SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 8502446 DvMF_3152 extracellular solute-binding protein family 3 (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5eyfB Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
41% identity, 86% coverage: 25:257/271 of query aligns to 6:239/243 of 5eyfB

query
sites
5eyfB

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binding glutamic acid: K20 (= K39), S65 (= S81), R68 (= R84), T83 (= T99), M84 (= M100), T85 (= T101), R90 (= R106), G132 (= G147), S133 (= S148), T134 (= T149), Y154 (= Y169), T171 (= T186), D172 (= D187), E196 (= E214)

4zv2A An ancestral arginine-binding protein bound to glutamine (see paper)
43% identity, 83% coverage: 31:254/271 of query aligns to 3:225/225 of 4zv2A

query
sites
4zv2A

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binding glutamine: E11 (≠ K39), F14 (≠ T42), F52 (≠ S81), A69 (= A98), G70 (≠ T99), M71 (= M100), T72 (= T101), R77 (= R106), S120 (= S148), T121 (= T149), D159 (= D187)

4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
43% identity, 82% coverage: 31:253/271 of query aligns to 3:226/226 of 4zv1A

query
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4zv1A

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binding arginine: E11 (≠ K39), F14 (≠ T42), F52 (≠ S81), A69 (= A98), G70 (≠ T99), M71 (= M100), T72 (= T101), R77 (= R106), Q117 (≠ A145), S120 (= S148), T121 (= T149), D161 (= D187)

2ia4B Crystal structure of novel amino acid binding protein from shigella flexneri
37% identity, 86% coverage: 20:252/271 of query aligns to 4:246/278 of 2ia4B

query
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2ia4B

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binding glutamic acid: R23 (≠ K39), S71 (= S81), R74 (= R84), S89 (≠ T99), T90 (≠ M100), T91 (= T101), R96 (= R106), T138 (≠ S148), T139 (= T149), H163 (≠ Y169), M180 (≠ T186), D181 (= D187), L184 (≠ I190), E208 (= E214), Y210 (= Y216)

6h20A Glnh bound to asn, mycobacterium tuberculosis (see paper)
35% identity, 84% coverage: 25:252/271 of query aligns to 44:271/287 of 6h20A

query
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6h20A

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binding asparagine: R106 (= R84), T121 (= T99), M122 (= M100), S123 (≠ T101), R128 (= R106), T170 (≠ S148), T171 (= T149), W191 (≠ Y169), D209 (= D187), I212 (= I190), Q233 (≠ E214)

6h1uA Glnh bound to asp, mycobacterium tuberculosis (see paper)
35% identity, 84% coverage: 25:252/271 of query aligns to 44:271/287 of 6h1uA

query
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6h1uA

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S

T

K

G

Q

E

I

I

V

T

G

G

F

F

D

D

I

V

D

D

I

I

C

A

K

G

A

E

V

V

A

A

-

R

D

D

K

I

L

F

G

G

V

V

-

P

-

S

K

H

L

V

E

E

L

Y

K

R

T

I

V

L

T

S

S

A

A

A

T

E

R
|
R

I

V

P

T

M

A

L

L

T

Q

Q

K

G

S

S

Q

V

V

D

D

M

I

V

V

A

V

A

K

T
|
T

M
|
M

T
x
S

H

I

K

T

F

C

E

E

R
|
R

D

R

D

K

V

L

I

V

D

N

F

F

S

S

I

T

T

V

Y

Y

F

L

M

D

D

A

G

N

Q

Q

K

R

L

I

L

L

V

A

K

P

K

R

G

D

G

S

G

P

V

I

K

T

S

K

A

V

A

S

D

D

L

L

K

S

G

G

K

K

K

R

V

V

A

C

T

V

A

A

K

R

G

G

S
x
T

T
|
T

S

S

E

L

K

R

N

R

I

I

K

R

A

E

A

I

Q

A

P

P

E

P

A

P

T

V

V

I

V

V

S

S

F

V

D

V

E

N

Y
x
W

P

A

Q

D

A

C

F

L

L

V

A

A

L

L

K

Q

Q

Q

G

R

K

E

A

I

E

D

A

A

V

V

T

S

T

T

D
|
D

S

D

T

T

I
|
I

L

L

L

A

G

G

L

L

R

V

N

E

S

E

D

D

P

P

E

-

P

-

D

-

K

Y

W

L

E

H

I

I

V

V

G

G

D

P

Y

D

I

M

S

A

P

D

E
x
Q

P

P

Y

Y

G

G

L

V

G

G

L

I

A

N

E

L

N

D

D

N

S

T

K

G

F

L

R

V

D

R

L

F

V

V

N

N

R

G

T

T

L

L

V

E

D

R

L

I

W

R

N

N

S

D

G

G

E

T

Y

W

V

N

K

T

L

L

Y

Y

D

R

K

K

W

W

F

L

binding aspartic acid: R106 (= R84), T121 (= T99), M122 (= M100), S123 (≠ T101), R128 (= R106), T170 (≠ S148), T171 (= T149), W191 (≠ Y169), D209 (= D187), I212 (= I190), Q233 (≠ E214)

6h2tA Glnh bound to glu, mycobacterium tuberculosis (see paper)
35% identity, 84% coverage: 25:252/271 of query aligns to 45:272/288 of 6h2tA

query
sites
6h2tA

I

V

E

A

D

D

I

I

K

R

A

A

R

R

G

G

A

R

L

L

V

I

C

V

G

G

V

L

K

D

D

I

S

G

T

S

V

N

P

L

F

F

G

S

Y

F

I

R

D

D

E

P

Q

I

S

T

K

G

Q

E

I

I

V

T

G

G

F

F

D

D

I

V

D

D

I

I

C

A

K

G

A

E

V

V

A

A

-

R

D

D

K

I

L

F

G

G

V

V

-

P

-

S

K

H

L

V

E

E

L

Y

K

R

T

I

V

L

T

S

S

A

A

A

T

E

R
|
R

I

V

P

T

M

A

L

L

T

Q

Q

K

G

S

S

Q

V

V

D

D

M

I

V

V

A

V

A

K

T
|
T

M
|
M

T
x
S

H

I

K

T

F

C

E

E

R
|
R

D

R

D

K

V

L

I

V

D

N

F

F

S

S

I

T

T

V

Y

Y

F

L

M

D

D

A

G

N

Q

Q

K

R

L

I

L

L

V

A

K

P

K

R

G

D

G

S

G

P

V

I

K

T

S

K

A

V

A

S

D

D

L

L

K

S

G

G

K

K

K

R

V

V

A

C

T

V

A

A

K

R

G

G

S
x
T

T
|
T

S
|
S

E

L

K

R

N

R

I

I

K

R

A

E

A

I

Q

A

P

P

E

P

A

P

T

V

V

I

V

V

S

S

F

V

D

V

E

N

Y
x
W

P

A

Q

D

A

C

F

L

L

V

A

A

L

L

K

Q

Q

Q

G

R

K

E

A

I

E

D

A

A

V

V

T

S

T
|
T

D
|
D

S

D

T

T

I
|
I

L

L

L

A

G

G

L

L

R

V

N

E

S

E

D

D

P

P

E

-

P

-

D

-

K

Y

W

L

E

H

I

I

V

V

G

G

D

P

Y

D

I

M

S

A

P

D

E
x
Q

P

P

Y

Y

G

G

L

V

G

G

L

I

A

N

E

L

N

D

D

N

S

T

K

G

F

L

R

V

D

R

L

F

V

V

N

N

R

G

T

T

L

L

V

E

D

R

L

I

W

R

N

N

S

D

G

G

E

T

Y

W

V

N

K

T

L

L

Y

Y

D

R

K

K

W

W

F

L

binding glutamic acid: R107 (= R84), T122 (= T99), M123 (= M100), S124 (≠ T101), R129 (= R106), T171 (≠ S148), T172 (= T149), S173 (= S150), W192 (≠ Y169), T209 (= T186), D210 (= D187), I213 (= I190), Q234 (≠ E214)

6svfA Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
36% identity, 85% coverage: 25:254/271 of query aligns to 3:229/229 of 6svfA

query
sites
6svfA

I

I

E

D

D

E

I

I

K

K

A

S

R

R

G

G

A

Y

L

L

V

L

C

V

G

G

V

L

K
x
S

D

A

S
x
D

T
x
F

V

P

P

P

F

F

G
x
E

Y

F

I

V

D

D

E

E

Q

N

S

G

K

-

Q

N

I

I

V

V

G

G

F

F

D

D

I

V

D

D

I

L

C

A

K

K

A

E

V

I

A

A

D

R

K

R

L

L

G

G

V

V

K

E

L

L

E

K

L

I

K

V

T

D

V

M

T

T

S
x
F

A

D

T

G

R

L

I

I

P

P

M

S

L

L

T

L

Q

T

G

K

S

K

V

I

D

D

M

V

V

I

A

I

A
x
S

T
x
G

M
|
M

T
|
T

H

I

K

T

F

E

E

E

R
|
R

D

K

V

V

I

V

D

A

F

F

S

S

I

D

T

P

Y

Y

F

F

M

D

D

A

G

G

Q

Q

K

V

L

I

L

V

V

V

K

R

K

K

G

D

G

S

G

D

V

F

-

R

-

P

K

K

S

T

A

Y

A

E

D

D

L

L

K

V

G

G

K

K

K

T

V

V

A

A

T

V

A
x
Q

K

I

G

G

S
x
T

T
|
T

S

G

E

-

K

-

N

D

I

I

K

E

A

V

A

S

Q

K

P

Y

E

D

A

G

T

I

-

K

V

V

S

R

F

F

D

D

E

K

Y

F

P

T

Q

D

A

A

F

F

L

L

A

E

L

L

K

K

Q

R

G

G

K

R

A

A

E

D

A

A

V

V

T

V

T

L

D
|
D

S

S

T

A

I

T

L

A

L

R

G

A

L

F

R

V

N

A

S

K

D

N

P

P

E

D

P

-

D

-

K

-

W

L

E

V

I

I

V

S

G

S

D

G

Y

V

I

L

S

S

P

S

E

E

P

Q

Y

Y

G

G

L

I

G

A

L

V

A

R

E

K

N

E

D

D

S

T

K

D

F

L

R

L

D

E

L

F

V

I

N

N

R

S

T

V

L

L

V

R

D

E

L

L

W

K

N

K

S

S

G

G

E

K

Y

Y

V

D

K

V

L

L

Y

I

D

E

K

K

W

W

F

F

G

S

K

E

binding arginine: S17 (≠ K39), D19 (≠ S41), F20 (≠ T42), E24 (≠ G46), F58 (≠ S81), S75 (≠ A98), G76 (≠ T99), M77 (= M100), T78 (= T101), R83 (= R106), Q124 (≠ A145), T127 (≠ S148), T128 (= T149), D165 (= D187)

