SitesBLAST
Comparing 8501148 FitnessBrowser__Miya:8501148 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
58% identity, 91% coverage: 23:581/615 of query aligns to 3:539/539 of 6lpiB
- active site: I27 (= I47), G29 (= G49), G30 (= G50), S31 (≠ A51), I32 (≠ N52), E53 (= E73), C76 (≠ T96), F115 (= F135), Q116 (= Q136), E117 (= E137), K165 (= K185), M256 (= M281), A283 (= A308), V375 (= V412), G401 (= G438), M403 (= M440), D428 (= D465), N455 (= N492), A457 (= A494), L458 (= L495), L460 (= L497), V461 (= V498), Q464 (= Q501)
- binding flavin-adenine dinucleotide: R155 (= R175), G212 (= G235), G213 (= G236), G214 (= G237), T236 (= T261), L237 (= L262), M238 (= M263), L254 (= L279), M256 (= M281), H257 (= H282), G276 (= G301), A277 (= A302), R278 (= R303), D280 (= D305), R282 (= R307), A283 (= A308), D300 (= D325), I301 (= I326), D319 (= D344), V320 (= V345), M380 (= M417), G398 (= G435)
- binding magnesium ion: D428 (= D465), N455 (= N492)
- binding thiamine diphosphate: E53 (= E73), C76 (≠ T96), P79 (= P99), G376 (= G413), Q377 (= Q414), H378 (= H415), G401 (= G438), M403 (= M440), G427 (= G464), D428 (= D465), G429 (= G466), S430 (= S467), M433 (= M470), N455 (= N492), A457 (= A494), L458 (= L495), G459 (= G496), L460 (= L497), V461 (= V498)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
43% identity, 92% coverage: 7:574/615 of query aligns to 79:651/667 of P09342
- C161 (≠ F93) modified: Disulfide link with 307
- P194 (= P126) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A240) modified: Disulfide link with 161
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/583 of 5k3sA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R307), M485 (≠ L497), W489 (≠ Q501), G569 (= G574)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), M266 (= M281), G286 (= G301), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), D453 (= D465), G454 (= G466), S455 (= S467), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
42% identity, 90% coverage: 21:574/615 of query aligns to 96:654/670 of P17597
- A122 (= A51) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L53) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E73) binding
- S186 (= S115) binding
- P197 (= P126) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ G128) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q136) binding
- K220 (= K149) binding
- R246 (= R175) binding ; binding
- K256 (= K185) binding
- G308 (= G236) binding
- TL 331:332 (= TL 261:262) binding
- C340 (≠ A270) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 279:282) binding
- GVRFD 371:375 (≠ GARFD 301:305) binding
- DR 376:377 (= DR 306:307) binding
- DI 395:396 (= DI 325:326) binding
- DV 414:415 (= DV 344:345) binding
- QH 487:488 (= QH 414:415) binding
- GG 508:509 (= GG 435:436) binding
- GAM 511:513 (≠ GTM 438:440) binding
- D538 (= D465) binding
- DGS 538:540 (= DGS 465:467) binding
- N565 (= N492) binding
- NQHLGM 565:570 (≠ NNALGL 492:497) binding
- H567 (≠ A494) binding
- W574 (≠ Q501) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P573) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/585 of 5k2oA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M281), R292 (= R307), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), G286 (= G301), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), Q404 (= Q416), M405 (= M417), G423 (= G435)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), M428 (= M440), D453 (= D465), G454 (= G466), S455 (= S467), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 10:568/582 of 3ea4A
- active site: Y32 (≠ I47), G34 (= G49), G35 (= G50), A36 (= A51), S37 (≠ N52), E58 (= E73), T81 (= T96), F120 (= F135), Q121 (= Q136), E122 (= E137), K170 (= K185), M265 (= M281), V292 (≠ A308), V399 (= V412), G425 (= G438), M427 (= M440), D452 (= D465), N479 (= N492), H481 (≠ A494), L482 (= L495), M484 (≠ L497), V485 (= V498), W488 (≠ Q501), H557 (≠ A563)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D306), R291 (= R307), W488 (≠ Q501), S567 (≠ P573)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R175), G221 (= G235), G222 (= G236), G223 (= G237), T245 (= T261), L246 (= L262), M247 (= M263), L263 (= L279), G264 (= G280), M265 (= M281), H266 (= H282), G285 (= G301), R287 (= R303), D289 (= D305), R291 (= R307), D309 (= D325), I310 (= I326), G327 (= G343), D328 (= D344), V329 (= V345), M404 (= M417), G422 (= G435)
- binding magnesium ion: D452 (= D465), N479 (= N492), H481 (≠ A494)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V412), G400 (= G413), Q401 (= Q414), H402 (= H415), M427 (= M440), G451 (= G464), D452 (= D465), G453 (= G466), S454 (= S467), N479 (= N492), H481 (≠ A494), L482 (= L495), G483 (= G496), M484 (≠ L497), V485 (= V498)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 10:568/582 of 3e9yA
- active site: Y32 (≠ I47), G34 (= G49), G35 (= G50), A36 (= A51), S37 (≠ N52), E58 (= E73), T81 (= T96), F120 (= F135), Q121 (= Q136), E122 (= E137), K170 (= K185), M265 (= M281), V292 (≠ A308), V399 (= V412), G425 (= G438), M427 (= M440), D452 (= D465), N479 (= N492), H481 (≠ A494), L482 (= L495), M484 (≠ L497), V485 (= V498), W488 (≠ Q501), H557 (≠ A563)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D306), R291 (= R307), W488 (≠ Q501), S567 (≠ P573)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R175), G221 (= G235), G222 (= G236), G223 (= G237), T245 (= T261), L246 (= L262), M247 (= M263), L263 (= L279), G285 (= G301), R287 (= R303), D289 (= D305), R291 (= R307), D309 (= D325), I310 (= I326), G327 (= G343), D328 (= D344), V329 (= V345), M404 (= M417), G422 (= G435)
- binding magnesium ion: D452 (= D465), N479 (= N492), H481 (≠ A494)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V412), G400 (= G413), Q401 (= Q414), H402 (= H415), M427 (= M440), G451 (= G464), G453 (= G466), S454 (= S467), N479 (= N492), H481 (≠ A494), L482 (= L495), G483 (= G496), M484 (≠ L497), V485 (= V498)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
43% identity, 90% coverage: 21:574/615 of query aligns to 90:648/664 of P09114
- P191 (= P126) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ Q501) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), G452 (= G464), D453 (= D465), G454 (= G466), S455 (= S467), M458 (= M470), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), R292 (= R307), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435)
- binding magnesium ion: F370 (≠ M382), D453 (= D465), M458 (= M470), Q461 (= Q473), N480 (= N492), H482 (≠ A494), K533 (≠ S538)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M281), R292 (= R307), M485 (≠ L497), W489 (≠ Q501), S568 (≠ P573)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 5wj1A
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), M263 (= M278), L264 (= L279), G286 (= G301), R288 (= R303), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M281), D291 (= D306), R292 (= R307), M485 (≠ L497), W489 (≠ Q501), S568 (≠ P573)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), M428 (= M440), D453 (= D465), G454 (= G466), S455 (= S467), M458 (= M470), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 5k6tA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H282), R292 (= R307), M485 (≠ L497), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), G286 (= G301), R288 (= R303), D290 (= D305), R292 (= R307), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), Q404 (= Q416), M405 (= M417), G423 (= G435)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), G452 (= G464), G454 (= G466), S455 (= S467), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 5k6rA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R307), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), M266 (= M281), G286 (= G301), R288 (= R303), R292 (= R307), V293 (≠ A308), D310 (= D325), I311 (= I326), G328 (= G343), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), D453 (= D465), G454 (= G466), S455 (= S467), M458 (= M470), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1z8nA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K149), R161 (= R175), Y191 (≠ Q205), R194 (vs. gap), D291 (= D306), R292 (= R307), D312 (= D327), W489 (≠ Q501), G569 (= G574)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), G265 (= G280), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), R292 (= R307), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492)
- binding thiamine diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), G452 (= G464), G454 (= G466), S455 (= S467), N480 (= N492), H482 (≠ A494), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1yi1A
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D306), R292 (= R307), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), M263 (= M278), L264 (= L279), G265 (= G280), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1yi0A
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D306), R292 (= R307), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), G265 (= G280), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), R292 (= R307), V293 (≠ A308), D310 (= D325), I311 (= I326), G328 (= G343), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1yhzA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D306), R292 (= R307), M485 (≠ L497), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), Q404 (= Q416), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1yhyA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D306), R292 (= R307), V486 (= V498), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), G265 (= G280), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), Q404 (= Q416), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 1ybhA
- active site: Y33 (≠ I47), G35 (= G49), G36 (= G50), A37 (= A51), S38 (≠ N52), E59 (= E73), T82 (= T96), F121 (= F135), Q122 (= Q136), E123 (= E137), K171 (= K185), M266 (= M281), V293 (≠ A308), V400 (= V412), G426 (= G438), M428 (= M440), D453 (= D465), N480 (= N492), H482 (≠ A494), L483 (= L495), M485 (≠ L497), V486 (= V498), W489 (≠ Q501), H558 (≠ A563)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M281), D291 (= D306), R292 (= R307), M485 (≠ L497), W489 (≠ Q501), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R175), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), L264 (= L279), M266 (= M281), H267 (= H282), G286 (= G301), V287 (≠ A302), R288 (= R303), D290 (= D305), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), Q404 (= Q416), M405 (= M417), G423 (= G435), G424 (= G436)
- binding magnesium ion: D453 (= D465), N480 (= N492), H482 (≠ A494)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
42% identity, 90% coverage: 21:574/615 of query aligns to 11:569/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M281), R292 (= R307), W489 (≠ Q501), S568 (≠ P573)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G438), M428 (= M440), G452 (= G464), D453 (= D465), G454 (= G466), S455 (= S467), L483 (= L495), G484 (= G496), M485 (≠ L497), V486 (= V498)
- binding flavin-adenine dinucleotide: R161 (= R175), G222 (= G235), G223 (= G236), G224 (= G237), T246 (= T261), L247 (= L262), M248 (= M263), M263 (= M278), L264 (= L279), M266 (= M281), H267 (= H282), G286 (= G301), R288 (= R303), V293 (≠ A308), D310 (= D325), I311 (= I326), D329 (= D344), V330 (= V345), M405 (= M417), G423 (= G435)
- binding magnesium ion: A37 (= A51), T82 (= T96), S83 (= S97), Q122 (= Q136), Y381 (≠ G393), D453 (= D465), M458 (= M470), Q461 (= Q473), N480 (= N492), H482 (≠ A494), K533 (≠ S538)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
38% identity, 95% coverage: 28:612/615 of query aligns to 12:599/599 of 1n0hA
- active site: Y31 (≠ I47), G33 (= G49), G34 (= G50), A35 (= A51), I36 (≠ N52), E57 (= E73), T80 (= T96), F119 (= F135), Q120 (= Q136), E121 (= E137), K169 (= K185), R230 (≠ D245), M266 (= M281), V293 (≠ A308), V409 (= V412), L434 (= L437), G435 (= G438), M437 (= M440), D462 (= D465), N489 (= N492), E491 (≠ A494), Q492 (≠ L495), M494 (≠ L497), V495 (= V498), W498 (≠ Q501), L520 (≠ I524), G525 (= G529), L526 (≠ V530), K559 (≠ A563)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V412), G410 (= G413), Q411 (= Q414), H412 (= H415), G435 (= G438), M437 (= M440), G461 (= G464), D462 (= D465), A463 (≠ G466), S464 (= S467), M467 (= M470), N489 (= N492), E491 (≠ A494), Q492 (≠ L495), G493 (= G496), V495 (= V498)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G50), A35 (= A51), V109 (= V125), P110 (= P126), F119 (= F135), K169 (= K185), M266 (= M281), D291 (= D306), R292 (= R307), V495 (= V498), W498 (≠ Q501)
- binding flavin-adenine dinucleotide: R159 (= R175), G219 (= G235), A220 (≠ G236), G221 (= G237), N224 (≠ A240), T246 (= T261), L247 (= L262), Q248 (≠ M263), L264 (= L279), G265 (= G280), M266 (= M281), H267 (= H282), G286 (= G301), A287 (= A302), R288 (= R303), D290 (= D305), R292 (= R307), V293 (≠ A308), E319 (≠ D325), V320 (≠ I326), N324 (≠ E330), G337 (= G343), D338 (= D344), A339 (≠ V345), M414 (= M417), G432 (= G435), G433 (= G436)
- binding magnesium ion: D462 (= D465), N489 (= N492), E491 (≠ A494)
- binding thiamine diphosphate: Y31 (≠ I47), E57 (= E73), P83 (= P99)
Query Sequence
>8501148 FitnessBrowser__Miya:8501148
MPAHTPSRTAPGTASGAAPTPRKRQPNGADLVIRLLERQGIDVIAGIPGGANLPLYDALG
RAGSIRHVLARHEQGAGFMAQGMARVTGRPAVFFATSGPGATNTLTAIADAKLDSVPVVC
ITGQVPLGLVGSDAFQEVDIYGMSIPVTKHNFLVRSVEELAEVIPAAFRIAASGRPGPVL
VDIPKNVQMAEVDQAVFDNPPQPGQPAAPPAPDPAGISRAAALLNAAQRPMLYLGGGVVA
SGASDMAVQLAERAGLPTVMTLMALGAMPAGHPLSLGMLGMHAARHTNLLLAECDVLLVA
GARFDDRAVGKAERFCPGATIIHIDIDESELDKILPVHCGITGDVGLALAELLPLLRTRA
EAGREAWLTRVEECRRRHPFVMPGADDPRTPYGLIRCAADAVDHDAIVATDVGQHQMRTA
QAYPLRGPRRWLTSGGLGTMGFGLPAAIGAALARPEATVLCFTGDGSLQMNIQELATAAE
EGVNVKILLADNNALGLVRQQQELFYEGRLVASTYRRKVDFARIAEGFGVPAVDLDASEH
PLRDLADALRAPGPCLIRVTVPAGANVYPMVPPGADNLQMIGGEPEPGDAMPALSYDDDD
CDTHADATGGRHVHA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory