Comparing AO353_02430 FitnessBrowser__pseudo3_N2E3:AO353_02430 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 5 hits to proteins with known functional sites (download)
O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
25% identity, 95% coverage: 3:209/217 of query aligns to 181:371/409 of O53289
Sites not aligning to the query:
A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium avium (strain 104) (see paper)
26% identity, 95% coverage: 3:209/217 of query aligns to 183:373/411 of A0QJI1
5jlpA Crystal structure of mycobacterium avium serb2 in complex with serine at act domain
26% identity, 95% coverage: 3:209/217 of query aligns to 179:369/396 of 5jlpA
Sites not aligning to the query:
8a21A Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with phenylimidazole (see paper)
26% identity, 95% coverage: 3:209/217 of query aligns to 179:369/396 of 8a21A
Sites not aligning to the query:
8a1zA Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with 1-(2,4-dichlorophenyl)-3-hydroxyurea (see paper)
26% identity, 95% coverage: 3:209/217 of query aligns to 179:369/396 of 8a1zA
>AO353_02430 FitnessBrowser__pseudo3_N2E3:AO353_02430
MALAIFDLDETLIHGDCASLWSEQMARLGWVDGESFLRRDKELMDAYGRGHLAMEDYMTF
SLEPMAGRTPEEIEHLVAPWVEDFIEPIIFSDACKAIAEHRKAGDRILVISASGTHLVKP
IAERLGIDEILAIELEVTHGVYSGNTVGTLTYREGKITRLLEWLDAEEENLEGASFYSDS
RNDLPLLIKVDHPHVVNPDPVLLEHAEKAGWPIHIWK
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory