SitesBLAST
Comparing 7025177 FitnessBrowser__ANA3:7025177 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6cz7B The arsenate respiratory reductase (arr) complex from shewanella sp. Ana-3 (see paper)
100% identity, 100% coverage: 1:234/234 of query aligns to 1:234/234 of 6cz7B
- binding iron/sulfur cluster: C12 (= C12), V13 (= V13), G14 (= G14), C15 (= C15), G16 (= G16), C18 (= C18), C22 (= C22), N26 (= N26), Y52 (= Y52), P54 (= P54), C57 (= C57), N58 (= N58), H59 (= H59), C60 (= C60), A63 (= A63), P64 (= P64), C65 (= C65), C69 (= C69), P70 (= P70), T82 (= T82), C89 (= C89), I90 (= I90), G91 (= G91), C92 (= C92), K93 (= K93), C95 (= C95), C99 (= C99), Y101 (= Y101), V103 (= V103), I104 (= I104), T161 (= T161), K163 (= K163), C164 (= C164), F166 (= F166), C167 (= C167), C179 (= C179), C183 (= C183), P184 (= P184), R188 (= R188)
Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
100% identity, 100% coverage: 1:234/234 of query aligns to 1:234/234 of Q7WTT9
- C12 (= C12) binding
- C15 (= C15) binding
- C18 (= C18) binding
- C22 (= C22) binding
- C57 (= C57) binding
- C60 (= C60) binding
- C65 (= C65) binding
- C69 (= C69) binding
- C89 (= C89) binding
- C92 (= C92) binding
- C95 (= C95) binding
- C99 (= C99) binding
- C164 (= C164) binding
- C167 (= C167) binding
- C179 (= C179) binding
- C183 (= C183) binding
2vpyF Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (pcp) (see paper)
35% identity, 97% coverage: 2:227/234 of query aligns to 3:180/193 of 2vpyF
- binding pentachlorophenol: I91 (= I90), C93 (= C92)
- binding iron/sulfur cluster: C13 (= C12), G15 (= G14), C16 (= C15), C19 (= C18), C23 (= C22), N27 (= N26), L36 (≠ S35), I38 (≠ H37), P55 (= P54), Q57 (≠ L56), C58 (= C57), L59 (≠ N58), C61 (= C60), P65 (= P64), C66 (= C65), C70 (= C69), P71 (= P70), V83 (≠ T82), C90 (= C89), I91 (= I90), A92 (≠ G91), C93 (= C92), G94 (≠ K93), C96 (= C95), C100 (= C99), P101 (= P100), Y102 (= Y101), R105 (≠ I104), V113 (= V127), C116 (= C164), F118 (= F166), C119 (= C167), P129 (= P177), A130 (= A178), C131 (= C179), C135 (= C183), C139 (≠ A187), R140 (= R188)
Sites not aligning to the query:
2vpwF Polysulfide reductase with bound menaquinone (see paper)
35% identity, 97% coverage: 2:227/234 of query aligns to 3:180/193 of 2vpwF
- binding iron/sulfur cluster: C13 (= C12), G15 (= G14), C16 (= C15), C19 (= C18), C23 (= C22), N27 (= N26), L36 (≠ S35), I38 (≠ H37), P55 (= P54), Q57 (≠ L56), C58 (= C57), L59 (≠ N58), H60 (= H59), C61 (= C60), P65 (= P64), C66 (= C65), C70 (= C69), P71 (= P70), V83 (≠ T82), C90 (= C89), I91 (= I90), A92 (≠ G91), C93 (= C92), G94 (≠ K93), C96 (= C95), C100 (= C99), P101 (= P100), Y102 (= Y101), R105 (≠ I104), V113 (= V127), C116 (= C164), F118 (= F166), C119 (= C167), P129 (= P177), A130 (= A178), C131 (= C179), C135 (= C183), C139 (≠ A187), R140 (= R188)
Sites not aligning to the query:
6f0kB Alternative complex iii (see paper)
28% identity, 95% coverage: 4:225/234 of query aligns to 725:948/961 of 6f0kB
- binding fe3-s4 cluster: C803 (= C69), V805 (≠ T71), M818 (≠ Q84), C823 (= C89), I824 (= I90), G825 (= G91), C829 (= C95), M869 (≠ T161)
- binding heme c: N821 (≠ D87), R822 (≠ E88), R884 (vs. gap), N887 (vs. gap)
- binding iron/sulfur cluster: C733 (= C12), T734 (≠ V13), G735 (= G14), C736 (= C15), N737 (≠ G16), A738 (≠ G17), C739 (= C18), C743 (= C22), W765 (= W34), I768 (vs. gap), C791 (= C57), M792 (≠ N58), H793 (= H59), C794 (= C60), P798 (= P64), C799 (= C65), N816 (≠ T82), C833 (= C99), C872 (= C164), Y874 (≠ F166), C875 (= C167), A901 (= A178), C902 (= C179), C906 (= C183)
Sites not aligning to the query:
6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
31% identity, 96% coverage: 2:225/234 of query aligns to 682:917/929 of 6lodB
- binding fe3-s4 cluster: V758 (= V68), C759 (= C69), P760 (= P70), C779 (= C89), V780 (≠ I90), G781 (= G91), T782 (≠ C92), C785 (= C95), M838 (≠ T161)
- binding heme c: N777 (≠ D87), R778 (≠ E88), R852 (vs. gap), I853 (vs. gap), R856 (vs. gap)
- binding iron/sulfur cluster: C692 (= C12), N693 (≠ V13), S694 (≠ G14), C695 (= C15), N696 (≠ G16), A697 (≠ G17), C698 (= C18), C702 (= C22), N706 (= N26), W724 (= W34), I727 (vs. gap), L746 (= L56), C747 (= C57), Q748 (≠ N58), Q749 (≠ H59), C750 (= C60), P754 (= P64), C755 (= C65), N772 (≠ T82), C789 (= C99), Y791 (= Y101), V793 (= V103), R794 (≠ I104), K840 (= K163), C841 (= C164), F843 (= F166), C844 (= C167), T869 (≠ P177), C871 (= C179), C875 (= C183), I880 (≠ R188)
2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
29% identity, 81% coverage: 43:231/234 of query aligns to 122:264/337 of 2ivfB
- binding fe3-s4 cluster: C148 (= C69), T150 (= T71), I153 (≠ M74), C169 (= C89), K170 (≠ I90), G171 (= G91), H172 (≠ C92), R173 (≠ K93), H174 (≠ K94), C175 (= C95), S193 (≠ T161)
- binding protoporphyrin ix containing fe: T150 (= T71), K170 (≠ I90), H172 (≠ C92)
- binding iron/sulfur cluster: M135 (≠ L56), C136 (= C57), N137 (= N58), H138 (= H59), C139 (= C60), P142 (≠ A63), C144 (= C65), V162 (≠ T82), C179 (= C99), A183 (≠ V103), I184 (= I104), K195 (= K163), C196 (= C164), I197 (≠ T165), L198 (≠ F166), C199 (= C167), N209 (≠ P177), C211 (= C179), C215 (= C183), V219 (≠ A187), R220 (= R188)
Sites not aligning to the query:
- binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41
P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
28% identity, 94% coverage: 2:220/234 of query aligns to 4:191/205 of P18776
- C102 (= C92) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
24% identity, 94% coverage: 5:224/234 of query aligns to 686:942/948 of 6btmB
- binding fe3-s4 cluster: C789 (= C69), C809 (= C89), V810 (≠ I90), T812 (≠ C92), C815 (= C95), M862 (≠ T161)
- binding iron/sulfur cluster: C777 (= C57), Q778 (≠ N58), C780 (= C60), C785 (= C65), N802 (≠ T82), C819 (= C99), R824 (≠ I104)
Sites not aligning to the query:
5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
29% identity, 78% coverage: 43:225/234 of query aligns to 119:255/329 of 5ch7B
- binding fe3-s4 cluster: C145 (= C69), I150 (≠ M74), C166 (= C89), K167 (≠ I90), G168 (= G91), A169 (≠ C92), Q170 (≠ K93), A171 (≠ K94), C172 (= C95), A190 (≠ T161)
- binding iron/sulfur cluster: P130 (= P54), C133 (= C57), N134 (= N58), C136 (= C60), P139 (≠ A63), C141 (= C65), C176 (= C99), C193 (= C164), G195 (≠ F166), C196 (= C167), C208 (= C179), C212 (= C183), V213 (≠ P184), G214 (≠ S185)
Sites not aligning to the query:
7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
29% identity, 78% coverage: 5:187/234 of query aligns to 7:158/183 of 7qv7B
- binding iron/sulfur cluster: C14 (= C12), G16 (= G14), C17 (= C15), K18 (≠ G16), A19 (≠ G17), C20 (= C18), C24 (= C22), H28 (≠ N26), R48 (vs. gap), C63 (= C57), R64 (≠ N58), H65 (= H59), C66 (= C60), A69 (= A63), C71 (= C65), C75 (= C69), A79 (= A73), I80 (≠ M74), C94 (= C89), I95 (= I90), C97 (= C92), C100 (= C95), C104 (= C99), I109 (= I104), C139 (= C164), L141 (≠ F166), C142 (= C167), P148 (= P177), C150 (= C179), C154 (= C183), P155 (= P184)
Sites not aligning to the query:
4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
26% identity, 98% coverage: 5:234/234 of query aligns to 6:198/274 of 4v4cB
- binding calcium ion: I61 (≠ Y50), N62 (≠ T51)
- binding iron/sulfur cluster: C13 (= C12), Q14 (≠ V13), D15 (≠ G14), C16 (= C15), N17 (≠ G16), N18 (≠ G17), C19 (= C18), C23 (= C22), C68 (= C57), M69 (≠ N58), H70 (= H59), C71 (= C60), C76 (= C65), V92 (≠ T82), C109 (= C99), V113 (= V103), C126 (= C164), M128 (≠ F166), C129 (= C167), P143 (= P177), C145 (= C179), C149 (= C183), S151 (= S185), V153 (= V189), Y154 (≠ I190)
7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
26% identity, 84% coverage: 5:200/234 of query aligns to 5:158/174 of 7qv7A
- binding iron/sulfur cluster: C12 (= C12), L13 (≠ V13), G14 (= G14), C15 (= C15), Y16 (≠ G16), C18 (= C18), C22 (= C22), H26 (= H33), L37 (≠ V48), C51 (= C57), R52 (≠ N58), C54 (= C60), C59 (= C65), C63 (= C69), C82 (= C89), I83 (= I90), G84 (= G91), C85 (= C92), C88 (= C95), C92 (= C99), I97 (= I104), F99 (= F106), C125 (= C164), L127 (≠ F166), C128 (= C167), A136 (= A178), C137 (= C179), C141 (= C183)
7z0sB Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
28% identity, 82% coverage: 1:192/234 of query aligns to 1:168/170 of 7z0sB
- binding iron/sulfur cluster: C12 (= C12), I13 (≠ V13), G14 (= G14), C15 (= C15), H16 (≠ G16), T17 (≠ G17), C18 (= C18), C22 (= C22), H26 (≠ N27), R36 (≠ D47), L37 (≠ V48), P48 (= P54), L50 (= L56), C51 (= C57), H52 (≠ N58), H53 (= H59), C54 (= C60), C59 (= C65), C63 (= C69), P64 (= P70), I68 (≠ M74), V75 (≠ L81), L77 (= L83), C82 (= C89), V83 (≠ I90), C85 (= C92), K86 (= K93), C88 (= C95), C92 (= C99), I97 (= I104), A140 (≠ T161), K142 (= K163), C143 (= C164), D144 (≠ T165), L145 (≠ F166), C146 (= C167), P153 (= P177), C155 (= C179), C159 (= C183), P160 (= P184), T161 (≠ S185), L164 (≠ R188)
7b04A of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis.
25% identity, 75% coverage: 50:225/234 of query aligns to 167:305/409 of 7b04A
- binding fe3-s4 cluster: C186 (= C69), I191 (≠ M74), C207 (= C89), R208 (≠ I90), G209 (= G91), Y210 (≠ C92), R211 (≠ K93), K212 (= K94), C213 (= C95), S231 (≠ T161)
- binding protoporphyrin ix containing fe: R188 (≠ T71), R208 (≠ I90), Y210 (≠ C92)
- binding iron/sulfur cluster: Q171 (≠ P54), I173 (≠ L56), C174 (= C57), N175 (= N58), H176 (= H59), C177 (= C60), P180 (≠ A63), C182 (= C65), C217 (= C99), P222 (≠ I104), K233 (= K163), C234 (= C164), A236 (≠ F166), C237 (= C167), T255 (≠ P177), R256 (≠ A178), C257 (= C179), C261 (= C183), V262 (≠ P184), I265 (≠ A187), R266 (= R188)
Sites not aligning to the query:
- binding iron/sulfur cluster: 34, 35, 36, 37, 38, 40, 44, 48, 59, 60, 62
3egwB The crystal structure of the narghi mutant narh - c16a
26% identity, 64% coverage: 45:193/234 of query aligns to 172:273/509 of 3egwB
- binding fe3-s4 cluster: P181 (= P54), C196 (= C69), S198 (≠ T71), I201 (≠ M74), C217 (= C89), R218 (≠ I90), G219 (= G91), W220 (≠ C92), R221 (≠ K93), C223 (= C95), S241 (≠ T161), C263 (= C183), G265 (≠ S185), R268 (= R188)
- binding protoporphyrin ix containing fe: W220 (≠ C92), R221 (≠ K93)
- binding iron/sulfur cluster: C184 (= C57), E185 (≠ N58), H186 (= H59), C187 (= C60), P190 (≠ A63), C192 (= C65), C227 (= C99), I232 (= I104), K243 (= K163), C244 (= C164), F246 (= F166), C247 (= C167), T257 (≠ P177), C259 (= C179)
Sites not aligning to the query:
1kqfB Formate dehydrogenase n from e. Coli (see paper)
22% identity, 96% coverage: 2:225/234 of query aligns to 28:226/289 of 1kqfB
- binding protoporphyrin ix containing fe: Y137 (≠ K94)
- binding iron/sulfur cluster: K31 (≠ M5), C38 (= C12), I39 (≠ V13), G40 (= G14), C41 (= C15), K42 (≠ G16), C44 (= C18), C48 (= C22), N52 (= N26), T77 (≠ S35), M79 (≠ H37), C99 (= C57), M100 (≠ N58), H101 (= H59), C102 (= C60), P105 (≠ A63), C107 (= C65), C111 (= C69), P112 (= P70), I117 (≠ M74), V125 (≠ T82), C132 (= C89), I133 (= I90), G134 (= G91), C135 (= C92), G136 (≠ K93), Y137 (≠ K94), C138 (= C95), C142 (= C99), I146 (≠ V103), P147 (= P142), V156 (≠ T151), K158 (= K163), C159 (= C164), L161 (≠ F166), C162 (= C167), P172 (= P177), C174 (= C179), C178 (= C183), P179 (= P184), I183 (≠ R188)
Sites not aligning to the query:
P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
26% identity, 64% coverage: 45:193/234 of query aligns to 172:273/512 of P11349
- C184 (= C57) binding
- C187 (= C60) binding
- C192 (= C65) binding
- C196 (= C69) binding
- C217 (= C89) binding
- C223 (= C95) binding
- C227 (= C99) binding
- C244 (= C164) binding
- C247 (= C167) binding
- C259 (= C179) binding
- C263 (= C183) binding
Sites not aligning to the query:
- 16 binding
- 19 binding
- 22 binding
- 26 binding
P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
22% identity, 96% coverage: 2:225/234 of query aligns to 29:227/294 of P0AAJ3
- C39 (= C12) binding
- C42 (= C15) binding
- C45 (= C18) binding
- C49 (= C22) binding
- C100 (= C57) binding
- C103 (= C60) binding
- C108 (= C65) binding
- C112 (= C69) binding
- C133 (= C89) binding
- C136 (= C92) binding
- C139 (= C95) binding
- C143 (= C99) binding
- C160 (= C164) binding
- C163 (= C167) binding
- C175 (= C179) binding
- C179 (= C183) binding
6x6uB Wor5 from pyrococcus furiosus, taurine-bound (see paper)
37% identity, 42% coverage: 2:100/234 of query aligns to 2:96/167 of 6x6uB
- binding phosphate ion: D10 (≠ Q10)
- binding iron/sulfur cluster: C12 (= C12), S13 (≠ V13), C15 (= C15), R16 (≠ G16), C18 (= C18), C22 (= C22), H26 (≠ N26), R36 (≠ H37), I37 (= I38), V39 (≠ T40), C52 (= C57), V53 (≠ N58), C55 (= C60), P59 (= P64), C60 (= C65), C64 (= C69), P65 (= P70), L69 (≠ M74), C85 (= C89), I86 (= I90), T87 (≠ G91), C88 (= C92), G89 (≠ K93), C91 (= C95), C95 (= C99)
Sites not aligning to the query:
- binding phosphate ion: 128, 130, 161, 162
- binding iron/sulfur cluster: 100, 112, 113, 114, 115, 119, 121, 125, 130, 133
Query Sequence
>7025177 FitnessBrowser__ANA3:7025177
MRLGMVIDLQKCVGCGGCSLACKTENNTNDGIHWSHHIATTEGTFPDVKYTYIPTLCNHC
DDAPCVKVCPTGAMHKDKRGLTLQNNDECIGCKKCMNACPYGVISFNAATPHRRWQDDSE
VVANGTVSPLMLLKRTGATATPNENPERGDTYPMIRPKRTTEKCTFCDHRLDKGLNPACV
DACPSEARVIGDLDDPQSKVSQLIKLHKPMQLKPEAGTGPRVFYIRSFGVKTAY
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory