Comparing 8502167 FitnessBrowser__Miya:8502167 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
P23533 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Staphylococcus carnosus (strain TM300) (see paper)
38% identity, 97% coverage: 1:574/591 of query aligns to 1:572/573 of P23533
2wqdA Crystal structure of enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state (see paper)
37% identity, 96% coverage: 4:572/591 of query aligns to 2:570/570 of 2wqdA
P08839 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Escherichia coli (strain K12) (see 2 papers)
36% identity, 98% coverage: 5:582/591 of query aligns to 1:574/575 of P08839
2hwgA Structure of phosphorylated enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system (see paper)
37% identity, 97% coverage: 6:581/591 of query aligns to 1:572/572 of 2hwgA
2xz7A Crystal structure of the phosphoenolpyruvate-binding domain of enzyme i in complex with phosphoenolpyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
47% identity, 54% coverage: 252:572/591 of query aligns to 1:321/324 of 2xz7A
2xz9A Crystal structure from the phosphoenolpyruvate-binding domain of enzyme i in complex with pyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
48% identity, 53% coverage: 262:572/591 of query aligns to 4:314/317 of 2xz9A
Q02KR1 Phosphoenolpyruvate synthase; PEP synthase; Pyruvate, water dikinase; EC 2.7.9.2 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
25% identity, 63% coverage: 161:533/591 of query aligns to 388:777/791 of Q02KR1
5lu4A C4-type pyruvate phosphate dikinase: conformational intermediate of central domain in the swiveling mechanism (see paper)
23% identity, 65% coverage: 149:534/591 of query aligns to 415:841/850 of 5lu4A
Sites not aligning to the query:
5jvjB C4-type pyruvate phosphate dikinase: different conformational states of the nucleotide binding domain in the dimer (see paper)
23% identity, 65% coverage: 149:534/591 of query aligns to 342:786/797 of 5jvjB
Sites not aligning to the query:
1kc7A Pyruvate phosphate dikinase with bound mg-phosphonopyruvate (see paper)
23% identity, 64% coverage: 157:534/591 of query aligns to 421:859/872 of 1kc7A
Sites not aligning to the query:
P22983 Pyruvate, phosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Clostridium symbiosum (Bacteroides symbiosus) (see 4 papers)
23% identity, 64% coverage: 157:534/591 of query aligns to 422:860/874 of P22983
Sites not aligning to the query:
Q39735 Pyruvate, phosphate dikinase, chloroplastic; Cold-sensitive pyruvate, orthophosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Flaveria bidentis (Coastal plain yellowtops) (Ethulia bidentis) (see 2 papers)
22% identity, 65% coverage: 149:534/591 of query aligns to 494:942/953 of Q39735
Sites not aligning to the query:
5jvlA C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
22% identity, 65% coverage: 149:534/591 of query aligns to 415:863/874 of 5jvlA
Sites not aligning to the query:
O23404 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
22% identity, 67% coverage: 141:534/591 of query aligns to 496:951/963 of O23404
5jvlB C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
28% identity, 34% coverage: 337:534/591 of query aligns to 289:509/520 of 5jvlB
Sites not aligning to the query:
1vbgA Pyruvate phosphate dikinase from maize (see paper)
23% identity, 67% coverage: 141:534/591 of query aligns to 407:863/874 of 1vbgA
Sites not aligning to the query:
P11155 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Zea mays (Maize) (see 7 papers)
21% identity, 67% coverage: 141:534/591 of query aligns to 480:936/947 of P11155
Sites not aligning to the query:
1vbhA Pyruvate phosphate dikinase with bound mg-pep from maize (see paper)
23% identity, 67% coverage: 141:534/591 of query aligns to 398:851/862 of 1vbhA
Sites not aligning to the query:
P37349 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM; Dihydroxyacetone kinase subunit M; EC 2.7.1.121 from Escherichia coli (strain K12) (see paper)
27% identity, 31% coverage: 18:202/591 of query aligns to 258:440/472 of P37349
Sites not aligning to the query:
>8502167 FitnessBrowser__Miya:8502167
MAREILQGIAVSAGVSIGKAFFTNRRRRSVSFEIIPPGAADSEVARLEQAASDVRDDLAR
ARDNVPAELRDHAAIINSHMMICQDPKLIRAASQRIRDHHICAEWALDQAVEAIAAAFSA
IEDPYIRERVQDVRAVAERIQTRLVGRHAEPLRTPDERIVLMAHDLTPADAMGLPTVKIM
SFATAEGGKTSHTGILARSLQIPAVVGVSSLEESVADGDLVIVDALRGLIVVDPDETELA
DYTDLKYQFENYQKSIRRQSTLPAETLDGYRIDVQANIELVEEVPQVLDGGGDGVGLYRT
EYAFLNRRTSPTEEELYDEYSQLAGLLSPRRVVFRTLDVGADKMLSEQSQLEEPNPALGL
RAIRFCLRHQDVFRRQLRAILRASAHGSASLLFPMISGLHELRQAKHILNEVRAELDAAG
LPYDPDMPVGIMVELPSAVMISEALAQEVDFFSIGTNDLIQYSLGIDRGNKHVSYLYQPL
HPAIVRSIKYVVDSAHRMGISVCVCGEVASDPYCLPILLGMQIDAISIAPQAIPGIKHIL
RRTNMEECKELLRDVLSASTVSTINRMVKETIYNRFPEELTFFSSMLDQDD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory