SitesBLAST

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
41% identity, 87% coverage: 20:163/165 of query aligns to 7:153/157 of Q0QLF3

query
sites
Q0QLF3

N

N

L

L

T

N

I

L

N

N

G

G

R

E

S

A

F

R

T

S

L

I

N

V

A

T

D

E

P

P

N

N

M

K

P

R

I

L

L

L

W

D

A

L

L

L

R

R

D

E

I

D

L

F

G

G

L

L

T

T

G

S

T

V

K

K

Y

E

G

G

C
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C

G

S

A

E

G

G

L

E

C
|
C

G

G

A

A

C
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C

T

T

V

V

H

I

L

F

D

N

G

G

Q

D

P

P

V

V

R

T

A

T

C
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C

L

C

T

M

S

L

V

A

S

G

Q

Q

A

A

Q

D

G

E

K

S

Q

T

L

I

T

I

T

T

I

L

E

E

G

G

L

V

D

A

N

E

Q

D

K

G

-

K

-

P

-

S

-

L

L

L

K

Q

N

Q

A

C

W

F

A

L

E

E

H

A

N

G

V

A

P

V

Q

Q

C
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C

G

G

Y

Y

C
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C

Q

T

A

P

G

G

Q

M

L

I

M

L

S

T

A

A

A

K

A

A

L

L

V

L

T

D

Q

K

H

N

P

P

K

D

P

P

S

T

A

D

E

E

Q

E

I

I

D

T

A

V

A

A

M

M

S

S

G

G

N

N

L

L

C
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C

R

R

C
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C

G

T

T

G

Y

Y

P

I

R

K

I

I

K

H

A

A

L

V

Q

R

S

-

Y

Y

A

A

K

V

Q

E

C42 (= C55) binding
C47 (= C60) binding
C50 (= C63) binding
C62 (= C75) binding
C101 (= C110) binding
C104 (= C113) binding
C136 (= C145) binding
C138 (= C147) binding

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
40% identity, 87% coverage: 21:163/165 of query aligns to 65:226/229 of P77165

query
sites
P77165

L

L

T

K

I

V

N

N

G

G

R

K

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T

F

E

T

Q

L

L

N

E

A

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D

D

P

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N

R

M

T

P

T

I

L

L

L

W

D

A

T

L

L

R

R

D

E

I

N

L

L

G

H

L

L

T

I

G

G

T

T

K

K

Y

K

G

G

C
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C

G

D

A

H

G

G

L

Q

C
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C

G
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G

A

A

C
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C

T

T

V

V

H

L

L

V

D

N

G

G

Q

R

P

R

V

L

R

N

A

A

C
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C

L

L

T

T

S

L

V

A

S

V

Q

M

A

H

Q

Q

G

G

K

A

Q

E

L

I

T

T

I

I

E

E

G

G

L

L

-

G

-

S

-

P

D

D

N

N

-

L

Q

H

K

P

L

M

K

Q

N

A

A

A

W

F

A

I

E

K

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H

N

D

V

G

P

F

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Q

C
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C

G

G

Y

Y

C
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C

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T

A

S

G

G

Q

Q

L

I

M

C

S

S

A

S

A

V

A

A

L

V

V

L

T

K

Q

E

-

I

-

Q

-

D

-

G

-

I

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P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

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S

H

A

P

P

K

E

P

T

S

T

A

A

E

D

Q

E

I

I

D

R

A

E

A

R

M

M

S

S

G

G

N

N

L

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C
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C

R

R

C
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C

G

G

T

A

Y

Y

P

A

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A

A

L

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D

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A

A

A

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G

Q

E

C99 (= C55) binding
C104 (= C60) binding
G105 (= G61) binding
C107 (= C63) binding
C119 (= C75) binding
C158 (= C110) binding
C161 (= C113) binding
C208 (= C145) binding
C210 (= C147) binding

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
40% identity, 87% coverage: 21:163/165 of query aligns to 14:175/175 of 5g5gA

query
sites
5g5gA

L

L

T

K

I

V

N

N

G

G

R

K

S

T

F

E

T

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L

L

N

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A

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D

D

P

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N

R

M

T

P

T

I

L

L

L

W

D

A

T

L

L

R

R

D

E

I

N

L

L

G

H

L

L

T

I

G

G

T

T

K

K

Y
x
K

G
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G

C
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C

G
x
D

A

H

G
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G

L
x
Q

C
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C

G
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G

A

A

C
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C

T

T

V

V

H

L

L

V

D

N

G

G

Q

R

P

R

V

L

R
x
N

A

A

C
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C

L

L

T

T

S

L

V

A

S

V

Q

M

A

H

Q

Q

G

G

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A

Q

E

L

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T

I

I

E

E

G

G

L

L

-

G

-

S

-

P

D

D

N

N

-

L

Q

H

K

P

L

M

K

Q

N

A

A

A

W

F

A

I

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H

H

N

D

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G

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F

Q
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Q

C
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C

G
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G

Y

Y

C
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C

Q

T

A

S

G

G

Q

Q

L

I

M

C

S

S

A

S

A

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A

A

L

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V

L

T

K

Q

E

-

I

-

Q

-

D

-

G

-

I

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P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

-

S

H

A

P

P

K

E

P

T

S

T

A

A

E

D

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E

I

I

D

R

A

E

A

R

M

M

S

S

G

G

N

N

L

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C
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C

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C
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C

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A

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Y

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A

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N

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I

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L

A

A

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A

A

A

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G

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E

binding flavin-adenine dinucleotide: G51 (= G58), Q52 (≠ L59)
binding fe2/s2 (inorganic) cluster: K46 (≠ Y53), G47 (= G54), C48 (= C55), D49 (≠ G56), G51 (= G58), Q52 (≠ L59), C53 (= C60), G54 (= G61), C56 (= C63), N66 (≠ R73), C68 (= C75), Q106 (= Q109), C107 (= C110), G108 (= G111), C110 (= C113), C157 (= C145), C159 (= C147)
binding pterin cytosine dinucleotide: Q106 (= Q109), C159 (= C147)

4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
36% identity, 93% coverage: 11:163/165 of query aligns to 7:159/161 of 4zohC

query
sites
4zohC

D

D

Q

Q

S

K

L

V

A

K

M

I

P

-

S

-

Q

-

N

T

L

L

T

K

I

I

N

N

G

G

R

E

S

K

F

Y

T

E

L

T

N

E

A

V

D

E

P

P

N

R

M

R

P

L

I

L

L

V

W

H

A

V

L

L

R

R

D

E

I

-

L

L

G

G

L

F

T

T

G

G

T

V

K

H

Y
x
I

G
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G

C
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C

G

D

A

T

G
x
S

L
x
N

C
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C

G
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G

A

A

C
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C

T

T

V

V

H

I

L

M

D

N

G

G

Q

K

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S

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A

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C
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C

L

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A

S

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E

A

A

Q

D

G

G

K

A

Q

E

L

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L

T

T

I

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E

E

G

G

L

L

D

A

N

K

-

D

-

G

-

K

-

L

Q

H

K

P

L

I

K

Q

N

E

A

A

W

F

A

W

E

E

H

N

N

H

V

A

P

L

Q
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Q

C
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C

G
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G

Y

Y

C
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C

Q

T

A

P

G

G

Q

M

L

I

M

M

S

E

A

A

A

Y

A

W

L

L

V

L

T

R

Q

E

H

K

P

P

K

N

P

P

S

T

A

E

E

E

Q

E

I

I

D

R

A

E

A

G

M

I

S

S

G

G

N

N

L

L

C
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C

R
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R

C
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C

G

T

T

G

Y

Y

P

Q

R

N

I

I

K

V

A

K

A

A

L

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S

A

Y

A

A

A

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E

Q

K

binding fe2/s2 (inorganic) cluster: I45 (≠ Y53), G46 (= G54), C47 (= C55), S50 (≠ G58), N51 (≠ L59), C52 (= C60), G53 (= G61), C55 (= C63), C67 (= C75), Q105 (= Q109), C106 (= C110), G107 (= G111), C109 (= C113), C141 (= C145), R142 (= R146), C143 (= C147)
binding pterin cytosine dinucleotide: Q105 (= Q109), C143 (= C147)

1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
36% identity, 87% coverage: 21:163/165 of query aligns to 7:153/156 of 1ffuD

query
sites
1ffuD

L

V

T

N

I

V

N

N

G

G

R

K

S

A

F

Q

T

E

L

K

N

A

A

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E

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P

N

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L

I

L

L

I

W

H

A

F

L

L

R

R

D

E

I

E

L

L

G

N

L

L

T

T

G

G

T

A

K

H

Y
x
I

G
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G

C
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C

G

E

A

T

G
x
S

L
x
H

C
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C

G
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G

A

A

C
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C

T

T

V

V

H

D

L

I

D

D

G

G

Q

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V

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x
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C

L

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L

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S

V

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Q

A

C

Q

D

G

G

K

S

Q

E

L

V

T

L

T

T

I

V

E

E

G

G

L

L

D

A

N

N

Q

K

K

G

L

V

K

L

N

H

A

A

-

V

-

Q

-

E

-

G

-

F

W

Y

A

K

E

E

H

H

N

G

V

L

P

-

Q
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Q

C
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C

G
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G

Y

F

C
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C

Q

T

A

P

G

G

Q

M

L

L

M

M

S

R

A

A

A

Y

A

R

L

F

V

L

T

Q

Q

E

H

N

P

P

K

N

P

P

S

T

A

E

E

A

Q

E

I

I

D

R

A

M

A

G

M

M

S

T

G

G

N

N

L

L

C
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C

R
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R

C
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C

G

T

T

G

Y

Y

P

Q

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N

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I

K

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A

K

A

A

L

V

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Q

S

Y

Y

A

A

A

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R

Q

K

binding flavin-adenine dinucleotide: S44 (≠ G58), H45 (≠ L59)
binding fe2/s2 (inorganic) cluster: I39 (≠ Y53), G40 (= G54), C41 (= C55), S44 (≠ G58), H45 (≠ L59), C46 (= C60), G47 (= G61), C49 (= C63), K59 (≠ R73), C61 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C135 (= C145), R136 (= R146), C137 (= C147)

1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
36% identity, 87% coverage: 21:163/165 of query aligns to 6:152/155 of 1ffvA

query
sites
1ffvA

L

V

T

N

I

V

N

N

G

G

R

K

S

A

F

Q

T

E

L

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N

A

A

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D

E

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P

N

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M

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L

I

L

L

I

W

H

A

F

L

L

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R

D

E

I

E

L

L

G

N

L

L

T

T

G

G

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A

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H

Y
x
I

G
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G

C
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C

G

E

A
x
T

G
x
S

L
x
H

C
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C

G
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G

A

A

C
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C

T

T

V

V

H

D

L

I

D

D

G

G

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x
K

A

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C
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C

L

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A

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V

Q

Q

A

C

Q

D

G

G

K

S

Q

E

L

V

T

L

T

T

I

V

E

E

G

G

L

L

D

A

N

N

Q

K

K

G

L

V

K

L

N

H

A

A

-

V

-

Q

-

E

-

G

-

F

W

Y

A

K

E

E

H

H

N

G

V
x
L

P

-

Q
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Q

C
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C

G
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G

Y

F

C
|
C

Q

T

A

P

G

G

Q

M

L

L

M

M

S

R

A

A

A

Y

A

R

L

F

V

L

T

Q

Q

E

H

N

P

P

K

N

P

P

S

T

A

E

E

A

Q

E

I

I

D

R

A

M

A

G

M

M

S

T

G

G

N

N

L

L

C
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C

R
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R

C
|
C

G

T

T

G

Y

Y

P

Q

R

N

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I

K

V

A

K

A

A

L

V

Q

Q

S

Y

Y

A

A

A

K

R

Q

K

binding flavin-adenine dinucleotide: T42 (≠ A57), S43 (≠ G58), H44 (≠ L59)
binding fe2/s2 (inorganic) cluster: I38 (≠ Y53), G39 (= G54), C40 (= C55), S43 (≠ G58), H44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), K58 (≠ R73), C60 (= C75), L97 (≠ V107), Q98 (= Q109), C99 (= C110), G100 (= G111), C102 (= C113), C134 (= C145), R135 (= R146), C136 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q109), C136 (= C147)

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/906 of 1dgjA

query
sites
1dgjA

M

M

P

E

S

T

Q

K

N

T

L

L

T

I

I

V

N

N

G

G

R

M

S

A

F

R

T

R

L

L

N

L

A

V

D

S

P

P

N

N

M

D

P

L

I

L

L

V

W

D

A

V

L

L

R

R

D

S

I

Q

L

L

G

Q

L

L

T

T

G

S

T

V

K

K

Y
x
V

G
|
G

C
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C

G
|
G

A

K

G
|
G

L
x
Q

C
|
C

G
|
G

A
|
A

C
|
C

T

T

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
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R

A

A

C
|
C

L

I

T

I

S

K

V

M

S

S

Q

R

-

V

A

A

Q

E

G

N

K

A

Q

S

L

V

T

T

I

L

E

E

G

G

L

I

D

G

N

A

-

P

-

D

-

C

-

L

Q

H

K

P

L

L

K

Q

N

H

A

A

W

W

A

I

E

Q

H

H

N

G

V

A

P

A

Q
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Q

C
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C

G
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G

Y

F

C
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C

Q

T

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

A

L

L

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L

T

D

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N

P

V

K

A

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

N

N

L

I

C
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C

R
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R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

I

Q

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G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), G41 (= G56), G43 (= G58), Q44 (≠ L59), C45 (= C60), G46 (= G61), A47 (= A62), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding pterin cytosine dinucleotide: Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 533, 534, 535, 655, 698, 869
binding pterin cytosine dinucleotide: 421, 422, 423, 424, 535, 652, 655, 656, 657, 658, 662, 697, 698, 700, 701, 702, 703, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
36% identity, 87% coverage: 21:163/165 of query aligns to 8:155/166 of P19921

query
sites
P19921

L

L

T

T

I

I

N

N

G

G

R

H

S

P

F

V

T

E

L

A

N

L

A

V

D

E

P

P

N

R

M

T

P

L

I

L

L

I

W

H

A

F

L

I

R

R

D

E

I

Q

L

Q

G

N

L

L

T

T

G

G

T

A

K

H

Y

I

G

G

C
|
C

G

D

A

T

G

S

L

H

C
|
C

G

G

A

A

C
|
C

T

T

V

V

H

D

L

L

D

D

G

G

Q

M

P

S

V

V

R

K

A

S

C
|
C

L

T

T

M

S

F

V

A

S

V

Q

Q

A

A

Q

N

G

G

K

A

Q

S

L

I

T

T

I

I

E

E

G

G

L

M

D

A

N

A

-

P

-

D

-

G

-

T

-

L

Q

S

K

A

L

L

K

Q

N

E

A

G

W

F

A

R

E

M

H

M

N

H

V

G

P

L

Q

Q

C
|
C

G

G

Y

Y

C
|
C

Q

T

A

P

G

G

Q

M

L

I

M

M

S

R

A

S

A

H

A

R

L

L

V

L

T

Q

Q

E

H

N

P

P

K

S

P

P

S

T

A

E

E

A

Q

E

I

I

D

R

A

F

A

G

M

I

S

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

G

T

T

G

Y

Y

P

Q

R

N

I

I

K

V

A

K

A

A

L

I

Q

Q

S

Y

Y

A

A

A

K

A

Q

K

C42 (= C55) binding
C47 (= C60) binding
C50 (= C63) binding
C62 (= C75) binding
C102 (= C110) binding
C105 (= C113) binding
C137 (= C145) binding
C139 (= C147) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
36% identity, 87% coverage: 21:163/165 of query aligns to 6:153/161 of 1n5wA

query
sites
1n5wA

L

L

T

T

I

I

N

N

G

G

R

H

S

P

F

V

T

E

L

A

N

L

A

V

D

E

P

P

N

R

M

T

P

L

I

L

L

I

W

H

A

F

L

I

R

R

D

E

I

Q

L

Q

G

N

L

L

T

T

G

G

T

A

K

H

Y
x
I

G
|
G

C
|
C

G

D

A
x
T

G
x
S

L
x
H

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

H

D

L

L

D

D

G

G

Q

M

P

S

V

V

R
x
K

A

S

C
|
C

L

T

T

M

S

F

V

A

S

V

Q

Q

A

A

Q

N

G

G

K

A

Q

S

L

I

T

T

I

I

E

E

G

G

L

M

D

A

N

A

-

P

-

D

-

G

-

T

-

L

Q

S

K

A

L

L

K

Q

N

E

A

G

W

F

A

R

E

M

H

M

N

H

V

G

P
x
L

Q
|
Q

C
|
C

G
|
G

Y

Y

C
|
C

Q

T

A

P

G

G

Q

M

L

I

M

M

S

R

A

S

A

H

A

R

L

L

V

L

T

Q

Q

E

H

N

P

P

K

S

P

P

S

T

A

E

E

A

Q

E

I

I

D

R

A

F

A

G

M

I

S

G

G

G

N

N

L

L

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

P

Q

R

N

I

I

K

V

A

K

A

A

L

I

Q

Q

S

Y

Y

A

A

A

K

A

Q

K

binding flavin-adenine dinucleotide: T42 (≠ A57), S43 (≠ G58), H44 (≠ L59)
binding fe2/s2 (inorganic) cluster: I38 (≠ Y53), G39 (= G54), C40 (= C55), S43 (≠ G58), H44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), K58 (≠ R73), C60 (= C75), L98 (≠ P108), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C135 (= C145), R136 (= R146), C137 (= C147)
binding pterin cytosine dinucleotide: Q99 (= Q109), C137 (= C147)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 4usaA

query
sites
4usaA

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), Q44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 501, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 4us9A

query
sites
4us9A

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 256, 257, 258, 752, 753, 755
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 4us8A

query
sites
4us8A

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), Q44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding benzaldehyde: 255, 255, 394, 394, 425, 425, 425, 425, 494, 497, 497, 497, 501, 501, 531, 531, 535, 535, 626, 626, 626, 627, 694, 696, 697, 697, 869
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 4c7yA

query
sites
4c7yA

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 3fc4A

query
sites
3fc4A

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), Q44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
39% identity, 91% coverage: 16:165/165 of query aligns to 1:158/907 of 3fahA

query
sites
3fahA

M

M

P

I

S

Q

Q

K

N

V

L

I

T

T

I

V

N

N

G

G

R

I

S

E

F

Q

T

N

L

L

N

F

A

V

D

D

P

A

N

E

M

A

P

L

I

L

L

S

W

D

A

V

L

L

R

R

D

Q

I

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

Y
x
V

G
|
G

C
|
C

G
x
E

A

Q

G
|
G

L
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

D

D

G

G

Q

K

P

V

V

V

R
|
R

A

A

C
|
C

L

V

T

T

S

K

V

M

S

K

Q

R

-

V

A

A

Q

D

G

G

K

A

Q

Q

L

I

T

T

I

I

E

E

G

G

L

V

D

G

N

Q

-

P

-

E

-

N

-

L

Q

H

K

P

L

L

K

Q

N

K

A

A

W

W

A

V

E

L

H

H

N

G

V

G

P

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

A

P

G

G

Q

F

L

I

M

V

S

S

A

A

A

K

A

G

L

L

V

L

T

D

Q

T

H

N

P

A

K

D

P

P

S

S

A

R

E

E

Q

D

I

V

D

R

A

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

-

K

P

P

R

L

I

V

K

D

A

A

A

V

L

M

Q

D

S

A

Y

A

A

A

K

V

Q

I

E

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ Y53), G39 (= G54), C40 (= C55), E41 (≠ G56), G43 (= G58), Q44 (≠ L59), C45 (= C60), G46 (= G61), C48 (= C63), R58 (= R73), C60 (= C75), Q99 (= Q109), C100 (= C110), G101 (= G111), C103 (= C113), C137 (= C145), R138 (= R146), C139 (= C147)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q109), C139 (= C147)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 425, 531, 535, 622, 683, 696, 697, 869, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>7024304 FitnessBrowser__ANA3:7024304
MAIPSSEAAKDQSLAMPSQNLTINGRSFTLNADPNMPILWALRDILGLTGTKYGCGAGLC
GACTVHLDGQPVRACLTSVSQAQGKQLTTIEGLDNQKLKNAWAEHNVPQCGYCQAGQLMS
AAALVTQHPKPSAEQIDAAMSGNLCRCGTYPRIKAALQSYAKQEG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory