Comparing 8501302 FitnessBrowser__Miya:8501302 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P25665 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Escherichia coli (strain K12) (see 3 papers)
53% identity, 100% coverage: 3:779/780 of query aligns to 5:753/753 of P25665
Sites not aligning to the query:
Q9UT19 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
47% identity, 100% coverage: 1:778/780 of query aligns to 2:761/764 of Q9UT19
4l61A Crystal structure of the candida albicans methionine synthase in complex with methionine (see paper)
46% identity, 100% coverage: 1:777/780 of query aligns to 2:753/755 of 4l61A
P82610 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 4 papers)
46% identity, 100% coverage: 1:777/780 of query aligns to 2:764/767 of P82610
Sites not aligning to the query:
4qquA Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation (see paper)
46% identity, 100% coverage: 1:777/780 of query aligns to 2:763/766 of 4qquA
4l6hA Crystal structure of the candida albicans methionine synthase in complex with methotrexate and homocysteine (see paper)
46% identity, 100% coverage: 1:777/780 of query aligns to 2:758/761 of 4l6hA
O50008 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1; Cobalamin-independent methionine synthase 1; AtMS1; Vitamin-B12-independent methionine synthase 1; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
46% identity, 100% coverage: 1:777/780 of query aligns to 1:758/765 of O50008
4l6oA Crystal structure of the candida albicans methionine synthase in complex with glutamine (see paper)
45% identity, 100% coverage: 1:777/780 of query aligns to 2:743/746 of 4l6oA
4ztxA Neurospora crassa cobalamin-independent methionine synthase complexed with zn2+ (see paper)
45% identity, 100% coverage: 1:778/780 of query aligns to 1:762/768 of 4ztxA
3ppcB Crystal structure of the candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc (see paper)
45% identity, 100% coverage: 1:777/780 of query aligns to 3:732/735 of 3ppcB
1u22A A. Thaliana cobalamine independent methionine synthase (see paper)
46% identity, 99% coverage: 3:777/780 of query aligns to 2:744/746 of 1u22A
1u1jA A. Thaliana cobalamine independent methionine synthase (see paper)
46% identity, 99% coverage: 3:777/780 of query aligns to 2:744/746 of 1u1jA
1u1hA A. Thaliana cobalamine independent methionine synthase (see paper)
46% identity, 99% coverage: 3:777/780 of query aligns to 2:744/746 of 1u1hA
4l64A Crystal structure of the candida albicans methionine synthase in complex with 5-methyl-tetrahydrofolate (see paper)
44% identity, 100% coverage: 1:777/780 of query aligns to 2:733/733 of 4l64A
Q8CWX6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
44% identity, 100% coverage: 2:778/780 of query aligns to 3:741/745 of Q8CWX6
3t0cA Crystal structure of streptococcus mutans mete complexed with zinc (see paper)
45% identity, 100% coverage: 2:778/780 of query aligns to 4:735/737 of 3t0cA
Q9X112 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
41% identity, 100% coverage: 1:778/780 of query aligns to 1:730/734 of Q9X112
1t7lA Crystal structure of cobalamin-independent methionine synthase from t. Maritima (see paper)
41% identity, 100% coverage: 2:778/780 of query aligns to 3:731/734 of 1t7lA
1xpgA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and methyltetrahydrofolate (see paper)
41% identity, 100% coverage: 2:778/780 of query aligns to 3:731/734 of 1xpgA
1xdjA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine (see paper)
40% identity, 100% coverage: 2:778/780 of query aligns to 2:719/722 of 1xdjA
>8501302 FitnessBrowser__Miya:8501302
MRTHTLGFPRIGGNRELKKAVEDYWKGAATRQQLEDAARAIRLRNWTLQREAGIDVVPVG
DFALYDHILDAALLLGVIPPRFRNDDAPRDIDLMFRMARGQGGDRPVAPLEMTKWFDTNY
HYLVPELDAATTFAPDAAPLLALIDEALAAGFTPKAVLPGPMTFLWLSKRVDGGTRWSLL
PALLDAYGALLRDVAARCPLIQLDEPILSLDLADDIRSRFVPAYARLRVAVPDATLLLAS
YFAPVGDNLPVALSLPVDVVHLDLVRGPEDLTPALDILTRAAARQPADSGLPQSGSQSGI
ALSLGVINGRNVWRVDADKAAAPVRAAVAALGPDRVWVAPSCSLLHCPVDLDAETGLDPE
VAQWLAFARQKCAEVRLVADMCDLNGRADAPETAAALARNRAALAARAASPVIHDPAVAV
RAGTVTPEMGWRATPYTARIAAQRAALRLPVLPATTIGSFPQTVDIRAQRRKLRTGQITE
AQYDAAMREAIATAIREQEALGLDVLVHGEPERNDMVEYFGEQLRGFCITANGWVQSYGT
RCVKPPLLYGDVARPGPMTVRWITHAQSLTQKPVKGMLTGPVTIACWSFVRDDVPRPVVF
RQLALAIRDEVADLEAAGIGVIQIDEPALREGLPLRRAAHAAYLDAAVGAFRLASSGVRD
ATQIHTHMCYCDFHDIIDHVAALDADVISLEASRSRMELLDVFATHAYPNEVGPGVYDIH
SPRVPSIDEMETLLRAASRVLPLDRLWANPDCGLKTRDWPETRASLAHLVAAATRVREGG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory