R

S

S

A

V

S

P

Q

E

C

I

E

E

A

A

L

L

I

V

Q

A

A

A

T

V

I

V

A

E

H

R

Y

Y

G

G

R

P

L

V

D

D

I

V

L

L

V

V

N

N

N
|
N

A

A

G
|
G

M

R

T

P

M

G

W

G

S

G

R

A

F

T

D

A

E

E

L

L

N

A

Q

D

L

E

S

L

V

W

L

L

E

-

D

D

I

V

M

V

R

E

V

T

N
|
N

Y

L

L

T

G

G

P

V

A

F

Y

R

L

V

T

T

H

K

A

Q

A

V

L

L

P

K

-

A

-

G

Y

M

L

L

K

E

S

R

S

G

Q

T

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S
|
S

V

T

A

G

G

G

L

K

T

Q

G

G

V

V

P

V

T

H

R

A

S

A

G

P

Y
|
Y

A

S

A

A

S

S

K
|
K

H

H

A

G

V

V

I

V

G

G

F

F

F

T

D

K

S

A

L

L

R

G

I

L

E

E

L

L

A

A

D

R

D

T

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

C

P
|
P

D
x
G

F

F

V
|
V

active site: G15 (= G17), N112 (= N115), S142 (= S142), Y155 (= Y155), K159 (= K159)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G13), T13 (≠ S15), S14 (≠ E16), G15 (= G17), I16 (= I18), R36 (= R38), G37 (≠ N39), D61 (= D63), V62 (= V64), N88 (= N90), G90 (= G92), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), G186 (≠ D186), V188 (= V188)

Sites not aligning to the query:

active site: 200
binding nadp nicotinamide-adenine-dinucleotide phosphate: 190

2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
35% identity, 68% coverage: 7:188/267 of query aligns to 3:186/257 of 2rh4A

query
sites
2rh4A

K

E

V

V

V

A

I

L

I

V

T

T

G
|
G

A

A

S
x
T

E
x
S

G
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G

I
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I

G

G

R

L

A

E

L

I

A

A

I

R

A

R

M

L

A

G

R

K

V

E

G

G

C

L

Q

R

L

V

V

F

L

V

S

C

A
|
A

R
|
R

N
x
G

E

E

T

E

R

G

L

L

A

R

S

T

L

T

A

L

L

K

E

E

I

L

A

R

N

E

Y

A

G

G

P

V

T

E

P

A

F

D

V

G

F

R

A

T

A
x
C

D
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D

V
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V

S

R

S

S

A

V

S

P

Q

E

C

I

E

E

A

A

L

L

I

V

Q

A

A

A

T

V

I

V

A

E

H

R

Y

Y

G

G

R

P

L

V

D

D

I

V

L

L

V

V

N

N

N
|
N

A

A

G
|
G

M

R

T

P

M

G

W

G

S

G

R

A

F

T

D

A

E

E

L

L

N

A

Q

D

L

E

S

L

V

W

L

L

E

-

D

D

I

V

M

V

R

E

V

T

N
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N

Y

L

L

T

G

G

P

V

A

F

Y

R

L

V

T

T

H

K

A

Q

A

V

L

L

P

K

-

A

-

G

Y

M

L

L

K

E

S

R

S

G

Q

T

G

G

Q

R

V

I

V

V

V

N

V

I

A

A

S
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S

V
x
T

A

G

G

G

L

K

T
x
Q

G

G

V
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V

P

V

T

H

R

A

S

A

G

P

Y
|
Y

A

S

A

A

S

S

K
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K

H

H

A

G

V

V

I

V

G

G

F

F

F

T

D

K

S

A

L

L

R

G

I

L

E

E

L

L

A

A

D

R

D

T

N

G

V

I

A

T

V

V

T

N

V

A

I

V

C

C

P
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P

D
x
G

F
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F

V
|
V

active site: G13 (= G17), N110 (= N115), S140 (= S142), Y153 (= Y155), K157 (= K159)
binding 3-methyl-1,6,8-trihydroxyanthraquinone: T141 (≠ V143), Q145 (≠ T147), V147 (= V149), Y153 (= Y155), F185 (= F187)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G9 (= G13), T11 (≠ S15), S12 (≠ E16), G13 (= G17), I14 (= I18), A33 (= A37), R34 (= R38), G35 (≠ N39), C58 (≠ A62), D59 (= D63), V60 (= V64), N86 (= N90), G88 (= G92), S140 (= S142), Y153 (= Y155), K157 (= K159), P183 (= P185), G184 (≠ D186), V186 (= V188)

Sites not aligning to the query:

4ijuB Crystal structure of 11b-hsd1 double mutant (l262r, f278e) in complex with (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3- yl]bicyclo[2.2.1]heptan-1-ol (see paper)
34% identity, 73% coverage: 4:199/267 of query aligns to 23:220/282 of 4ijuB

query
sites
4ijuB

L

L

T

Q

G

G

K

K

V

K

V

V

I

I

I

V

T

T

G
|
G

A

A

S
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S

E

K

G
|
G

I
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I

G

G

R

R

A

E

L

M

A

A

I

Y

A

H

M

L

A

A

R

K

V

M

G

G

C

A

Q

H

L

V

V

V

L

V

S

T

A
|
A

R
|
R

N
x
S

E

K

T

E

R

T

L

L

A

Q

S

K

L

V

A

V

L

S

E

H

I

C

A

L

N

E

Y

L

G

G

P

A

-

A

T

S

P

A

F

H

V

Y

F

I

A

A

A

G

D
x
T

V
x
M

S

E

S

D

A

M

S

T

Q

F

C

A

E

E

A

Q

L

F

I

V

Q

A

A

Q

T

A

I

G

A

K

H

L

Y

M

G

G

R

G

L

L

D

D

I

M

L

L

V

I

-

L

N
|
N

N

H

A
x
I

G

T

M

N

T
|
T

M

S

W

L

S

N

R

L

F

F

-

H

D

D

E

D

L

I

N

H

Q

H

L

V

S

-

V

-

L

-

E

R

D

K

I

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M

M

R

E

V

V

N

N

Y

F

L

L

G

S

P

Y

A

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Y

V

L

L

T

T

H

V

A

A

L

L

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P

Y

M

L

L

K

K

S

Q

S

S

Q

N

G

G

Q

S

V

I

V

V

V
|
V

A

S

S
|
S

V
x
L

A

A

G

G

L

K

T

V

G

A

V
x
Y

P

P

T

M

R

V

S

A

G

A

Y
|
Y

A

S

A

A

S

S

K
|
K

H

F

A

A

V

L

I

D

G

G

F

F

D

S

S

S

L

I

R

R

I

K

E

E

L

Y

A

S

D

V

D

S

-

R

-

V

N

N

V

V

A

S

V

I

T

T

V

L

I

C

C

V

P
x
L

D
x
G

F
x
L

V
x
I

V

D

S
x
T

Q

E

I
x
T

H
x
A

K

M

R

K

A

A

L

V

N

S

G

G

active site: S161 (= S142), Y174 (= Y155), K178 (= K159)
binding (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol: T115 (= T94), S161 (= S142), L162 (≠ V143), Y168 (≠ V149), Y174 (= Y155), G207 (≠ D186), A214 (≠ H193)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G32 (= G13), S34 (= S15), G36 (= G17), I37 (= I18), A56 (= A37), R57 (= R38), S58 (≠ N39), T83 (≠ D63), M84 (≠ V64), N110 (= N89), I112 (≠ A91), V159 (= V140), S161 (= S142), Y174 (= Y155), K178 (= K159), L206 (≠ P185), G207 (≠ D186), L208 (≠ F187), I209 (≠ V188), T211 (≠ S190), T213 (≠ I192), A214 (≠ H193)

4k1lA 4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta- hsd1 inhibitors for the treatment of diabetes (see paper)
34% identity, 73% coverage: 4:199/267 of query aligns to 12:209/263 of 4k1lA

query
sites
4k1lA

L

L

T

Q

G

G

K

K

V

K

V

V

I

I

I

V

T

T

G
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G

A

A

S
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S

E
x
K

G
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G

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|
I

G

G

R

R

A

E

L

M

A

A

I

Y

A

H

M

L

A

A

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K

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M

G

G

C

A

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H

L

V

V

V

L

V

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A

A

R
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R

N
x
S

E

K

T

E

R

T

L

L

A

Q

S

K

L

V

A

V

L

S

E

H

I

C

A

L

N

E

Y

L

G

G

P

A

-

A

T

S

P

A

F

H

V

Y

F

I

A

A

A

G

D
x
T

V
x
M

S

E

S

D

A

M

S

T

Q

F

C

A

E

E

A

Q

L

F

I

V

Q

A

A

Q

T

A

I

G

A

K

H

L

Y

M

G

G

R

G

L

L

D

D

I

M

L

L

V

I

-

L

N
|
N

N
x
H

A
x
I

G

T

M

N

T
|
T

M

S

W

L

S

N

R

L

F

F

-

H

D

D

E

D

L

I

N

H

Q

H

L

V

S

-

V

-

L

-

E

R

D

K

I

S

M

M

R

E

V

V

N

N

Y

F

L

L

G

S

P

Y

A

V

Y

V

L

L

T

T

H

V

A

A

L

L

P

P

Y

M

L

L

K

K

S

Q

S

S

Q

N

G

G

Q

S

V

I

V

V

V
|
V

A

S

S
|
S

V
x
L

A
|
A

G

G

L

K

T

V

G

A

V
x
Y

P

P

T

M

R

V

S

A

G

A

Y
|
Y

A

S

A

A

S

S

K
|
K

H

F

A

A

V

L

I

D

G

G

F

F

D

S

S

S

L

I

R

R

I

K

E

E

L

Y

A

S

D

V

D

S

-

R

-

V

N

N

V

V

A

S

V

I

T

T

V

L

I

C

C

V

P
x
L

D
x
G

F

L

V
x
I

V

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S
x
T

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E

I
x
T

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x
A

K

M

R

K

A

A

L
x
V

N

S

G

G

active site: S150 (= S142), Y163 (= Y155), K167 (= K159)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G21 (= G13), S23 (= S15), K24 (≠ E16), G25 (= G17), I26 (= I18), R46 (= R38), S47 (≠ N39), T72 (≠ D63), M73 (≠ V64), N99 (= N89), H100 (≠ N90), I101 (≠ A91), V148 (= V140), S150 (= S142), Y163 (= Y155), K167 (= K159), L195 (≠ P185), G196 (≠ D186), I198 (≠ V188), T200 (≠ S190), T202 (≠ I192), A203 (≠ H193)
binding (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide: I101 (≠ A91), T104 (= T94), L151 (≠ V143), A152 (= A144), Y157 (≠ V149), Y163 (= Y155), G196 (≠ D186), V207 (≠ L197)

5pgwA Crystal structure of 11beta-hsd1 double mutant (l262r, f278e) complexed with 2-[(1r,3s,5r,7s)-2-[4-(4-fluorophenyl)phenyl]-6- hydroxyadamantan-2-yl]-1-(3- hydroxyazetidin-1-yl)ethan-1-one (see paper)
34% identity, 73% coverage: 4:199/267 of query aligns to 7:204/259 of 5pgwA

query
sites
5pgwA

L

L

T

Q

G

G

K

K

V

K

V

V

I

I

I

V

T

T

G
|
G

A

A

S
|
S

E
x
K

G
|
G

I
|
I

G

G

R

R

A

E

L

M

A

A

I

Y

A

H

M

L

A

A

R

K

V

M

G

G

C

A

Q

H

L

V

V

V

L

V

S

T

A
|
A

R
|
R

N
x
S

E

K

T

E

R

T

L

L

A

Q

S

K

L

V

A

V

L

S

E

H

I

C

A

L

N

E

Y

L

G

G

P

A

-

A

T

S

P

A

F

H

V

Y

F

I

A

A

A

G

D
x
T

V
x
M

S

E

S

D

A

M

S

T

Q

F

C

A

E

E

A

Q

L

F

I

V

Q

A

A

Q

T

A

I

G

A

K

H

L

Y

M

G

G

R

G

L

L

D

D

I

M

L

L

V

I

-

L

N
|
N

N

H

A
x
I

G

T

M

N

T
|
T

M

S

W
x
L

S

N

R

L

F

F

-

H

D

D

E

D

L

I

N

H

Q

H

L

V

S

-

V

-

L

-

E

R

D

K

I

S

M

M

R

E

V

V

N

N

Y

F

L

L

G

S

P

Y

A

V

Y

V

L

L

T

T

H

V

A

A

L

L

P

P

Y

M

L

L

K

K

S

Q

S

S

Q

N

G

G

Q

S

V

I

V

V

V
|
V

A

S

S
|
S

V

L

A

A

G

G

L

K

T

V

G

A

V
x
Y

P
|
P

T

M

R
x
V

S

A

G

A

Y
|
Y

A

S

A

A

S

S

K
|
K

H

F

A

A

V

L

I

D

G

G

F

F

D

S

S

S

L

I

R

R

I

K

E

E

L

Y

A

S

D

V

D

S

-

R

-

V

N

N

V

V

A

S

V

I

T

T

V

L

I

C

C

V

P
x
L

D

G

F
x
L

V
x
I

V

D

S
x
T

Q

E

I
x
T

H
x
A

K

M

R

K

A

A

L
x
V

N

S

G

G

active site: S145 (= S142), Y158 (= Y155), K162 (= K159)
binding 2-[(1r,3s,5r,7s)-2-[4-(4-fluorophenyl)phenyl]-6-hydroxyadamantan-2-yl]-1-(3-hydroxyazetidin-1-yl)ethan-1-one: T99 (= T94), L101 (≠ W96), S145 (= S142), Y152 (≠ V149), P153 (= P150), V155 (≠ R152), Y158 (= Y155), A198 (≠ H193), V202 (≠ L197)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G16 (= G13), S18 (= S15), K19 (≠ E16), G20 (= G17), I21 (= I18), A40 (= A37), R41 (= R38), S42 (≠ N39), T67 (≠ D63), M68 (≠ V64), N94 (= N89), I96 (≠ A91), V143 (= V140), S145 (= S142), Y158 (= Y155), K162 (= K159), L190 (≠ P185), L192 (≠ F187), I193 (≠ V188), T195 (≠ S190), T197 (≠ I192), A198 (≠ H193)

Query Sequence

>7023203 FitnessBrowser__ANA3:7023203
MDGLTGKVVIITGASEGIGRALAIAMARVGCQLVLSARNETRLASLALEIANYGPTPFVF
AADVSSASQCEALIQATIAHYGRLDILVNNAGMTMWSRFDELNQLSVLEDIMRVNYLGPA
YLTHAALPYLKSSQGQVVVVASVAGLTGVPTRSGYAASKHAVIGFFDSLRIELADDNVAV
TVICPDFVVSQIHKRALNGEGKPLGKSPMQEAKIITAEQCANMMLPVIATRGRQLITSLR
GRLGRWLKLIAPGLIDKIARKAIASGH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory