SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
33% identity, 95% coverage: 4:181/188 of query aligns to 2:225/234 of Q7WTT9

query
sites
Q7WTT9

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C12 (= C14) binding
C15 (= C17) binding
C18 (= C20) binding
C22 (= C24) binding
C57 (= C60) binding
C60 (= C63) binding
C65 (= C68) binding
C69 (= C72) binding
C89 (= C92) binding
C92 (= C95) binding
C95 (= C98) binding
C99 (= C102) binding
C164 (= C119) binding
C167 (= C122) binding
C179 (= C135) binding
C183 (= C139) binding

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
34% identity, 93% coverage: 4:178/188 of query aligns to 682:914/929 of 6lodB

query
sites
6lodB

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binding fe3-s4 cluster: V758 (= V71), C759 (= C72), P760 (= P73), C779 (= C92), V780 (= V93), G781 (= G94), T782 (≠ C95), C785 (= C98), M838 (≠ A116)
binding heme c: N777 (≠ D90), R778 (≠ K91), R852 (vs. gap), I853 (vs. gap), R856 (vs. gap)
binding iron/sulfur cluster: C692 (= C14), N693 (≠ I15), S694 (≠ G16), C695 (= C17), N696 (≠ Q18), A697 (= A19), C698 (= C20), C702 (= C24), N706 (= N28), W724 (≠ Q38), I727 (≠ V41), L746 (vs. gap), C747 (= C60), Q748 (= Q61), Q749 (= Q62), C750 (= C63), P754 (= P67), C755 (= C68), N772 (≠ V85), C789 (= C102), Y791 (= Y104), V793 (= V106), R794 (= R107), K840 (= K118), C841 (= C119), F843 (= F121), C844 (= C122), T869 (≠ P133), C871 (= C135), C875 (= C139), I880 (≠ L144)

6f0kB Alternative complex iii (see paper)
32% identity, 93% coverage: 4:177/188 of query aligns to 723:944/961 of 6f0kB

query
sites
6f0kB

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binding fe3-s4 cluster: C803 (= C72), V805 (≠ T74), M818 (≠ I87), C823 (= C92), I824 (≠ V93), G825 (= G94), C829 (= C98), M869 (≠ A116)
binding heme c: N821 (≠ D90), R822 (≠ K91), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C14), T734 (≠ I15), G735 (= G16), C736 (= C17), N737 (≠ Q18), A738 (= A19), C739 (= C20), C743 (= C24), W765 (≠ H50), I768 (≠ F53), C791 (= C60), M792 (≠ Q61), H793 (≠ Q62), C794 (= C63), P798 (= P67), C799 (= C68), N816 (≠ V85), C833 (= C102), C872 (= C119), Y874 (≠ F121), C875 (= C122), A901 (= A134), C902 (= C135), C906 (= C139)

Sites not aligning to the query:

binding heme c: 719

P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
33% identity, 97% coverage: 1:183/188 of query aligns to 1:192/205 of P18776

query
sites
P18776

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M1 (= M1) modified: Initiator methionine, Removed
C102 (= C95) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.

6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
29% identity, 90% coverage: 10:179/188 of query aligns to 689:941/948 of 6btmB

query
sites
6btmB

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T

T

K

K

P

P

R

N

V

V

Y

F

binding fe3-s4 cluster: C789 (= C72), C809 (= C92), V810 (= V93), T812 (≠ C95), C815 (= C98), M862 (≠ A116)
binding iron/sulfur cluster: C777 (= C60), Q778 (= Q61), C780 (= C63), C785 (= C68), N802 (≠ V85), C819 (= C102), R824 (= R107)

Sites not aligning to the query:

binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: 1, 2

1kqfB Formate dehydrogenase n from e. Coli (see paper)
33% identity, 87% coverage: 10:173/188 of query aligns to 34:211/289 of 1kqfB

query
sites
1kqfB

D

D

E

V

N

S

K

T

C
|
C

I
|
I

G
|
G

C
|
C

Q
x
K

A

A

C
|
C

N

Q

V

V

A

A

C
|
C

R

S

S

E

E

W

N
|
N

G

D

V

I

P

R

E

D

G

E

V

V

T

G

R

H

L

C

Q

V

V

G

R

V

V

Y

E

D

G

N

P

P

-

A

-

D

-

L

-

S

-

A

-

K

-

S

-

W

-
x
T

-

V

-
x
M

-

R

Y

F

G

S

E

E

M

T

P

E

H

Q

-

N

-

G

-

K

L

L

H

E

F

W

K

L

Y

I

H

R

R

K

V

D

S

G

C
|
C

Q
x
M

Q
x
H

C
|
C

E

E

D

D

A
x
P

P

G

C
|
C

V

L

K

K

V

A

C
|
C

P
|
P

T

S

G

A

A

G

A

A

Y
x
I

V

I

G

Q

-

Y

E

A

D

N

G

G

I

I

V
|
V

S

D

I

F

H

Q

G

S

D

E

K

N

C
|
C

V
x
I

G
|
G

C
|
C

M
x
G

Y
|
Y

C
|
C

V

I

A

A

A

G

C
|
C

P

P

Y

F

K

N

V
x
I

R
x
P

F

R

M

L

N

N

P

K

E

E

T

D

K

N

V

R

A
x
V

D

Y

K
|
K

C
|
C

N

T

F
x
L

C
|
C

K

V

D

D

T

-

R

R

L

V

A

S

R

V

G

G

E

Q

E

E

P
|
P

A

A

C
|
C

V

V

T

K

V

T

C
|
C

P
|
P

T

T

D

G

A

A

L
x
I

V

H

F

F

G

G

D

T

A

K

N

K

D

E

P

-

Q

M

S

L

E

E

V

L

A

A

M

E

L

Q

L

R

N

V

T

A

K

K

I

L

T

K

Y

A

Q

R

D

G

K

Y

T

E

H

H

L

A

G

G

binding protoporphyrin ix containing fe: Y137 (= Y97)
binding iron/sulfur cluster: C38 (= C14), I39 (= I15), G40 (= G16), C41 (= C17), K42 (≠ Q18), C44 (= C20), C48 (= C24), N52 (= N28), T77 (vs. gap), M79 (vs. gap), C99 (= C60), M100 (≠ Q61), H101 (≠ Q62), C102 (= C63), P105 (≠ A66), C107 (= C68), C111 (= C72), P112 (= P73), I117 (≠ Y78), V125 (= V85), C132 (= C92), I133 (≠ V93), G134 (= G94), C135 (= C95), G136 (≠ M96), Y137 (= Y97), C138 (= C98), C142 (= C102), I146 (≠ V106), P147 (≠ R107), V156 (≠ A116), K158 (= K118), C159 (= C119), L161 (≠ F121), C162 (= C122), P172 (= P133), C174 (= C135), C178 (= C139), P179 (= P140), I183 (≠ L144)

Sites not aligning to the query:

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
35% identity, 73% coverage: 10:147/188 of query aligns to 35:187/294 of P0AAJ3

query
sites
P0AAJ3

D

D

E

V

N

S

K

T

C
|
C

I

I

G

G

C
|
C

Q

K

A

A

C
|
C

N

Q

V

V

A

A

C
|
C

R

S

S

E

E

W

N

N

G

D

V

I

P

R

E

D

G

E

V

V

T

G

R

H

L

C

Q

V

V

G

R

V

V

Y

E

D

G

N

P

P

-

A

-

D

-

L

-

S

-

A

-

K

-

S

-

W

-

T

-

V

-

M

-

R

Y

F

G

S

E

E

M

T

P

E

H

Q

-

N

-

G

-

K

L

L

H

E

F

W

K

L

Y

I

H

R

R

K

V

D

S

G

C
|
C

Q

M

Q

H

C
|
C

E

E

D

D

A

P

P

G

C
|
C

V

L

K

K

V

A

C
|
C

P

P

T

S

G

A

A

G

A

A

Y

I

V

I

G

Q

-

Y

E

A

D

N

G

G

I

I

V

V

S

D

I

F

H

Q

G

S

D

E

K

N

C
|
C

V

I

G

G

C
|
C

M

G

Y

Y

C
|
C

V

I

A

A

A

G

C
|
C

P

P

Y

F

K

N

V

I

R

P

F

R

M

L

N

N

P

K

E

E

T

D

K

N

V

R

A

V

D

Y

K

K

C
|
C

N

T

F

L

C
|
C

K

V

D

D

T

-

R

R

L

V

A

S

R

V

G

G

E

Q

E

E

P

P

A

A

C
|
C

V

V

T

K

V

T

C
|
C

P

P

T

T

D

G

A

A

L

I

V

H

F

F

G

G

C39 (= C14) binding
C42 (= C17) binding
C45 (= C20) binding
C49 (= C24) binding
C100 (= C60) binding
C103 (= C63) binding
C108 (= C68) binding
C112 (= C72) binding
C133 (= C92) binding
C136 (= C95) binding
C139 (= C98) binding
C143 (= C102) binding
C160 (= C119) binding
C163 (= C122) binding
C175 (= C135) binding
C179 (= C139) binding

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
39% identity, 75% coverage: 46:186/188 of query aligns to 119:260/329 of 5ch7B

query
sites
5ch7B

G

G

E

E

M

Y

P

P

H

N

L

N

H

S

F

F

K

F

Y

Y

H

L

R
x
P

V

R

S

M

C
|
C

Q
x
N

Q

H

C
|
C

E

T

D

K

A
x
P

P

A

C
|
C

V

L

K

E

V

A

C
|
C

P

P

T

N

G

E

A

A

A
x
I

Y

Y

V

K

G

R

E

E

-

Q

D

D

G

G

I

I

V

V

S

V

I

I

H

H

G

Q

D

D

K

K

C
|
C

V
x
K

G
|
G

C
x
A

M
x
Q

Y
x
A

C
|
C

V

V

A

Q

A

S

C
|
C

P

P

Y

Y

K

A

V

K

R

P

F

Y

M

F

N

N

P

P

E

L

T

T

K

N

V

K

A
|
A

D

N

K

K

C
|
C

N

I

F
x
G

C
|
C

K

F

D

-

T

P

R

R

L

I

A

E

R

Q

G

G

E

V

E

A

P

P

A

A

C
|
C

V

V

T

A

V

Q

C
|
C

P
x
V

T
x
G

D

R

A

A

L

M

V

H

F

V

G

G

D

F

A

V

N

D

D

D

P

V

Q

N

S

S

E

S

V

V

A

Y

M

K

L

L

L

I

N

K

T

Q

-

Y

K

K

I

V

T

A

Y

L

Q

P

D

L

K

H

T

P

H

E

L

F

G

G

T

T

K

E

P

P

R

N

V

V

Y

F

R

Y

V

V

P

P

T

P

K

V

R

L

G

G

binding fe3-s4 cluster: C145 (= C72), I150 (≠ A77), C166 (= C92), K167 (≠ V93), G168 (= G94), A169 (≠ C95), Q170 (≠ M96), A171 (≠ Y97), C172 (= C98), A190 (= A116)
binding iron/sulfur cluster: P130 (≠ R57), C133 (= C60), N134 (≠ Q61), C136 (= C63), P139 (≠ A66), C141 (= C68), C176 (= C102), C193 (= C119), G195 (≠ F121), C196 (= C122), C208 (= C135), C212 (= C139), V213 (≠ P140), G214 (≠ T141)

Sites not aligning to the query:

binding iron/sulfur cluster: 17, 18, 19, 20, 21, 23, 27, 31, 43, 45

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
37% identity, 73% coverage: 46:182/188 of query aligns to 122:259/337 of 2ivfB

query
sites
2ivfB

G

G

E

K

M

W

P

P

H

N

L

P

H

F

F

F

K

F

Y

Y

H

L

R

A

V

R

S
x
M

C
|
C

Q
x
N

Q
x
H

C
|
C

E

T

D

N

A
x
P

P

A

C
|
C

V

L

K

A

V

A

C
|
C

P

P

T
|
T

G

G

A

A

A
x
I

Y

Y

V

K

G

R

E

E

D

D

-

N

G

G

I

I

V
|
V

S

L

I

V

H

D

G

Q

D

E

K

R

C
|
C

V
x
K

G
|
G

C
x
H

M
x
R

Y
x
H

C
|
C

V

V

A

E

A

A

C
|
C

P

P

Y

Y

K

K

V
x
A

R
x
I

F

Y

M

F

N

N

P

P

E

V

T

S

K

Q

V

T

A
x
S

D

E

K
|
K

C
|
C

N
x
I

F
x
L

C
|
C

K

Y

D

-

T

P

R

R

L

I

A

E

R

K

G

G

E

I

E

A

P
x
N

A

A

C
|
C

V

N

T

R

V

Q

C
|
C

P

P

T

G

D

R

A
x
V

L
x
R

V

A

F

F

G

G

D

Y

A

L

N

D

D

D

P

T

Q

T

S

S

E

H

V

V

A

H

M

K

L

L

L

V

-

K

N

K

T

W

K

K

I

V

T

A

Y

L

Q

P

D

L

K

H

T

A

H

E

L

Y

G

G

T

T

K

G

P

P

R

N

V

I

Y

Y

R

Y

V

V

P

P

binding fe3-s4 cluster: C148 (= C72), T150 (= T74), I153 (≠ A77), C169 (= C92), K170 (≠ V93), G171 (= G94), H172 (≠ C95), R173 (≠ M96), H174 (≠ Y97), C175 (= C98), S193 (≠ A116)
binding protoporphyrin ix containing fe: T150 (= T74), K170 (≠ V93), H172 (≠ C95)
binding iron/sulfur cluster: M135 (≠ S59), C136 (= C60), N137 (≠ Q61), H138 (≠ Q62), C139 (= C63), P142 (≠ A66), C144 (= C68), V162 (= V85), C179 (= C102), A183 (≠ V106), I184 (≠ R107), K195 (= K118), C196 (= C119), I197 (≠ N120), L198 (≠ F121), C199 (= C122), N209 (≠ P133), C211 (= C135), C215 (= C139), V219 (≠ A143), R220 (≠ L144)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41

4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
32% identity, 94% coverage: 3:179/188 of query aligns to 2:187/274 of 4v4cB

query
sites
4v4cB

K

E

R

Q

Y

Y

V

Y

M

M

V

V

H

I

D

D

E

V

N

A

K

K

C
|
C

I
x
Q

G
x
D

C
|
C

Q
x
N

A
x
N

C
|
C

N

F

V

M

A

G

C
|
C

R

M

S

D

E

E

N

H

G

E

V

L

P

N

E

E

-

W

-

P

G

G

V

Y

T

T

-

A

-

S

-

M

-

Q

-

R

-

G

-

H

-

R

-

W

-

M

R

N

L

I

Q

E

V

R

R

R

V

E

E

R

G

G

P

T

Y

Y

G

-

E

-

M

-

P

P

H

R

L

N

H

D

F
x
I

K
x
N

Y

Y

H

R

R

P

V

T

S

P

C
|
C

Q
x
M

Q
x
H

C
|
C

E

E

D

N

A

A

P

P

C
|
C

V

V

K

-

V

A

C

K

P

G

T

N

G

G

A

A

A

V

Y

Y

V

Q

G

R

E

E

D

D

G

G

I

I

V
|
V

S

L

I

I

H

D

G

P

D

E

K

K

C

A

V

K

G

G

C

K

M

K

Y

E

C

L

V

L

A

D

A

T

C
|
C

P

P

Y

Y

K

G

V
|
V

R

M

F

Y

M

W

N

N

P

E

E

E

T

E

K

N

V

V

A

A

D

Q

K

K

C
|
C

N

T

F
x
M

C
|
C

K

A

-

H

-

L

D

D

T

D

R

E

L

S

A

W

R

A

G

P

E

K

E

M

P
|
P

A

R

C
|
C

V

A

T

H

V

N

C
|
C

P

G

T
x
S

D

-

A

-

L

F

V
|
V

F
x
Y

G

E

D

F

A

L

N

K

D

T

P

T

Q

P

S

E

E

A

V

M

A

A

M

K

L

K

L

V

N

E

T

E

K

E

I

G

T

L

Y

E

Q

V

D

I

K

K

T

P

H

E

L

L

G

G

T

T

K

K

P

P

R

R

V

V

Y

Y

binding calcium ion: I61 (≠ F53), N62 (≠ K54)
binding iron/sulfur cluster: C13 (= C14), Q14 (≠ I15), D15 (≠ G16), C16 (= C17), N17 (≠ Q18), N18 (≠ A19), C19 (= C20), C23 (= C24), C68 (= C60), M69 (≠ Q61), H70 (≠ Q62), C71 (= C63), C76 (= C68), V92 (= V85), C109 (= C102), V113 (= V106), C126 (= C119), M128 (≠ F121), C129 (= C122), P143 (= P133), C145 (= C135), C149 (= C139), S151 (≠ T141), V153 (= V145), Y154 (≠ F146)

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
32% identity, 74% coverage: 7:146/188 of query aligns to 7:161/183 of 7qv7B

query
sites
7qv7B

M

V

V

V

H

A

D

N

E

P

N

A

K

K

C
|
C

I

I

G
|
G

C
|
C

Q
x
K

A
|
A

C
|
C

N

E

V

V

A

A

C
|
C

R

F

S

A

E

V

N
x
H

G

N

V

R

P

N

E

N

G

H

V

V

T

G

R

A

L

T

Q

V

V

G

R

T

V

V

E

S

G

I

P

P

Y

V

G

-

E

-

M

I

P

P

H
x
R

L

L

H

H

F

L

K

I

Y

K

H

T

R

E

-

H

-

G

-

T

-

M

-

P

V

I

S

Q

C
|
C

Q
x
R

Q
x
H

C
|
C

E

E

D

D

A
|
A

P

P

C
|
C

V

A

K

N

V

V

C
|
C

P

T

T

V

G

G

A
|
A

A
x
I

Y

K

V

R

G

E

E

G

D

N

G

A

I

I

V

V

S

-

I

V

H

D

G

E

D

K

K

L

C
|
C

V
x
I

G

G

C
|
C

M

K

Y

S

C
|
C

V

L

A

L

A

A

C
|
C

P

P

Y

F

K

G

V

A

R
x
I

F

E

M

L

N

L

P

P

E

Q

T

Y

K

E

-

D

-

G

-

R

-

E

-

V

-

F

-

Q

-

I

-

N

-

L

-

K

-

L

-

V

-

Q

-

E

-

P

-

R

-

I

V

I

A

A

D

Y

K

K

C
|
C

N

D

F
x
L

C
|
C

K

N

D

D

T

L

R

G

L

-

A

-

R

-

G

-

E

-

E

E

P
|
P

A

A

C
|
C

V

V

T

K

V

A

C
|
C

P
|
P

T

E

D

N

A

A

L
|
L

V

T

F

L

binding iron/sulfur cluster: C14 (= C14), G16 (= G16), C17 (= C17), K18 (≠ Q18), A19 (= A19), C20 (= C20), C24 (= C24), H28 (≠ N28), R48 (≠ H50), C63 (= C60), R64 (≠ Q61), H65 (≠ Q62), C66 (= C63), A69 (= A66), C71 (= C68), C75 (= C72), A79 (= A76), I80 (≠ A77), C94 (= C92), I95 (≠ V93), C97 (= C95), C100 (= C98), C104 (= C102), I109 (≠ R107), C139 (= C119), L141 (≠ F121), C142 (= C122), P148 (= P133), C150 (= C135), C154 (= C139), P155 (= P140), L159 (= L144)

3egwB The crystal structure of the narghi mutant narh - c16a
33% identity, 70% coverage: 45:176/188 of query aligns to 169:303/509 of 3egwB

query
sites
3egwB

Y

Y

G

S

E

Q

M

F

P

E

H

N

L

T

H

F

F

M

K

M

Y

Y

H

L

R
x
P

V

R

S

L

C
|
C

Q
x
E

Q
x
H

C
|
C

E

L

D

N

A
x
P

P

A

C
|
C

V

V

K

A

V

T

C
|
C

P

P

T
x
S

G

G

A

A

A
x
I

Y

Y

V

K

-

R

G

E

E

E

D

D

G

G

I

I

V

V

S

L

I

I

H

D

G

Q

D

D

K

K

C
|
C

V
x
R

G
|
G

C
x
W

M
x
R

Y

M

C
|
C

V

I

A

T

A

G

C
|
C

P

P

Y

Y

K

K

V

K

R
x
I

F

Y

M

F

N

N

P

W

E

K

T

S

K

G

V

K

A
x
S

D

E

K
|
K

C
|
C

N

I

F
|
F

C
|
C

K

Y

D

-

T

P

R

R

L

I

A

E

R

A

G

G

E

Q

E

P

P
x
T

A

V

C
|
C

V

S

T

E

V

T

C
|
C

P

V

T
x
G

D

R

A

I

L
x
R

V

Y

F

L

G

G

-

V

-

L

-

Y

D

D

A

A

N

-

D

D

P

A

Q

I

S

E

E

R

V

A

A

A

M

S

L

T

L

E

N

N

T

E

K

K

I

D

T

L

Y

Y

Q

Q

D

R

K

Q

T

L

H

D

L

V

G

F

T

L

K

D

P

P

binding fe3-s4 cluster: P181 (≠ R57), C196 (= C72), S198 (≠ T74), I201 (≠ A77), C217 (= C92), R218 (≠ V93), G219 (= G94), W220 (≠ C95), R221 (≠ M96), C223 (= C98), S241 (≠ A116), C263 (= C139), G265 (≠ T141), R268 (≠ L144)
binding protoporphyrin ix containing fe: W220 (≠ C95), R221 (≠ M96)
binding iron/sulfur cluster: C184 (= C60), E185 (≠ Q61), H186 (≠ Q62), C187 (= C63), P190 (≠ A66), C192 (= C68), C227 (= C102), I232 (≠ R107), K243 (= K118), C244 (= C119), F246 (= F121), C247 (= C122), T257 (≠ P133), C259 (= C135)

Sites not aligning to the query:

binding fe3-s4 cluster: 17, 18, 19, 20, 22
binding protoporphyrin ix containing fe: 88, 89
binding iron/sulfur cluster: 26, 30, 41, 42

P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
33% identity, 70% coverage: 45:176/188 of query aligns to 169:303/512 of P11349

query
sites
P11349

Y

Y

G

S

E

Q

M

F

P

E

H

N

L

T

H

F

F

M

K

M

Y

Y

H

L

R

P

V

R

S

L

C
|
C

Q

E

Q

H

C
|
C

E

L

D

N

A

P

P

A

C
|
C

V

V

K

A

V

T

C
|
C

P

P

T

S

G

G

A

A

A

I

Y

Y

V

K

-

R

G

E

E

E

D

D

G

G

I

I

V

V

S

L

I

I

H

D

G

Q

D

D

K

K

C
|
C

V

R

G

G

C

W

M

R

Y

M

C
|
C

V

I

A

T

A

G

C
|
C

P

P

Y

Y

K

K

V

K

R

I

F

Y

M

F

N

N

P

W

E

K

T

S

K

G

V

K

A

S

D

E

K

K

C
|
C

N

I

F

F

C
|
C

K

Y

D

-

T

P

R

R

L

I

A

E

R

A

G

G

E

Q

E

P

P

T

A

V

C
|
C

V

S

T

E

V

T

C
|
C

P

V

T

G

D

R

A

I

L

R

V

Y

F

L

G

G

-

V

-

L

-

Y

D

D

A

A

N

-

D

D

P

A

Q

I

S

E

E

R

V

A

A

A

M

S

L

T

L

E

N

N

T

E

K

K

I

D

T

L

Y

Y

Q

Q

D

R

K

Q

T

L

H

D

L

V

G

F

T

L

K

D

P

P

C184 (= C60) binding
C187 (= C63) binding
C192 (= C68) binding
C196 (= C72) binding
C217 (= C92) binding
C223 (= C98) binding
C227 (= C102) binding
C244 (= C119) binding
C247 (= C122) binding
C259 (= C135) binding
C263 (= C139) binding

Sites not aligning to the query:

16 binding
19 binding
22 binding
26 binding

8c0zC Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
30% identity, 75% coverage: 10:150/188 of query aligns to 8:137/158 of 8c0zC

query
sites
8c0zC

D

D

E

P

N

A

K

K

C
|
C

I
x
T

G

G

C
|
C

Q

L

A

Q

C
|
C

N

E

V

M

A

A

C
|
C

R

S

S

Y

E

E

N

H

G

T

V

G

P

V

E

I

G

N

V

P

T

S

R

K

L

S

Q

R

V

I

R

K

V

V

E

F

G

S

P

F

Y

E

G

H

E

E

M

G

P

R

H

K

L

V

H

P

F

Y

K

-

Y

-

H

-

R

-

V

-

S

T

C
|
C

Q

T

Q

Q

C
|
C

E

T

D

E

A

A

P

W

C
|
C

V

L

K

H

V

S

C
|
C

P

P

T

V

G

D

A

A

A
x
I

Y

R

V

L

G

D

-

L

E

T

D

T

G

G

I

A

V

K

S

M

I

V

H

F

G

E

D

D

K

T

C
|
C

V

V

G

G

C
|
C

M

K

Y

V

C
|
C

V

T

A

I

A

A

C
|
C

P

P

Y

F

K

G

V
x
T

R

I

F

N

M

Y

N

N

P

Q

E

D

T

T

K

G

V

K

A

V

D

Q

K
|
K

C
|
C

N

D

F

L

C
|
C

K

E

D

G

T

-

R

-

L

-

A

-

R

-

G

-

E

-

E

D

P

P

A

A

C
|
C

V

A

T

K

V

A

C
|
C

P

P

T
|
T

D

A

A

A

L

I

V

T

F

Y

G

I

D

D

A

A

N

D

binding iron/sulfur cluster: C12 (= C14), T13 (≠ I15), C15 (= C17), C18 (= C20), C22 (= C24), C53 (= C60), C56 (= C63), C61 (= C68), C65 (= C72), I70 (≠ A77), C86 (= C92), C89 (= C95), C92 (= C98), C96 (= C102), T100 (≠ V106), K112 (= K118), C113 (= C119), C116 (= C122), C122 (= C135), C126 (= C139), T128 (= T141)

7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
31% identity, 79% coverage: 4:151/188 of query aligns to 3:153/174 of 7qv7A

query
sites
7qv7A

R

R

Y

F

V

V

M

-

V

I

H

A

D

D

E

P

N

K

K

R

C
|
C

I
x
L

G
|
G

C
|
C

Q
x
Y

A

T

C
|
C

N

I

V

A

A

A

C
|
C

R

A

S

F

E

-

N

-

G

-

V

-

P

-

E

-

G

-

V

-

T

-

R

-

L

-

Q

-

V

V

R
x
H

V

E

E

E

G

Q

P

G

Y

L

G

Q

E

P

M

F

P

P

H

R

L
|
L

H

Y

F

L

K

T

Y

Y

H

T

R

S

-

E

-

G

-

I

-

M

-

P

V

I

S

Q

C
|
C

Q
x
R

Q

H

C
|
C

E

E

D

D

A

A

P

P

C
|
C

V

A

K

E

V

V

C
|
C

P

P

T

V

G

E

A

A

A

I

Y

K

V

K

G

E

E

G

D

N

G

A

I

I

V

I

S

-

I

I

H

D

G

E

D

K

K

A

C
|
C

V
x
I

G
|
G

C
|
C

M

K

Y

T

C
|
C

V

L

A

L

A

A

C
|
C

P

S

Y

F

-

G

K

A

V
x
I

R

D

F
|
F

M

S

-

V

-

Q

-

D

-

S

-

L

-

E

-

Q

-

S

-

I

-

F

-

K

-

D

-

I

-

K

-

E

N

N

P

L

E

M

T

R

K

I

V

V

A

A

D

V

K

K

C
|
C

N

D

F
x
L

C
|
C

K

N

D

-

T

-

R

-

L

-

A

F

R

R

G

E

E

E

E

G

P

P

A
|
A

C
|
C

V

V

T

Q

V

F

C
|
C

P

P

T

T

D

K

A

A

L

L

V

K

F

L

G

V

D

D

A

G

N

D

D

E

binding iron/sulfur cluster: C12 (= C14), L13 (≠ I15), G14 (= G16), C15 (= C17), Y16 (≠ Q18), C18 (= C20), C22 (= C24), H26 (≠ R40), L37 (= L51), C51 (= C60), R52 (≠ Q61), C54 (= C63), C59 (= C68), C63 (= C72), C82 (= C92), I83 (≠ V93), G84 (= G94), C85 (= C95), C88 (= C98), C92 (= C102), I97 (≠ V106), F99 (= F108), C125 (= C119), L127 (≠ F121), C128 (= C122), A136 (= A134), C137 (= C135), C141 (= C139)

6x6uB Wor5 from pyrococcus furiosus, taurine-bound (see paper)
34% identity, 73% coverage: 3:139/188 of query aligns to 1:125/167 of 6x6uB

query
sites
6x6uB

K

E

R

R

Y

I

V

W

M

I

V

L

H

I

D

T

E

P

N
x
D

K

K

C
|
C

I
x
S

G

G

C
|
C

Q
x
R

A

L

C
|
C

N

E

V

V

A

T

C
|
C

R

S

S

L

E

E

N
x
H

G

-

V

-

P

-

E

E

G

G

V

I

-

I

-

W

-

P

-

E

-

A

T

S

R
|
R

L
x
I

Q

R

V
|
V

R

F

V

E

E

L

G

F

P

P

Y

G

G

I

E

N

M

V

P

P

H

H

L

-

H

-

F

-

K

-

Y

-

H

-

R

-

V

-

S

T

C
|
C

Q
x
V

Q

Q

C
|
C

E

P

D

D

A

Y

P
|
P

C
|
C

V

V

K

N

V

A

C
|
C

P
|
P

T

T

G

N

A

A

A
x
L

Y

S

V

V

G

D

E

E

D

K

-

T

G

G

I

A

V

V

S

V

I

V

H

N

G

E

D

E

K

K

C
|
C

V
x
I

G
x
T

C
|
C

M
x
G

Y

A

C
|
C

V

V

A

L

A

A

C
|
C

P

P

Y

G

K

K

V

V

R
x
P

F

R

M

I

N

P

P

A

E

G

T

K

K

G

V

S

A

V

D

V

K

I

C
|
C

N
x
D

F
x
L

C
|
C

K

-

D

-

T

-

R

-

L

-

A

-

R

-

G

G

E

G

E

N

P
|
P

A

K

C
|
C

V

V

T

E

V

I

C
|
C

binding phosphate ion: D10 (≠ N12)
binding iron/sulfur cluster: C12 (= C14), S13 (≠ I15), C15 (= C17), R16 (≠ Q18), C18 (= C20), C22 (= C24), H26 (≠ N28), R36 (= R36), I37 (≠ L37), V39 (= V39), C52 (= C60), V53 (≠ Q61), C55 (= C63), P59 (= P67), C60 (= C68), C64 (= C72), P65 (= P73), L69 (≠ A77), C85 (= C92), I86 (≠ V93), T87 (≠ G94), C88 (= C95), G89 (≠ M96), C91 (= C98), C95 (= C102), P100 (≠ R107), C112 (= C119), D113 (≠ N120), L114 (≠ F121), C115 (= C122), P119 (= P133), C121 (= C135), C125 (= C139)

Sites not aligning to the query:

8cm6D W-formate dehydrogenase c872a from desulfovibrio vulgaris - with formamide (see paper)
26% identity, 87% coverage: 10:173/188 of query aligns to 7:186/214 of 8cm6D

query
sites
8cm6D

D

D

E

L

N

S

K

R

C
|
C

I
x
T

G
x
A

C
|
C

Q
x
R

A

G

C
|
C

N

Q

V

I

A

A

C
|
C

R

K

S

Q

E

W

N
x
K

G

N

V

L

P

P

E

A

G

E

V

E

T

T

R

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

-

D

-

L

-

S

-

Y

-

V

-

T

-

L

L
x
K

Q

T

V

V

R

R

V

F

E

T

G

E

P

K

Y

S

G
x
R

E

K

M

G

P
|
P

H

G

L

I

H

D

F

W

K

L

Y

F

H

F

R

P

V

E

S

Q

C
|
C

Q
x
R

Q

H

C
|
C

E

V

D

E

A
x
P

P
|
P

C
|
C

V

-

K

-

V

-

C

-

P

-

T

K

G

G

A

Q

A

A

Y

D

V

V

G

D

E

L

D

E

G

G

I

-

V

-

S

A

I

V

H

V

G

K

D

D

K

E

C

T

V

T

G

G

C

A

M
x
V

Y

L

C

F

V

T

-

E

-

L

-

T

-

A

-

K

-

V

-

D

-

G

-

E

-

S

-

V

-

R

A

S

A

A

C
|
C

P

P

Y

Y

K

D

V
x
I

R
x
P

F

R

M

I

N

D

P

P

E

V

T

T

K

K

V

R

A

L

D

S

K
|
K

C
|
C

N
x
D

F
x
M

C
|
C

K

N

D

D

T

-

R

R

L

V

A

Q

R

N

G

G

E

L

P

P

A

A

C
|
C

V

V

T

K

V

T

C
|
C

P
|
P

T
|
T

D

G

A
x
T

L
x
M

V

N

F

F

G

G

D

D

A

-

N

-

D

-

P

-

Q

E

S

Q

E

E

V

M

A

L

M

A

L

L

L

A

N

E

T

K

K

R

I

L

T

A

Y

E

Q

V

D

K

K

K

T

T

H

Y

L

P

G

G

binding formamide: R59 (≠ G46), P62 (= P49)
binding iron/sulfur cluster: C11 (= C14), T12 (≠ I15), A13 (≠ G16), C14 (= C17), R15 (≠ Q18), C17 (= C20), C21 (= C24), K25 (≠ N28), K50 (≠ L37), C73 (= C60), R74 (≠ Q61), C76 (= C63), P79 (≠ A66), P80 (= P67), C81 (= C68), V102 (≠ M96), C120 (= C102), I124 (≠ V106), P125 (≠ R107), K136 (= K118), C137 (= C119), D138 (≠ N120), M139 (≠ F121), C140 (= C122), C152 (= C135), C156 (= C139), P157 (= P140), T158 (= T141), T160 (≠ A143), M161 (≠ L144)

Sites not aligning to the query:

binding iron/sulfur cluster: 4

Query Sequence

>7026476 FitnessBrowser__ANA3:7026476
MTKRYVMVHDENKCIGCQACNVACRSENGVPEGVTRLQVRVEGPYGEMPHLHFKYHRVSC
QQCEDAPCVKVCPTGAAYVGEDGIVSIHGDKCVGCMYCVAACPYKVRFMNPETKVADKCN
FCKDTRLARGEEPACVTVCPTDALVFGDANDPQSEVAMLLNTKITYQDKTHLGTKPRVYR
VPTKRGGI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory