Comparing 8499452 FitnessBrowser__Miya:8499452 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 10 hits to proteins with known functional sites (download)
1wyvA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in inhibitor-bound form (see paper)
46% identity, 100% coverage: 1:443/443 of query aligns to 1:437/437 of 1wyvA
1wyuA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
46% identity, 100% coverage: 1:443/443 of query aligns to 1:437/437 of 1wyuA
P15505 Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); EC 1.4.4.2 from Gallus gallus (Chicken) (see paper)
38% identity, 76% coverage: 10:346/443 of query aligns to 64:388/1004 of P15505
Sites not aligning to the query:
6i33B Crystal structure of human glycine decarboxylase (p-protein)
36% identity, 77% coverage: 9:350/443 of query aligns to 23:358/925 of 6i33B
Sites not aligning to the query:
6i35A Crystal structure of human glycine decarboxylase (p-protein) bound with pyridoxyl-glycine-5'-monophosphate
36% identity, 77% coverage: 9:350/443 of query aligns to 25:360/953 of 6i35A
Sites not aligning to the query:
6i33A Crystal structure of human glycine decarboxylase (p-protein)
36% identity, 77% coverage: 9:350/443 of query aligns to 25:360/950 of 6i33A
Sites not aligning to the query:
6i34B Crystal structure of neanderthal glycine decarboxylase (p-protein)
36% identity, 77% coverage: 9:350/443 of query aligns to 23:358/954 of 6i34B
Sites not aligning to the query:
Q94B78 Glycine dehydrogenase (decarboxylating) 1, mitochondrial; Glycine cleavage system P protein 1; Glycine decarboxylase 1; Glycine decarboxylase P-protein 1; AtGLDP1; Glycine dehydrogenase (aminomethyl-transferring) 1; EC 1.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 86% coverage: 7:388/443 of query aligns to 87:455/1037 of Q94B78
Sites not aligning to the query:
4lhdA Crystal structure of synechocystis sp. Pcc 6803 glycine decarboxylase (p-protein), holo form with pyridoxal-5'-phosphate and glycine, closed flexible loop (see paper)
34% identity, 77% coverage: 10:350/443 of query aligns to 30:365/952 of 4lhdA
Sites not aligning to the query:
1wyuB Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
26% identity, 78% coverage: 97:443/443 of query aligns to 94:437/473 of 1wyuB
Sites not aligning to the query:
>8499452 FitnessBrowser__Miya:8499452
MPFIPHSPEEVREMLSVIGVQSIEDLFVDIPAEMRPRSFELPLGLSEMQVLAKMEEMAAR
NRTDVVSFLGGGFYSHHIPAAVDALVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRL
LDMDCANASVYDGGSAIFEAMMMAVRATKRRKLVIDEAVSPIWRTMLASYTSNLSLDLVT
VPQVDGRSDMAAMKAAVDTGCAAVVVQNPNFFGVVEDFTDLFAHAKSQKAASVISVYPVM
QSVLKTPGEMGADIAVAEGQSLGQPLSFGGPYLGIMTCTKDMVRQMPGRIVGRTNDTEGR
TGYVLTLQAREQHIRRAKATSNICSNQALCALRTLVHLCLLGPEGLIRTAELSMERARYA
MERLTAIAGVRPLNTAPFGNEFAVRLPIPAFEAVDRLTARGYVPGFPVGRYYAGMDDVLL
VACTEKNSFEQVGILAEMLGGIL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory