SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 7023819 FitnessBrowser__ANA3:7023819 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 13 hits to proteins with known functional sites (download)

4pd7A Structure of vccnt bound to zebularine (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pd7A

query
sites
4pd7A

N

S

I

L

L

F

M

M

S

S

L

L

V

I

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L
|
L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V

V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I

V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding decyl-beta-d-maltopyranoside: L283 (= L287), L357 (= L370), I360 (= I373), A379 (= A392)
binding Zebularine: Q153 (= Q147), V187 (= V181), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372), I362 (= I375)

3tijA Crystal structure of a concentrative nucleoside transporter from vibrio cholerae (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 3tijA

query
sites
3tijA

N

S

I

L

L

F

M

M

S

S

L

L

V

I

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I
x
L

G

G

G

G

G

G

L
|
L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N
|
N

I

I

F
|
F

V
|
V

G
|
G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S
|
S

I
|
I

A

A

G

G

S

G

V

V

L
|
L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F
|
F

V

I

G

G

L
|
L

I

I

A

A

M

L

I
|
I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V

V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N

N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding decyl-beta-d-maltopyranoside: L127 (≠ I121), L131 (= L125), F150 (= F144), L188 (= L182), F258 (= F262), L261 (= L265), I265 (= I269), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)
binding sodium ion: N148 (= N142), V151 (= V145), G152 (= G146), S182 (= S176), I183 (= I177)
binding uridine: Q153 (= Q147), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), S359 (= S372), I362 (= I375)

4pdaA Structure of vccnt-7c8c bound to cytidine (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pdaA

query
sites
4pdaA

N

S

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V

V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding 4-amino-1-beta-d-ribofuranosyl-2(1h)-pyrimidinone: Q153 (= Q147), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372), I362 (= I375)
binding decyl-beta-d-maltopyranoside: V317 (= V321), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)

4pd9A Structure of vccnt-7c8c bound to adenosine (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pd9A

query
sites
4pd9A

N

S

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G
|
G

Q
|
Q

T
|
T

E
|
E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L
|
L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding adenosine: G152 (= G146), Q153 (= Q147), T154 (= T148), E155 (= E149), V187 (= V181), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372), I362 (= I375)
binding decyl-beta-d-maltopyranoside: L283 (= L287), V317 (= V321), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)

4pd8A Structure of vccnt-7c8c bound to pyrrolo-cytidine (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pd8A

query
sites
4pd8A

N

S

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A
|
A

G

G

S
x
G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding decyl-beta-d-maltopyranoside: V317 (= V321), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)
binding 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one: Q153 (= Q147), A184 (= A178), G186 (≠ S180), V187 (= V181), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372), I362 (= I375)

4pb2A Structure of vccnt-7c8c bound to 5-fluorouridine (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pb2A

query
sites
4pb2A

N

S

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I
|
I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I

I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding 5-fluorouridine: Q153 (= Q147), V187 (= V181), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372)
binding decyl-beta-d-maltopyranoside: I265 (= I269), V317 (= V321), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)

4pb1A Structure of vccnt-7c8c bound to ribavirin (see paper)
68% identity, 99% coverage: 2:417/419 of query aligns to 1:404/404 of 4pb1A

query
sites
4pb1A

N

S

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G
|
G

Q
|
Q

T

T

E
|
E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L
|
L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding decyl-beta-d-maltopyranoside: L283 (= L287), V317 (= V321), L357 (= L370), I360 (= I373), A379 (= A392), V383 (≠ I396)
binding 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide: G152 (= G146), Q153 (= Q147), E155 (= E149), V187 (= V181), L247 (= L251), N319 (= N323), E320 (= E324), F321 (= F325), F354 (= F367), N356 (= N369), S359 (= S372), I362 (= I375)

4pd5A Crystal structure of vccnt-7c8c bound to gemcitabine (see paper)
68% identity, 99% coverage: 3:417/419 of query aligns to 1:403/403 of 4pd5A

query
sites
4pd5A

I

L

L

F

M

M

S

S

L

C

V

C

G

G

V

M

V

A

V

V

L

L

L

L

A

G

I

I

G

A

F

V

L

L

L

L

S

S

N

S

N

N

K

R

K

K

A

A

I

I

N

N

L

L

R

R

T

T

V

V

G

G

G

G

A

A

L

F

A

A

I

I

Q

Q

A

F

A

S

F

L

G

G

G

A

F

F

V

I

L

L

Y

Y

V

V

P

P

V

W

G

G

K

Q

D

E

I

L

L

L

K

R

S

G

V

F

S

S

D

D

A

A

V

V

S

S

S

N

V

V

I

I

G

N

Y

Y

A

G

Q

N

N

D

G

G

I

T

G

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

G

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

I

F

F

A

A

V

F

N

R

V

V

L

L

P

P

V

T

I

L

V

I

F

F

F

F

S

S

S

A

L

L

I

I

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

V

M

M

Q

Q

W

W

I

V

I

I

R

R

I

I

I

L

G

G

G

G

G

G

L

L

Q

Q

K

K

A

A

L

L

G

G

T

T

S

S

R

R

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

Q

Q

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

C

G

G

G

G

L

L

A

A

S

S

I

I

A

A

G

G

S

G

V
|
V

L

L

A

A

G

G

Y

Y

A

A

Q

S

M

M

G

G

V

V

P

K

I

I

E

E

Y

Y

L

L

V

V

A

A

A

A

S

S

F

F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

M

H

M

P

P

E

E

T

T

E

E

V

-

A

-

K

-

N

-

D

-

M

-

D

-

E

-

L

-

P

-

E

K

D

P

P

Q

D

D

K

K

P

P

A

A

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

G

G

G

A

A

S

S

S

A

G

G

M

L

H

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

A

A

M

M

L

L

L

I

A

A

F

F

V

I

G

G

L

L

I

I

A

A

M

L

I

I

N

N

G

G

I

M

I

L

G

G

G

G

V

I

G

G

G

G

W

W

F

F

G

G

V

M

E

P

G

E

L

L

T

K

L

L

E

E

L

M

I

L

L

L

G

G

Y

W

I

L

F

F

M

A

P

P

L

L

A

A

F

F

L

L

I

I

G

G

V

V

P

P

W

W

N

N

E

E

A

A

L

T

V

V

A

A

G

G

S

E

F

F

I

I

G

G

Q

L

K

K

I

T

V
|
V

V

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

Q

F

F

A

A

P

P

Y

Y

L

L

K

T

D

E

I

A

A

A

D

P

G

-

G

-

M

-

I

-

V

-

A

-

D

-

T

-

G

-

L

V

A

V

M

L

T

S

D

E

R

K

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L
|
L

S

S

S
|
S

I
|
I

A

A

I
|
I

L

L

L

L

G

G

G

G

L

L

G

G

A

S

M

L

A

A

P

P

N

K

R

R

R

R

H

G

D

D

L

I

A
|
A

K

R

L

M

G

G

I
x
V

R

K

A

A

V

V

I

I

A

A

G

G

S

T

L

L

A

S

N

N

L

L

M

M

S

A

A

A

T

T

I

I

A

A

G

G

L

F

F

F

L

L

binding decyl-beta-d-maltopyranoside: V316 (= V321), L356 (= L370), I359 (= I373), A378 (= A392), V382 (≠ I396)
binding gemcitabine: Q152 (= Q147), V186 (= V181), L246 (= L251), N318 (= N323), E319 (= E324), F320 (= F325), F353 (= F367), N355 (= N369), S358 (= S372), I361 (= I375)

5l26A Structure of cntnw in an inward-facing substrate-bound state (see paper)
63% identity, 99% coverage: 1:416/419 of query aligns to 3:412/419 of 5l26A

query
sites
5l26A

M

M

N

V

I

V

L

L

M

H

S

S

L

L

V

L

G

G

V

M

V

A

V

V

L

L

L

I

A

A

I

I

G

A

F

V

L

L

L

L

S

S

N

T

N

D

K

R

K

K

A

A

I

I

N

N

L

I

R

R

T

T

V

V

G

A

G

G

A

A

L

F

A

L

I

I

Q

Q

A

V

A

A

F
x
L

G

G

G

A

F

L

V
|
V

L

L

Y

Y

V

V

P

P

V

Q

G

G

K

R

D

D

I
x
M

L

L

K

G

S

E

V

A

S

S

D

K

A
x
T

V
x
I

S

S

S

N

V

V

I

I

G

A

Y

Y

A

G

Q

N

N

N

G

G

I

V

G

D

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

E

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

V

F

F

A

A

V

L

N

R

V

V

L

L

P

P

V

M

I

I

V

V

F

F

F

F

S

S

S

S

L

L

I

M

A

A

V

V

L

L

Y

Y

Y
|
Y

L
x
I

G

G

I

V

M

M

Q

Q

W

L

I

L

I

I

R

K

I
x
V

I

I

G

G

G

G

G
x
F

L

L

Q

Q

K

K

A

M

L

L

G

G

T

T

S

S

R

K

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

N

I

I

F

F

V

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

Y

I

I

P

R

T

R

M

M

T

T

Q

E

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

S

G

G

G

G

L

L

A

A

S

S

I

V

A

A

G

G

S

S

V

V

L

L

A

A

G

G

Y

Y

A

V

Q

Q

M

M

G

G

V

V

P

P

I

L

E

P

Y

Y

L

L

V

I

A

A

A

A

S

S

F
|
F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

L

H

V

P

P

E

E

T

T

E

E

V

R

A

T

K

Q

N

N

D

D

M

A

D

E

E

V

L

L

P

A

E

E

D

N

P

E

D

D

-

E

K

K

P

P

A

T

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

S

G

G

A

A

S

V

S

T

G

G

M

A

H

Q

L

I

A

A

L

I

N

A

V

V

G

G

A

A

M

S

L

L

L

L

A

A

F

F

V

V

G

A

L

L

I

I

A

A

M
|
M

I

I

N

N

G
|
G

I
|
I

I

I

G

G

G
|
G

V

V

G

-

G

-

W

-

F

-

G

-

V

G

E

G

G

D

L

L

T

T

L

L

E

Q

L

A

I

I

L

L

G

G

Y

W

I

L

F

F

M

S

P

P

L

L

A

A

F

W

L

V

I

I

G

G

V

V

P

P

W

W

N

S

E

E

A

A

L

G

V

I

A

A

G

G

S

S

F

L

I

I

G

G

Q

Q

K

K

I

V

V

V

V

I

N

N

E
|
E

F
|
F

V

V

A

A

Y

Y

L

S

N

E

F

F

A

V

P

K

Y

Y

L

L

K

K

D

P

I

-

A

-

D

-

G

-

G

-

M

-

I

-

V

-

A

-

D

E

T

A

G

A

L

V

A

Q

M

L

T

S

D

D

R

T

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F
|
F

A

A

N
|
N

L

L

S

G

S
|
S

I

I

A

A

I
x
V

L

L

L

V

G

G

G

G

L

L

G

S

A

I

M

M

A

A

P

P

N

K

R

R

R

R

H

K

D

D

L

V

A

A

K

R

L

L

G

G

I

I

R

K

A

A

V

V

I

V

A

A

G

G

S

S

L

L

A

S

N

N

L

L

M

M

S

S

A

A

T

V

I

I

A

A

G

G

L

L

F

F

binding 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: L44 (≠ F42), V48 (= V46), M57 (≠ I55), T64 (≠ A62), I65 (≠ V63), Y119 (= Y110), I120 (≠ L111), V129 (≠ I120), F133 (≠ G124), F209 (= F200), M278 (= M268), G281 (= G271), I282 (= I272), G285 (= G275)
binding uridine: Q156 (= Q147), E329 (= E324), F330 (= F325), F363 (= F367), N365 (= N369), S368 (= S372), V371 (≠ I375)

5l2aA Structure of cntnw n149s,f366a in an outward-facing state (see paper)
64% identity, 99% coverage: 1:416/419 of query aligns to 4:418/422 of 5l2aA

query
sites
5l2aA

M

M

N

V

I

V

L

L

M

H

S

S

L

L

V

L

G

G

V

M

V

A

V

V

L

L

L

I

A

A

I

I

G

A

F

V

L

L

L

L

S

S

N

T

N

D

K

R

K

K

A

A

I

I

N

N

L

I

R

R

T

T

V

V

G

A

G

G

A

A

L

F

A

L

I

I

Q

Q

A

V

A

A

F

L

G

G

G

A

F

L

V

V

L

L

Y

Y

V

V

P

P

V

Q

G

G

K

R

D

D

I
x
M

L

L

K

G

S
x
E

V

A

S

S

D

K

A
x
T

V

I

S

S

S

N

V

V

I

I

G

A

Y

Y

A

G

Q

N

N

N

G

G

I

V

G

D

F

F

L

L

F

F

G

G

D

G

L

L

A

V

N

S

F

E

K

K

L

M

-

F

-

E

-

V

-

F

-

G

-

G

-

G

G

G

F

F

I

V

F

F

A

A

V

L

N

R

V

V

L

L

P

P

V

M

I

I

V

V

F

F

F

F

S

S

S

S

L

L

I

M

A

A

V

V

L

L

Y

Y

Y

Y

L

I

G

G

I

V

M

M

Q

Q

W

L

I

L

I

I

R

K

I

V

I

I

G

G

G

G

G

F

L

L

Q

Q

K

K

A

M

L

L

G

G

T

T

S

S

R

K

T

A

E

E

S

S

M

M

S

S

A

A

T

A

A

A

N

S

I

I

F

F

V

V

G

G

Q

Q

T

T

E

E

A

A

P

P

L

L

V

V

V

V

R

R

P

P

F

Y

I

I

P

R

T

R

M

M

T

T

Q

E

S

S

E

E

L

L

F

F

A

A

I

V

M

M

V

S

G

G

G

G

L

L

A

A

S

S

I

V

A

A

G

G

S

S

V

V

L

L

A

A

G

G

Y

Y

A

V

Q

Q

M

M

G

G

V

V

P

P

I

L

E

P

Y

Y

L

L

V

I

A

A

A

A

S

S

F
|
F

M

M

A

A

A

A

P

P

G

G

G

G

L

L

L

L

M

F

A

A

K

K

L

L

M

L

H

V

P

P

E

E

T

T

E

E

V

R

A

T

K

Q

N

N

D

D

M

A

D

E

E

V

L

L

P

A

E

E

D

N

P

E

D

D

-

E

K

K

P

P

A

T

N

N

V

V

L

I

D

D

A

A

A

A

A

A

A

S

G

G

A

A

S

V

S

T

G

G

M

A

H

Q

L

I

A

A

L

I

N

A

V

V

G

G

A

A

M

S

L

L

L

L

A

A

F

F

V

V

G

A

L

L

I

I

A

A

M

M

I

I

N

N

G

G

I

I

I

I

G

G

G

G

V

V

G

G

G

G

W

W

F

F

G

G

V

H

E

G

G

D

L

L

T

T

L

L

E

Q

L

A

I

I

L

L

G

G

Y

W

I

L

F

F

M

S

P

P

L

L

A

A

F

W

L

V

I

I

G

G

V

V

P

P

W

W

N

S

E

E

A

A

L

G

V

I

A

A

G

G

S

S

F

L

I

I

G

G

Q

Q

K

K

I

V

V

V

V

I

N

N

E

E

F

F

V

V

A

A

Y

Y

L

S

N

E

F

F

A

V

P

K

Y

Y

L

L

K

K

D

P

I

-

A

-

D

-

G

-

G

-

M

-

I

-

V

-

A

-

D

E

T

A

G

A

L

V

A

Q

M

L

T

S

D

D

R

T

T

T

K

K

A

A

I

I

I

I

S

S

F

F

A

A

L

L

C

C

G

G

F

A

A

A

N

N

L

L

S

G

S

S

I

I

A

A

I

V

L

L

L

V

G

G

G

G

L

L

G

S

A

I

M

M

A

A

P

P

N

K

R

R

R

R

H

K

D

D

L

V

A

A

K

R

L

L

G

G

I

I

R

K

A

A

V

V

I

V

A

A

G

G

S

S

L

L

A

S

N

N

L

L

M

M

S

S

A

A

T

V

I

I

A

A

G

G

L

L

F

F

binding 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: M58 (≠ I55), E61 (≠ S58), T65 (≠ A62), F210 (= F200)

Q62674 Sodium/nucleoside cotransporter 1; Concentrative nucleoside transporter 1; CNT 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 from Rattus norvegicus (Rat) (see paper)
38% identity, 98% coverage: 4:415/419 of query aligns to 179:589/648 of Q62674

query
sites
Q62674

L

L

M

V

S

S

L

F

V

A

G

G

V

I

V

C

V

V

L

F

L

L

A

V

I

L

G

L

F

F

L

A

L

G

S

S

N

K

N

H

K

H

K

R

A

A

I

V

N

S

L

W

R

R

T

A

V

V

G

S

G

W

A

G

L

L

A

G

I

L

Q

Q

A

F

A

V

F

L

G

G

G

L

F

F

V

V

L

I

Y

R

V

T

P

E

V

P

G

G

K

F

D

I

I

A

L

F

K

Q

S

W

V

L

S

G

D

D

A

Q

V

I

S

Q

S

V

V

F

I

L

G

S

Y

Y

A

T

Q

E

N

A

G

G

I

S

G

S

F

F

L

V

F

F

G

G

D

E

L

A

A

L

N

-

F

-

K

-

L

V

G

K

F

D

I

V

F

F

A

A

V

F

N

Q

V

V

L

L

P

P

V

I

I

I

V

I

F

F

F

F

S

S

S

C

L

V

I

M

A

S

V

V

L

L

Y

Y

Y

Y

L

L

G

G

I

L

M

M

Q

Q

W

W

I

V

I

I

R

L

I

K

I

I

G

A

G

W

G

L

L

M

Q

Q

K

V

A

T

L

M

G

G

T

T

S

S

R

A

T

T

E

E

S

T

M

L

S

S

A

V

T

A

A

G

N

N

I

I

F

F

V

V

G

S

Q

Q

T

T

E

E

A

A

P

P

L

L

V

L

V

I

R

R

P

P

F

Y

I

L

P

A

T

D

M

M

T

T

Q

L

S

S

E

E

L

V

F

H

A

V

I

V

M

M

V

T

G

G

G

G

L

Y

A

A

S

T

I

I

A

A

G

G

S

S

V

L

L

L

A

G

G

A

Y

Y

A

I

Q

S

M

F

G

G

V

I

P

D

I

A

E

A

Y

S

L

L

V

I

A

A

A

A

S

S

F

V

M

M

A

A

A

A

P

P

G

C

G

A

L

L

L

A

M

L

A

S

K

K

L

L

M

V

H

Y

P

P

E

E

T

V

E

E

V

E

A

S

K

K

-

F

N

R

D

S

M

E

D

N

E

G

L

V

P

K

E

L

D

T

P

Y

D

G

K

D

P

A

A

Q

N

N

V

L

L

L

D

E

A

A

A

A

A

S

A

A

G

G

A

A

S

A

S

I

G

S

M

V

H

K

L

V

A

V

L

A

N

N

V

I

G

A

A

A

M

N

L

L

L

I

A

A

F

F

V

L

G

A

L

V

I

L

A

A

M

F

I

V

N

N

G

A

I

A<