SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AO353_11690 FitnessBrowser__pseudo3_N2E3:AO353_11690 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 9 hits to proteins with known functional sites (download)

P54582 Glycine betaine transporter BetP; Glycine betaine permease from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 6 papers)
38% identity, 69% coverage: 53:509/667 of query aligns to 97:556/595 of P54582

query
sites
P54582

N

D

T

N

V

L

G

G

W
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Y

A

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F

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I

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Q

W101 (= W57) mutation to A: Mainly monomeric, shows a decrease in activity and cannot be activated in response to increased osmolality; when associated with A-351.
E135 (= E91) mutation to A: Strongly decreased betaine transport.
G149 (= G105) mutation to A: Decreases betaine transport. No effect on activation by increased osmolality.
M150 (≠ I106) mutation to F: No effect on activation by increased osmolality; when associated with A-152.
G151 (≠ S107) mutation to A: Nearly abolishes betaine transport.
I152 (= I108) mutation to A: No effect on activation by increased osmolality; when associated with F-150.
IG 152:153 (≠ IT 108:109) binding
G153 (≠ T109) mutation to A: Decreases betaine transport and alters activation at higher osmolality.; mutation to D: Changes substrate specificity, giving rise to proton-coupled choline transport. Decreases sodium-dependent betaine transport.
F156 (= F112) mutation to A: Decreases betaine transport, but has no major effect on affinity for glycine betaine.
W189 (= W147) mutation to C: Mildly decreased betaine transport.
W194 (= W152) mutation to L: Strongly decreased betaine transport.
Y197 (≠ F155) mutation to L: Nearly abolishes betaine transport.
R210 (= R168) mutation to A: Nearly abolishes betaine transport.
S253 (≠ D210) binding
G301 (= G257) mutation to L: Strongly decreased betaine transport.
N309 (= N265) mutation to A: Decreases affinity for sodium ions.
T351 (≠ D306) mutation to A: Mainly trimeric, but shows reduced activity at high osmolalities. Mainly monomeric, shows a decrease in activity and cannot be activated in response to increased osmolality; when associated with A-101.
W362 (= W316) mutation to C: Strongly decreased betaine transport.
W366 (= W320) mutation to C: No effect on betaine transport.
F369 (= F323) mutation to G: Decreases affinity for glycine betaine. Decreases betaine transport.
W371 (= W325) mutation to L: No effect on betaine transport.
W373 (= W327) mutation to A: Strongly decreases affinity for glycine betaine and betaine transport.
WWISW 373:377 (≠ WWIAW 327:331) binding
W374 (= W328) mutation to A: Strongly decreases betaine transport, but has no major effect on affinity for glycine betaine.; mutation to L: No effect on betaine transport.
W377 (= W331) mutation to A: Abolishes betaine transport.; mutation to L: Nearly abolishes betaine transport.
F380 (= F334) mutation to A: Decreases betaine transport, but has no effect on affinity for glycine betaine.
F384 (= F338) mutation to A: Decreases betaine transport, but has no effect on affinity for glycine betaine.
R387 (= R341) mutation to A: Mildly decreased betaine transport.
R392 (= R346) mutation to K: Moderately decreased betaine transport.

4llhA Substrate bound outward-open state of the symporter betp (see paper)
38% identity, 69% coverage: 53:509/667 of query aligns to 41:497/524 of 4llhA

query
sites
4llhA

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binding 2-(trimethyl-lambda~5~-arsanyl)ethanol: M94 (≠ I106), G95 (≠ S107), D97 (≠ T109), W314 (= W327), W315 (= W328), W318 (= W331)
binding 5-cyclohexyl-1-pentyl-beta-d-maltoside: R495 (≠ Q507)
binding sodium ion: A91 (= A103), M94 (≠ I106), G95 (≠ S107), F405 (= F422), T408 (= T425), S409 (= S426)

Sites not aligning to the query:

binding 5-cyclohexyl-1-pentyl-beta-d-maltoside: 499

3p03C Crystal structure of betp-g153d with choline bound (see paper)
38% identity, 69% coverage: 53:509/667 of query aligns to 41:496/508 of 3p03C

query
sites
3p03C

N

D

T

N

V

L

G

G

W

W

Y

A

Y

F

M

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L

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W

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M

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F

A

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A
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A

G

G

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x
M

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L

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T

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E

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P

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A

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W

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Y

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N

G

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A

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W

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G

G

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D

G

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K

G

G

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S

D

N

I

A

N

N

M

M

L

V

L

L

A

A

C

A

A

L

L

L

L

A

L

I

F

F

V

V

L

F

F

V

A

V

G

G

P

P

T

T

Q

V

H

S

L

I

L

L

N

N

T

L

L

L

I

P

Q

G

N

S

L

I

G

G

D

N

Y

Y

L

L

G

S

A

N

L

F

-

F

P

Q

M

M

K

A

S

G

F

R

D

T

L

A

Y

M

A

S

Y

A

D

D

K

G

P

T

S

A

-

G

D

E

W

W

L

L

G

G

G

S

W

W

T

T

V

I

F

F

Y

Y

W

W

A

A

W

W

I

I

A

S

W

W

S

S

P

P

F
|
F

V

V

G

G

L

M

F

F

I

L

A

A

R

R

I

I

S

S

R

R

G

G

R

R

T

S

I

I

R

R

E

E

F

F

V

I

F

L

G

G

V

V

L

L

I

V

P

P

L

A

G

G

F

V

T

S

L

T

A

V

W

W

M

F

S

S

I

I

F

F

G

G

N

G

S

T

A

A

I

I

D

-

Q

V

V

F

L

E

N

Q

H

N

G

G

M

E

S

S

A

I

L

W

G

G

L

D

S

G

A

A

I

A

E

E

N

E

P

Q

S

-

M

-

T

-

L

L

Y

F

L

G

L

L

E

H

T

A

Y

L

P

P

W

G

S

G

K

Q

T

I

V

M

I

G

A

I

V

I

T

A

V

M

F

I

I

L

S

L

F

G

V

T

F

F

V

I

T

T

S

S

A

A

D

D

S

S

G

A

T

S

V

T

V

V

L

M

S

G

T

T

L

M

S

S

A

Q

K

H

G

G

G

-

N

-

A

-

D

Q

E

L

D

E

G

A

P

N

K

K

W

W

L

V

R

T

V

A

F

A

W

W

G

G

A

V

M

A

T

T

A

A

L

A

V

I

T

G

S

L

A

T

L

L

F

L

A

S

G

G

-

G

-

D

-

N

S

A

I

L

D

S

S

N

L

L

K

Q

S

N

A

V

V

T

V

I

L

V

T

A

S

A

L

T

P

P

F

F

S

L

L

F

I

V

L

V

L

I

L

G

M

L

M

M

W

F

G

A

L

L

H

V

K

K

-

D

-

L

-

S

-

N

-

D

A

V

F

I

Y

Y

L

L

E

E

S

Y

Q

R

K

E

Q

Q

binding choline ion: A92 (= A104), M94 (≠ I106), D97 (≠ T109), F320 (= F334)

P31553 L-carnitine/gamma-butyrobetaine antiporter from Escherichia coli (strain K12) (see 3 papers)
28% identity, 66% coverage: 46:486/667 of query aligns to 42:482/504 of P31553

query
sites
P31553

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

V

M

M

T

L

L

F

-

G

-

W

-

F

Y

W

L

L

V

V

F

F

V

-

T

-

A

-

L

-

S

G

G

P

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

-

H

N

D

E

E

P

P

P

E

E

F

F

S

S

Y

T

L

A

S

S

W

W

A

I

G

F

M

M

L

M

F

F

A

A

A

S

G

C

I

T

S

S

I

A

T

A

L

V

F

L

F

F

F

W

C

G

V

S

S

I

E

E

P

I

L

Y

T
x
Y

H

Y

M

I

L

S

Q

T

P

P

Q

F

G

G

-

L

E

E

A

P

G

N

T

S

A

T

D

G

A

A

A

K

R

E

Q

L

A

G

M

L

Q

A

V

Y

L

S

F

L

L

F

H

H

W
|
W

G

G

L

P

H

L

G

P

W

W

G

A

V

T

F

Y

A

S

F

F

V

L

G

S

M

V

A

A

L

F

A

A

Y

Y

F

F

A

F

Y

F

R

V

H

R

N

K

L

M

P

E

L

V

A

I

L

R

-

P

R

S

S

S

A

T

L

L

Y

V

P

P

L

L

I

V

G

G

-

E

K

K

R

H

I

A

N

K

G

G

P

L

I

F

G

G

Y

T

A

I

V

V

D

D

G

N

F

F

G

Y

I

L

I

V

A

A

T

L

V

I

F

F

G

A

L

M

G

G

A

T

D

S

M

L

G

G

F

L

G

A

V

T

L

P

H

L

L

V

N

T

S

E

G

C

L

M

D

Q

Y

W

L

L

F

F

G

G

I

I

A

P

H

H

T

T

Q

L

W

Q

I

L

Q

D

V

A

G

I

L

I

I

I

T

T

L

C

M

W

M

I

G

I

A

L

A

N

I

A

I

I

V

C

A

V

V

A

A

C

G

G

V

L

D

Q

K

K

G

G

V

V

R

R

V

I

M

A

S

S

D

D

I

V

N

R

M

S

L

Y

L

L

A

S

C

F

A

L

L

M

L

L

L

G

F

W

V

V

L

F

F

I

A

V

G

S

P

G

T

A

Q

S

H

F

L

I

L

M

N

N

T

Y

L

F

I

T

Q
x
D

N

S

L

V

G

G

D

M

Y

L

L

L

G
x
M

A

Y

L

L

P

P

M
x
R

K

M

S

L

F

F

D

-

L

-

Y

-

A

-

Y

Y

D
x
T

K

D

P

P

S

I

D

A

W

K

L

G

G

G

-

F

-

P

-

Q

G
|
G

W
|
W

T

T

V

V

F

F

Y

Y

W

W

A

A

W
|
W

I

V

A

I

W
x
Y

S
x
A

P
x
I

F
x
Q

V
x
M

G

S

L

I

F

F

I

L

A

A

R

R

I

I

S

S

R

R

G

G

R

R

T

T

I

V

R

R

E

E

F

L

V

C

F

F

G

G

V

M

L

V

L

L

I

G

P

L

L

T

G

A

F

S

T

T

L

W

A

I

W

L

M

W

S

T

I

V

F

L

G

G

N

S

S

N

A

T

I

L

D

L

Q

L

V

I

L

D

N

K

H

N

G

I

M

I

S

N

A

I

L

P

G

N

L

L

S

-

A

-

I

I

E

E

N

Q

P

Y

S

G

M

V

T

A

L

-

Y

R

L

A

L

I

E

E

T

T

Y

W

-

A

-

L

P

P

W

L

S

S

K

T

T

A

V

T

I

M

A

W

V

G

T

F

V

F

F

I

I

L

S

C

F

F

V

I

F

A

F

T

V

V

T

T

S

L

A

V

D

N

S

A

G

C

T

S

V

Y

V

T

L

L

S

A

T

M

L

S

S

T

A

C

K

R

G

E

G

V

N

R

A

D

D

G

E

E

D

E

G

P

P

P

K

L

W

L

L

V

R

R

V

I

F

G

W

W

G

S

A

I

M

L

T

V

A

G

L

I

V

I

T

G

S

I

A

V

L

L

F

A

A

L

G

G

S

G

I

L

D

K

S

P

L

I

K

Q

S

T

A

A

V

I

L

A

T

G

S

G

L

C

P

P

Y114 (≠ T120) binding ; mutation to L: Small decrease in transport activity.
W142 (= W147) binding
D288 (≠ Q291) mutation to A: Retains 70% of transport activity. Forms mostly monomers.; mutation to R: Abolishes transport activity. Forms mostly monomers.; mutation to W: Retains 4% of transport activity. Forms mostly monomers.
M295 (≠ G298) mutation to E: Does not affect transport activity. Forms mostly monomers. Can also form small amounts of homodimers and homotrimers.
R299 (≠ M302) mutation to A: Does not affect transport activity. Forms mostly monomers. Can also form small amounts of homodimers and homotrimers. Shows a high tendency to aggregate.
T304 (≠ D311) mutation to A: Does not affect transport activity. Forms mostly monomers. Shows a high tendency to aggregate.
GW 315:316 (= GW 319:320) binding
W316 (= W320) mutation to L: Decrease in transport activity.
W323 (= W327) binding ; mutation to L: Abolishes transport activity.
WW 323:324 (= WW 327:328) binding
W324 (= W328) mutation to L: Abolishes transport activity.
Y327 (≠ W331) mutation to L: Strong decrease in transport activity.
YAIQ 327:330 (≠ WSPF 331:334) binding
Q330 (≠ F334) mutation to L: Decrease in transport activity.
M331 (≠ V335) binding

