Comparing 8499451 FitnessBrowser__Miya:8499451 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
1wyuB Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
53% identity, 99% coverage: 5:478/481 of query aligns to 6:468/473 of 1wyuB
P15505 Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); EC 1.4.4.2 from Gallus gallus (Chicken) (see paper)
40% identity, 84% coverage: 45:448/481 of query aligns to 515:915/1004 of P15505
6i34B Crystal structure of neanderthal glycine decarboxylase (p-protein)
38% identity, 88% coverage: 28:448/481 of query aligns to 458:881/954 of 6i34B
Sites not aligning to the query:
6i35A Crystal structure of human glycine decarboxylase (p-protein) bound with pyridoxyl-glycine-5'-monophosphate
38% identity, 88% coverage: 28:448/481 of query aligns to 456:879/953 of 6i35A
Sites not aligning to the query:
Q94B78 Glycine dehydrogenase (decarboxylating) 1, mitochondrial; Glycine cleavage system P protein 1; Glycine decarboxylase 1; Glycine decarboxylase P-protein 1; AtGLDP1; Glycine dehydrogenase (aminomethyl-transferring) 1; EC 1.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 84% coverage: 45:449/481 of query aligns to 551:955/1037 of Q94B78
Sites not aligning to the query:
6i33A Crystal structure of human glycine decarboxylase (p-protein)
38% identity, 88% coverage: 28:448/481 of query aligns to 457:876/950 of 6i33A
Sites not aligning to the query:
4lhdA Crystal structure of synechocystis sp. Pcc 6803 glycine decarboxylase (p-protein), holo form with pyridoxal-5'-phosphate and glycine, closed flexible loop (see paper)
38% identity, 84% coverage: 45:447/481 of query aligns to 489:878/952 of 4lhdA
Sites not aligning to the query:
6i33B Crystal structure of human glycine decarboxylase (p-protein)
37% identity, 88% coverage: 28:448/481 of query aligns to 458:852/925 of 6i33B
Sites not aligning to the query:
>8499451 FitnessBrowser__Miya:8499451
MKTAFAASVPGRNACLPAQPKMHAADMLPANLLRASRPALPELGELDVVRHFTRLSRLNF
GVDSNFYPLGSCTMKYNPKFTEQVAALPGFTRLHPLMAQLKGAGQYTQGALEVMWETERL
LCEITGMRAFTLHPMAGAHGELTGVMLIAAYHKDKGNRKTKVICPDSAHGTNPASAALAG
YEVVNIESKDGMVDPDALEAALDDDVAALMMTCPNTLGLFENHLPRIVEKLRAVDALLYY
DGANLNAILGKMRVGDVGFDVVHLNLHKTFATPHGGGGPGAGPVGVSERLVPYLPISRVE
KLHDGRYYLNYDHPKSIGFMAPFYGNFGVLLKAYAYILRLGGEGLERVSEYAVLNANYLR
KRLEKVLEIPHDRICMHEFVASACNHAECGIRALDVAKALLDKGYHAPTIYFPLIVKECM
MFEPTETESRQTLDEFADDLIAILESAAQNPDALHAAPVTTPVRRLDETAAARNMVLTDD
A
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory