SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 8499909 FitnessBrowser__Miya:8499909 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1khrA Crystal structure of vat(d) in complex with virginiamycin and coenzyme a (see paper)
45% identity, 27% coverage: 136:188/194 of query aligns to 116:170/206 of 1khrA

query
sites
1khrA
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
 
G
N
 
K
G
 
D
A
 
V
I
 
V
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
V
A
|
A
A
|
A
G
 
N
S
 
S
V
 
V
V
 
V
A
x
V
A
 
K
A
 
D
L
 
I
A
 
A
P
 
P
Y
 
Y
S
 
M
I
x
L
A
 
A
A
x
G
G
 
G
I
 
N
P
|
P
A
 
A
R
 
N
V
 
E
L
x
I
G
 
K
R
 
Q
R
 
R
G
 
F
D
 
D
R
 
Q

Sites not aligning to the query:

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
45% identity, 27% coverage: 136:188/194 of query aligns to 116:170/205 of 1kk4A

query
sites
1kk4A
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
|
G
N
x
K
G
 
D
A
 
V
I
 
V
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
V
A
|
A
A
|
A
G
 
N
S
 
S
V
 
V
V
 
V
A
x
V
A
x
K
A
 
D
L
 
I
A
 
A
P
 
P
Y
 
Y
S
 
M
I
x
L
A
 
A
A
x
G
G
|
G
I
 
N
P
|
P
A
 
A
R
 
N
V
 
E
L
x
I
G
 
K
R
 
Q
R
 
R
G
 
F
D
 
D
R
 
Q

Sites not aligning to the query:

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
45% identity, 27% coverage: 136:188/194 of query aligns to 116:170/204 of 1mrlA

query
sites
1mrlA
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
 
W
I
 
I
G
 
G
N
 
K
G
 
D
A
 
V
I
 
V
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
V
A
 
A
A
 
A
G
 
N
S
 
S
V
 
V
V
 
V
A
 
V
A
 
K
A
 
D
L
 
I
A
 
A
P
 
P
Y
 
Y
S
 
M
I
 
L
A
 
A
A
 
G
G
 
G
I
 
N
P
 
P
A
 
A
R
 
N
V
 
E
L
 
I
G
 
K
R
 
Q
R
 
R
G
 
F
D
 
D
R
 
Q

Sites not aligning to the query:

P50870 Streptogramin A acetyltransferase; Virginiamycin acetyltransferase D; Vat(D); EC 2.3.1.- from Enterococcus faecium (Streptococcus faecium) (see paper)
45% identity, 27% coverage: 136:188/194 of query aligns to 116:170/209 of P50870

query
sites
P50870
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
 
W
I
 
I
G
 
G
N
 
K
G
 
D
A
 
V
I
 
V
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
V
A
 
A
A
 
A
G
 
N
S
 
S
V
 
V
V
 
V
A
 
V
A
 
K
A
 
D
L
 
I
A
 
A
P
 
P
Y
 
Y
S
 
M
I
 
L
A
 
A
A
 
G
G
 
G
I
 
N
P
 
P
A
 
A
R
 
N
V
 
E
L
 
I
G
 
K
R
 
Q
R
 
R
G
 
F
D
 
D
R
 
Q

Sites not aligning to the query:

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
45% identity, 27% coverage: 136:188/194 of query aligns to 116:170/203 of 3dhoA

query
sites
3dhoA
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
 
W
I
 
I
G
 
G
N
 
K
G
 
D
A
 
V
I
 
V
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
x
I
V
 
V
A
|
A
A
 
A
G
 
N
S
 
S
V
 
V
V
 
V
A
x
V
A
 
K
A
 
D
L
 
I
A
 
A
P
 
P
Y
 
Y
S
 
M
I
x
L
A
 
A
A
x
G
G
 
G
I
 
N
P
|
P
A
 
A
R
 
N
V
 
E
L
x
I
G
 
K
R
 
Q
R
 
R
G
 
F
D
 
D
R
 
Q

Sites not aligning to the query:

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
30% identity, 55% coverage: 79:184/194 of query aligns to 77:183/186 of 4isxA

query
sites
4isxA
I
 
V
G
 
G
R
 
E
N
 
N
V
 
F
Y
 
F
I
 
A
G
x
N
A
 
Y
Y
 
D
C
 
C
-
 
I
-
 
F
-
 
L
N
 
D
I
 
V
G
 
C
H
 
K
A
 
I
D
 
E
I
 
I
G
 
G
D
 
D
D
 
N
S
 
V
L
 
M
L
 
L
G
x
A
T
 
P
H
 
N
V
 
V
M
 
Q
V
 
I
T
 
Y
S
 
T
G
 
A
K
 
Y
H
 
H
T
 
P
H
 
-
F
 
-
F
 
-
D
 
-
D
 
-
P
 
I
D
 
D
V
 
A
P
 
Q
I
 
L
R
 
R
L
 
N
Q
 
S
G
 
G
-
 
I
G
 
E
R
 
Y
D
 
G
E
 
S
C
 
P
V
 
V
R
 
K
I
 
I
G
 
G
R
 
D
D
 
N
C
 
V
W
|
W
I
 
I
G
|
G
N
x
G
G
 
G
A
 
V
I
 
I
V
 
I
M
 
T
A
 
P
-
 
G
-
 
I
D
 
T
V
 
I
G
 
G
D
 
D
G
 
N
C
 
V
V
 
V
V
 
I
A
 
G
A
|
A
G
 
G
S
 
S
V
 
V
V
 
V
A
 
T
A
 
K
A
 
D
L
 
I
A
 
P
P
 
P
Y
 
N
S
 
T
I
 
V
A
 
A
A
x
V
G
 
G
I
 
N
P
 
P
A
 
C
R
 
R
V
 
V
L
 
I
G
x
K
R
 
K

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
31% identity, 56% coverage: 78:185/194 of query aligns to 55:166/211 of 4hurA

query
sites
4hurA
V
 
V
I
 
I
G
 
G
R
 
D
N
 
K
V
 
L
Y
 
I
I
 
I
G
 
G
A
 
R
Y
 
F
C
 
C
N
x
S
I
|
I
G
|
G
H
 
P
A
 
-
D
 
-
I
 
-
G
 
G
D
 
T
D
 
T
S
 
F
L
 
I
L
 
M
G
 
N
-
 
G
-
x
A
T
x
N
H
 
H
V
 
R
M
 
M
V
 
D
T
 
G
S
 
S
G
 
T
K
 
Y
H
 
P
T
 
F
H
 
H
F
 
L
F
 
F
-
 
R
-
 
M
-
 
G
-
 
W
-
 
E
-
 
K
-
 
Y
-
 
M
-
 
P
D
 
S
D
 
L
P
 
K
D
 
D
V
 
L
P
 
P
I
 
L
R
x
K
L
 
G
Q
 
D
G
 
-
G
 
-
R
 
-
D
 
-
E
 
-
C
 
-
V
 
I
R
 
E
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
|
I
G
|
G
N
x
R
G
 
D
A
 
V
I
 
T
V
 
I
M
|
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
I
A
|
A
A
|
A
G
 
E
S
 
A
V
 
V
V
 
V
A
x
T
A
 
K
A
 
N
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
S
I
 
I
A
 
V
A
x
G
G
 
G
I
 
N
P
|
P
A
 
L
R
 
K
V
 
F
L
x
I
G
x
R
R
 
K
R
 
R

Sites not aligning to the query:

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
31% identity, 56% coverage: 78:185/194 of query aligns to 55:166/212 of 4husA

query
sites
4husA
V
 
V
I
 
I
G
 
G
R
 
D
N
 
K
V
 
L
Y
 
I
I
 
I
G
 
G
A
 
R
Y
 
F
C
 
C
N
 
S
I
 
I
G
 
G
H
 
P
A
 
-
D
 
-
I
 
-
G
 
G
D
 
T
D
 
T
S
 
F
L
 
I
L
 
M
G
 
N
-
 
G
-
 
A
T
 
N
H
 
H
V
 
R
M
 
M
V
 
D
T
 
G
S
 
S
G
 
T
K
 
Y
H
 
P
T
 
F
H
 
H
F
 
L
F
 
F
-
 
R
-
 
M
-
 
G
-
 
W
-
 
E
-
 
K
-
 
Y
-
 
M
-
 
P
D
 
S
D
 
L
P
 
K
D
 
D
V
 
L
P
 
P
I
 
L
R
 
K
L
 
G
Q
 
D
G
 
-
G
 
-
R
 
-
D
 
-
E
 
-
C
 
-
V
 
I
R
 
E
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
 
W
I
 
I
G
 
G
N
 
R
G
 
D
A
 
V
I
 
T
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
I
A
 
A
A
 
A
G
 
E
S
 
A
V
 
V
V
 
V
A
 
T
A
 
K
A
 
N
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
S
I
 
I
A
 
V
A
 
G
G
 
G
I
 
N
P
 
P
A
 
L
R
 
K
V
 
F
L
 
I
G
 
R
R
 
K
R
 
R

Sites not aligning to the query:

6x3cA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
31% identity, 56% coverage: 78:185/194 of query aligns to 55:166/207 of 6x3cA

query
sites
6x3cA
V
 
V
I
 
I
G
 
G
R
 
D
N
 
K
V
 
L
Y
 
I
I
 
I
G
 
G
A
 
R
Y
 
F
C
 
C
N
 
S
I
 
I
G
|
G
H
 
P
A
 
-
D
 
-
I
 
-
G
 
G
D
 
T
D
 
T
S
 
F
L
 
I
L
 
M
G
 
N
-
x
G
-
 
A
T
x
N
H
|
H
V
 
R
M
 
M
V
 
D
T
 
G
S
 
S
G
 
T
K
 
Y
H
 
P
T
 
F
H
|
H
F
x
L
F
 
F
-
 
R
-
 
M
-
 
G
-
 
W
-
 
E
-
 
K
-
 
Y
-
x
M
-
x
P
D
 
S
D
x
L
P
 
K
D
 
D
V
 
L
P
 
P
I
 
L
R
 
K
L
 
G
Q
 
D
G
 
-
G
 
-
R
 
-
D
 
-
E
 
-
C
 
-
V
 
I
R
 
E
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
|
G
N
x
R
G
 
D
A
 
V
I
 
T
V
 
I
M
|
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
I
A
|
A
A
|
A
G
 
E
S
 
A
V
 
V
V
 
V
A
 
T
A
 
K
A
 
N
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
S
I
 
I
A
 
V
A
 
G
G
 
G
I
 
N
P
 
P
A
 
L
R
 
K
V
 
F
L
 
I
G
 
R
R
 
K
R
 
R

Sites not aligning to the query:

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46) (see paper)
31% identity, 56% coverage: 78:185/194 of query aligns to 55:166/206 of 6x3jA

query
sites
6x3jA
V
|
V
I
 
I
G
 
G
R
 
D
N
 
K
V
 
L
Y
 
I
I
 
I
G
 
G
A
 
R
Y
 
F
C
 
C
N
 
S
I
 
I
G
|
G
H
 
P
A
 
-
D
 
-
I
 
-
G
 
G
D
 
T
D
 
T
S
 
F
L
 
I
L
 
M
G
 
N
-
 
G
-
x
A
T
 
N
H
|
H
V
 
R
M
 
M
V
 
D
T
 
G
S
 
S
G
 
T
K
 
Y
H
 
P
T
 
F
H
|
H
F
x
L
F
 
F
-
 
R
-
 
M
-
 
G
-
 
W
-
 
E
-
 
K
-
 
Y
-
x
M
-
x
P
D
 
S
D
 
L
P
 
K
D
 
D
V
x
L
P
 
P
I
 
L
R
 
K
L
 
G
Q
 
D
G
 
-
G
 
-
R
 
-
D
 
-
E
 
-
C
 
-
V
 
I
R
 
E
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
|
G
N
 
R
G
 
D
A
 
V
I
 
T
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
I
A
 
A
A
 
A
G
 
E
S
 
A
V
 
V
V
 
V
A
 
T
A
 
K
A
 
N
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
S
I
 
I
A
 
V
A
 
G
G
 
G
I
 
N
P
 
P
A
 
L
R
 
K
V
 
F
L
 
I
G
 
R
R
 
K
R
 
R

Sites not aligning to the query:

6x3cE Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
31% identity, 56% coverage: 78:185/194 of query aligns to 55:166/203 of 6x3cE

query
sites
6x3cE
V
 
V
I
 
I
G
 
G
R
 
D
N
 
K
V
 
L
Y
 
I
I
 
I
G
 
G
A
 
R
Y
 
F
C
 
C
N
 
S
I
 
I
G
|
G
H
 
P
A
 
-
D
 
-
I
 
-
G
 
G
D
 
T
D
 
T
S
 
F
L
 
I
L
 
M
G
 
N
-
x
G
-
 
A
T
x
N
H
|
H
V
 
R
M
|
M
V
 
D
T
 
G
S
 
S
G
 
T
K
 
Y
H
 
P
T
 
F
H
|
H
F
x
L
F
 
F
-
 
R
-
 
M
-
 
G
-
 
W
-
 
E
-
 
K
-
 
Y
-
x
M
-
x
P
D
 
S
D
 
L
P
 
K
D
 
D
V
 
L
P
 
P
I
 
L
R
 
K
L
 
G
Q
 
D
G
 
-
G
 
-
R
 
-
D
 
-
E
 
-
C
 
-
V
 
I
R
 
E
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
|
G
N
 
R
G
 
D
A
 
V
I
 
T
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
 
I
V
 
I
A
|
A
A
|
A
G
 
E
S
 
A
V
 
V
V
 
V
A
 
T
A
 
K
A
 
N
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
S
I
 
I
A
 
V
A
 
G
G
 
G
I
x
N
P
|
P
A
 
L
R
 
K
V
 
F
L
 
I
G
 
R
R
 
K
R
 
R

Sites not aligning to the query:

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
32% identity, 42% coverage: 102:182/194 of query aligns to 99:183/188 of 3igjC

query
sites
3igjC
L
 
I
G
 
G
T
 
D
H
 
H
V
 
C
M
 
M
V
 
F
T
x
A
S
 
P
G
 
G
K
 
V
H
 
H
T
 
I
H
x
Y
F
 
T
F
x
A
D
 
T
D
x
H
P
 
P
D
 
L
V
 
H
P
 
P
I
 
V
R
 
E
L
 
R
Q
 
N
G
 
S
G
 
G
R
 
K
D
 
E
-
 
Y
-
 
G
E
 
K
C
 
P
V
 
V
R
 
K
I
 
I
G
 
G
R
 
N
D
 
N
C
 
V
W
 
W
I
 
V
G
|
G
N
 
G
G
 
G
A
 
A
I
 
I
V
 
I
M
x
N
A
 
P
-
 
G
-
 
V
D
 
S
V
 
I
G
 
G
D
 
D
G
 
N
C
 
A
V
 
V
V
 
I
A
|
A
A
x
S
G
 
G
S
 
A
V
 
V
V
 
V
A
x
T
A
 
K
A
 
D
L
 
V
A
 
P
P
 
N
Y
 
N
S
 
V
I
 
V
A
 
V
A
 
G
G
 
G
I
x
N
P
 
P
A
 
A
R
 
K
V
 
V
L
 
I

Sites not aligning to the query:

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
32% identity, 57% coverage: 79:188/194 of query aligns to 78:188/203 of P07464

query
sites
P07464
I
 
I
G
 
G
R
 
R
N
 
N
V
 
F
Y
 
Y
I
 
-
G
 
-
A
 
A
Y
x
N
C
 
F
N
 
N
I
 
L
G
 
T
H
 
I
A
 
V
D
 
D
-
x
D
-
 
Y
-
 
T
-
 
V
-
 
T
I
 
I
G
 
G
D
 
D
D
 
N
S
 
V
L
 
L
L
 
I
G
 
A
T
 
P
H
 
N
V
 
V
M
 
T
V
 
L
T
 
S
S
 
V
G
 
T
K
 
G
H
|
H
T
 
P
H
 
V
F
 
H
F
 
H
D
 
E
D
 
-
P
 
-
D
 
-
V
 
-
P
 
-
I
 
L
R
 
R
L
 
K
Q
 
N
G
 
G
G
 
E
R
 
M
D
 
Y
E
 
S
C
 
F
-
 
P
V
 
I
R
 
T
I
 
I
G
 
G
R
 
N
D
 
N
C
 
V
W
 
W
I
 
I
G
 
G
N
x
S
G
 
H
A
 
V
I
 
V
V
 
I
M
 
N
A
 
P
D
 
G
V
 
V
-
 
T
-
 
I
G
 
G
D
 
D
G
 
N
C
 
S
V
 
V
V
 
I
A
 
G
A
|
A
G
 
G
S
 
S
V
 
I
V
 
V
A
x
T
A
x
K
A
 
D
L
 
I
A
 
P
P
 
P
Y
 
N
S
 
V
I
 
V
A
 
A
A
 
A
G
 
G
I
 
V
P
 
P
A
 
C
R
|
R
V
 
V
L
 
I
G
x
R
R
 
E
R
 
I
G
 
N
D
 
D
R
 
R

Sites not aligning to the query:

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
32% identity, 57% coverage: 79:188/194 of query aligns to 77:187/200 of 1krrA

query
sites
1krrA
I
 
I
G
 
G
R
 
R
N
 
N
V
 
F
Y
 
Y
I
 
-
G
 
-
A
 
A
Y
x
N
C
 
F
N
 
N
I
 
L
G
 
T
H
 
I
A
 
V
D
 
D
-
 
D
-
 
Y
-
 
T
-
 
V
-
 
T
I
 
I
G
 
G
D
 
D
D
 
N
S
 
V
L
 
L
L
x
I
G
x
A
T
x
P
H
 
N
V
 
V
M
 
T
V
 
L
T
 
S
S
 
V
G
x
T
K
 
G
H
|
H
T
 
P
H
 
V
F
 
H
F
 
H
D
 
E
D
 
-
P
 
-
D
 
-
V
 
-
P
 
-
I
 
L
R
 
R
L
 
K
Q
 
N
G
 
G
G
 
E
R
 
M
D
 
Y
E
 
S
C
 
F
-
 
P
V
 
I
R
 
T
I
 
I
G
 
G
R
 
N
D
 
N
C
 
V
W
 
W
I
 
I
G
|
G
N
x
S
G
 
H
A
 
V
I
 
V
V
 
I
M
x
N
A
 
P
D
 
G
V
 
V
-
 
T
-
 
I
G
 
G
D
 
D
G
 
N
C
 
S
V
 
V
V
 
I
A
x
G
A
|
A
G
 
G
S
 
S
V
 
I
V
 
V
A
 
T
A
 
K
A
 
D
L
 
I
A
 
P
P
 
P
Y
 
N
S
 
V
I
 
V
A
 
A
A
|
A
G
 
G
I
 
V
P
|
P
A
 
C
R
 
R
V
 
V
L
 
I
G
x
R
R
 
E
R
 
I
G
 
N
D
 
D
R
 
R

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
32% identity, 57% coverage: 79:188/194 of query aligns to 77:187/201 of 1krvA

query
sites
1krvA
I
 
I
G
 
G
R
 
R
N
 
N
V
 
F
Y
|
Y
I
 
-
G
 
-
A
 
A
Y
x
N
C
 
F
N
 
N
I
 
L
G
 
T
H
 
I
A
x
V
D
 
D
-
x
D
-
 
Y
-
 
T
-
 
V
-
 
T
I
 
I
G
 
G
D
 
D
D
 
N
S
 
V
L
 
L
L
 
I
G
x
A
T
 
P
H
 
N
V
 
V
M
 
T
V
 
L
T
x
S
S
 
V
G
x
T
K
 
G
H
 
H
T
 
P
H
 
V
F
 
H
F
 
H
D
 
E
D
 
-
P
 
-
D
 
-
V
 
-
P
 
-
I
 
L
R
 
R
L
 
K
Q
 
N
G
 
G
G
 
E
R
x
M
D
 
Y
E
 
S
-
 
F
C
 
P
V
 
I
R
 
T
I
 
I
G
 
G
R
 
N
D
 
N
C
 
V
W
|
W
I
 
I
G
|
G
N
x
S
G
 
H
A
 
V
I
 
V
V
 
I
M
x
N
A
 
P
D
 
G
V
 
V
-
 
T
-
 
I
G
 
G
D
 
D
G
 
N
C
 
S
V
 
V
V
 
I
A
 
G
A
|
A
G
 
G
S
 
S
V
 
I
V
 
V
A
 
T
A
 
K
A
 
D
L
 
I
A
 
P
P
 
P
Y
 
N
S
 
V
I
 
V
A
 
A
A
 
A
G
 
G
I
 
V
P
|
P
A
 
C
R
|
R
V
 
V
L
 
I
G
x
R
R
 
E
R
 
I
G
 
N
D
 
D
R
 
R

Sites not aligning to the query:

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
32% identity, 57% coverage: 79:188/194 of query aligns to 77:187/201 of 1kruA

query
sites
1kruA
I
 
I
G
 
G
R
 
R
N
 
N
V
 
F
Y
|
Y
I
 
-
G
 
-
A
 
A
Y
x
N
C
 
F
N
 
N
I
 
L
G
 
T
H
 
I
A
x
V
D
 
D
-
x
D
-
 
Y
-
 
T
-
 
V
-
 
T
I
 
I
G
 
G
D
 
D
D
 
N
S
 
V
L
|
L
L
 
I
G
 
A
T
 
P
H
 
N
V
 
V
M
 
T
V
 
L
T
 
S
S
 
V
G
 
T
K
 
G
H
|
H
T
 
P
H
 
V
F
 
H
F
 
H
D
 
E
D
 
-
P
 
-
D
 
-
V
 
-
P
 
-
I
 
L
R
 
R
L
 
K
Q
 
N
G
 
G
G
 
E
R
x
M
D
 
Y
E
 
S
-
 
F
C
 
P
V
 
I
R
 
T
I
 
I
G
 
G
R
 
N
D
 
N
C
 
V
W
|
W
I
 
I
G
|
G
N
x
S
G
 
H
A
 
V
I
 
V
V
 
I
M
 
N
A
 
P
D
 
G
V
 
V
-
 
T
-
 
I
G
 
G
D
 
D
G
 
N
C
 
S
V
 
V
V
 
I
A
x
G
A
|
A
G
 
G
S
 
S
V
 
I
V
 
V
A
 
T
A
 
K
A
 
D
L
 
I
A
 
P
P
 
P
Y
 
N
S
 
V
I
 
V
A
 
A
A
 
A
G
 
G
I
 
V
P
|
P
A
 
C
R
 
R
V
 
V
L
 
I
G
x
R
R
 
E
R
 
I
G
 
N
D
 
D
R
 
R

Sites not aligning to the query:

8j40A Crystal structure of catb8 in complex with chloramphenicol (see paper)
29% identity, 55% coverage: 85:190/194 of query aligns to 58:168/209 of 8j40A

query
sites
8j40A
I
 
I
G
 
G
A
 
S
Y
 
F
C
 
C
N
 
S
I
 
I
G
 
G
H
 
S
A
 
G
D
 
-
I
 
-
G
 
-
D
 
-
D
 
-
S
 
-
L
 
-
L
 
-
G
 
A
T
 
S
H
 
F
V
 
I
M
 
M
V
 
A
T
 
G
S
 
N
G
 
Q
K
 
G
H
 
H
T
 
Q
H
 
H
-
 
D
-
 
W
-
 
A
-
 
S
-
 
S
-
 
F
-
 
P
F
 
F
F
 
F
-
x
Y
-
 
M
-
 
Q
D
 
E
D
 
E
P
 
P
D
 
A
V
 
F
P
 
S
I
 
R
R
 
A
L
 
L
Q
 
D
G
 
A
-
 
F
G
 
Q
R
 
R
D
 
A
E
 
G
C
 
D
V
 
T
R
 
V
I
 
I
G
 
G
R
 
N
D
 
D
C
 
V
W
|
W
I
 
I
G
 
G
N
 
S
G
 
E
A
 
A
I
 
M
V
 
I
M
 
M
A
 
P
-
 
G
-
 
I
D
 
K
V
 
I
G
 
G
D
 
D
G
 
G
C
 
A
V
|
V
V
 
I
A
 
G
A
x
S
G
 
R
S
 
S
V
 
L
V
 
V
A
 
T
A
 
K
A
 
D
L
 
V
A
 
E
P
 
P
Y
 
Y
S
 
A
I
 
I
A
 
I
A
 
G
G
 
G
I
 
N
P
 
P
A
 
A
R
 
K
V
 
Q
L
 
I
G
 
K
R
 
K
R
 
R
G
 
F
D
 
S
R
 
D
R
 
E
E
 
E

Sites not aligning to the query:

6u9cA The 2.2 a crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with acetyl coa
29% identity, 52% coverage: 85:185/194 of query aligns to 58:162/206 of 6u9cA

query
sites
6u9cA
I
 
I
G
 
G
A
 
S
Y
 
F
C
 
C
N
 
S
I
 
I
G
 
G
H
 
S
A
 
G
D
 
-
I
 
-
G
 
-
D
 
-
D
 
-
S
 
-
L
 
-
L
 
-
G
 
-
T
 
-
H
 
A
V
 
V
M
 
F
V
 
M
T
 
M
S
 
A
G
 
G
K
 
N
H
 
Q
T
 
G
H
 
H
-
 
R
-
 
S
-
 
D
-
 
W
-
 
I
-
 
S
-
 
T
-
 
F
-
 
P
-
 
F
F
 
F
F
 
Y
D
 
Q
D
 
D
P
 
N
D
 
D
V
 
-
P
 
-
I
 
-
R
 
N
L
 
F
Q
 
A
G
 
D
G
 
A
R
 
R
D
 
D
E
 
G
C
 
F
V
 
T
R
 
R
-
 
S
-
 
G
-
 
D
-
 
T
-
 
I
I
 
I
G
 
G
R
 
H
D
 
D
C
 
V
W
|
W
I
 
I
G
 
G
N
 
T
G
 
E
A
 
A
I
 
M
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
H
G
 
G
C
 
A
V
 
I
V
 
I
A
|
A
A
 
S
G
 
R
S
 
S
V
 
V
V
 
V
A
 
T
A
 
K
A
 
D
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
E
I
 
V
A
 
V
A
 
G
G
 
S
I
 
N
P
 
P
A
 
A
R
 
K
V
 
H
L
x
I
G
 
K
R
 
F
R
 
R

6pubA Crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with crystal violet
29% identity, 52% coverage: 85:185/194 of query aligns to 61:165/210 of 6pubA

query
sites
6pubA
I
 
I
G
 
G
A
 
S
Y
 
F
C
 
C
N
 
S
I
 
I
G
 
G
H
 
S
A
 
G
D
 
-
I
 
-
G
 
-
D
 
-
D
 
-
S
 
-
L
 
-
L
 
-
G
 
-
T
 
-
H
 
A
V
 
V
M
 
F
V
 
M
T
 
M
S
 
A
G
 
G
K
 
N
H
 
Q
T
 
G
H
 
H
-
 
R
-
 
S
-
 
D
-
 
W
-
 
I
-
 
S
-
 
T
-
 
F
-
 
P
-
 
F
F
 
F
F
 
Y
D
 
Q
D
 
D
P
 
N
D
 
D
V
 
-
P
 
-
I
 
-
R
 
N
L
 
F
Q
 
A
G
 
D
G
 
A
R
 
R
D
 
D
E
 
G
C
 
F
V
 
T
R
 
R
-
 
S
-
 
G
-
 
D
-
 
T
-
 
I
I
 
I
G
 
G
R
 
H
D
 
D
C
 
V
W
 
W
I
 
I
G
 
G
N
 
T
G
 
E
A
 
A
I
 
M
V
 
I
M
 
M
A
 
P
-
 
G
-
 
V
D
 
K
V
 
I
G
 
G
D
 
H
G
 
G
C
 
A
V
 
I
V
 
I
A
 
A
A
 
S
G
 
R
S
 
S
V
 
V
V
 
V
A
 
T
A
 
K
A
 
D
L
 
V
A
 
A
P
 
P
Y
 
Y
S
 
E
I
 
V
A
 
V
A
 
G
G
 
S
I
 
N
P
 
P
A
 
A
R
 
K
V
 
H
L
 
I
G
 
K
R
 
F
R
 
R

Sites not aligning to the query:

8i04A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with serine (see paper)
37% identity, 34% coverage: 125:189/194 of query aligns to 183:247/258 of 8i04A

query
sites
8i04A
R
 
K
L
 
T
Q
 
S
G
 
G
G
 
D
R
|
R
D
x
H
E
 
P
C
 
K
V
 
I
R
 
R
I
 
E
G
 
G
R
 
-
D
 
-
C
 
V
W
 
M
I
 
I
G
 
G
N
 
A
G
 
G
A
 
A
I
 
K
V
 
I
M
 
L
A
 
G
-
 
N
-
 
I
D
 
E
V
 
V
G
 
G
D
 
R
G
 
G
C
 
A
V
 
K
V
 
I
A
 
G
A
 
A
G
 
G
S
 
S
V
 
V
V
 
V
A
 
L
A
 
Q
A
 
P
L
 
V
A
 
P
P
 
P
Y
 
H
S
 
T
I
 
T
A
 
A
A
 
A
G
 
G
I
 
V
P
 
P
A
 
A
R
 
R
V
 
I
L
 
V
G
 
G
R
 
K
R
 
P
G
 
G
D
 
S
R
 
D
R
 
K

Sites not aligning to the query:

Query Sequence

>8499909 FitnessBrowser__Miya:8499909
MLKAFVLVCAVPFYVLHRLEALVLGRERSFAGMTQLLALLPGVYGVLLRVAFLRLALHGC
TSACVVEFMTTFVTPQTVIGRNVYIGAYCNIGHADIGDDSLLGTHVMVTSGKHTHFFDDP
DVPIRLQGGRDECVRIGRDCWIGNGAIVMADVGDGCVVAAGSVVAAALAPYSIAAGIPAR
VLGRRGDRREREEA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory