SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 8500412 FitnessBrowser__Miya:8500412 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
53% identity, 100% coverage: 1:240/241 of query aligns to 5:238/240 of 1ji0A

query
sites
1ji0A

M

I

L

V

L

L

S

E

I

V

E

Q

N

S

L

L

Y

H

V

V

K

Y

Y
|
Y

G

G

N

A

I

I

E

H

A

A

L

I

H

K

G

G

L

I

S

D

F

L

H

K

V

V

N

P

E

R

G

G

E

Q

I

I

V

V

T

T

L

L

I

I

G

G

A

A

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

L

K

S

S

A

I

I

M

A

R

G

L

L

P

V

P

-

P

-

E

-

A

-

P

-

K

R

V

A

S

Q

G

K

G

G

D

K

I

I

L

I

F

F

K

N

G

G

K

Q

S

D

L

I

L

T

N

N

V

-

E

K

P

P

H

A

D

H

V

V

V

I

S

N

K

R

L

M

H

G

V

I

A

A

L

L

V

V

P

P

E
|
E

G

G

R

R

H

R

I

I

F

F

G

P

N

E

L

L

T

T

V

V

M

Y

E

E

N

N

L

L

M

M

L

M

A

G

T

A

Y

Y

A

N

R

R

K

K

N

D

D

K

P

E

A

G

I

I

S

K

R

R

D

D

L

L

E

E

R

W

I

I

F

F

D

S

L

L

F

F

P

P

R

R

L

L

A

K

E

E

R

R

R

L

T

K

Q

Q

R

L

S

G

D

G

T

T

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

M

M

L

L

A

A

V

I

G

G

R

R

A

A

L

L

M

M

T

S

S

R

C

P

E

K

V

L

L

L

L

M

L

M

D

D

E
|
E

P

P

S

S

M

L

G

G

L

L

A

A

P

P

L

I

L

L

M

V

Y

S

E

E

M

V

F

F

R

E

T

V

L

I

K

Q

E

K

L

I

N

N

R

Q

E

E

G

G

L

T

T

T

I

I

I

L

V

L

V

V

E

E

Q

Q

N

N

A

A

R

L

L

G

A

A

L

L

Q

K

V

V

A

A

S

H

R

Y

G

G

Y

Y

V

V

L

L

D

E

T

T

G

G

E

Q

I

I

V

V

A

L

Q

E

G

G

P

K

S

A

E

S

S

E

L

L

L

L

N

D

D

N

P

E

E

M

V

V

K

R

K

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y12), G42 (= G38), G44 (= G40), K45 (= K41), T46 (≠ S42), T47 (= T43), E88 (= E90), E165 (= E167)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
30% identity, 99% coverage: 2:240/241 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

L

I

L

L

S

R

I

T

E

E

N

N

L

I

Y

V

V

K

K

Y

Y
x
F

G

G

N

E

I
x
F

E

K

A

A

L

L

H

D

G

G

L

V

S

S

F

I

H

S

V

V

N

N

E

K

G

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

A

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

K

N

S

V

I

I

M

T

R

G

L

F

P

L

P

-

P

-

E

-

A

-

P

-

K

K

V

A

S

D

G

E

G

G

D

R

I

V

L

Y

F

F

K

E

G

N

K

K

S

D

L

I

L

T

N

N

V

K

E

E

P

P

H

A

D

E

V

L

V

-

S

-

K

-

L

Y

H

H

V

Y

A

G

L

I

V

V

P

R

-

T

-

F

E

Q

G

T

R

P

H

Q

I

P

F

L

G

K

N

E

L

M

T

T

V

V

M

L

E

E

N

N

L

L

M

L

L

I

-

G

-

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P

-

L

-

N

A

S

T

L

Y

F

A

Y

R

K

K

K

N

W

D

I

P

P

A

K

I

E

S

E

R

E

D

M

L

V

E

E

R

K

I

A

F

F

D

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

R

Y

T

D

Q

R

R

K

S

A

D

G

T

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

V

I

G

G

R

R

A

A

L

L

M

M

T

T

S

N

C

P

E

K

V

M

L

I

L

V

L

M

D

D

E

E

P

P

S

I

M

A

G

G

L

V

A

A

P

P

L

G

L

L

M

A

Y

H

E

D

M

I

F

F

R

N

T

H

L

V

K

L

E

E

L

L

N

K

R

A

E

K

G

G

L

I

T

T

I

F

I

L

V

I

V

I

E

E

Q

H

N

R

A

L

R

D

L

I

A

V

L

L

Q

N

V

Y

A

I

S

D

R

H

G

L

Y

Y

V

V

L

M

D

F

T

N

G

G

E

Q

I

I

V

I

A

A

Q

E

G

G

P

R

S

G

E

E

-

E

-

E

-

I

-

K

S

N

L

V

L

L

N

S

D

D

P

P

E

K

V

V

K

V

K

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y12), F17 (≠ I15), N39 (= N37), G40 (= G38), G42 (= G40), K43 (= K41), S44 (= S42), T45 (= T43)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 95% coverage: 2:229/241 of query aligns to 1:224/240 of 4ymuJ

query
sites
4ymuJ

L

M

L

I

S

F

I

V

E

N

N

D

L

V

Y

Y

V

K

K

N

Y
x
F

G

G

N

S

I

L

E

E

A
x
V

L

L

H

K

G

G

L

V

S

T

F

L

H

K

V

V

N

N

E

K

G

G

E

E

I

V

V

V

T

V

L

I

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

L

K

R

S

C

I

I

M

N

R

L

L

L

P

E

P

E

P

P

E

-

A

-

P

-

K

-

V

-

S

T

G

K

G

G

D

E

I

V

L

F

F

I

K

D

G

G

K

V

S

K

L

I

L

N

N

N

V

G

E

K

P

V

H

N

D

I

V

N

V

K

S

V

K

R

L

Q

H

K

V

V

A

G

L

M

V

V

P

F

E

Q

G

H

R

F

H

N

I

L

F

F

G

P

N

H

L

L

T

T

V

A

M

I

E

E

N

N

L

I

M

T

L

L

A

A

-

P

T

V

Y

K

A

V

R

K

K

K

N

M

D

N

P

K

A

K

I

E

S

A

R

E

D

E

L

L

E

A

R

-

I

-

F

V

D

D

L

L

F

L

P

A

R

K

-

V

-

G

L

L

A

L

E

D

R

K

R

K

T

D

Q

Q

R

Y

S

P

D

I

T

K

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

Q

C

P

E

E

V

V

L

M

L

L

L

F

D

D

E
|
E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

K

E

E

M

V

F

L

R

N

T

V

L

M

K

K

E

Q

L

L

N

A

R

N

E

E

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q
x
H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

G

S

D

R

R

G

V

Y

I

V

F

L

M

D

D

T

D

G

G

E

V

I

I

V

V

A

E

Q

E

G

G

P

T

S

P

E

E

S

E

L

I

L

F

binding adenosine-5'-triphosphate: F11 (≠ Y12), V16 (≠ A17), S36 (≠ N37), G37 (= G38), S38 (≠ A39), G39 (= G40), K40 (= K41), S41 (= S42), T42 (= T43), E162 (= E167), H194 (≠ Q199)
binding magnesium ion: S41 (= S42), E162 (= E167)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
29% identity, 99% coverage: 2:240/241 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

S

R

I

T

E

E

N

N

L

I

Y

V

V

K

K

Y

Y
x
F

G

G

N

E

I
x
F

E

K

A

A

L

L

H

D

G

G

L

V

S

S

F

I

H

S

V

V

N

C

E

K

G

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

A

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

K

N

S

V

I

I

M

T

R

G

L

F

P

L

P

-

P

-

E

-

A

-

P

-

K

K

V

A

S

D

G

E

G

G

D

R

I

V

L

Y

F

F

K

E

G

N

K

K

S

D

L

I

L

T

N

N

V

K

E

E

P

P

H

A

D

E

V

L

V

-

S

-

K

-

L

Y

H

H

V

Y

A

G

L

I

V

V

P

R

-

T

-

F

E

Q

G

T

R

P

H

Q

I

P

F

L

G

K

N

E

L

M

T

T

V

V

M

L

E

E

N

N

L

L

M

L

L

I

-

G

-

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

A

S

T

L

Y

F

A

Y

R

K

K

K

N

W

D

I

P

P

A

K

I

E

S

E

R

E

D

M

L

V

E

E

R

K

I

A

F

F

D

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

R

Y

T

D

Q

R

R

K

S

A

D

G

T

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

V

I

G

G

R

R

A

A

L

L

M

M

T

T

S

N

C

P

E

K

V

M

L

I

L

V

L

M

D

D

E
|
E

P

P

S

I

M

A

G

G

L

V

A

A

P

P

L

G

L

L

M

A

Y

H

E

D

M

I

F

F

R

N

T

H

L

V

K

L

E

E

L

L

N

K

R

A

E

K

G

G

L

I

T

T

I

F

I

L

V

I

V

I

E

E

Q

H

N

R

A

L

R

D

L

I

A

V

L

L

Q

N

V

Y

A

I

S

D

R

H

G

L

Y

Y

V

V

L

M

D

F

T

N

G

G

E

Q

I

I

V

I

A

A

Q

E

G

G

P

R

S

G

E

E

-

E

-

E

-

I

-

K

S

N

L

V

L

L

N

S

D

D

P

P

E

K

V

V

K

V

K

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y12), F17 (≠ I15), G40 (= G38), S41 (≠ A39), G42 (= G40), K43 (= K41), S44 (= S42), T45 (= T43)
binding magnesium ion: S44 (= S42), E176 (= E167)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
32% identity, 99% coverage: 3:240/241 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y

Y

G

K

N

G

I

R

E

R

A

V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

H

S

I

I

F

F

G
x
R

N

R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R
x
M

S
x
G

D
x
Q

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ G96), M133 (≠ R138), G134 (≠ S139), Q135 (≠ D140)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
32% identity, 99% coverage: 3:240/241 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I
x
R

E

R

A

V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

H

S

I

I

F

F

G

R

N

R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D

Q

T
x
S

L

L

S
|
S

G

G

G

G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y12), R15 (≠ I15), N37 (= N37), G40 (= G40), K41 (= K41), T42 (≠ S42), T43 (= T43), Q84 (≠ E90), S136 (≠ T141), S138 (= S143), E141 (= E146)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
32% identity, 99% coverage: 3:240/241 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I

R

E

R

A

V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

H

S

I

I

F

F

G

R

N

R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D

Q

T
x
S

L

L

S
|
S

G
|
G

G
|
G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E
|
E

P

P

S

F

M

A

G
|
G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q
x
H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y12), N37 (= N37), G38 (= G38), G40 (= G40), K41 (= K41), T42 (≠ S42), T43 (= T43), Q84 (≠ E90), S136 (≠ T141), S138 (= S143), G139 (= G144), G140 (= G145), E162 (= E167), G166 (= G171), H194 (≠ Q199)

6mbnA Lptb e163q in complex with atp (see paper)
31% identity, 99% coverage: 3:240/241 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

H

S

I

I

F

F

G

R

N

R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D

Q

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q
x
H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y12), R16 (≠ I15), V18 (≠ A17), N38 (= N37), G39 (= G38), G41 (= G40), K42 (= K41), T43 (≠ S42), T44 (= T43), H195 (≠ Q199)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 99% coverage: 2:239/241 of query aligns to 3:238/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

S

D

I

V

E

H

N

Q

L

L

Y

K

V

K

K

S

Y
x
F

G

G

N

S

I

L

E

E

A
x
V

L

L

H

K

G

G

L

I

S

N

F

V

H

H

V

I

N

R

E

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

K

R

S

C

I

L

M

N

R

L

L

L

P

E

P

-

P

-

E

-

A

-

P

-

K

D

V

F

S

D

G

E

G

G

D

E

I

I

L

I

F

I

K

D

G

G

K

I

S

N

L

L

L

K

N

A

V

K

E

D

P

T

H

N

D

L

V

N

V

K

S

V

K

R

L

E

H

E

V

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

H

N

I

L

F

F

G

P

N

H

L

M

T

T

V

V

M

L

E

N

N

N

L

I

M

T

L

L

A

A

T

P

Y

M

A

K

R

V

K

R

N

K

D

W

P

P

A

R

I

-

S

E

R

K

D

A

L

E

E

A

R

K

I

A

F

M

D

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

A

K

E

D

R

K

R

A

T

H

Q

A

R

Y

S

P

D

D

T

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

E

C

P

E

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

G

E

E

M

V

F

L

R

S

T

V

L

M

K

K

E

Q

L

L

N

A

R

N

E

E

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q

H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

G

S

D

R

R

G

V

Y

L

V

F

L

M

D

D

T

G

G

G

E

Y

I

I

V

I

A

E

Q

E

G

G

P

K

S

P

E

E

S

D

L

L

L

F

N

D

D

R

P

P

-

Q

-

H

E

E

V

R

K

T

K

K

A

A

Y

F

L

L

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y12), V18 (≠ A17), S38 (≠ N37), G39 (= G38), S40 (≠ A39), G41 (= G40), K42 (= K41), S43 (= S42), T44 (= T43)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 99% coverage: 2:239/241 of query aligns to 3:238/242 of 3c41J

query
sites
3c41J

L

M

L

I

S

D

I

V

E

H

N

Q

L

L

Y

K

V

K

K

S

Y
x
F

G

G

N

S

I

L

E

E

A
x
V

L

L

H

K

G

G

L

I

S

N

F

V

H

H

V

I

N

R

E

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

K

R

S

C

I

L

M

N

R

L

L

L

P

E

P

-

P

-

E

-

A

-

P

-

K

D

V

F

S

D

G

E

G

G

D

E

I

I

L

I

F

I

K

D

G

G

K

I

S

N

L

L

L

K

N

A

V

K

E

D

P

T

H

N

D

L

V

N

V

K

S

V

K

R

L

E

H

E

V

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

H

N

I

L

F

F

G

P

N

H

L

M

T

T

V

V

M

L

E

N

N

N

L

I

M

T

L

L

A

A

T

P

Y

M

A

K

R

V

K

R

N

K

D

W

P

P

A

R

I

-

S

E

R

K

D

A

L

E

E

A

R

K

I

A

F

M

D

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

A

K

E

D

R

K

R

A

T

H

Q

A

R

Y

S

P

D

D

T

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

E

C

P

E

K

V

I

L

M

L

L

L

F

D
|
D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

G

E

E

M

V

F

L

R

S

T

V

L

M

K

K

E

Q

L

L

N

A

R

N

E

E

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q

H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

G

S

D

R

R

G

V

Y

L

V

F

L

M

D

D

T

G

G

G

E

Y

I

I

V

I

A

E

Q

E

G

G

P

K

S

P

E

E

S

D

L

L

L

F

N

D

D

R

P

P

-

Q

-

H

E

E

V

R

K

T

K

K

A

A

Y

F

L

L

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y12), V18 (≠ A17), S38 (≠ N37), G39 (= G38), G41 (= G40), K42 (= K41), S43 (= S42), T44 (= T43)
binding magnesium ion: S43 (= S42), D163 (= D166)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 99% coverage: 2:239/241 of query aligns to 3:238/242 of 2olkA

query
sites
2olkA

L

M

L

I

S

D

I

V

E

H

N

Q

L

L

Y

K

V

K

K

S

Y
x
F

G

G

N

S

I

L

E

E

A
x
V

L

L

H

K

G

G

L

I

S

N

F

V

H

H

V

I

N

R

E

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

K

R

S

C

I

L

M

N

R

L

L

L

P

E

P

-

P

-

E

-

A

-

P

-

K

D

V

F

S

D

G

E

G

G

D

E

I

I

L

I

F

I

K

D

G

G

K

I

S

N

L

L

L

K

N

A

V

K

E

D

P

T

H

N

D

L

V

N

V

K

S

V

K

R

L

E

H

E

V

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

H

N

I

L

F

F

G

P

N

H

L

M

T

T

V

V

M

L

E

N

N

N

L

I

M

T

L

L

A

A

T

P

Y

M

A

K

R

V

K

R

N

K

D

W

P

P

A

R

I

-

S

E

R

K

D

A

L

E

E

A

R

K

I

A

F

M

D

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

A

K

E

D

R

K

R

A

T

H

Q

A

R

Y

S

P

D

D

T

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

E

C

P

E

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

G

E

E

M

V

F

L

R

S

T

V

L

M

K

K

E

Q

L

L

N

A

R

N

E

E

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q

H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

G

S

D

R

R

G

V

Y

L

V

F

L

M

D

D

T

G

G

G

E

Y

I

I

V

I

A

E

Q

E

G

G

P

K

S

P

E

E

S

D

L

L

L

F

N

D

D

R

P

P

-

Q

-

H

E

E

V

R

K

T

K

K

A

A

Y

F

L

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y12), V18 (≠ A17), S38 (≠ N37), G39 (= G38), S40 (≠ A39), G41 (= G40), K42 (= K41), S43 (= S42), T44 (= T43)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 99% coverage: 2:239/241 of query aligns to 3:238/242 of 2oljA

query
sites
2oljA

L

M

L

I

S

D

I

V

E

H

N

Q

L

L

Y

K

V

K

K

S

Y
x
F

G

G

N

S

I

L

E

E

A
x
V

L

L

H

K

G

G

L

I

S

N

F

V

H

H

V

I

N

R

E

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

K

R

S

C

I

L

M

N

R

L

L

L

P

E

P

-

P

-

E

-

A

-

P

-

K

D

V

F

S

D

G

E

G

G

D

E

I

I

L

I

F

I

K

D

G

G

K

I

S

N

L

L

L

K

N

A

V

K

E

D

P

T

H

N

D

L

V

N

V

K

S

V

K

R

L

E

H

E

V

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

H

N

I

L

F

F

G

P

N

H

L

M

T

T

V

V

M

L

E

N

N

N

L

I

M

T

L

L

A

A

T

P

Y

M

A

K

R

V

K

R

N

K

D

W

P

P

A

R

I

-

S

E

R

K

D

A

L

E

E

A

R

K

I

A

F

M

D

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

A

K

E

D

R

K

R

A

T

H

Q

A

R

Y

S

P

D

D

T

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

E

C

P

E

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

G

E

E

M

V

F

L

R

S

T

V

L

M

K

K

E

Q

L

L

N

A

R

N

E

E

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q

H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

G

S

D

R

R

G

V

Y

L

V

F

L

M

D

D

T

G

G

G

E

Y

I

I

V

I

A

E

Q

E

G

G

P

K

S

P

E

E

S

D

L

L

L

F

N

D

D

R

P

P

-

Q

-

H

E

E

V

R

K

T

K

K

A

A

Y

F

L

L

binding adenosine-5'-diphosphate: F13 (≠ Y12), V18 (≠ A17), S38 (≠ N37), G39 (= G38), S40 (≠ A39), G41 (= G40), K42 (= K41), S43 (= S42), T44 (= T43)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
31% identity, 98% coverage: 3:239/241 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H
x
L

D
x
H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P
|
P

E
x
Q

G

E

R
x
A

H
x
S

I

I

F
|
F

G
x
R

N
x
R

L
|
L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A
x
V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D
x
Q

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R
|
R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ I15), V17 (≠ A17), N37 (= N37), G38 (= G38), G40 (= G40), K41 (= K41), T42 (≠ S42), T43 (= T43)
binding magnesium ion: T42 (≠ S42), Q84 (≠ E90)
binding novobiocin: L71 (≠ H77), H72 (≠ D78), P83 (= P89), A86 (≠ R92), S87 (≠ H93), F89 (= F95), R90 (≠ G96), R91 (≠ N97), L92 (= L98), V101 (≠ A107), Q135 (≠ D140), R149 (= R154)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
31% identity, 98% coverage: 3:239/241 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

H

S

I

I

F

F

G

R

N

R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D

Q

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ I15), V17 (≠ A17), G38 (= G38), G40 (= G40), K41 (= K41), T42 (≠ S42), T43 (= T43)
binding magnesium ion: T42 (≠ S42), Q84 (≠ E90)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
31% identity, 98% coverage: 3:238/241 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

S

T

I

A

E

K

N

N

L

L

Y

A

V

K

K

A

Y
|
Y

G

K

N

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

L

V

S

S

F

L

H

T

V

V

N

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

F

K

Y

S

M

I

V

M

V

R

G

L

I

P

V

P

P

P

R

E

D

A

A

P

G

K

N

V

I

S

I

G

-

G

-

D

-

I

I

L

D

F

D

K

D

G

D

K

I

S

S

L

L

L

L

N

-

V

-

E

-

P

P

H

L

D

H

V

A

V

R

S

A

K

R

L

R

H

G

V

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

H

S

I

I

F
|
F

G
x
R

N
x
R

L

L

T

S

V

V

M

Y

E

D

N

N

L

L

M

M

L

A

A

V

T

L

Y

Q

A

I

R

R

K

D

N

D

D

L

P

S

A

A

I

E

S

Q

R

R

D

E

L

-

E

D

R

R

I

A

F

N

D

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

A

E

E

H

R

L

R

R

T

D

Q

S

R

M

S

G

D

Q

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

K

V

F

L

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

R

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

S

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

A

V

V

A

C

S

E

R

R

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

H

I

L

V

I

A

A

Q

H

G

G

P

T

S

P

E

T

S

E

L

I

L

L

N

Q

D

D

P

E

E

H

V

V

K

K

K

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ I15), V17 (≠ A17), G38 (= G38), G40 (= G40), K41 (= K41), T42 (≠ S42), T43 (= T43)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F95), R90 (≠ G96), R91 (≠ N97)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
27% identity, 99% coverage: 2:240/241 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

S

K

I

A

E

Q

N

H

L

L

Y

A

V

K

K

S

Y

Y

G

K

N

K

I

R

E

K

A

V

L

V

H

S

G

D

L

V

S

S

F

L

H

Q

V

V

N

E

E

S

G

G

E

Q

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

T

S

L

F

K

Y

S

M

I

I

M

V

R

G

L

L

P

V

P

A

P

R

E

D

A

E

P

G

K

T

V

I

S

T

G

I

G

D

D

D

I

-

L

-

F

-

K

-

G

-

K

-

S

N

L

D

L

I

N

S

V

I

E

L

P

P

H

M

D

H

V

S

V

R

S

S

K

R

L

M

H

G

V

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

H

S

I

I

F

F

G

R

N

K

L

L

T

S

V

V

M

E

E

D

N

N

L

I

M

M

L

A

A

V

T

L

Y

Q

A

T

R

R

K

E

N

E

D

L

P

T

A

H

I
x
E

S

E

R

R

D

Q

L

-

E
x
D

R

K

I

L

F

E

D

D

L

L

F

L

P

E

R

E

L

F

A

H

E

I

R

Q

R

H

T

I

Q

R

R

K

S

S

D

A

-

G

-

M

T

A

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

V

I

G

A

R

R

A

A

L

L

M

A

T

A

S

N

C

P

E

Q

V

F

L

I

L

L

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

A

D

P

P

L

I

L

S

M

V

Y

I

E

D

M

I

F

K

R

K

T

I

L

I

K

E

E

H

L

L

N

R

R

D

E

R

G

G

L

L

T

G

I

V

I

L

V

I

V

T

E

D

Q

H

N

N

A

V

R

R

L

E

A

T

L

L

Q

D

V

V

A

C

S

E

R

K

G

A

Y

Y

V

I

L

V

D

S

T

Q

G

G

E

R

I

L

V

I

A

A

Q

E

G

G

P

T

S

P

E

Q

S

D

L

V

L

L

N

N

D

N

P

E

E

Q

V

V

K

K

K

Q

A

V

Y

Y

L

L

G

G

binding calcium ion: E111 (≠ I117), D115 (≠ E122)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
28% identity, 98% coverage: 2:237/241 of query aligns to 2:232/241 of 4u00A

query
sites
4u00A

L

I

L

I

S

R

I

I

E

R

N

N

L

L

Y

H

V

K

K

W

Y
x
F

G

G

N

P

I

L

E

H

A
x
V

L

L

H

K

G

G

L

I

S

H

F

L

H

E

V

V

N

A

E

P

G

G

E

E

I

K

V

L

T

V

L

I

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

K

R

S

T

I

I

M

N

R

R

L

L

P

E

P

-

P

-

E

-

A

-

P

-

K

D

V

F

S

Q

G

E

G

G

D

E

I

V

L

V

F

V

K

D

G

G

K

L

S

S

L

V

L

K

N

D

V

D

E

R

P

A

H

L

D

R

V

E

V

I

S

R

K

R

L

-

H

E

V

V

A

G

L

M

V

V

P

F

E

Q

G

Q

R

F

H

N

I

L

F

F

G

P

N

H

L

M

T

T

V

V

M

L

E

E

N

N

L

V

M

T

L

L

A

A

T

P

Y

M

A

R

R

V

K

R

N

R

D

W

P

P

A

R

I

-

S

E

R

K

D

A

L

E

E

K

R

K

I

A

F

L

D

E

L

L

F

L

P

E

R

R

L

V

A

G

-

I

-

L

E

D

R

Q

R

A

T

R

Q

K

R

Y

S

P

D

A

T

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

M

R

L

V

A

A

V

I

G

A

R

R

A

A

L

L

M

A

T

M

S

E

C

P

E

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

L

E

L

M

M

V

Y

G

E

E

M

V

F

L

R

D

T

V

L

M

K

R

E

D

L

L

N

A

R

Q

E

G

G

G

L

M

T

T

I

M

I

V

V

V

V

V

E

T

Q

H

N

E

A

M

R

G

L

F

A

A

L

R

Q

E

V

V

A

A

S

D

R

R

G

V

Y

V

V

F

L

M

D

D

T

G

G

G

E

Q

I

I

V

V

A

E

Q

E

G

G

P

R

S

P

E

E

S

E

L

I

L

F

N

T

D

R

P

P

E

K

V

E

K

E

K

R

A

T

binding adenosine-5'-diphosphate: F12 (≠ Y12), V17 (≠ A17), S37 (≠ N37), G38 (= G38), S39 (≠ A39), G40 (= G40), K41 (= K41), S42 (= S42), T43 (= T43)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
32% identity, 93% coverage: 2:226/241 of query aligns to 4:222/285 of 4yerA

query
sites
4yerA

L

I

L

I

S

V

I

V

E

E

N

N

L

L

Y

V

V

K

K

K

Y
x
F

G

G

N

D

I
x
F

E

E

A

A

L

V

H

K

G

G

L

V

S

S

F

F

H

S

V

V

N

K

E

K

G

G

E

E

I

I

V

F

T

A

L

F

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

I

K

H

S

M

I

L

M

T

R

T

L

L

P

L

P

K

P

P

E

T

A

S

P

G

K

K

-

A

-

W

V

V

S

A

G

G

G

H

D

D

I

V

L

L

F

-

K

-

G

-

K

-

S

-

L

-

L

-

N

-

V

K

E

E

P

P

H

R

D

E

V

V

V

R

S

R

K

K

L

-

H

-

V

I

A

G

L

I

V

V

P

F

E

Q

G

D

R

Q

H

S

I

L

F

D

G

R

N

E

L

L

T

T

V

A

M

Y

E

E

N

N

L

M

M

Y

L

I

-

H

-

G

A

K

T

I

Y

Y

A

G

R

Y

K

G

N

G

D

E

P

K

A

L

I

K

S

K

R

R

D

I

L

L

E

E

R

L

I

L

F

E

D

F

L

V

F

E

P

L

R

L

L

E

A

F

E

K

R

D

R

K

T

P

Q

V

R

K

S

-

D

-

T
|
T

L
x
F

S
|
S

G

G

G

G

E

M

Q

A

Q

R

M

R

L

L

A

E

V

I

G

A

R

R

A

S

L

L

M

I

T

H

S

E

C

P

E

E

V

V

L

L

L

F

L

L

D

D

E

E

P

P

S

T

M

I

G

G

L

L

A

D

P

P

L

H

L

T

M

R

Y

A

E

H

M

M

F

W

R

E

T

Y

L

I

K

S

E

K

L

M

N

K

R

K

E

E

-

H

G

N

L

M

T

T

I

I

I

F

V

L

V

T

E

T

Q

H

N

Y

A

M

R

D

L

E

A

A

L

E

Q

Q

V

L

A

A

S

D

R

R

G

V

Y

A

V

I

L

I

D

D

T

H

G

G

E

K

I

I

V

I

A

A

Q

L

G

G

-

T

P

P

S

T

E

E

binding adenosine-5'-diphosphate: F14 (≠ Y12), F17 (≠ I15), N39 (= N37), G40 (= G38), G42 (= G40), K43 (= K41), T44 (≠ S42), T45 (= T43), T135 (= T141), F136 (≠ L142), S137 (= S143)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
32% identity, 92% coverage: 1:222/241 of query aligns to 4:226/233 of P75957

query
sites
P75957

M

I

L

L

L

L

S

Q

I

C

E

D

N

N

L

L

Y

C

V

K

K

R

Y

Y

-

Q

-

E

G

G

N

S

I

V

E

Q

A

T

-

D

-

V

L

L

H

H

G

N

L

V

S

S

F

F

H

S

V

V

N

G

E

E

G

G

E

E

I

M

V

M

T

A

L

I

I

V

G
|
G

A

S

N

S

G

G

A

S

G

G

K

K

S

S

T

T

T

L

L

L

K

H

S

L

I

L

M

G

R

G

L

L

P

D

P

T

P

P

E

-

A

-

P

-

K

-

V

-

S

T

G

S

G

G

D

D

I

V

L

I

F

F

K

N

G

G

K

Q

-

P

-

M

S

S

L

K

L

L

N

S

V

S

E

A

P

A

H

K

D

A

V

E

V

L

S

R

K

N

L

Q

H

K

V

L

A

G

L

F

V

I

P

Y

E

Q

G

F

R

H

H

H

I

L

F

L