5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
35% identity, 84% coverage: 25:252/271 of query aligns to 3:228/229 of 5t0wA

query
sites
5t0wA

I

L

E

D

D

E

I

I

K

M

A

K

R

R

G

G

A

T

L

L

V

R

C

V

G

G

V

T

K
x
D

D

A

S

D

T
x
Y

V

K

P

P

F

F

G

S

Y

F

I

K

D

D

E

K

Q

N

S

G

K

-

Q

Q

I

Y

V

T

G

G

F

F

D

D

I

I

D

D

I

L

C

A

K

K

A

A

V

L

A

A

D

K

K

E

L

L

G

G

V

V

K

K

L

V

E

E

L

F

K

V

T

P

V

T

T

T

S
x
W

A

D

T

G

R

I

I

I

P

P

M

A

L

L

T

Q

Q

T

G

G

S

K

V

F

D

D

M

I

V

V

A

M

A
x
S

T
x
G

M
|
M

T
|
T

H

I

K

T

F

P

E

E

R
|
R

D

K

V

K

I

V

D

D

F

F

S

S

I

D

T

P

Y

Y

F

M

M

T

D

A

G

G

Q

Q

K

T

L

I

L

L

V

V

K

K

G

D

G

N

G

A

-

D

-

K

V

I

K

K

S

S

A

F

A

E

D

D

L

L

K

N

G

K

K

P

-

D

-

V

K

K

V

V

A

A

T

V

A
x
Q

K

L

G

G

S
x
T

T
|
T

S

S

E

E

K

Q

N

A

I

A

K

K

A

E

A

F

Q

L

P

P

E

K

A

A

T

K

V

I

V

R

S

T

F

F

D

E

E

N

Y

N

P

A

Q

E

A

A

F

F

L

Q

A

E

L

V

K

V

Q

S

G

G

K

R

A

A

E

D

A

A

V

M

T

V

T

T

D
|
D

S

S

T

P

I

V

L

A

G

Y

L

Y

R

A

N

K

S

L

D

-

P

-

E

-

P

-

D

-

K

A

W

V

E

V

I

V

V

V

G

D

D

E

Y

P

I

F

S

T

P

H

E

E

P

P

Y

L

G

G

L

F

G

A

L

I

A

R

E

K

N

G

D

D

S

P

K

E

F

L

R

L

D

N

L

W

V

V

N

N

R

N

T

W

L

L

V

K

D

Q

L

M

W

K

N

K

S

D

G

G

E

T

Y

Y

V

D

K

K

L

L

Y

Y

D

E

K

K

W

W

F

F

binding arginine: D17 (≠ K39), Y20 (≠ T42), W58 (≠ S81), S75 (≠ A98), G76 (≠ T99), M77 (= M100), T78 (= T101), R83 (= R106), Q126 (≠ A145), T129 (≠ S148), T130 (= T149), D168 (= D187)

2v25A Structure of the campylobacter jejuni antigen peb1a, an aspartate and glutamate receptor with bound aspartate (see paper)
35% identity, 85% coverage: 23:251/271 of query aligns to 1:229/231 of 2v25A

query
sites
2v25A

G

G

K

K

I

L

E

E

D

S

I

I

K

K

A

S

R

K

G

G

A

Q

L

L

V

I

C

V

G

G

V

V

K
|
K

D

N

S

D

T

V

V

P

P

H

F

Y

G

A

Y

L

I

L

D

D

E

Q

Q

A

S

T

K

G

Q

E

I

I

V

K

G

G

F

F

D

E

I

V

D

D

I

V

C

A

K

K

A

L

V

L

A

A

D

K

K

S

L

I

-

L

-

G

-

D

G

D

V

K

K

K

L

I

E

K

L

L

K

V

T

A

V

V

T

N

S

A

A

K

T

T

R
|
R

I

G

P

P

M

L

L

L

T

D

Q

N

G

G

S

S

V

V

D

D

M

A

V

V

A

I

A

A

T
|
T

M
x
F

T
|
T

H

I

K

T

F

P

E

E

R
|
R

D

K

D

R

V

I

I

Y

D

N

F

F

S

S

I

E

T

P

Y

Y

F

Y

M

Q

D

D

G

A

Q

I

K

G

L

L

V

V

K

L

K

K

G

E

G

K

V

Y

K

K

S

S

A

L

A

A

D

D

L

M

K

K

G

G

K

A

K

N

V

I

A

G

T

V

A

A

K

Q

G

A

S
x
A

T
|
T

S

T

E

K

K

K

N

A

I

I

-

G

K

E

A

A

Q

K

P

K

E

I

A

G

T

I

V

D

V

V

S

K

F

F

D

S

E

E

-

F

-

P

-

D

Y
|
Y

P

P

Q

S

A

I

F

K

L

A

A

A

L

L

K

D

Q

A

G

K

K

R

A

V

E

D

A

A

V

F

T

S

T

V

D
|
D

S

K

T

S

I
|
I

L

L

G

G

L

Y

R

V

N

D

S

-

D

-

P

-

E

-

P

-

D

D

K

K

W

S

E

E

I

I

V

L

G

P

D

D

Y

S

I

F

S

E

P

P

E
x
Q

P

S

Y

Y

G

G

L

I

G

V

L

T

A

K

E

K

N

D

D

D

S

P

K

A

F

F

R

A

D

K

L

Y

V

V

N

D

R

D

T

F

L

V

V

K

D

E

L

H

W

K

N

N

S

-

G

-

E

E

Y

I

V

D

K

A

L

L

Y

A

D

K

K

K

W

W

binding aspartic acid: K17 (= K39), R65 (= R84), T80 (= T99), F81 (≠ M100), T82 (= T101), R87 (= R106), A129 (≠ S148), T130 (= T149), Y154 (= Y169), D172 (= D187), I175 (= I190), Q194 (≠ E214)

4z9nB Abc transporter / periplasmic binding protein from brucella ovis with glutathione bound
32% identity, 83% coverage: 21:244/271 of query aligns to 4:237/324 of 4z9nB

query
sites
4z9nB

H

H

A

A

G

D

K

T

I

L

E

S

D

D

I

V

K

K

A

A

R

K

G

G

A

F

L

L

V

Q

C

C

G

G

V

V

K
x
N

D
x
T

S

G

T
x
L

V

L

P

G

F

F

G

A

Y

S

I

P

D

N

E

D

Q

K

S

G

K

-

Q

E

I

W

V

S

G

G

F

F

D

D

I

V

D

D

I

Y

C

C

K

R

A

A

V

V

A

A

D

S

K

A

L

I

-

F

-

G

-

D

G

P

V

T

K

K

L

V

E

K

L

F

K

T

T

P

V

L

T
x
N

S
x
A

A

K

T

E

R
|
R

I

F

P

T

M

A

L

L

T

Q

Q

S

G

G

S

E

V

V

D

D

M

V

V

L

A

I

A
x
R

T
x
N

M
x
T

T
|
T

H

W

K

T

F

I

E

S

R
|
R

D

D

D

T

V

S

I

L

-

G

-

L

D

D

F

F

S

A

I

G

T

I

Y

N

F

Y

M

Y

D

D

G

G

Q

Q

K

G

L

F

L

M

V

I

-

N

-

S

K

K

G

L

G

A

G

G

V

I

K

N

S

S

A

A

A

L

D

Q

L

L

K

S

G

G

K

A

K

S

V

I

A

C

T

V

A
x
Q

K

A

G

G

S
x
T

T
|
T

S
x
T

E

E

K

L

N

N

I

M

-

A

-

D

-

Y

-

F

K

R

A

A

A

N

Q

K

P

M

E

E

A

Y

T

N

V

P

V

V

S

V

F

F

D

E

E

K

Y
x
I

P

E

Q

E

A

A

F

N

L

A

A

A

L

Y

K

D

Q

S

G

G

K

R

A

C

E

D

A

A

V

Y

T

T

T
|
T

D
|
D

S

Q

T

S

I
x
S

L

L

L

Y

G

G

L

V

R

R

N

L

S

A

D

L

P

A

E

N

P

P

D

D

K

D

W

H

E

V

I

I

V

L

G

P

D

E

Y

I

I

I

S

S

P

K

E

E

P

P

Y

F

G

G

L

L

G

T

L

V

A

R

E

Q

N

G

D

D

S

A

K

R

F

W

R

A

D

D

L

V

V

V

N

R

R

W

T

T

L

H

V

N

D

A

L

L

W

L

N

N

S

A

G

E

E

E

Y

Y

binding glutathione: N22 (≠ K39), T23 (≠ D40), L25 (≠ T42), N65 (≠ T80), A66 (≠ S81), R69 (= R84), R83 (≠ A98), N84 (≠ T99), T85 (≠ M100), T86 (= T101), R91 (= R106), Q134 (≠ A145), T137 (≠ S148), T138 (= T149), T139 (≠ S150), I162 (≠ Y169), T179 (= T186), D180 (= D187), S183 (≠ I190)

4ymxA Crystal structure of the substrate binding protein of an amino acid abc transporter (see paper)
35% identity, 82% coverage: 32:252/271 of query aligns to 1:222/224 of 4ymxA

query
sites
4ymxA

G

G

A

V

L

I

V

V

C

M

G

G

V

T

K
x
S

D

A

S
x
D

T
x
F

V

P

P

P

F

F

G
x
E

Y

F

-

H

-

K

I

V

D

E

E

G

Q

G

S

K

K

D

Q

E

I

I

V

V

G

G

F

F

D

D

I

I

D

D

I

I

C

A

K

N

A

A

V

I

A

A

D

K

K

K

L

L

G

G

V

V

K

K

L

L

E

E

L

I

K

K

T

D

V

M

T

D

S
x
F

A

K

T

G

R

L

I

I

P

P

M

A

L

L

T

Q

Q

A

G

G

S

R

V

V

D

D

M

M

V

V

A

I

A
|
A

T
x
G

M
|
M

T
|
T

H

P

K

T

F

A

E

E

R
|
R

D

K

V

S

I

V

D

D

F

F

S

S

I

D

T

L

Y

Y

F

Y

M

D

D

S

G

R

Q

Q

K

V

L

V

V

V

K

K

K

N

G

D

G

S

G

P

V

I

K

S

S

K

A

F

A

D

D

D

L

L

K

K

G

V

K

K

K

T

V

I

A

A

T

V

A
x
Q

K

I

G

G

S
x
T

T
|
T

S

S

E

E

K

E

N

A

I

A

K

K

A

K

A

I

Q

-

P

P

E

N

A

V

T

K

V

L

V

K

S

Q

F

L

D

N

E

R

Y

V

P

S

Q

D

A

E

F

F

L

M

A

D

L

L

K

Q

Q

N

G

G

K

R

A

C

E

D

A

A

V

I

T

V

D
x
E

S

D

T

T

I

V

L

A

L

K

G

A

L

Y

R

L

N

K

S

E

D

-

P

-

E

Y

P

K

D

D

K

M

W

K

E

I

I

L

V

Y

G

M

D

D

Y

E

I

I

S

N

P

N

E

V

P

E

Y

N

G

G

-

S

-

A

L

V

G

A

L

V

A

A

E

K

N

G

D

N

S

K

K

S

F

L

R

L

D

D

L

V

V

V

N

N

R

E

T

V

L

I

V

K

D

E

L

L

W

K

N

Q

S

S

G

G

E

E

Y

Y

V

D

K

K

L

L

Y

V

D

D

K

K

W

W

F

F

binding arginine: S8 (≠ K39), D10 (≠ S41), F11 (≠ T42), E15 (≠ G46), F52 (≠ S81), A69 (= A98), G70 (≠ T99), M71 (= M100), T72 (= T101), R77 (= R106), Q116 (≠ A145), T119 (≠ S148), T120 (= T149), E157 (≠ D187)

8eyzA Engineered glutamine binding protein bound to gln and a cobaloxime ligand (see paper)
33% identity, 83% coverage: 34:257/271 of query aligns to 5:226/226 of 8eyzA

query
sites
8eyzA

L

L

V

V

C

V

G

A

V

T

K
x
D

D

T

S

A

T
x
F

V

V

P

P

F

F

G

E

Y

F

I

-

D

-

E

K

Q

Q

S

G

K

D

Q

I

I

Y

V

V

G

G

F

F

D

D

I

V

D

D

I

L

C

W

K

A

A

A

V

I

A

A

D

K

K

E

L

L

G

K

V

L

K

D

L

Y

E

E

L

L

K

K

T

P

V

M

T

D

S
x
F

A

S

T

G

R

I

I

I

P

P

M

A

L

L

T

Q

Q

T

G

K

S

N

V

V

D

D

M

L

V

A

A

L

A
|
A

T
x
G

M

I

T
|
T

H

I

K
x
C

F
x
D

E
|
E

R
|
R

D

K

V

A

I

I

D

D

F

F

S

S

I

D

T

G

Y

Y

F

Y

M

K

D

S

G

G

Q

L

K

L

L

V

L

M

V

V

K

K

K

A

G

N

-

D

V

V

K

K

S

S

A

V

A

K

D

D

L

L

K

D

G

G

K

K

K

V

V

V

A

A

T

V

A
x
K

K

S

G

G

S
x
T

T
x
G

S

S

E

V

K
x
D

N

Y

I

A

K

K

A

A

A

N

Q

I

P

K

E

T

A

K

T

D

V

L

V

R

S

Q

F

F

D

P

E

N

Y

I

P

D

Q

N

A

A

F

Y

L

M

A

E

L

L

K

G

Q

T

G

N

K

R

A

A

E

D

A

A

V

V

T

L

T
x
H

D
|
D

S

T

-

P

T

N

I

I

L

L

L

Y

G

F

L

I

R

K

N

T

S

A

D

G

P

-

E

-

P

N

D

G

K

Q

W

F

E

K

I

A

V

V

G

G

D

D

Y

S

I

L

S
x
E

P

A

E

Q

P

Q

Y

Y

G

G

L

I

G

A

L

F

A

P

E

K

N

G

D

S

S

D

K

E

F

L

R

R

D

D

L

K

V

V

N

N

R

G

T

A

L

L

V

K

D

T

L

L

W

R

N

E

S

N

G

G

E

T

Y

Y

V

N

K

E

L

I

Y

Y

D

K

K

K

W

W

F

F

G

G

K

T

D

E

T

P

K

K

binding glutamine: D10 (≠ K39), F13 (≠ T42), F50 (≠ S81), A67 (= A98), G68 (≠ T99), T70 (= T101), R75 (= R106), K115 (≠ A145), T118 (≠ S148), G119 (≠ T149), H156 (≠ T186), D157 (= D187)
binding azidobis[N~2~,N~3~-dihydroxybut-2-ene-2,3-diaminato(2-)-kappa~2~N,N']cobalt: C72 (≠ K103), D73 (≠ F104), E74 (= E105), G119 (≠ T149), D122 (≠ K152), E181 (≠ S212)

2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
33% identity, 83% coverage: 34:257/271 of query aligns to 3:225/231 of 2q2cA

query
sites
2q2cA

L

V

V

V

C

V

G

G

V

T

K

D

D

A

S

A

T
x
F

V

A

P

P

F

F

G

E

Y

Y

I

M

D

-

E

-

Q

Q

S

K

K

G

Q

K

I

I

V

V

G

G

F

F

D

D

I

V

D

D

I

L

C

L

K

D

A

A

V

V

A

M

D

K

K

A

L

A

G

G

V

L

K

D

L

Y

E

E

L

L

K

K

T

N

V

I

T

G

S
x
W

A

D

T

P

R

L

I

F

P

A

M

S

L

L

T

Q

Q

S

G

K

S

E

V

V

D

D

M

M

V

G

A

I

A
x
S

T
x
G

M
x
I

T
|
T

H

I

K

T

F

D

E

E

R
|
R

D

K

D

Q

V

S

I

Y

D

D

F

F

S

S

I

D

T

P

Y

Y

F

F

M

E

D

A

G

T

Q

Q

K

V

L

I

L

L

V

V

K

K

K

Q

G

G

G

S

G

P

V

V

K

K

S

N

A

A

A

L

D

D

L

L

K

K

G

G

K

K

K

T

V

I

A

G

T

V

A
x
Q

K

N

G

A

S
x
T

T
|
T

S

G

E

Q

K

E

N

A

I

A

-

E

K

K

A

L

A

F

Q

G

P

K

E

G

A

P

T

H

V

I

V

K

S

K

F

F

D

E

E

T

Y

T

P

V

Q

V

A

A

F

I

L

M

A

E

L

L

K

L

Q

N

G

G

K

G

A

V

E

D

A

A

V

V

T

I

T

T

D
|
D

S

N

T

A

I

V

L

A

L

N

G

E

L

Y

R

V

N

K

S

N

D

N

P

P

E

N

P

-

D

K

K

K

W

L

E

Q

I

V

V

I

G

E

D

D

-

P

-

K

Y

N

I

F

S

A

P

S

E

E

P

Y

Y

Y

G

G

L

M

G

I

L

F

A

P

E

K

N

N

D

-

S

S

K

E

F

L

R

K

D

A

L

K

V

V

N

D

R

E

T

A

L

L

V

K

D

N

L

V

W

I

N

N

S

S

G

G

E

K

Y

Y

V

T

K

E

L

I

Y

Y

D

K

K

K

W

W

F

F

G

G

K

K

D

E

T

P

K

K

binding histidine: F11 (≠ T42), W48 (≠ S81), S65 (≠ A98), G66 (≠ T99), I67 (≠ M100), T68 (= T101), R73 (= R106), Q112 (≠ A145), T115 (≠ S148), T116 (= T149), D155 (= D187)

3vv5A Crystal structure of ttc0807 complexed with (s)-2-aminoethyl-l- cysteine (aec) (see paper)
28% identity, 86% coverage: 25:257/271 of query aligns to 6:235/237 of 3vv5A

query
sites
3vv5A

I

F

E

E

D

E

I

I

K

K

A

R

R

S

G

G

A

E

L

I

V

R

C

I

G

G

V

T

K
x
E

D

G

S

A

T
x
F

V

P

P

P

F

F

G
x
N

Y

Y

I

F

D

D

E

E

Q

R

S

N

K

-

Q

Q

I

L

V

T

G

G

F

F

D

E

I

V

D

D

I

L

C

G

K

N

A

A

V

I

A

A

D

E

K

R

L

L

G

G

V

L

K

K

L

P

E

R

L

W

K

I

T

A

V

Q

T

S

S
x
F

A

D

T

T

R

L

I

L

P

I

M

Q

L

L

T

N

Q

Q

G

G

S

R

V

F

D

D

M

F

V

V

A

I

A
|
A

T
x
S

M
x
H

T
x
G

H

I

K

T

F

E

E

E

R
|
R

D

A

D

R

V

A

I

V

D

D

F

F

S

T

I

N

T

P

Y

H

F

Y

M

C

D

T

G

G

Q

-

K

G

L

V

L

I

V

V

K

S

K

R

G

K

G

G

V

P

K

R

S

T

A

A

A

K

D

D

L

L

K

Q

G

G

K

K

K

V

V

V

A

G

T

V

A
x
Q

K

V

G

G

S
x
T

T
|
T

S
x
Y

E

M

K

E

N

A

I

A

K

Q

A

K

A

I

Q

P

P

G

E

I

A

K

T

E

V

V

V

R

S

T

F

Y

D

Q

E

R

Y

D

P

P

Q

D

A

A

F

L

L

Q

A

D

L

L

K

L

Q

A

G

G

K

R

A

I

E

D

A

T

V

W

T

I

T

T

D

D

S

R

T

F

I

V

L

A

L

K

G

E

L

A

R

I

N

K

S

E

D

R

P

K

E

L

P

E

D

N

K

T

W

L

E

Q

I

-

V

V

G

G

D

E

Y

L

I

V

S

F

P

Q

E
|
E

P

R

Y

V

G

A

L

M

G

A

L

V

A

A

E

K

N

G

D

N

S

K

K

S

F

L

R

L

D

D

L

A

V

L

N

N

R

R

T

A

L

L

V

A

D

E

L

L

W

M

N

Q

S

D

G

G

E

T

Y

Y

V

A

K

R

L

I

Y

S

D

Q

K

K

W

W

F

F

G

G

K

E

D

D

T

V

K

R

binding l-thialysine: E20 (≠ K39), F23 (≠ T42), N27 (≠ G46), F61 (≠ S81), A78 (= A98), S79 (≠ T99), H80 (≠ M100), G81 (≠ T101), R86 (= R106), Q124 (≠ A145), T127 (≠ S148), T128 (= T149), Y129 (≠ S150), E192 (= E214)

3vvfA Crystal structure of ttc0807 complexed with arginine (see paper)
27% identity, 89% coverage: 17:257/271 of query aligns to 2:239/241 of 3vvfA

query
sites
3vvfA

G

G

T

S

M

E

A

F

H

Q

A

V

G

R

K

S

I

F

E

E

D

E

I

I

K

K

A

R

R

S

G

G

A

E

L

I

V

R

C

I

G

G

V

T

K
x
E

D

G

S

A

T
x
F

V

P

P

P

F

F

G
x
N

Y

Y

I

F

D

D

E

E

Q

R

S

N

K

-

Q

Q

I

L

V

T

G

G

F

F

D

E

I

V

D

D

I

L

C

G

K

N

A

A

V

I

A

A

D

E

K

R

L

L

G

G

V

L

K

K

L

P

E

R

L

W

K

I

T

A

V

Q

T

S

S
x
F

A

D

T

T

R

L

I

L

P

I

M

Q

L

L

T

N

Q

Q

G

G

S

R

V

F

D

D

M

F

V

V

A

I

A
|
A

T
x
S

M
x
H

T
x
G

H

I

K

T

F

E

E

E

R
|
R

D

A

D

R

V

A

I

V

D

D

F

F

S

T

I

N

T

P

Y

H

F

Y

M

C

D

T

G

G

Q

-

K

G

L

V

L

I

V

V

K

S

K

R

G

K

G

G

V

P

K

R

S

T

A

A

A

K

D

D

L

L

K

Q

G

G

K

K

K

V

V

V

A

G

T

V

A
x
Q

K

V

G

G

S
x
T

T
|
T

S
x
Y

E

M

K

E

N

A

I

A

K

Q

A

K

A

I

Q

P

P

G

E

I

A

K

T

E

V

V

V

R

S

T

F

Y

D

Q

E

R

Y

D

P

P

Q

D

A

A

F

L

L

Q

A

D

L

L

K

L

Q

A

G

G

K

R

A

I

E

D

A

T

V

W

T

I

T

T

D

D

S

R

T

F

I

V

L

A

L

K

G

E

L

A

R

I

N

K

S

E

D

R

P

K

E

L

P

E

D

N

K

T

W

L

E

Q

I

-

V

V

G

G

D

E

Y

L

I

V

S

F

P

Q

E
|
E

P

R

Y

V

G

A

L

M

G

A

L

V

A

A

E

K

N

G

D

N

S

K

K

S

F

L

R

L

D

D

L

A

V

L

N

N

R

R

T

A

L

L

V

A

D

E

L

L

W

M

N

Q

S

D

G

G

E

T

Y

Y

V

A

K

R

L

I

Y

S

D

Q

K

K

W

W

F

F

G

G

K

E

D

D

T

V

K

R

binding arginine: E24 (≠ K39), F27 (≠ T42), N31 (≠ G46), F65 (≠ S81), A82 (= A98), S83 (≠ T99), H84 (≠ M100), G85 (≠ T101), R90 (= R106), Q128 (≠ A145), T131 (≠ S148), T132 (= T149), Y133 (≠ S150), E196 (= E214)

3vveA Crystal structure of ttc0807 complexed with lysine (see paper)
27% identity, 89% coverage: 17:257/271 of query aligns to 2:239/241 of 3vveA

query
sites
3vveA

G

G

T

S

M

E

A

F

H

Q

A

V

G

R

K

S

I

F

E

E

D

E

I

I

K

K

A

R

R

S

G

G

A

E

L

I

V

R

C

I

G

G

V

T

K
x
E

D

G

S

A

T
x
F

V

P

P

P

F

F

G

N

Y

Y

I

F

D

D

E

E

Q

R

S

N

K

-

Q

Q

I

L

V

T

G

G

F

F

D

E

I

V

D

D

I

L

C

G

K

N

A

A

V

I

A

A

D

E

K

R

L

L

G

G

V

L

K

K

L

P

E

R

L

W

K

I

T

A

V

Q

T

S

S
x
F

A

D

T

T

R

L

I

L

P

I

M

Q

L

L

T

N

Q

Q

G

G

S

R

V

F

D

D

M

F

V

V

A

I

A
|
A

T
x
S

M
x
H

T
x
G

H

I

K

T

F

E

E

E

R
|
R

D

A

D

R

V

A

I

V

D

D

F

F

S

T

I

N

T

P

Y

H

F

Y

M

C

D

T

G

G

Q

-

K

G

L

V

L

I

V

V

K

S

K

R

G

K

G

G

V

P

K

R

S

T

A

A

A

K

D

D

L

L

K

Q

G

G

K

K

K

V

V

V

A

G

T

V

A
x
Q

K

V

G

G

S
x
T

T
|
T

S
x
Y

E

M

K

E

N

A

I

A

K

Q

A

K

A

I

Q

P

P

G

E

I

A

K

T

E

V

V

V

R

S

T

F

Y

D

Q

E

R

Y

D

P

P

Q

D

A

A

F

L

L

Q

A

D

L

L

K

L

Q

A

G

G

K

R

A

I

E

D

A

T

V

W

T

I

T

T

D

D

S

R

T

F

I

V

L

A

L

K

G

E

L

A

R

I

N

K

S

E

D

R

P

K

E

L

P

E

D

N

K

T

W

L

E

Q

I

-

V

V

G

G

D

E

Y

L

I

V

S

F

P

Q

E
|
E

P

R

Y

V

G

A

L

M

G

A

L

V

A

A

E

K

N

G

D

N

S

K

K

S

F

L

R

L

D

D

L

A

V

L

N

N

R

R

T

A

L

L

V

A

D

E

L

L

W

M

N

Q

S

D

G

G

E

T

Y

Y

V

A

K

R

L

I

Y

S

D

Q

K

K

W

W

F

F

G

G

K

E

D

D

T

V

K

R

binding lysine: E24 (≠ K39), F27 (≠ T42), F65 (≠ S81), A82 (= A98), S83 (≠ T99), H84 (≠ M100), G85 (≠ T101), R90 (= R106), Q128 (≠ A145), T131 (≠ S148), T132 (= T149), Y133 (≠ S150), E196 (= E214)

3vvdA Crystal structure of ttc0807 complexed with ornithine (see paper)
27% identity, 89% coverage: 17:257/271 of query aligns to 2:239/241 of 3vvdA

query
sites
3vvdA

G

G

T

S

M

E

A

F

H

Q

A

V

G

R

K

S

I

F

E

E

D

E

I

I

K

K

A

R

R

S

G

G

A

E

L

I

V

R

C

I

G

G

V

T

K
x
E

D

G

S

A

T
x
F

V

P

P

P

F

F

G

N

Y

Y

I

F

D

D

E

E

Q

R

S

N

K

-

Q

Q

I

L

V

T

G

G

F

F

D

E

I

V

D

D

I

L

C

G

K

N

A

A

V

I

A

A

D

E

K

R

L

L

G

G

V

L

K

K

L

P

E

R

L

W

K

I

T

A

V

Q

T

S

S
x
F

A

D

T

T

R

L

I

L

P

I

M

Q

L

L

T

N

Q

Q

G

G

S

R

V

F

D

D

M

F

V

V

A

I

A

A

T
x
S

M
x
H

T
x
G

H

I

K

T

F

E

E

E

R
|
R

D

A

D

R

V

A

I

V

D

D

F

F

S

T

I

N

T

P

Y

H

F

Y

M

C

D

T

G

G

Q

-

K

G

L

V

L

I

V

V

K

S

K

R

G

K

G

G

V

P

K

R

S

T

A

A

A

K

D

D

L

L

K

Q

G

G

K

K

K

V

V

V

A

G

T

V

A
x
Q

K

V

G

G

S
x
T

T
|
T

S
x
Y

E

M

K

E

N

A

I

A

K

Q

A

K

A

I

Q

P

P

G

E

I

A

K

T

E

V

V

V

R

S

T

F

Y

D

Q

E

R

Y

D

P

P

Q

D

A

A

F

L

L

Q

A

D

L

L

K

L

Q

A

G

G

K

R

A

I

E

D

A

T

V

W

T

I

T

T

D

D

S

R

T

F

I

V

L

A

L

K

G

E

L

A

R

I

N

K

S

E

D

R

P

K

E

L

P

E

D

N

K

T

W

L

E

Q

I

-

V

V

G

G

D

E

Y

L

I

V

S

F

P

Q

E
|
E

P

R

Y

V

G

A

L

M

G

A

L

V

A

A

E

K

N

G

D

N

S

K

K

S

F

L

R

L

D

D

L

A

V

L

N

N

R

R

T

A

L

L

V

A

D

E

L

L

W

M

N

Q

S

D

G

G

E

T

Y

Y

V

A

K

R

L

I

Y

S

D

Q

K

K

W

W

F

F

G

G

K

E

D

D

T

V

K

R

binding L-ornithine: E24 (≠ K39), F27 (≠ T42), F65 (≠ S81), S83 (≠ T99), H84 (≠ M100), G85 (≠ T101), R90 (= R106), Q128 (≠ A145), T131 (≠ S148), T132 (= T149), Y133 (≠ S150), E196 (= E214)

2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
33% identity, 83% coverage: 34:257/271 of query aligns to 7:229/235 of 2pvuA

query
sites
2pvuA

L

V

V

V

C

V

G

G

V

T

K
x
D

D

A

S

A

T
x
F

V

A

P

P

F

F

G

E

Y

Y

I

M

D

-

E

-

Q

Q

S

K

K

G

Q

K

I

I

V

V

G

G

F

F

D

D

I

V

D

D

I

L

C

L

K

D

A

A

V

V

A

M

D

K

K

A

L

A

G

G

V

L

K

D

L

Y

E

E

L

L

K

K

T

N

V

I

T

G

S
x
W

A

D

T

P

R

L

I

F

P

A

M

S

L

L

T

Q

Q

S

G

K

S

E

V

V

D

D

M

M

V

G

A

I

A
x
S

T
x
G

M
x
I

T
|
T

H

I

K

T

F

D

E

E

R
|
R

D

K

D

Q

V

S

I

Y

D

D

F

F

S

S

I

D