SitesBLAST

Q05344 FACT complex subunit Ssrp1; Chorion-factor 5; Facilitates chromatin transcription complex subunit Ssrp1; Recombination signal sequence recognition protein; Single-strand recognition protein; dSSRP1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
60% identity, 93% coverage: 6:73/73 of query aligns to 557:626/723 of Q05344

query
sites
Q05344

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Sites not aligning to the query:

443 modified: Phosphoserine
628 modified: Phosphoserine
664 modified: Phosphoserine
668 modified: Phosphoserine
669 modified: Phosphothreonine
670 modified: Phosphoserine
671 modified: Phosphoserine

Q08945 FACT complex subunit SSRP1; Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hSSRP1; T160 from Homo sapiens (Human) (see 2 papers)
53% identity, 93% coverage: 4:71/73 of query aligns to 547:616/709 of Q08945

query
sites
Q08945

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Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylalanine
450 D→A: Abolishes cleavage by caspase.
510 S→A: Unable to bind DNA; when associated with A-657 and A-688.
657 modified: Phosphoserine; S→A: Unable to bind DNA; when associated with A-510 and A-688. Still able to bind DNA; when associated with A-688.
688 S→A: Unable to bind DNA; when associated with A-510 and A-657. Still able to bind DNA; when associated with A-657.

1j5nA Solution structure of the non-sequence-specific hmgb protein nhp6a in complex with sry DNA (see paper)
44% identity, 82% coverage: 4:63/73 of query aligns to 21:82/93 of 1j5nA

query
sites
1j5nA

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binding : K22 (= K5), R23 (= R6), R23 (= R6), L25 (= L8), S26 (= S9), Y28 (= Y11), Y28 (= Y11), M29 (= M12), R36 (= R19), R40 (≠ K23), T47 (≠ K30), F48 (≠ V31), F48 (≠ V31), K53 (= K36), W59 (= W42), K60 (≠ R43), K78 (= K59), Y81 (= Y62)

Sites not aligning to the query:

binding : 11, 12, 13, 14, 16, 85

P11632 Non-histone chromosomal protein 6A from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 82% coverage: 4:63/73 of query aligns to 21:82/93 of P11632

query
sites
P11632

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P21 (= P4) mutation to A: Shows a 4-fold reduced affinity for DNA.
Y28 (= Y11) mutation to D: Shows a strongly reduced affinity for linear and circular DNA.
M29 (= M12) mutation M->A,D: Unable to form 75 bp microcircles.
F30 (≠ L13) mutation to V: Does not affect affinity for DNA.
F31 (≠ W14) mutation to D: Shows a strongly reduced affinity for linear and circular DNA.

Sites not aligning to the query:

18 P→A: Does not affect affinity for DNA.

Q9YH06 High mobility group protein B1; High mobility group protein 1; HMG-1 from Gallus gallus (Chicken) (see paper)
43% identity, 96% coverage: 4:73/73 of query aligns to 95:166/215 of Q9YH06

query
sites
Q9YH06

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Sites not aligning to the query:

3 K→A: Impairs binding to distorted DNA; when associated with A-12.
12 K→A: Impairs binding to distorted DNA; when associated with A-3.

P12682 High mobility group protein B1; High mobility group protein 1; HMG-1 from Sus scrofa (Pig) (see paper)
43% identity, 96% coverage: 4:73/73 of query aligns to 95:166/215 of P12682

query
sites
P12682

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Sites not aligning to the query:

51 modified: Phosphothreonine; T→A: Loss of phosphorylation and ssociated secretion.

P63159 High mobility group protein B1; Amphoterin; Heparin-binding protein p30; High mobility group protein 1; HMG-1 from Rattus norvegicus (Rat) (see 10 papers)
43% identity, 96% coverage: 4:73/73 of query aligns to 95:166/215 of P63159

query
sites
P63159

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F103 (≠ M12) mutation to A: Disrupts association with chromatin; when associated A-38 and A-122.
C106 (≠ L15) mutation to A: Disrupts interaction with TLR4:LY96 receptor complex and abolishes TNF release from macrophages.; mutation to S: Abolishes cytokine-stimulating activity; no effect on chemoattractant activity; impaired nuclear and enhanced cytoplasmic localization, retained activity in autophagy regulation.
I122 (≠ V31) mutation to A: Disrupts association with chromatin; when associated A-38 and A-103.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
3 modified: N6-acetyllysine
23 modified: Disulfide link with 45, In disulfide HMGB1; alternate; C→S: No effect on nuclear localization. Decreases interaction with BCN1 and impairs in autophagy induction. Abolishes cytokine-stimulating activity and no effect on chemoattractant activity; when associated with S-45.
27:43 Nuclear localization signal (NLS) 1
28:30 KKK→AAA: Partial cytoplasmic localization; when associated with 181-A--A-183.; KKK→QQQ: Partial cytoplasmic localization (mimicks acetylation); when associated with 181-Q--Q-183.
38 F→A: Disrupts association with chromatin; when associated A-103 and A-122.
45 modified: Disulfide link with 23, In disulfide HMGB1; alternate; C→S: No effect on nuclear localization. Decreases interaction with BCN1 and impairs autophagy induction. Abolishes cytokine-stimulating activity and no effect on chemoattractant activity; when associated with S-23.
150:183 Binding to AGER/RAGE
178:184 Nuclear localization signal (NLS) 2
182:184 KKK→AAA: Partial cytoplasmic localization; when associated with 27-A--A-29.; KKK→QQQ: Partial cytoplasmic localization (mimicks acetylation); when associated with 27-Q--Q-29.

P09429 High mobility group protein B1; High mobility group protein 1; HMG-1 from Homo sapiens (Human) (see 8 papers)
43% identity, 96% coverage: 4:73/73 of query aligns to 95:166/215 of P09429

query
sites
P09429

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C106 (≠ L15) mutation to S: Inhibits oxidation-dependent inactivation of immunostimmulatory activity in apoptotic cells.
A149 (= A56) to E: in gastric-carcinoma cell line
E156 (≠ D63) natural variant: E -> Q

Sites not aligning to the query:

3:15 LPS binding (delipidated)
11 G → R: in gastric-carcinoma cell line
28 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
35 S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-39; A-42; A-46; A-53 and A-181.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-39; E-42; E-46; E-53 and E-181.
39 S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-42; A-46; A-53 and A-181.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-42; E-46; E-53 and E-181.
42 S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-46; A-53 and A-181.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-46; E-53 and E-181.
43 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
44 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
46 S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-53 and A-181.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-53 and E-181.
53 S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-181.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-181.
67 D→A: Abolishes cleavage by CASP1 and impairs ability to antagonize apoptosis-induced immune tolerance.
67:68 Cleavage; by CASP1
68 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
80:96 LPS binding (Lipid A)
89:108 Cytokine-stimulating activity
180 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
181 modified: ADP-ribosylserine; S→A: Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-53.; S→E: Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-53.
182 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
183 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
184 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
190 D → G: in gastric-carcinoma cell line

P10103 High mobility group protein B1; High mobility group protein 1; HMG-1 from Bos taurus (Bovine) (see 4 papers)
43% identity, 96% coverage: 4:73/73 of query aligns to 95:166/215 of P10103

query
sites
P10103

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K127 (= K36) modified: N6-acetyllysine
K128 (≠ R37) modified: N6-acetyllysine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2:10 binding heparin
3 modified: N6-acetyllysine
7 modified: N6-acetyllysine
8 modified: N6-acetyllysine
10:11 Cleavage; by thrombin:thrombomodulin
12 modified: N6-acetyllysine
28 modified: N6-acetyllysine
29 modified: N6-acetyllysine
30 modified: N6-acetyllysine
172 modified: N6-acetyllysine
173 modified: N6-acetyllysine
177 modified: N6-acetyllysine
180 modified: N6-acetyllysine
182 modified: N6-acetyllysine
183 modified: N6-acetyllysine
184 modified: N6-acetyllysine
185 modified: N6-acetyllysine

5jh0D Crystal structure of the mitochondrial DNA packaging protein abf2p in complex with DNA at 2.18 angstrom resolution (see paper)
36% identity, 92% coverage: 4:70/73 of query aligns to 19:87/157 of 5jh0D

query
sites
5jh0D

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binding : K20 (= K5), R21 (= R6), R21 (= R6), T23 (≠ L8), S24 (= S9), Y26 (= Y11), F27 (≠ M12), F27 (≠ M12), R45 (≠ K30), P46 (≠ V31), A47 (≠ T32), S50 (≠ A35), K51 (= K36), W57 (= W42), Q58 (≠ R43), Y76 (≠ K59)

Sites not aligning to the query:

binding : 2, 3, 5, 5, 6, 7, 8, 93, 94, 94, 99, 100, 104, 119, 120, 123, 130, 131, 145

P40625 High mobility group protein; Non-histone chromosomal protein from Tetrahymena pyriformis (see paper)
35% identity, 92% coverage: 4:70/73 of query aligns to 11:79/99 of P40625

query
sites
P40625

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S16 (= S9) modified: Phosphoserine

2gzkA Structure of a complex of tandem hmg boxes and DNA (see paper)
43% identity, 93% coverage: 4:71/73 of query aligns to 89:158/159 of 2gzkA

query
sites
2gzkA

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N

S

S

E

A

Y

R
|
R

E

P

S

K

I

I

K

K

R

G

E

E

N

H

P

P

G

G

I

L

K

S

V
x
I

T
x
G

E

D

V

V

A
|
A

K
|
K

R

K

G

L

G

G

E

E

L

M

W

W

R

N

-

N

-

T

A

A

M

A

K

D

D

D

K

K

S

Q

E

P

W

Y

E

E

A

K

K

K

A

A

K

K

A

L

K

K

D

E

D

K

Y
|
Y

D

E

R

K

A

D

V
x
I

K

A

E

A

F

Y

E
x
R

A

A

binding : K90 (= K5), R91 (= R6), R91 (= R6), F96 (≠ Y11), F97 (≠ M12), F97 (≠ M12), R104 (= R19), I116 (≠ V31), G117 (≠ T32), A120 (= A35), K121 (= K36), Y149 (= Y62), I153 (≠ V66), R157 (≠ E70)

Sites not aligning to the query:

binding : 4, 6, 7, 7, 9, 10, 10, 12, 13, 17, 20, 21, 30, 32, 32, 36, 37, 40, 43, 44, 55, 62, 74, 74, 76, 76, 77, 78, 79, 81, 84

6cijN Cryo-em structure of mouse rag1/2 hfc complex containing partial hmgb1 linker(3.9 a) (see paper)
49% identity, 53% coverage: 4:42/73 of query aligns to 72:110/133 of 6cijN

query
sites
6cijN

P

P

K

K

R
|
R

P

P

L

P

S

S

A

A

Y

F

M
x
F

L

L

W

F

L

C

N

S

S

E

A

Y

R

R

E

P

S

K

I

I

K

K

R

G

E

E

N

H

P

P

G

G

I

L

K

S

V
x
I

T

G

E

D

V

V

A

A

K

K

R

K

G

L

G

G

E

E

L

M

W

W

binding : R74 (= R6), F80 (≠ M12), I99 (≠ V31), I99 (≠ V31)

Sites not aligning to the query:

binding : 7, 8, 30, 34, 41, 111

Q8BU11 TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1 from Mus musculus (Mouse) (see paper)
29% identity, 97% coverage: 2:72/73 of query aligns to 221:293/619 of Q8BU11

query
sites
Q8BU11

D

N

K

E

P

P

K

Q

R

K

P

P

L

V

S

S

A

A

Y

Y

M

A

L

L

W

F

L

F

N

R

S

D

A

T

R

Q

E

A

S

A

I

I

K

K

R

G

E

Q

N

N

P

P

G

N

I

A

K

T

V

F

T

G

E

E

V

V

A

S

K

K

R

I

G

V

G

A

E

S

L

M

W

W

R

D

A

S

M

L

-

G

-

E

K

E

D

Q

K

K

S

Q

E

V

W

Y

E

K

A

R

K

K

A

T

A

E

K

A

A

A

K

K

D

K

D

E

Y

Y

D

L

R

K

A

A

V

L

K

A

E

A

F

Y

E

K

A

D

N

N

Sites not aligning to the query:

213:218 Nuclear localization signal; mutation Missing: Loss of transcriptional regulation of gluconeogenic genes expression.

Q9DDD7 Transcription factor Sox-19b; Protein sox-31 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
39% identity, 63% coverage: 2:47/73 of query aligns to 50:95/292 of Q9DDD7

query
sites
Q9DDD7

D

D

K

K

P

V

K

K

R

R

P

P

L

M

S

N

A

A

Y

F

M

M

L

V

W

W

L

S

N

R

S

G

A

Q

R

R

E

R

S

K

I

M

K

A

R

Q

E

E

N

N

P

P

G

K

I

M

K

H

V

N

T

S

E

E

V

I

A

S

K

K

R

R

G

L

G

G

E

A

L

E

W

W

R

K

A

L

M

L

K

T

D

D

Sites not aligning to the query:

159 modified: Phosphoserine

P55863 Transcription factor Sox-3-A; xSox3; xSox-B1 from Xenopus laevis (African clawed frog) (see paper)
35% identity, 67% coverage: 2:50/73 of query aligns to 38:86/309 of P55863

query
sites
P55863

D

D

K

R

P

V

K

K

R

R

P

P

L
x
M

S
x
N

A

A

Y

F

M

M

L

V

W

W

L

S

N

R

S

G

A

Q

R
|
R

E

R

S

K

I

M

K

A

R

Q

E

E

N

N

P

P

G

K

I

M

K

H

V

N

T

S

E

E

V

I

A

S

K

K

R

R

G

L

G

G

E

A

L

D

W
|
W

R

K

A

L

M

L

K

S

D

D

K

S

S

D

E

K

M44 (≠ L8) mutation to L: Abolishes binding to 5'-ATTGTT-3' DNA sequence. Does not affect ctnnb1-binding.
N45 (≠ S9) mutation to I: Abolishes binding to 5'-ATTGTT-3' DNA sequence. Reduces binding to the nodal5 promoter. Does not affect ctnnb1-binding.
R55 (= R19) mutation to G: Abolishes binding to 5'-ATTGTT-3' DNA sequence.
W78 (= W42) mutation to R: Abolishes binding to 5'-ATTGTT-3' DNA sequence.

Sites not aligning to the query:

93 A→S: Does not abolish binding to 5'-ATTGTT-3' DNA sequence.
105 P→A: Abolishes binding to 5'-ATTGTT-3' DNA sequence.

Q6EJB7 Transcription factor Sox-3 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
37% identity, 63% coverage: 2:47/73 of query aligns to 33:78/300 of Q6EJB7

query
sites
Q6EJB7

D

D

K

R

P

V

K

K

R

R

P

P

L

M

S

N

A

A

Y

F

M

M

L

V

W

W

L

S

N

R

S

G

A

Q

R

R

E

R

S

K

I

M

K

A

R

Q

E

E

N

N

P

P

G

K

I

M

K

H

V

N

T

S

E

E

V

I

A

S

K

K

R

R

G

L

G

G

E

A

L

D

W

W

R

K

A

L

M

L

K

T

D

D

Sites not aligning to the query:

235 modified: Phosphoserine

Query Sequence

>73 a.a. (SDKPKRPLSA...)
SDKPKRPLSAYMLWLNSARESIKRENPGIKVTEVAKRGGELWRAMKDKSEWEAKAAKAKD
DYDRAVKEFEANG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory