SitesBLAST
Comparing 7025957 FitnessBrowser__ANA3:7025957 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
75% identity, 99% coverage: 7:498/498 of query aligns to 4:495/495 of 5iuwA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), M170 (≠ L173), C300 (= C303), D457 (= D460), F465 (= F468)
- binding nicotinamide-adenine-dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), G222 (= G225), G226 (= G229), K227 (= K230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (= I249), Y253 (= Y256), E265 (= E268), A266 (= A269), C300 (= C303), E399 (= E402), F401 (= F404)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
75% identity, 99% coverage: 7:498/498 of query aligns to 4:495/495 of 5iuvA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding nicotinamide-adenine-dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), S191 (= S194), G222 (= G225), G226 (= G229), K227 (= K230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (= I249), Y253 (= Y256), E265 (= E268), A266 (= A269), C300 (= C303), E399 (= E402), F401 (= F404)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
74% identity, 99% coverage: 7:498/498 of query aligns to 4:495/495 of 7jsoA
- active site: N166 (= N169), E265 (= E268), A300 (≠ C303), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), W174 (= W177), V299 (= V302), A300 (≠ C303), T301 (= T304), D457 (= D460), F465 (= F468)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), K189 (= K192), E192 (= E195), G222 (= G225), G226 (= G229), K227 (= K230), F240 (= F243), G242 (= G245), S243 (= S246), I246 (= I249), A266 (= A269), G267 (= G270), A300 (≠ C303), E399 (= E402), F401 (= F404)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
47% identity, 96% coverage: 22:498/498 of query aligns to 12:488/494 of 4pz2B
- active site: N159 (= N169), K182 (= K192), E258 (= E268), C292 (= C303), E392 (= E402), D469 (= D479)
- binding nicotinamide-adenine-dinucleotide: I155 (= I165), I156 (≠ V166), P157 (= P167), W158 (= W168), N159 (= N169), M164 (= M174), K182 (= K192), A184 (≠ S194), E185 (= E195), G215 (= G225), G219 (= G229), F233 (= F243), T234 (= T244), G235 (= G245), S236 (= S246), V239 (≠ I249), E258 (= E268), L259 (≠ A269), C292 (= C303), E392 (= E402), F394 (= F404)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
45% identity, 100% coverage: 1:496/498 of query aligns to 1:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (≠ I165), L166 (≠ V166), P167 (= P167), W168 (= W168), K192 (= K192), G225 (= G225), G229 (= G229), F243 (= F243), G245 (= G245), S246 (= S246), T249 (≠ I249), L252 (≠ Q252), F253 (≠ L253), Y256 (= Y256), C269 (≠ A269), G270 (= G270), C303 (= C303), H350 (≠ Q350), K353 (≠ T353), F400 (= F404)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
45% identity, 96% coverage: 22:498/498 of query aligns to 7:480/486 of 4pxlA
- active site: N154 (= N169), K177 (= K192), E253 (= E268), C287 (= C303), E384 (= E402), D461 (= D479)
- binding nicotinamide-adenine-dinucleotide: I150 (= I165), V151 (= V166), P152 (= P167), W153 (= W168), K177 (= K192), E180 (= E195), G210 (= G225), G214 (= G229), A215 (≠ K230), F228 (= F243), G230 (= G245), S231 (= S246), V234 (≠ I249), E253 (= E268), G255 (= G270), C287 (= C303), Q334 (= Q350), K337 (≠ T353), E384 (= E402), F386 (= F404)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 96% coverage: 22:498/498 of query aligns to 21:495/501 of Q56YU0
- G152 (= G152) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A419) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
5l13A Structure of aldh2 in complex with 2p3 (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 5l13A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F170), M168 (= M174), W171 (= W177), F290 (= F297), C295 (≠ V302), C296 (= C303), C297 (≠ T304), D451 (= D460), F453 (≠ G462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 4kwgA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F170), M168 (= M174), C295 (≠ V302), C296 (= C303), C297 (≠ T304), D451 (= D460), F453 (≠ G462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 4kwfA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F170), M168 (= M174), W171 (= W177), E262 (= E268), C295 (≠ V302), C296 (= C303), C297 (≠ T304), D451 (= D460), F453 (≠ G462), F459 (= F468)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 3sz9A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F170), C295 (≠ V302), C296 (= C303), D451 (= D460), F453 (≠ G462), F459 (= F468)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 3injA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ G124), F164 (= F170), L167 (= L173), F286 (≠ E293), F290 (= F297), D451 (= D460), F453 (≠ G462)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 2vleA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding daidzin: M118 (≠ G124), F164 (= F170), M168 (= M174), W171 (= W177), F286 (≠ E293), F290 (= F297), C295 (≠ V302), C296 (= C303), D451 (= D460), V452 (≠ G461), F453 (≠ G462)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 1o01B
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding (2e)-but-2-enal: C296 (= C303), C297 (≠ T304), F453 (≠ G462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), A224 (≠ K230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (= I249), L263 (≠ A269), G264 (= G270), C296 (= C303), Q343 (= Q350), E393 (= E402), F395 (= F404)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 1cw3A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding magnesium ion: V34 (= V41), D103 (= D109), Q190 (≠ K196)
- binding nicotinamide-adenine-dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), G219 (= G225), G223 (= G229), A224 (≠ K230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (= I249), L263 (≠ A269), G264 (= G270), C296 (= C303), Q343 (= Q350), K346 (≠ T353), E393 (= E402), F395 (= F404)
P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 5 papers)
44% identity, 95% coverage: 24:498/498 of query aligns to 40:512/517 of P05091
- E337 (= E321) to V: in dbSNP:rs1062136
- E496 (≠ M482) to K: in allele ALDH2*3; dbSNP:rs769724893
- E504 (= E490) to K: in AMEDS; allele ALDH2*2; drastic reduction of enzyme activity; dbSNP:rs671
Sites not aligning to the query:
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 19:491/496 of 4fr8C
- active site: N165 (= N169), K188 (= K192), Q264 (≠ E268), C298 (= C303), E395 (= E402), E472 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I161 (= I165), I162 (≠ V166), W164 (= W168), K188 (= K192), G221 (= G225), G225 (= G229), A226 (≠ K230), F239 (= F243), G241 (= G245), S242 (= S246), I245 (= I249), Q345 (= Q350), E395 (= E402), F397 (= F404)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 16:488/493 of 4fr8A
- active site: N162 (= N169), K185 (= K192), Q261 (≠ E268), C295 (= C303), E392 (= E402), E469 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I158 (= I165), I159 (≠ V166), W161 (= W168), K185 (= K192), G218 (= G225), G222 (= G229), A223 (≠ K230), F236 (= F243), G238 (= G245), S239 (= S246), I242 (= I249), Q342 (= Q350), K345 (≠ T353), E392 (= E402), F394 (= F404)
- binding propane-1,2,3-triyl trinitrate: F163 (= F170), L166 (= L173), W170 (= W177), F289 (= F297), S294 (≠ V302), C295 (= C303), D450 (= D460), F452 (≠ G462)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
44% identity, 95% coverage: 24:496/498 of query aligns to 43:513/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
44% identity, 95% coverage: 24:498/498 of query aligns to 17:489/494 of 1nzwA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), S296 (≠ C303), E393 (= E402), E470 (≠ D479)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), K186 (= K192), E189 (= E195), G219 (= G225), P220 (≠ H226), G223 (= G229), A224 (≠ K230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (= I249), E262 (= E268), G264 (= G270), S296 (≠ C303), Q343 (= Q350), E393 (= E402), F395 (= F404)
Query Sequence
>7025957 FitnessBrowser__ANA3:7025957
MSTPKKRSDWESLAASLAINGKAYINGEYRDAAAGSTFDCVSPIDGRVLAKVASCDQMDA
NIAVANAREVFESGVWSKTAPVKRKQVMIRFAELLEENANELALLETLDMGKPIRFSKAV
DIAGAARAIRWSGEAVDKLYDELAPTAHNEIGMITREPVGVVAAIVPWNFPLLMACWKLG
PALATGNSVILKPSEKSPLTAIRIAELAVQAGIPKGVLNVLPGYGHTVGKALALHMDVDT
LVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFNDAPDLKAAAVAAAEAIAFNQG
EVCTAGSRLLVESGVKDQLIELIAEELASWQPGHPLDPATVSGAVVDKQQLDTILSYIKA
GQDEGASLVHGGQQVLAETGGVYVQPTIFSQVNNKMKIASEEIFGPVLSVIEFNGMEEAI
AIANDTIYGLAAGVWTADISKAHKTAKALRSGMVWINHYDGGDMTAPFGGYKQSGNGRDK
SMHSFDKYTEIKATWIAL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory