SitesBLAST
Comparing 8502321 DvMF_3029 ABC transporter related (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
33% identity, 89% coverage: 26:505/537 of query aligns to 1:484/501 of P04983
- K43 (= K68) mutation to R: Loss of transport.
4u00A Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 40% coverage: 28:244/537 of query aligns to 1:217/241 of 4u00A
3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 40% coverage: 37:250/537 of query aligns to 11:225/242 of 3c4jA
- binding phosphothiophosphoric acid-adenylate ester: F13 (= F39), V18 (≠ A44), P37 (≠ E63), S38 (≠ N64), G39 (= G65), S40 (≠ A66), G41 (= G67), K42 (= K68), S43 (= S69), T44 (= T70), H133 (≠ A158), Y135 (≠ R160), E164 (= E189)
3c41J Abc protein artp in complex with amp-pnp/mg2+
29% identity, 40% coverage: 37:250/537 of query aligns to 11:225/242 of 3c41J
- binding phosphoaminophosphonic acid-adenylate ester: F13 (= F39), V18 (≠ A44), P37 (≠ E63), S38 (≠ N64), G39 (= G65), S40 (≠ A66), G41 (= G67), K42 (= K68), S43 (= S69), T44 (= T70), R47 (≠ S73), H133 (≠ A158), Y135 (≠ R160)
- binding magnesium ion: S43 (= S69), D163 (= D188)
2olkA Abc protein artp in complex with adp-beta-s
29% identity, 40% coverage: 37:250/537 of query aligns to 11:225/242 of 2olkA
2oljA Abc protein artp in complex with adp/mg2+
29% identity, 40% coverage: 37:250/537 of query aligns to 11:225/242 of 2oljA
- binding adenosine-5'-diphosphate: F13 (= F39), V18 (≠ A44), S38 (≠ N64), G39 (= G65), S40 (≠ A66), G41 (= G67), K42 (= K68), S43 (= S69), T44 (= T70), H133 (≠ A158), Y135 (≠ R160)
4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
28% identity, 40% coverage: 29:244/537 of query aligns to 1:217/240 of 4ymuJ
- binding adenosine-5'-triphosphate: F11 (= F39), L14 (≠ V42), V16 (≠ A44), S36 (≠ N64), G37 (= G65), S38 (≠ A66), G39 (= G67), K40 (= K68), S41 (= S69), T42 (= T70), E51 (≠ L79), E162 (= E189), H194 (= H221)
- binding magnesium ion: S41 (= S69), E162 (= E189)
P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 45% coverage: 29:269/537 of query aligns to 1:249/343 of P30750
- 40:46 (vs. 64:70, 86% identical) binding
- E166 (= E189) mutation to Q: Exhibits little ATPase activity.
Sites not aligning to the query:
- 278:283 binding
- 295 N→A: Reduces the binding of L-methionine to undetectable levels.
- 295:296 binding
4hluC Structure of the ecfa-a' heterodimer bound to adp (see paper)
31% identity, 43% coverage: 30:259/537 of query aligns to 5:238/249 of 4hluC
4zirB Crystal structure of ecfaa' heterodimer bound to amppnp (see paper)
31% identity, 43% coverage: 30:259/537 of query aligns to 4:234/247 of 4zirB
- binding phosphoaminophosphonic acid-adenylate ester: Y13 (≠ F39), V18 (≠ A44), K37 (≠ E63), N38 (= N64), G39 (= G65), S40 (≠ A66), G41 (= G67), K42 (= K68), T43 (≠ S69), T44 (= T70), Q80 (= Q111), N129 (≠ G163), L130 (= L164), S131 (= S165), G132 (≠ M166), G133 (= G167), Q134 (≠ E168), E155 (= E189), H187 (= H221)
- binding magnesium ion: T43 (≠ S69), Q80 (= Q111), D154 (= D188)
1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
25% identity, 40% coverage: 29:244/537 of query aligns to 4:231/254 of 1g6hA
6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 45% coverage: 29:269/537 of query aligns to 2:250/344 of 6cvlD
- binding phosphothiophosphoric acid-adenylate ester: F12 (= F39), Q14 (≠ K41), I19 (≠ V42), S41 (≠ N64), G42 (= G65), A43 (= A66), G44 (= G67), K45 (= K68), S46 (= S69), T47 (= T70), N141 (≠ G163), L142 (= L164), S143 (= S165), G144 (≠ M166), G145 (= G167), Q146 (≠ E168), H200 (= H221)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
29% identity, 45% coverage: 29:269/537 of query aligns to 2:250/344 of 3tuzC
Sites not aligning to the query:
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
29% identity, 45% coverage: 29:269/537 of query aligns to 2:250/344 of 3tuiC
E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
29% identity, 45% coverage: 1:239/537 of query aligns to 1315:1553/2595 of E9Q876
- 1388:1461 (vs. 72:146, 28% identical) mutation to M: In a mouse model for harlequin ichthyosis (HI), smooth skin (smsk) mutant mice show a pronounced perinatal lethal skin phenotype in 25% of the offspring and newborn mutant pups die within a few hours after birth, and appear severely dehydrated with dry cracking skin. Smsk homozygous mutants embryos show a normal appearance at 14.5 dpc, but at 16.5 dpc develop a partial absence of normal skin folds around the trunk and limbs, and by 18.5 dpc develop a taut, thick skin and limb contractures.
Sites not aligning to the query:
- 1996 G→D: In a mouse model for harlequin ichthyosis (HI), homozygous mice are embryonic lethal but occasionally pups are found in the first few hours after birth but die and are severely dehydrated and fail to suckle normally. Homozygous pups show hallmarks of HI desease including hyperkeratosis, abnormal extracellular lipid lamellae and defects in cornified envelope processing. At 14.5 dpc and 15.5 dpc homozygous embryos appear normal; however from 16.5 dpc onwards they are characterized by an absence of normal skin folds around the trunk and limbs. As development progressed, embryos develop a taut, thick epidermis and multiple contractures affecting the limbs. Late stage embryos are smaller.
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
25% identity, 40% coverage: 29:244/537 of query aligns to 4:231/253 of 1g9xB
7mdyC Lolcde nucleotide-bound
29% identity, 41% coverage: 29:246/537 of query aligns to 2:225/226 of 7mdyC
- binding adp orthovanadate: Y12 (≠ F39), T19 (≠ A44), V21 (vs. gap), S40 (≠ E63), S41 (≠ N64), G42 (= G65), S43 (≠ A66), G44 (= G67), K45 (= K68), S46 (= S69), T47 (= T70), Q91 (= Q111), R135 (≠ D156), H138 (≠ A159), E142 (≠ G163), S144 (= S165), G145 (≠ M166), G146 (= G167), E147 (= E168), E168 (= E189), N172 (≠ V193), H201 (= H221)
- binding magnesium ion: S46 (= S69), Q91 (= Q111)
P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
29% identity, 41% coverage: 29:246/537 of query aligns to 5:228/233 of P75957