SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AO353_01825 FitnessBrowser__pseudo3_N2E3:AO353_01825 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6awaA 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from pseudomonas putida in complex with fad and adenosine-5'-monophosphate.
91% identity, 99% coverage: 1:475/478 of query aligns to 1:475/475 of 6awaA

query
sites
6awaA

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R

active site: L45 (= L45), C49 (= C49), C54 (= C54), S57 (= S57), V191 (= V191), E195 (= E195), F449 (= F449), H451 (= H451), E456 (= E456), N474 (= N474), R475 (= R475)
binding adenosine monophosphate: I187 (= I187), E211 (= E211), A212 (= A212), L213 (= L213), V245 (= V245), V277 (= V277)
binding flavin-adenine dinucleotide: I10 (= I10), G13 (= G13), P14 (= P14), G15 (= G15), E34 (= E34), K35 (= K35), T48 (= T48), C49 (= C49), G53 (= G53), C54 (= C54), K58 (= K58), H121 (= H121), G122 (= G122), S151 (≠ P151), G152 (= G152), I192 (= I192), R279 (= R279), G318 (= G318), D319 (= D319), M325 (= M325), L326 (= L326), A327 (= A327), Y358 (= Y358)

P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
83% identity, 100% coverage: 1:478/478 of query aligns to 1:478/478 of P14218

query
sites
P14218

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L
x
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A

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V

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M1 (= M1) modified: Initiator methionine, Removed
34:49 (vs. 34:49, 81% identical) binding FAD
C49 (= C49) modified: Disulfide link with 54, Redox-active
C54 (= C54) modified: Disulfide link with 49, Redox-active
K58 (= K58) binding FAD
G122 (= G122) binding FAD
D319 (= D319) binding FAD
A327 (= A327) binding FAD

5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
83% identity, 99% coverage: 1:475/478 of query aligns to 3:477/477 of 5u8uD

query
sites
5u8uD

M

M

T

S

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K

F

F

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I

G

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A

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G

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G

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G

Y

Y

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A

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L

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T

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C

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C

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A

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M

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A

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K

A

A

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F

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A

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K

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E

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A

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A

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x
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D

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A

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D

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K

T

T

T

S

V

V

P

P

G

G

V

V

Y

F

A

A

I

I

G
|
G

D
|
D

V

V

R

R

G

G

M

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S
|
S

E

E

G

G

I

V

M

M

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

H

K

K

A

A

Q

Q

M

M

N

N

Y

Y

D

D

L

L

I

I

P

P

S

S

V

V

I

I

Y

Y

T

T

H

H

P

P

E

E

I

I

A

A

W

W

V

V

G

G

K

K

T

T

E

E

Q

Q

A

T

L

L

K

K

A

A

E

E

G

G

V

V

E

E

V

V

N

N

V

V

G

G

T

T

F

F

P

P

F

F

A

A

S

S

G

G

R

R

A

A

M

M

A

A

N

N

D

D

T

T

G

T

G

G

F

L

V

V

K

K

V

V

I

I

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

V

L

L

G

G

V

V

H

H

V

V

I

I

G

G

P

P

S

S

A

A

E

E

L

L

V

V

Q

Q

G

G

A

A

I

I

G

G

M

M

E

E

F

F

G

G

T

T

S

S

A

A

E

E

D

D

L

L

G

G

M

M

V

V

F
|
F

S

S

H
|
H

P
|
P

T

T

L

L

S

S

E
|
E

A

A

L

L

H

H

E

E

A

A

L

L

A

A

V

V

N

N

G

G

G

H

A

A

I

I

H

H

I

I

A

A

N
|
N

R
|
R

active site: P16 (= P14), L47 (= L45), C51 (= C49), C56 (= C54), S59 (= S57), G85 (= G83), V86 (= V84), V193 (= V191), E197 (= E195), S333 (= S331), F451 (= F449), H453 (= H451), E458 (= E456), N476 (= N474), R477 (= R475)
binding flavin-adenine dinucleotide: I12 (= I10), G15 (= G13), P16 (= P14), G17 (= G15), E36 (= E34), K37 (= K35), G49 (= G47), T50 (= T48), C51 (= C49), G55 (= G53), C56 (= C54), K60 (= K58), H123 (= H121), G124 (= G122), A152 (= A150), S153 (≠ P151), G154 (= G152), I194 (= I192), R281 (= R279), G320 (= G318), D321 (= D319), M327 (= M325), L328 (= L326), A329 (= A327), H330 (= H328), H453 (= H451), P454 (= P452)

5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
83% identity, 99% coverage: 2:474/478 of query aligns to 1:473/473 of 5u8wA

query
sites
5u8wA

T

S

Q

Q

K

K

F

F

D

D

V

V

I
|
I

G

G

A

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

V

A

A

I

I

K

R

A

A

Q

Q

L

L

G

G

L

L

S

K

T

T

A

A

C

C

I

I

E
|
E

K
|
K

Y

Y

T

I

D

G

K

K

E

E

G

G

K

K

L

V

A

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

D

D

S

S

W

Y

K

K

F

Y

H

H

E

E

A

A

Q

K

D

E

G

A

F

F

A

K

I

V

H

H

G

G

I

I

N

E

H

A

A

K

G
|
G

V
|
V

T

T

M

I

D

D

V

V

P

P

A

A

M

M

V

V

G

A

R

R

K

K

A

A

N

N

I

I

V

V

K

K

G

N

L

L

T

T

S

G

G

G

V

I

A

A

T

T

L

L

F

F

K

K

A

A

N

N

G

G

V

V

T

T

S

S

L

F

Q

E

G

G

H
|
H

G
|
G

K

K

L

L

A

A

G

N

K

K

K

Q

V

V

E

E

L

V

T

T

K

G

P

L

D

D

G

G

S

K

V

T

E

Q

I

V

I

L

E

E

A

A

E

E

N

N

V

V

I

I

L

I

A
|
A

P
x
S

G
|
G

S

S

R

R

P

P

I

V

D

E

I

I

P

P

A

A

P

P

V

L

D

T

Q

D

N

D

V

I

I

I

V

V

D

D

S
|
S

T

T

G

G

A

A

L

L

E

E

F

F

Q

Q

S

A

V

V

P

P

K

K

R

K

L

L

G

G

V

V

I
|
I

G

G

A

A

G
|
G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

S

S

V

V

W

W

S

A

R

R

L

L

G

G

A

A

E

E

V

V

T

T

V

V

L

L

E
|
E

A
|
A

L
|
L

D

D

T

K

F

F

L

L

M

P

A

A

D

D

A

E

A

Q

V

I

S

A

K

K

E

E

A

A

L

L

K

K

T

V

L

L

T

T

K

K

Q

Q

G

G

L

L

D

N

I

I

K

R

L

L

G

G

A

A

R

R

V

V

T

T

G

A

S

S

K

E

V

V

N

K

G

K

N

K

E

Q

V

V

V

T

V

V

N

T

Y

F

T

T

D

D

A

A

N

N

G

G

E

E

Q

Q

N

K

I

E

T

T

F

F

D

D

K

K

L

L

I

I

V

V

A
|
A

V
|
V

G
|
G

R
|
R

R

R

P

P

V

V

T

T

D

D

L

L

S

A

A

A

D

D

C

S

G

G

V

V

T

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

H

Y

V

V

D

D

H

H

C

C

A

K

T

T

T

S

V

V

P

P

G

G

V

V

Y

F

A

A

I

I

G
|
G

D
|
D

V

V

R

R

G

G

M

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S
|
S

E

E

G

G

I

V

M

M

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

H

K

K

A

A

Q

Q

M

M

N

N

Y

Y

D

D

L

L

I

I

P

P

S

S

V
|
V

I

I

Y
|
Y

T

T

H

H

P

P

E

E

I

I

A

A

W

W

V

V

G

G

K

K

T

T

E

E

Q

Q

A

T

L

L

K

K

A

A

E

E

G

G

V

V

E

E

V

V

N

N

V

V

G

G

T

T

F

F

P

P

F

F

A

A

S

S

G

G

R

R

A

A

M

M

A

A

N

N

D

D

T

T

G

T

G

G

F

L

V

V

K

K

V

V

I

I

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

V

L

L

G

G

V

V

H

H

V

V

I

I

G

G

P

P

S

S

A

A

E

E

L

L

V

V

Q

Q

G

G

A

A

I

I

G

G

M

M

E

E

F

F

G

G

T

T

S

S

A

A

E

E

D

D

L

L

G

G

M

M

V

V

F
|
F

S

S

H
|
H

P
|
P

T

T

L

L

S

S

E
|
E

A

A

L

L

H

H

E

E

A

A

L

L

A

A

V

V

N

N

G

G

G

H

A

A

I

I

H

H

I

I

A

A

N
|
N

active site: P13 (= P14), L44 (= L45), C48 (= C49), C53 (= C54), S56 (= S57), G82 (= G83), V83 (= V84), V190 (= V191), E194 (= E195), S330 (= S331), F448 (= F449), H450 (= H451), E455 (= E456), N473 (= N474)
binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), P13 (= P14), G14 (= G15), E33 (= E34), K34 (= K35), G46 (= G47), T47 (= T48), C48 (= C49), G52 (= G53), C53 (= C54), K57 (= K58), H120 (= H121), G121 (= G122), A149 (= A150), S150 (≠ P151), G151 (= G152), S170 (= S171), G317 (= G318), D318 (= D319), M324 (= M325), L325 (= L326), A326 (= A327), H327 (= H328), Y357 (= Y358), H450 (= H451), P451 (= P452)
binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (= I187), G189 (= G190), V190 (= V191), I191 (= I192), E194 (= E195), E210 (= E211), A211 (= A212), L212 (= L213), A275 (= A276), V276 (= V277), G277 (= G278), R278 (= R279), M324 (= M325), L325 (= L326), V355 (= V356), Y357 (= Y358)

5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
83% identity, 99% coverage: 3:474/478 of query aligns to 1:472/472 of 5u8vA

query
sites
5u8vA

Q

Q

K

K

F

F

D

D

V

V

I
|
I

G

G

A

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

V

A

A

I

I

K

R

A

A

Q

Q

L

L

G

G

L

L

S

K

T

T

A

A

C

C

I

I

E
|
E

K

K

Y

Y

T

I

D

G

K

K

E

E

G

G

K

K

L

V

A

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

D

D

S

S

W

Y

K

K

F

Y

H

H

E

E

A

A

Q

K

D

E

G

A

F

F

A

K

I

V

H

H

G

G

I

I

N

E

H

A

A

K

G
|
G

V
|
V

T

T

M

I

D

D

V

V

P

P

A

A

M

M

V

V

G

A

R

R

K

K

A

A

N

N

I

I

V

V

K

K

G

N

L

L

T

T

S

G

G

G

V

I

A

A

T

T

L

L

F

F

K

K

A

A

N

N

G

G

V

V

T

T

S

S

L

F

Q

E

G

G

H
|
H

G
|
G

K

K

L

L

A

A

G

N

K

K

K

Q

V

V

E

E

L

V

T

T

K

G

P

L

D

D

G

G

S

K

V

T

E

Q

I

V

I

L

E

E

A

A

E

E

N

N

V

V

I

I

L

I

A
|
A

P
x
S

G
|
G

S

S

R

R

P

P

I

V

D

E

I

I

P

P

A

A

P

P

V

L

D

T

Q

D

N

D

V

I

I

I

V

V

D

D

S
|
S

T

T

G

G

A

A

L

L

E

E

F

F

Q

Q

S

A

V

V

P

P

K

K

R

K

L

L

G

G

V

V

I
|
I

G
|
G

A

A

G
|
G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

S

S

V

V

W

W

S

A

R

R

L

L

G

G

A

A

E

E

V

V

T

T

V

V

L
|
L

E
|
E

A
|
A

L

L

D

D

T

K

F

F

L

L

M

P

A

A

D

D

A

E

A

Q

V

I

S

A

K

K

E

E

A

A

L

L

K

K

T

V

L

L

T

T

K

K

Q

Q

G

G

L

L

D

N

I

I

K

R

L

L

G

G

A

A

R

R

V
|
V

T

T

G

A

S

S

K

E

V

V

N

K

G

K

N

K

E

Q

V

V

V

T

V

V

N

T

Y

F

T

T

D

D

A

A

N

N

G

G

E

E

Q

Q

N

K

I

E

T

T

F

F

D

D

K

K

L

L

I

I

V

V

A

A

V
|
V

G
|
G

R
|
R

R

R

P

P

V

V

T

T

D

D

L

L

S

A

A

A

D

D

C

S

G

G

V

V

T

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

H

Y

V

V

D

D

H

H

C

C

A

K

T

T

T

S

V

V

P

P

G

G

V

V

Y

F

A

A

I

I

G
|
G

D
|
D

V

V

R

R

G

G

M

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S
|
S

E

E

G

G

I

V

M

M

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

H

K

K

A

A

Q

Q

M

M

N

N

Y

Y

D

D

L

L

I

I

P

P

S

S

V

V

I

I

Y

Y

T

T

H

H

P

P

E

E

I

I

A

A

W

W

V

V

G

G

K

K

T

T

E

E

Q

Q

A

T

L

L

K

K

A

A

E

E

G

G

V

V

E

E

V

V

N

N

V

V

G

G

T

T

F

F

P

P

F

F

A

A

S

S

G

G

R

R

A

A

M

M

A

A

N

N

D

D

T

T

G

T

G

G

F

L

V

V

K

K

V

V

I

I

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

V

L

L

G

G

V

V

H

H

V

V

I

I

G

G

P

P

S

S

A

A

E

E

L

L

V

V

Q

Q

G

G

A

A

I

I

G

G

M

M

E

E

F

F

G

G

T

T

S

S

A

A

E

E

D

D

L

L

G

G

M

M

V

V

F
|
F

S

S

H
|
H

P
|
P

T

T

L

L

S

S

E
|
E

A

A

L

L

H

H

E

E

A

A

L

L

A

A

V

V

N

N

G

G

G

H

A

A

I

I

H

H

I

I

A

A

N
|
N

active site: P12 (= P14), L43 (= L45), C47 (= C49), C52 (= C54), S55 (= S57), G81 (= G83), V82 (= V84), V189 (= V191), E193 (= E195), S329 (= S331), F447 (= F449), H449 (= H451), E454 (= E456), N472 (= N474)
binding flavin-adenine dinucleotide: I8 (= I10), G11 (= G13), P12 (= P14), G13 (= G15), E32 (= E34), G45 (= G47), T46 (= T48), C47 (= C49), G51 (= G53), C52 (= C54), K56 (= K58), H119 (= H121), G120 (= G122), A148 (= A150), S149 (≠ P151), G150 (= G152), S169 (= S171), I190 (= I192), R277 (= R279), G316 (= G318), D317 (= D319), M323 (= M325), L324 (= L326), A325 (= A327), H326 (= H328), H449 (= H451), P450 (= P452)
binding nicotinamide-adenine-dinucleotide: I185 (= I187), G186 (= G188), G188 (= G190), V189 (= V191), I190 (= I192), L208 (= L210), E209 (= E211), A210 (= A212), V243 (= V245), V275 (= V277), G276 (= G278)

P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
79% identity, 100% coverage: 1:477/478 of query aligns to 1:477/477 of P18925

