SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AO353_07810 AO353_07810 choline dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
37% identity, 95% coverage: 2:540/567 of query aligns to 2:457/458 of 8b7sA

query
sites
8b7sA

S

S

H

K

E

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Y

F

D

D

Y

Y

I

I

I
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I

G
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G

A
x
G

G
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G

S
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S

A
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A

G

G

N

A

T

V

L

V

A

A

T

N

R

R

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L

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S

E

E

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D

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S

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G

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T

T

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L

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L
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L

E
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E

A
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A

G

G

P

S

D

D

Y

-

R

-

L

-

D

-

F

-

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T

-

Q

-

M

-

P

-

A

-

L

-

A

A

F

S

P

P

L

-

Q

-

G

-

R

-

R

K

Y

F

N

N

W
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W

A

M

Y

Y

E

D

T

V

D

E

P

P

E

D

P

P

H

S

M

R

D

D

G

G

R

R

R

V

M

D

E

I

C

W

G
x
P

R
x
A

G
|
G

K
|
K

G
x
V

L

L

G

G

S

G

S
|
S

L

M

I

-

N

-

G

-

M

-

C

-

Y

F

I

V

R

R

G

G

N

N

A

A

M

W

D

D

Y

Y

D

D

G

L

W

W

A

A

K

Q

N

K

P

-

G

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A

E

T

D

G

W

W

T

D

Y

Y

L

A

D

G

C

V

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P

Y

Y

F

F

R

R

K

K

A

M

E

E

T

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D

A

I

L

G

-

P

-

N

-

D

-

Y

-

H

-

G

-

E

-

G

-

P

-

V

-

S

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V

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P

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K

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A

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-

N

-

N

N

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A

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E

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N

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E

E

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Y

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D

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G

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S

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T

A

A

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A

Y

Y

L

I

-

R

D

G

I

I

A

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K

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T

N

L

F

N

T

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A
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A

L
x
F

T
x
V

D

E

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R

I

I

L

I

F

I

E

E

G

G

K

G

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R

A

A

I

V

G

G

V

V

R

R

Y

Y

L

-

V

-

G

S

S

K

A

N

E

G

E

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P

G

V

M

E

E

A

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R

A

A

R

R

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K

E

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V

L

V

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L

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x
S

S
x
A

G
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G

A

A

I

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A
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A

S

S

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P

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K

I

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L

L

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S

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A

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E

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E

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A

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Q

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H

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E

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M

V

V

H

V

D

D

L

S

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P

G

D

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V

G

G

E

A

N

N

L

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Q

D

E

H

H

L

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A

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E

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A

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A

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D

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E

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F

Y

I

I

R

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H

F

A

A

E

F

T

P

A

M

F
x
Y

H
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H

P

V

S

S

C

C

S

S

C

C

K

R

M

M

G

G

T

S

D

D

E

P

M

A

A

S

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V

D

D

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P

Q

E

G

L

R

R

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V

H

R

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G

M

V

Q

S

G

G

L

L

R

W

V

V

D
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D

A
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A

S

S

I

V

M

M

P

P

L

T

I

L

T

P

T

A

G

G

N

N

L
x
I

N
|
N

A

A

P

S

T
x
A

I

I

M

M

I

I

A

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E

E

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P

binding flavin-adenine dinucleotide: I10 (= I10), G11 (= G11), G12 (≠ A12), G13 (= G13), S14 (= S14), A15 (= A15), L34 (= L34), E35 (= E35), A36 (= A36), W47 (= W64), P65 (≠ G82), A66 (≠ R83), G67 (= G84), K68 (= K85), V69 (≠ G86), S74 (= S91), A178 (= A222), F179 (≠ L223), V180 (≠ T224), S213 (≠ C259), A214 (≠ S260), G215 (= G261), A218 (= A264), T270 (= T337), Y391 (≠ F474), H392 (= H475), D423 (= D506), A424 (= A507), I435 (≠ L518), N436 (= N519), A439 (≠ T522)

5nccA Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
34% identity, 95% coverage: 3:542/567 of query aligns to 22:578/578 of 5nccA

query
sites
5nccA

H

Q

E

K

Y

Y

D

D

Y

Y

I

I

I

L

I

V

G
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G

A
x
G

G
|
G

S
x
T

A
|
A

G

A

N

C

T

V

L

L

A

A

T

N

R

R

L

L

T

S

E

A

D

D

A

G

G

S

V

K

T

R

V

V

L

L

L

V

L
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L

E
|
E

A
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A

G

G

G

P

P

D

D

N

Y

T

R

S

L

R

D

D

F

V

R

K

T

-

Q

-

M

I

P

P

A

A

L

I

A

T

F

R

P

L

L
x
F

Q

R

G

-

R

S

R

P

Y

L

N

D

W
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W

A

N

Y

L

E

F

T

S

D

E

P

L

E

Q

P

E

H

Q

M

L

D

A

G

E

R

R

R

Q

M

I

E

Y

C

M

G
x
A

R
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R

G
|
G

K
x
R

G
x
L

L

L

G

G

G
|
G

S
|
S

L

A

I

T

N
|
N

G
x
A

M
x
T

C
x
L

Y

Y

I

H

R

R

G

G

N

A

A

A

M

G

D

D

Y

Y

D

D

G

A

W

W

A

-

K

-

N

-

P

-

G

G

L

V

E

E

D

G

W

W

T

S

Y

S

L

E

D

D

C

V

L

L

P

S

Y

W

F

F

R

V

K

Q

A

A

E

E

T

T

R

N

-

A

D

D

I

F

G

G

P

P

N

G

D

A

Y

Y

H

H

G

G

G

S

E

G

G

G

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P

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M

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Y

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H

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A

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A

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E

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D

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N

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W

Q

S

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H

E

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H

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A

G

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F

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x
M

T

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D

K

K

G

G

R

T

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R

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A

S

D

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M

A

Y

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Y

L

L

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K

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H

G

A
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A

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A

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x
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D

T

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K

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N

F

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G

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K

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A

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A

A

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G

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Y

F

L

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V

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G

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E

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P

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T

E

G

A

E

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R

A

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R

S

K

A

E

E

-

L

-

A

-

P

-

G

-

E

V

V

L

I

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M

C
|
C

S
x
A

G
|
G

A

A

I

V

A
x
H

S

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P

Q

F

I
x
L

L

L

Q

K

R

H

S

S

G

G

V

V

G

G

P

P

A

S

K

A

L

E

L

L

K

K

S

E

L

F

D

G

I

I

P

P

V

V

H

S

D

N

L

L

P

A

G

G

V

V

G

G

E

Q

N

N

L

L

Q

Q

D

D

H

-

L

-

E

-

L

-

Y

-

L

-

Q

Q

Y

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A

A

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T

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T

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R

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A

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G

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F

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D

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Q

Y

V

H

R

F

F

L

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P

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G

V

M

A

A

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Q

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K

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E

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G

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I

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H

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M
x
L

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x
I

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A

M

C

R

R

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P

P

Q

S

S

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T

G

G

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S

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A

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D

P

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F

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A

H

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I

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L

S

F

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N

G

Y

Y

M

L

A

T

T

D

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D

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G

-

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D

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L

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K

G

G

I

I

R

H

L

W

T

A

R

R

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I

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M

A

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S

A

A

L

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E

L

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E

D

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Q

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I

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D

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E

F

Y

I

I

R

R

E

R

H

S

A

I

E

H

T

S

A
x
S

F
x
N

H
x
A

P

I

S

T

C

G

S

T

C

C

K

K

M

M

G

G

T

N

-

A

-

G

D

D

E

S

M

S

A

S

V

V

D

D

G

N

Q

Q

G

L

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R

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V

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H

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G

M

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E

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L

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A
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A

S

S

I

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P

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K

I

I

T

P

T

G

G
|
G

N
x
Q

L
x
T

N
x
G

A

A

P

P

T
x
V

I

V

M

M

I

I

A

A

E

E

K

R

I

A

A

A

D

A

K

L

I

L

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G

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I

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S

S

active site: R347 (vs. gap), L420 (≠ M388), I421 (≠ G389), S507 (≠ A473), A509 (≠ H475), G552 (= G516), Q553 (≠ N517)
binding flavin-adenine dinucleotide: G30 (= G11), G31 (≠ A12), G32 (= G13), T33 (≠ S14), A34 (= A15), L53 (= L34), E54 (= E35), A55 (= A36), F74 (≠ L57), W80 (= W64), A98 (≠ G82), R99 (= R83), G100 (= G84), R101 (≠ K85), L102 (≠ G86), G105 (= G89), S106 (= S90), S107 (= S91), N110 (= N94), A111 (≠ G95), T112 (≠ M96), L113 (≠ C97), M207 (≠ V193), A236 (= A222), A237 (≠ L223), V238 (≠ T224), C277 (= C259), A278 (≠ S260), G279 (= G261), H282 (≠ A264), L286 (≠ I268), N508 (≠ F474), D542 (= D506), A543 (= A507), Q553 (≠ N517), T554 (≠ L518), G555 (≠ N519), V558 (≠ T522)

6yrvAAA structure of fap after illumination at 100k (see paper)
34% identity, 96% coverage: 3:544/567 of query aligns to 6:571/573 of 6yrvAAA

query
sites
6yrvAAA

H

Q

E

K

Y

Y

D

D

Y

Y

I

I

I

L

I

V

G
|
G

A
x
G

G
|
G

S
x
T

A
|
A

G

A

N

C

T

V

L

L

A

A

T

N

R

R

L

L

T

S

E

A

D

D

A

G

G

S

V

K

T

R

V

V

L

L

L

V

L
|
L

E
|
E

A
|
A

G

G

G

P

P

D

D

N

Y

T

R

S

L

R

D

D

F

V

R

K

T

-

Q

-

M

I

P

P

A
|
A

A

A

L

I

A
x
T

F

R

P

L

L
x
F

Q

R

G

-

R

S

R

P

Y

L

N

D

W
|
W

A

N

Y

L

E

F

T

S

D

E

P

L

E

Q

P

E

H

Q

M

L

D

A

G

E

R

R

R

Q

M

I

E

Y

C

M

G
x
A

R
|
R

G
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G

K
x
R

G
x
L

L

L

G

G

G
|
G

S
|
S

L

A

I
x
T

N
|
N

G
x
A

M
x
T

C
x
L

Y

Y

I

H

R

R

G

G

N

A

A

A

M

G

D

D

Y

Y

D

D

G

A

W

W

A

-

K

-

N

-

P

-

G

G

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V

E

E

D

G

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D

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C

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P

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Y

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F

F

R

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A

A

E

E

T

T

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-

A

D

D

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F

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P

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G

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A

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Y

H

H

G

G

G

S

E

G

G

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V

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S

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A

A

G

A

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A

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G

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Y

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N

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D

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N

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-

H

-

A

G

G

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-

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x
M

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V

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-

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x
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G

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x
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x
L

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T

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G

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A

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-
x
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G

-

V

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-
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T

-
x
Y

-

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-
x
F

-

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-
x
W

E

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H

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G

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T

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x
Q

M

L

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C

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D

P

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A

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I

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L

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T

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-

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-

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F

Y

I

I

R

R

E

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A

I

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A
x
S

F
x
N

H

A

P

I

S

T

C

G

S

T

C

C

K

K

M

M

G

G

T

N

-

A

-

G

D

D

E

S

M

S

A

S

V

V

D

D

G

N

Q

Q

G

L

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R

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H

H

G

G

M

V

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E

G

G

L

L

R

R

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V

D
|
D

A
|
A

S

S

I

V

M

V

P

P

L

K

I

I

T

P

T

G

G

G

N
x
Q

L
x
T

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x
G

A

A

P

P

T
x
V

I

V

M

M

I

I

A

A

E

E

K

R

I

A

A

A

D

A

K

L

I

L

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G

G

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A

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I

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G

R

A

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A

A

A

binding carbon dioxide: R375 (≠ H365), S498 (≠ A473), N499 (≠ F474)
binding flavin-adenine dinucleotide: G14 (= G11), G15 (≠ A12), G16 (= G13), T17 (≠ S14), A18 (= A15), L37 (= L34), E38 (= E35), A39 (= A36), F58 (≠ L57), W64 (= W64), A82 (≠ G82), R83 (= R83), G84 (= G84), R85 (≠ K85), L86 (≠ G86), G89 (= G89), S90 (= S90), S91 (= S91), T93 (≠ I93), N94 (= N94), A95 (≠ G95), T96 (≠ M96), L97 (≠ C97), M191 (≠ V193), A220 (= A222), A221 (≠ L223), V222 (≠ T224), C264 (= C259), A265 (≠ S260), G266 (= G261), H269 (≠ A264), L273 (≠ I268), N499 (≠ F474), D533 (= D506), A534 (= A507), Q544 (≠ N517), T545 (≠ L518), G546 (≠ N519), V549 (≠ T522)
binding heptadecane: A52 (= A51), T55 (≠ A54), F58 (≠ L57), I324 (= I328), S353 (= S342), T354 (≠ N343), V377 (≠ L367), G379 (vs. gap), M380 (≠ V369), A381 (= A370), G386 (= G375), T389 (vs. gap), Y390 (vs. gap), F393 (vs. gap), W403 (vs. gap), T408 (≠ Q385), Q410 (≠ H387)

A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see paper)
34% identity, 95% coverage: 3:539/567 of query aligns to 82:642/654 of A0A248QE08

query
sites
A0A248QE08

H

Q

E

K

Y

Y

D

D

Y

Y

I

I

I

L

I

V

G

G

A

G

G

G

S
x
T

A
|
A

G

A

N

C

T

V

L

L

A

A

T

N

R

R

L

L

T

S

E

A

D

D

A

G

G

S

V

K

T

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V

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L

L

L

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L

L

E
|
E

A

A

G

G

G

P

P

D

D

N

Y

T

R

S

L

R

D

D

F

V

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T

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Q

-

M

I

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P

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A

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I

A

T

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R

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L

L

F

Q

R

G

-

R

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A

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Q

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E

Y

C

M

G

A

R

R

G

G

K

R

G
x
L

L

L

G

G

S
|
S

S

S

L

A

I

T

N
|
N

G
x
A

M
x
T

C
x
L

Y

Y

I

H

R

R

G

G

N

A

A

A

M

G

D

D

Y

Y

D

D

G

A

W

W

A

-

K

-

N

-

P

-

G

G

L

V

E

E

D

G

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W

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S

Y

S

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E

D

D

C

V

L

L

P

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Y

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F

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A

A

E

E

T

T

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N

-

A

D

D

I

F

G

G

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P

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G

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A

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Y

H

H

G

G

G

S

E

G

G

G

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A

A

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A

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A

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E

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H

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Y

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A

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x
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R

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F

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E

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A

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E

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A

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F

N

H

A

P

I

S

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C

G

S

T

C

C

K

K

M

M

G

G

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N

-

A

-

G

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M

S

A

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E

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T

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G

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N

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L

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N
x
G

A

A

P

P

T

V

I

V

M

M

I

I

A

A

E

E

K

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I

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A

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L

I

TA 93:94 (≠ SA 14:15) binding
E114 (= E35) binding
L162 (≠ G86) binding
S166 (= S90) binding
NATL 170:173 (≠ NGMC 94:97) binding
V298 (≠ T224) binding
C432 (≠ F345) binding
R451 (≠ H365) binding
Y466 (vs. gap) binding
Q486 (≠ H387) binding
G622 (≠ N519) binding

3ljpA Crystal structure of choline oxidase v464a mutant (see paper)
33% identity, 94% coverage: 4:534/567 of query aligns to 13:527/530 of 3ljpA

query
sites
3ljpA

E

E

Y

F

D

D

Y

Y

I

I

I

V

I
x
V

G
|
G

A
x
G

G
|
G

S
|
S

A
|
A

G

G

N

A

T

A

L

V

A

A

T

A

R

R

L

L

T

S

E

E

D

D

A

P

G

A

V

V

T

S

V

V

L

A

L

L

L

V

E
|
E

A
|
A

G

G

G

P

P

D

D

D

Y

R

R

G

L

V

D

P

F

E

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T

L

Q

Q

M

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P

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A

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A

W

L

M

A

E

F

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P

L

L

E

Q

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G

G

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-

Y

Y

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D

W
|
W

A

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Y

Y

E

P

T

I

D

E

P

P

E

Q

P

E

H

N

M

G

D

N

G

S

R

F

R

-

M

M

E

R

C

H

G

A

R
|
R

G
x
A

K
|
K

G
x
V

L

M

G

G

G
|
G

S
x
C

S
|
S

L

S

I
x
H

N
|
N

G
x
S

M
x
C

C
x
I

Y

A

I

F

R

W

G

A

N

P

A

R

M

E

D

D

Y

L

D

D

G

E

W

W

A

E

K

A

N

K

P

Y

G

G

L

A

E

T

D

G

W

W

T

N

Y

A

L

E

D

A

C

A

L

W

P

P

Y

L

F

Y

R

K

K

R

A

L

E

E

T

T

-

N

R

E

D

D

I

A

G

G

P

P

N

D

D

A

-

P

Y

H

H

H

G

G

G

D

E

S

G

G

P

P

V

V

S

H

V

L

T

M

T

N

-

V

-

P

P

P

K

K

A

-

G

-

N

-

N

D

P

P

L

T

F

G

H

V

A

A

M

L

V

L

E

D

A

A

G

C

V

E

Q

Q

A

A

G

G

Y

I

P

P

R

R

T

A

E

K

D

F

L

N

N

T

G

G

-

T

-

V

Y

V

Q

N

Q

G

E

A

G

N

F

F

G

F

P

Q

M

I

D

N

R

R

T

R

V

A

T

-

P

-

K

D

G

G

R

T

R

R

S

S

T

S

A

S

R

V

G

S

Y

Y

L

I

D

H

I

P

A

I

K

V

K

E

R

Q

S

E

T

N

L

F

N

T

I

L

V

L

T

T

H

G

A
x
L

L
x
R

T
x
A

D

R

K

Q

I

L

L

V

F

F

E

D

G

A

-

D

K

R

R

R

A

C

I

T

G

G

V

V

R

D

Y

I

L

V

V

D

G

S

S

A

A

F

E

G

E

H

P

T

V

H

E

R

A

L

R

T

A

A

R

R

K

N

E

E

V

V

L

V

L

L

C
x
S

S
x
T

G
|
G

A

A

I

I

A
x
D

S

T

P

P

Q

K

I

L

L

L

Q

M

R

L

S

S

G

G

V

I

G

G

P

P

A

A

K

A

L

H

L

L

K

A

S

E

L

H

D

G

I

I

P

E

V

V

V

L

H

V

D

D

L

S

P

P

G

G

V

V

G

G

E

E

N

H

L

L

Q

Q

D

D

H

H

L

P

E

E

L

G

Y

V

L

V

Q

Q

Y

F

A

E

C

A

T

K

Q

Q

P

P

V

M

S

V

L

A

Y

E

P

S

S

T

L

Q

L

W

W

W

Y

-

N

-

Q

-

P

-

A

-

I

-

G

-

A

-

E

-

W

-

L

-

F

-

N

-

G

-

T

-

G

-

I

-

G

-

A

-

S

-

N

-

Q

-

F

-

E

E

A
x
I

G

G

G

I

F

F

I

T

R

P

T

T

R

E

P

D

D

G

F

L

E

D

W

R

P

P

N

D

I

L

Q

M

Y

M

H

H

F

Y

L

G

P

S

V

V

A

P

I

F

N

D

Y

M

N

N

G

T

S

L

N

R

G

H

-

G

-

Y

-

P

V

T

K

T

E

E

H

N

G

G

F

F

Q

S

A

L

H

T

M
x
P

G
x
N

S

V

M

T

R

H

S

A

P

R

S

S

R

R

G

G

R

T

I

V

Q

R

V

L

K

R

S

S

K

R

D

D

P

F

R

R

Q

D

H

K

P

P

S

M

I

V

L

D

F

P

N

R

Y

Y

M

F

A

T

T

D

E

P

Q

E

-

G

-

H

D

D

W

M

Q

R

E

V

F

M

R

V

D

A

G

G

I

I

R

R

L

K

T

A

R

R

E

E

I

I

M

A

Q

A

Q

Q

P

P

A

A

L

M

D

A

A

E

F

W

R

T

G

G

R

R

E

E

L

L

S

S

P

P

G

G

I

V

E

E

V

A

Q

Q

T

T

D

D

E

E

Q

E

L

L

D

Q

K

D

F

Y

I

I

R

R

E

K

H

T

A

H

E

N

T

T

A
|
A

F
x
Y

H
|
H

P

P

S

V

C

G

S

T

C

V

K

R

M

M

G

G

T

A

-

V

-

E

D

D

E

E

M

M

A

S

V

P

V

L

D

D

G

P

Q

E

G

L

R

R

V

V

H

K

G

G

M

V

Q

T

G

G

L

L

R

R

V

V

V

A

D
|
D

A
|
A

S

S

I

V

M

M

P

P

L

E

I

H

T

V

T

T

G
x
V

N
|
N

L
x
P

N
|
N

A

I

P

T

T
x
V

I

M

M

M

I

I

A

G

E

E

K

R

I

C

A

A

D

D

K

L

I

I

R

R

active site: I333 (≠ A347), P377 (≠ M388), N378 (≠ G389), A464 (= A473), H466 (= H475), V509 (≠ G516), N510 (= N517)
binding dihydroflavine-adenine dinucleotide: V19 (≠ I10), G20 (= G11), G21 (≠ A12), G22 (= G13), S23 (= S14), A24 (= A15), E44 (= E35), A45 (= A36), W71 (= W64), R89 (= R83), A90 (≠ G84), K91 (= K85), V92 (≠ G86), G95 (= G89), C96 (≠ S90), S97 (= S91), H99 (≠ I93), N100 (= N94), S101 (≠ G95), C102 (≠ M96), I103 (≠ C97), L230 (≠ A222), R231 (≠ L223), A232 (≠ T224), S268 (≠ C259), T269 (≠ S260), G270 (= G261), D273 (≠ A264), Y465 (≠ F474), H466 (= H475), D499 (= D506), A500 (= A507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)

4mjwA Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
33% identity, 94% coverage: 4:534/567 of query aligns to 13:527/532 of 4mjwA

query
sites
4mjwA

E

E

Y

F

D

D

Y

Y

I

I

I

V

G
|
G

A
x
G

G
|
G

S
|
S

A
|
A

G

G

N

A

T

A

L

V

A

A

T

A

R

R

L

L

T

S

E

E

D

D

A

P

G

A

V

V

T

S

V

V

L

A

L

L

L

V

E
|
E

A
|
A

G

G

G

P

P

D

D

D

Y

R

R

G

L

V

D

P

F

E

R

V

T

L

Q

Q

M

L

P

D

A

R

A

W

L

M

A

E

F

L

P

L

L

E

Q

S

G

G

R

-

Y

Y

N

D

W
|
W

A

D

Y

Y

E

P

T

I

D

E

P

P

E

Q

P

E

H

N

M

G

D

N

G

S

R

F

R

-

M

M

E

R

C

H

G
x
A

R
|
R

G
x
A

K
|
K

G
x
V

L

M

G

G

G
|
G

S
x
C

S
|
S

L

S

I
x
H

N
|
N

G
x
S

M
x
C

C
x
I

Y

A

I

F

R

W

G

A

N

P

A

R

M

E

D

D

Y

L

D

D

G

E

W

W

A

E

K

A

N

K

P

Y

G

G

L

A

E

T

D

G

W

W

T

N

Y

A

L

E

D

A

C

A

L

W

P

P

Y

L

F

Y

R

K

K

R

A

L

E

E

T

T

-

N

R

E

D

D

I

A

G

G

P

P

N

D

D

A

-

P

Y

H

H

H

G

G

G

D

E

S

G

G

P

P

V

V

S

H

V

L

T

M

T

N

-

V

-

P

P

P

K

K

A

-

G

-

N

-

N

D

P

P

L

T

F

G

H

V

A

A

M

L

V

L

E

D

A

A

G

C

V

E

Q

Q

A

A

G

G

Y

I

P

P

R

R

T

A

E

K

D

F

L

N

N

T

G

G

-

T

-

V

Y

V

Q

N

Q

G

E

A

G

N

F

F

G

F

P

Q

M

I

D

N

R

R

T

R

V

A

T

-

P

-

K

D

G

G

R

T

R

R

S

S

T

S

A

S

R

V

G

S

Y

Y

L

I

D

H

I

P

A

I

K

V

K

E

R

Q

S

E

T

N

L

F

N

T

I

L

V

L

T

T

H

G

A
x
L

L
x
R

T
x
A

D

R

K

Q

I

L

L

V

F

F

E

D

G

A

-

D

K

R

R

R

A

C

I

T

G

G

V

V

R

D

Y

I

L

V

V

D

G

S

S

A

A

F

E

G

E

H

P

T

V

H

E

R

A

L

R

T

A

A

R

R

K

N

E

E

V

V

L

V

L

L

C
x
S

S
x
T

G
|
G

A

A

I

I

A
x
D

S

T

P

P

Q

K

I
x
L

L

L

Q

M

R

L

S

S

G

G

V

I

G

G

P

P

A

A

K

A

L

H

L

L

K

A

S

E

L

H

D

G

I

I

P

E

V

V

V

L

H

V

D

D

L

S

P

P

G

G

V

V

G

G

E

E

N

H

L

L

Q

Q

D

D

H

H

L

P

E

E

L

G

Y

V

L

V

Q

Q

Y

F

A

E

C

A

T

K

Q

Q

P

P

V

M

S

V

L

A

Y

E

P

S

S

T

L

Q

L

W

W

W

Y

-

N

-

Q

-

P

-

A

-

I

-

G

-

A

-

E

-

W

-

L

-

F

-

N

-

G

-

T

-

G

-

I

-

G

-

A

-

S

-

N

-

Q

-

F

-

E

E

A
x
I

G

G

G

I

F

F

I

T

R

P

T

T

R

E

P

D

D

G

F

L

E

D

W

R

P

P

N

D

I

L

Q

M

Y

M

H

H

F

Y

L

G

P

S

V

V

A

P

I

F

N

D

Y

M

N

N

G

T

S

L

N

R

G

H

-

G

-

Y

-

P

V

T

K

T

E

E

H

N

G

G

F

F

Q

S

A

L

H

T

M
x
P

G
x
N

S

V

M

T

R

H

S

A

P

R

S

S

R

R

G

G

R

T

I

V

Q

R

V

L

K

R

S

S

K

R

D

D

P

F

R

R

Q

D

H

K

P

P

S

M

I

V

L

D

F

P

N

R

Y

Y

M

F

A

T

T

D

E

P

Q

E

-

G

-

H

D

D

W

M

Q

R

E

V

F

M

R

V

D

A

G

G

I

I

R

R

L

K

T

A

R

R

E

E

I

I

M

A

Q

A

Q

Q

P

P

A

A

L

M

D

A

A

E

F

W

R

T

G

G

R

R

E

E

L

L

S

S

P

P

G

G

I

V

E

E

V

A

Q

Q

T

T

D

D

E

E

Q

E

L

L

D

Q

K

D

F

Y

I

I

R

R

E

K

H

T

A

H

E

N

T

T

A
x
V

F
x
Y

H
|
H

P

P

S

V

C

G

S

T

C

V

K

R

M

M

G

G

T

A

-

V

-

E

D

D

E

E

M

M

A

S

V

P

V

L

D

D

G

P

Q

E

G

L

R

R

V

V

H

K

G

G

M

V

Q

T

G

G

L

L

R

R

V

V

V

A

D
|
D

A
|
A

S

S

I

V

M

M

P

P

L

E

I

H

T

V

T

T

G
x
V

N
|
N

L
x
P

N
|
N

A

I

P

T

T
x
V

I

M

M

M

I

I

A

G

E

E

K

R

I

C

A

A

D

D

K

L

I

I

R

R

active site: I333 (≠ A347), P377 (≠ M388), N378 (≠ G389), V464 (≠ A473), H466 (= H475), V509 (≠ G516), N510 (= N517)
binding flavin-adenine dinucleotide: G20 (= G11), G21 (≠ A12), G22 (= G13), S23 (= S14), A24 (= A15), E44 (= E35), A45 (= A36), W71 (= W64), A88 (≠ G82), R89 (= R83), A90 (≠ G84), K91 (= K85), V92 (≠ G86), G95 (= G89), C96 (≠ S90), S97 (= S91), H99 (≠ I93), N100 (= N94), S101 (≠ G95), C102 (≠ M96), I103 (≠ C97), L230 (≠ A222), R231 (≠ L223), A232 (≠ T224), S268 (≠ C259), T269 (≠ S260), G270 (= G261), D273 (≠ A264), L277 (≠ I268), Y465 (≠ F474), H466 (= H475), D499 (= D506), A500 (= A507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)

2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism (see paper)
33% identity, 94% coverage: 4:534/567 of query aligns to 13:527/527 of 2jbvA

query
sites
2jbvA

E

E

Y

F

D

D

Y

Y

I

I

I

V

G
|
G

A
x
G

G
|
G

S
|
S

A
|
A

G

G

N

A

T

A

L

V

A

A

T

A

R

R

L

L

T

S

E

E

D

D

A

P

G

A

V

V

T

S

V

V

L

A

L

L

L

V

E
|
E

A
|
A

G

G

G

P

P

D

D

D

Y

R

R

G

L

V

D

P

F

E

R

V

T

L

Q

Q

M

L

P

D

A

R

A

W

L

M

A

E

F

L

P

L

L

E

Q

S

G

G

R

-

Y

Y

N

D

W
|
W

A

D

Y

Y

E

P

T

I

D

E

P

P

E

Q

P

E

H

N

M

G

D

N

G

S

R

F

R

-

M

M

E

R

C

H

G

A

R
|
R

G
x
A

K

K

G
x
V

L

M

G

G

G
|
G

S
x
C

S
|
S

L

S

I
x
H

N
|
N

G
x
S

M
x
C

C
x
I

Y

A

I

F

R

W

G

A

N

P

A

R

M

E

D

D

Y

L

D

D

G

E

W

W

A

E

K

A

N

K

P

Y

G

G

L

A

E

T

D

G

W

W

T

N

Y

A

L

E

D

A

C

A

L

W

P

P

Y

L

F

Y

R

K

K

R

A

L

E

E

T

T

-

N

R

E

D

D

I

A

G

G

P

P

N

D

D

A

-

P

Y

H

H

H

G

G

G

D

E

S

G

G

P

P

V

V

S

H

V

L

T

M

T

N

-

V

-

P

P

P

K

K

A

-

G

-

N

-

N

D

P

P

L

T

F

G

H

V

A

A

M

L

V

L

E

D

A

A

G

C

V

E

Q

Q

A

A

G

G

Y

I

P

P

R

R

T

A

E

K

D

F

L

N

N

T

G

G

-

T

-

V

Y

V

Q

N

Q

G

E

A

G

N

F

F

G

F

P

Q

M

I

D

N

R

R

T

R

V

A

T

-

P

-

K

D

G

G

R

T

R

R

S

S

T

S

A

S

R

V

G

S

Y

Y

L

I

D

H

I

P

A

I

K

V

K

E

R

Q

S

E

T

N

L

F

N

T

I

L

V

L

T

T

H

G

A
x
L

L
x
R

T
x
A

D

R

K

Q

I

L

L

V

F

F

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D

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A

-

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N

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x
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G

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x
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active site: I333 (≠ A347), P377 (≠ M388), N378 (≠ G389), V464 (≠ A473), H466 (= H475), V509 (≠ G516), N510 (= N517)
binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate: G20 (= G11), G21 (≠ A12), G22 (= G13), S23 (= S14), A24 (= A15), E44 (= E35), A45 (= A36), W71 (= W64), R89 (= R83), A90 (≠ G84), V92 (≠ G86), G95 (= G89), C96 (≠ S90), S97 (= S91), H99 (≠ I93), N100 (= N94), S101 (≠ G95), C102 (≠ M96), I103 (≠ C97), L230 (≠ A222), R231 (≠ L223), A232 (≠ T224), S268 (≠ C259), T269 (≠ S260), G270 (= G261), D273 (≠ A264), V464 (≠ A473), Y465 (≠ F474), H466 (= H475), D499 (= D506), A500 (= A507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)

4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex (see paper)
33% identity, 93% coverage: 6:530/567 of query aligns to 3:501/508 of 4ha6A

query
sites
4ha6A

D

D

Y

I

I

V

I

I

I
x
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G
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G

A
x
G

G
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G

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N

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L

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L

A

A

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A

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A