query
sites
P18925

M

M

T

S

Q

Q

K

K

F

F

D

D

V

V

V

I

V

V

I

I

G

G

A

A

G

G

P

P

G

G

Y

Y

V

V

A

A

I

I

K

K

A

S

A

A

Q

Q

L

L

G

G

L

L

S

K

T

T

A

A

C

L

I

I

E
|
E

K
|
K

Y
|
Y

T
x
K

D
x
G

K
|
K

E
|
E

G
|
G

K
|
K

L
x
T

A
|
A

L
|
L

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G

G

C
|
C

I

I

P

P

S

S

K
|
K

A

A

L

L

D

D

S

S

W

Y

K

K

F

F

H

H

E

E

A

A

Q

H

D

E

G

S

F

F

A

K

I

L

H

H

G

G

I

I

N

S

H

T

A

G

G

E

V

V

T

A

M

I

D

D

V

V

P

P

A

T

M

M

V

I

G

A

R

R

K

K

A

D

N

Q

I

I

V

V

K

R

G

N

L

L

T

T

S

G

G

G

V

V

A

A

T

S

L

L

F

I

K

K

A

A

N

N

G

G

V

V

T

T

S

L

L

F

Q

E

G

G

H

H

G

G

K

K

L

L

A

A

G

G

K

K

V

V

E

E

L

V

T

T

K

A

P

A

D

D

G

G

S

S

V

S

E

Q

I

V

I

L

E

D

A

T

E

E

N

N

V

V

I

I

L

L

A

A

P

S

G

G

S

S

R

K

P

P

I

V

D

E

I

I

P

P

A

A

P

P

V

V

D

D

Q

Q

N

D

V

V

I

I

V

V

D

D

S

S

T

T

G

G

A

A

L

L

E

D

F

F

Q

Q

S

N

V

V

P

P

K

G

R

K

L

L

G

G

V

V

I

I

G

G

A

A

G

G

V

V

I

I

G

G

L

L

E

E

L

L

G

G

S

S

V

V

W

W

S

A

R

R

L

L

G

G

A

A

E

E

V

V

T

T

V

V

L

L

E

E

A

A

L

M

D

D

T

K

F

F

L

L

M

P

A

A

A

V

D

D

A

E

A

Q

V

V

S

A

K

K

E

E

A

A

L

Q

K

K

T

I

L

L

T

T

K

K

Q

Q

G

G

L

L

D

K

I

I

K

L

L

L

G

G

A

A

R

R

V

V

T

T

G

G

S

T

K

E

V

V

N

K

G

N

N

K

E

Q

V

V

V

T

V

V

N

K

Y

F

T

V

D

D

A

A

N

E

G

G

E

E

Q

K

N

S

I

Q

T

A

F

F

D

D

K

K

L

L

I

I

V

V

A

A

V

V

G

G

R

R

P

P

V

V

T

T

D

D

L

L

S

A

A

A

D

D

C

S

G

G

V

V

T

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

H

Y

V

V

D

D

H

Y

C

C

A

A

T

T

T

S

V

V

P

P

G

G

V

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

R

R

G

G

M

A

M

M

L

L

A
|
A

H

H

K

K

A

A

S

S

E

E

G

G

I

V

M

V

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

H

K

K

A

A

Q

Q

M

M

N

N

Y

Y

D

D

L

L

I

I

P

P

S

A

V

V

I

I

Y

Y

T

T

H

H

P

P

E

E

I

I

A

A

W

G

V

V

G

G

K

K

T

T

E

E

Q

Q

A

A

L

L

K

K

A

A

E

E

G

G

V

V

E

A

V

I

N

N

V

V

G

G

T

V

F

F

P

P

F

F

A

A

S

S

G

G

R

R

A

A

M

M

A

A

N

N

D

D

T

T

G

A

G

G

F

F

V

V

K

K

V

V

I

I

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

V

L

L

G

G

V

V

H

H

V

V

I

I

G

G

P

P

S

S

A

A

E

E

L

L

V

V

Q

Q

G

G

A

A

I

I

G

A

M

M

E

E

F

F

G

G

T

T

S

S

A

A

E

E

D

D

L

L

G

G

M

M

V

V

F

F

S

A

H

H

P

P

T

A

L

L

S

S

E

E

A

A

L

L

H

H

E

E

A

A

L

L

A

A

V

V

N

S

G

G

G

H

A

A

I

I

H

H

I

V

A

A

N

N

R

R

K

K

34:49 (vs. 34:49, 81% identical) binding FAD
C49 (= C49) modified: Disulfide link with 54, Redox-active
C54 (= C54) modified: Disulfide link with 49, Redox-active
K58 (= K58) binding FAD
D319 (= D319) binding FAD
A327 (= A327) binding FAD

3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
79% identity, 99% coverage: 2:473/478 of query aligns to 1:472/472 of 3ladA

query
sites
3ladA

T

S

Q

Q

K

K

F

F

D

D

V

V

V

I

V

V

I
|
I

G
|
G

A

A

G
|
G

P
|
P

G

G

Y

Y

V

V

A

A

I

I

K

K

A

S

A

A

Q

Q

L

L

G

G

L

L

S

K

T

T

A

A

C

L

I

I

E
|
E

K
|
K

Y

Y

T

K

D

G

K

K

E

E

G

G

K

K

L

T

A

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K

K

A

A

L

L

D

D

S

S

W

Y

K

K

F

F

H

H

E

E

A

A

Q

H

D

E

G

S

F

F

A

K

I

L

H

H

G

G

I

I

N

S

H

T

A

G

G

E

V

V

T

A

M

I

D

D

V

V

P

P

A

T

M

M

V

I

G

A

R

R

K

K

A

D

N

Q

I

I

V

V

K

R

G

N

L

L

T

T

S

G

G

G

V

V

A

A

T

S

L

L

F

I

K

K

A

A

N

N

G

G

V

V

T

T

S

L

L

F

Q

E

G

G

H
|
H

G
|
G

K

K

L

L

A

A

G

G

K

K

V

V

E

E

L

V

T

T

K

A

P

A

D

D

G

G

S

S

V

S

E

Q

I

V

I

L

E

D

A

T

E

E

N

N

V

V

I

I

L

L

A
|
A

P
x
S

G
|
G

S

S

R

K

P

P

I

V

D

E

I

I

P

P

A

A

P

P

V

V

D

D

Q

Q

N

D

V

V

I

I

V

V

D

D

S

S

T

T

G

G

A

A

L

L

E

D

F

F

Q

Q

S

N

V

V

P

P

K

G

R

K

L

L

G

G

V

V

I

I

G

G

A

A

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

S

S

V

V

W

W

S

A

R

R

L

L

G

G

A

A

E

E

V

V

T

T

V

V

L

L

E

E

A

A

L

M

D

D

T

K

F

F

L

L

M

P

A

A

A

V

D

D

A

E

A

Q

V

V

S

A

K

K

E

E

A

A

L

Q

K

K

T

I

L

L

T

T

K

K

Q

Q

G

G

L

L

D

K

I

I

K

L

L

L

G

G

A

A

R

R

V

V

T

T

G

G

S

T

K

E

V

V

N

K

G

N

N

K

E

Q

V

V

V

T

V

V

N

K

Y

F

T

V

D

D

A

A

N

E

G

G

E

E

Q

K

N

S

I

Q

T

A

F

F

D

D

K

K

L

L

I

I

V

V

A

A

V

V

G

G

R
|
R

R

R

P

P

V

V

T

T

D

D

L

L

S

A

A

A

D

D

C

S

G

G

V

V

T

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

H

Y

V

V

D

D

H

Y

C

C

A

A

T

T

T

S

V

V

P

P

G

G

V

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

R

R

G

G

M

A

M

M

L
|
L

A
|
A

H

H

K

K

A

A

S

S

E

E

G

G

I

V

M

V

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

H

K

K

A

A

Q

Q

M

M

N

N

Y

Y

D

D

L

L

I

I

P

P

S

A

V

V

I

I

Y

Y

T

T

H

H

P

P

E

E

I

I

A

A

W

G

V

V

G

G

K

K

T

T

E

E

Q

Q

A

A

L

L

K

K

A

A

E

E

G

G

V

V

E

A

V

I

N

N

V

V

G

G

T

V

F

F

P

P

F

F

A

A

S

S

G

G

R

R

A

A

M

M

A

A

N

N

D

D

T

T

G

A

G

G

F

F

V

V

K

K

V

V

I

I

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

V

L

L

G

G

V

V

H

H

V

V

I

I

G

G

P

P

S

S

A

A

E

E

L

L

V

V

Q

Q

G

G

A

A

I

I

G

A

M

M

E

E

F

F

G

G

T

T

S

S

A

A

E

E

D

D

L

L

G

G

M

M

V

V

F
|
F

S

A

H
|
H

P

P

T

A

L

L

S

S

E
|
E

A

A

L

L

H

H

E

E

A

A

L

L

A

A

V

V

N

S

G

G

G

H

A

A

I

I

H

H

I

V

A

A

active site: L44 (= L45), C48 (= C49), C53 (= C54), S56 (= S57), V190 (= V191), E194 (= E195), F448 (= F449), H450 (= H451), E455 (= E456)
binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), P13 (= P14), E33 (= E34), K34 (= K35), G46 (= G47), T47 (= T48), C48 (= C49), G52 (= G53), C53 (= C54), H120 (= H121), G121 (= G122), A149 (= A150), S150 (≠ P151), G151 (= G152), I191 (= I192), R278 (= R279), D318 (= D319), L325 (= L326), A326 (= A327)

6bz0A 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from acinetobacter baumannii in complex with fad.
63% identity, 98% coverage: 4:471/478 of query aligns to 1:467/469 of 6bz0A

query
sites
6bz0A

K

Q

F

F

D

D

V

L

V

V

I
|
I

G

G

A

G

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

E

A

A

I

I

K

R

A

A

Q

Q

L

L

G

G

L

F

S

K

T

V

A

A

C

C

I

I

E
|
E

K
|
K

Y
x
R

T

I

D

-

K

H

E

N

G

G

K

K

L

P

A

S

L

L

G

G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

D

D

S

S

W

H

K

R

F

Y

H

E

E

D

A

T

Q

V

D

H

G

H

F

L

A

A

I

D

H

H

G

G

I

I

N

T

H

T

A

G

G

E

V

V

T

N

M

F

D

D

V

L

P

A

A

K

M

L

V

L

G

A

R

R

K

K

A

D

N

K

I

I

V

V

K

D

G

Q

L

L

T

T

S

G

G

G

V

I

A

D

T

Q

L

L

F

L

K

K

A

G

N

N

G

G

V

I

T

E

S

W

L

L

Q

K

G

G

H
x
T

G
|
G

K

K

L

L

A

A

G

G

K

K

V

V

E

E

L

F

T

V

K

P

P

H

D

E

G

G

S

E

V

T

E

Q

I

I

I

L

E

E

A

P

E

K

N

Y

V

V

I

I

L

L

A

A

P
x
S

G
|
G

S

S

R

V

P

P

I

V

D

N

I

I

P

P

P

V

A

A

P

P

V

V

D

D

Q

Q

N

D

V

I

I

I

V

V

D

D

S
|
S

T

T

G

G

A

A

L

L

E

N

F

F

Q

P

S

E

V

V

P

P

K

K

R

R

L

L

G

G

V

V

I

I

G

G

A

A

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

S

S

V

V

W

W

S

R

R

R

L

L

G

G

A

A

E

E

V

V

T

V

V

V

L

F

E

E

A

A

L

M

D

D

T

A

F

F

L

L

M

P

A

M

A

A

D

D

A

K

A

A

V

L

S

S

K

K

E

E

A

Y

L

Q

K

K

T

I

L

L

T

T

K

K

Q

Q

G

G

L

L

D

D

I

I

K

R

L

I

G

G

A

A

R

K

V

V

T

S

G

G

S

T

K

E

V

V

N

N

G

G

N

R

E

E

V

V

V

T

V

V

N

K

Y

Y

T

T

D

Q

A

A

N

G

G

E

E

D

Q

K

N

E

I

Q

T

T

F

F

D

D

K

K

L

L

I

I

V

V

A

C

V

V

G

G

R
|
R

R

K

P

A

V
x
Y

T

A

T

E

D

G

L

L

S

A

A

E

D

D

C

S

G

G

V

I

T

K

L

L

D

T

E

E

R

R

G

G

F

L

V

V

H

E

V

V

D

N

D

D

H

H

C

C

A

A

T

T

T

S

V

V

P

E

G

G

V

V

Y

Y

A

A

I

I

G

G

D
|
D

V

L

V

V

R

R

G

G

M

P

M
|
M

L
|
L

A
|
A

H

H

K

K

A
|
A

S

M

E

E

G

G

I

V

M

M

V

A

V

V

E

E

R

R

I

I

K

H

G

G

H

H

K

A

A

A

Q

Q

M

V

N

N

Y

Y

D

D

L

T

I

I

P

I

S

S

V

I

I

I

Y
|
Y

T

T

H

H

P

P

E

E

I

A

A

A

W

W

V

V

G

G

K

L

T

T

E

E

Q

E

A

Q

L

A

K

K

A

E

E

K

G

G

V

H

E

E

V

V

N

K

V

T

G

G

T

Q

F

F

P

G

F

F

A

A

A

V

S

N

G

G

R

R

A

A

M

L

A

A

N

G

D

E

T

G

G

A

G

G

F

F

V

V

K

K

V

F

I

V

A

A

D

D

A

A

K

K

T

T

D

D

R

R

V

L

L

L

G

G

V

M

H

H

V

V

I

I

G

G

P

P

S

A

A

A

A

S

E

D

L

I

V

V

Q

H

Q

Q

G

G

A

M

I

I

G

A

M

L

E

E

F

F

G

V

T

S

S

S

A

V

E

E

D

D

L

L

G

Q

M

L

M

M

V

T

F

F

S

G

H
|
H

P

P

T

T

L

F

S

S

E
|
E

A

V

L

V

H

H

E

E

A

A

L

L

A

A

V

V

N

D

G

G

G

R

A

A

I

I

H

H

active site: C45 (= C49), C50 (= C54), S53 (= S57), V187 (= V191), E191 (= E195), H447 (= H451), E452 (= E456)
binding flavin-adenine dinucleotide: I7 (= I10), G10 (= G13), P11 (= P14), G12 (= G15), E31 (= E34), K32 (= K35), R33 (≠ Y36), G43 (= G47), T44 (= T48), C45 (= C49), G49 (= G53), C50 (= C54), K54 (= K58), T117 (≠ H121), G118 (= G122), S147 (≠ P151), G148 (= G152), S167 (= S171), I188 (= I192), R275 (= R279), Y278 (≠ V282), D315 (= D319), M321 (= M325), L322 (= L326), A323 (= A327), A326 (= A330), Y354 (= Y358)

6aonA 1.72 angstrom resolution crystal structure of 2-oxoglutarate dehydrogenase complex subunit dihydrolipoamide dehydrogenase from bordetella pertussis in complex with fad
55% identity, 97% coverage: 3:466/478 of query aligns to 1:467/473 of 6aonA

query
sites
6aonA

Q

K

K

Q

F

F

D

D

V

V

I
|
I

G

G

A

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

I

A

A

I

I

K

R

A

A

Q

Q

L

L

G

G

L

M

S

S

T

V

A

A

C

C

I

I

E
x
D

K
x
A

Y
x
W

T

Q

D

N

K

G

E

Q

G

G

K

G

L

P

A

A

L
x
P

G

G

G
|
G

T
|
T

C
|
C

L

T

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

D

Q

S

S

W

E

K

H

F

Y

H

E

E

Q

A

A

Q

N

D

H

G

H

F

F

A

A

I

E

H

H

G

G

I

I

N

E

H

V

A

K

G

G

V

V

T

S

M

L

D

K

V

L

P

D

A

T

M

L

V

I

G

G

R

R

K

K

A

N

N

T

I

V

V

V

K

K

G

Q

L

N

T

N

S

D

G

G

V

I

A

L

T

Y

L

L

F

F

K

K

A

K

N

N

G

K

V

V

T

T

S

Y

L

F

Q

H

G

G

H
x
K

G
|
G

-

A

-

F

-

A

-

G

K

Q

L

V

L

D

A

G

G

G

K

W

K

S

V

I

E

K

L

V

T

T

K

-

P

-

D

-

G

G

S

T

V

T

E

D

I

A

-

D

I

L

E

V

A

A

E

K

N

H

V

V

I

I

L

V

A

A

P
x
T

G
|
G

S

S

R

S

P

A

I

R

D

E

I

L

P

P

P

G

A

L

P

P

V

F

D

D

Q

E

N

K

V

N

I

I

V

L

D

S

S
x
N

T

D

G

G

A

A

L

L

E

N

F

I

Q

G

S

A

V

V

P

P

K

K

R

K

L

L

G

G

V

V

I

I

G

G

A

A

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

M

G

G

S

S

V

V

W

W

S

R

R

R

L

L

G

G

A

A

E

E

V

V

T

T

V

I

L

L

E

E

A

A

L

M

D

P

T

E

F

F

L

L

M
x
A

A

A

A
|
A

D

D

A
x
Q

A

Q

V

V

S

A

K

K

E

E

A

A

L

L

K

K

T

S

L

F

T

A

K

K

Q

Q

G

G

L

L

D

D

I

I

K

Q

L

T

G

G

A

V

R

K

V

I

T

G

G

E

S

I

K

K

V

A

N

A

G

A

N

K

E

S

V

I

V

T

V

V

N

P

Y

Y

T

V

D

D

A

A

N

K

G

G

-

A

E

E

Q

Q

N

K

I

L

T

V

F

V

D

D

K

K

L

L

I

I

V

V

A

S

V

I

G

G

R
|
R

R

V

P

P

V
x
Y

T

T

T

G

D

G

L

L

L

N

S

A

A

E

D

A

C

V

G

G

V

L

T

K

L

L

D

D

E

E

R

R

G

G

F

F

V

V

H

A

V

V

D

D

D

E

H

D

C

C

A

K

T

T

T

N

V

L

P

P

G

N

V

V

Y

W

A

A

I

V

G
|
G

D
|
D

V

V

R

R

G

G

M

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S

E

E

E

G

G

I

V

M

A

V

V

V

A

E

E

R

R

I

I

K

A

G

G

H

Q

K

H