3hfxA Crystal structure of carnitine transporter (see paper)
28% identity, 66% coverage: 46:486/667 of query aligns to 31:471/493 of 3hfxA

query
sites
3hfxA

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

V

M

M

T

L

L

F

-

G

-

W

-

F

Y

W

L

L

V

V

F

F

V

-

T

-

A

-

L

-

S

G

G

P

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

-

H

N

D

E

E

P

P

P

E

E

F

F

S

S

Y

T

L

A

S

S

W

W

A

I

G

F

M

M

L

M

F

F

A

A

A

S

G

C

I

T

S

S

I

A

T

A

L

V

F

L

F

F

F

W

C

G

V

S

S

I

E

E

P

I

L

Y

T
x
Y

H

Y

M

I

L

S

Q

T

P

P

Q

F

G

G

-

L

E

E

A

P

G

N

T

S

A

T

D

G

A

A

A

K

R

E

Q

L

A

G

M

L

Q

A

V

Y

L

S

F

L

L

F

H

H

W
|
W

G

G

L

P

H

L

G

P

W

W

G

A

V

T

F

Y

A

S

F

F

V

L

G

S

M

V

A

A

L

F

A

A

Y

Y

F

F

A

F

Y

F

R

V

H

R

N

K

L

M

P

E

L

V

A

I

L

R

-

P

R

S

S

S

A

T

L

L

Y

V

P

P

L

L

I

V

G

G

-

E

K

K

R

H

I

A

N

K

G

G

P

L

I

F

G

G

Y

T

A

I

V

V

D

D

G

N

F

F

G

Y

I

L

I

V

A

A

T

L

V

I

F

F

G

A

L

M

G

G

A

T

D

S

M

L

G

G

F

L

G

A

V

T

L

P

H

L

L

V

N

T

S

E

G

C

L

M

D

Q

Y

W

L

L

F

F

G

G

I

I

A

P

H

H

T

T

Q

L

W

Q

I

L

Q

D

V

A

G

I

L

I

I

I

T

T

L

C

M

W

M

I

G

I

A

L

A

N

I

A

I

I

V

C

A

V

V

A

A

C

G

G

V

L

D

Q

K

K

G

G

V

V

R

R

V

I

M

A

S

S

D

D

I

V

N

R

M

S

L

Y

L

L

A

S

C

F

A

L

L

M

L

L

L

G

F

W

V

V

L

F

F

I

A

V

G

S

P

G

T

A

Q

S

H

F

L

I

L

M

N

N

T

Y

L

F

I

T

Q

D

N

S

L

V

G

G

D

M

Y

L

L

L

G

M

A

Y

L

L

P

P

M

R

K

M

S

L

F

F

D

-

L

-

Y

-

A

-

Y

Y

D

T

K

D

P

P

S

I

D

A

W

K

L

G

G

G

-

F

-

P

-

Q

G

G

W
|
W

T

T

V

V

F

F

Y

Y

W

W

A

A

W
|
W

I

V

A

I

W
x
Y

S

A

P

I

F
x
Q

V

M

G

S

L

I

F
|
F

I

L

A

A

R

R

I

I

S

S

R

R

G

G

R

R

T

T

I

V

R

R

E

E

F

L

V

C

F

F

G

G

V

M

L

V

L

L

I

G

P

L

L

T

G

A

F

S

T

T

L

W

A

I

W

L

M

W

S

T

I

V

F

L

G

G

N

S

S

N

A

T

I

L

D

L

Q

L

V

I

L

D

N

K

H

N

G

I

M

I

S

N

A

I

L

P

G

N

L

L

S

-

A

-

I

I

E

E

N

Q

P

Y

S

G

M

V

T

A

L

-

Y

R

L

A

L

I

E

E

T

T

Y

W

-

A

-

L

P

P

W

L

S

S

K

T

T

A

V

T

I

M

A

W

V

G

T

F

V

F

F

I

I

L

S

C

F

F

V

I

F

A

F

T

V

V

T

T

S

L

A

V

D

N

S

A

G

C

T

S

V

Y

V

T

L

L

S

A

T

M

L

S

S

T

A

C

K

R

G

E

G

V

N

R

A

D

D

G

E

E

D

E

G

P

P

P

K

L

W

L

L

V

R

R

V

I

F

G

W

W

G

S

A

I

M

L

T

V

A

G

L

I

V

I

T

G

S

I

A

V

L

L

F

A

A

L

G

G

S

G

I

L

D

K

S

P

L

I

K

Q

S

T

A

A

V

I

L

A

T

G

S

G

L

C

P

P

binding carnitine: Y103 (≠ T120), W131 (= W147), W305 (= W320), W312 (= W327), W313 (= W328), Y316 (≠ W331), Y316 (≠ W331), Q319 (≠ F334), F323 (= F338)

2wswA Crystal structure of carnitine transporter from proteus mirabilis (see paper)
28% identity, 66% coverage: 46:486/667 of query aligns to 47:487/508 of 2wswA

query
sites
2wswA

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

I

M

M

T

F

-

G

-

W

L
x
F

Y

W

L

L

V

V

F
|
F

V

-

T

-

A

-

L

-

S

G

G
x
R

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

-

H

D

D

E

E

K

P

P

E

E

F

F

S

S

Y

T

L

A

S

S

W

W

A

I

G

F

M

M

L

M

F

F

A

A

A

S

G

C

I

T

S

S

I

A

T

A

L

V

F

L

F

F

F

W

C

G

V

S

S

I

E

E

P

I

L

Y

T

Y

H

Y

M

I

L

S

Q

S

P

P

Q

F

G

G

E

M

A

E

G

G

T

Y

A

S

D

A

A

P

A

A

R

K

Q

E

-

I

A

G

M

L

Q

A

V

Y

L

S

F

L

L

F

H

H

W

W

G

G

L

P

H

L

G

P

W

W

G

A

V

T

F

Y

A

S

F

F

V

L

G

S

M

V

A

A

L

F

A

A

Y

Y

F

F

A

F

Y

F

R

V

H

R

N

K

L

M

P

E

L

V

A

I

L

R

-

P

R

S

S

S

A

T

L

L

Y

V

P

P

L

L

I

V

G

G

-

E

K

K

R

H

I

V

N

N

G

G

P

L

I

F

G

G

Y

T

A

V

V

V

D

D

G

N

F

F

G

Y

I

L

I

V

A

A

T

L

V

I

F

L

G

A

L

M

G

G

A

T

D

S

M

L

G

G

F

L

G

A

V

T

L

P

H

L

L

V

N

T

S

E

G

C

L

I

D

Q

Y

Y

L

L

F

F

G

G

I

I

A

P

H

H

T

T

Q

L

W

Q

I

L

Q

D

V

A

G

I

L

I

I

I

T

S

L

C

M

W

M

I

G

L

A

L

A

N

I

A

I

I

V

C

A

V

V

A

A

F

G

G

V

L

D

Q

K

K

G

G

V

V

R

K

V

I

M

A

S

S

D

D

I

V

N

R

M

T

L

Y

L

L

A

S

C

F

A

L

L

M

L

L

L

G

F

W

V

V

L

F

F

I

A

V

G

G

P

G

T

A

Q

S

H

F

L

I

L

V

N

N

T

Y

L

F

I

T

Q

D

N

S

L

V

G

G

D

T

Y

L

L

L

G

M

A

Y

L

M

P

P

M

R

K

M

S

L

F

F

D

-

L

-

Y

-

A

-

Y

Y

D

T

K

D

P

P

S

I

D

G

W

K

L

G

G

G

-

F

-

P

-

Q

G

A

W

W

T

T

V

V

F

F

Y

Y

W

W

A

A

W

W

I

V

A

I

W

Y

S

A

P

I

F

Q

V

M

G

S

L

I

F

F

I

L

A

A

R

R

I

I

S

S

R

K

G

G

R

R

T

T

I

V

R

R

E

E

F

L

V

C

F

L

G

G

V

M

L

V

L

S

-

G

I

L

P

T

L

A

G

G

F

T

T

W

L

L

A

I

W

W

M

T

S

I

I

L

F

G

G

G

N

N

S

T

-

L

-

Q

A

L

I

I

D

D

Q

Q

V

-

L

-

N

-

H

-

G

-

M

-

S

N

A

I

L

L

G

N

L

I

S

P

A

Q

I

L

E

I

N

D

P

Q

S

Y

M

G

T

V

L

P

Y

R

L

A

L

I

E

E

T

T

Y

W

-

A

-

L

P

P

W

L

S

S

K

T

T

A

V

T

I

M

A

W

V

G

T

F

V

F

F

I

I

L

S

C

F

F

V

I

F

A

F

T

V

V

T

T

S

L

A

I

D

N

S

A

G

C

T

S

V

Y

V

T

L

L

S

A

T

M

L

S

S

T

A

C

K

R

G

S

G

M

N

K

A

E

D

G

E

A

D

D

G

P

P

P

K

L

W

L

L

V

R

R

V

I

F

G

W

W

G

S

A

V

M

L

T

V

A

G

L

I

V

I

T

G

S

I

A

I

L

L

F

A

A

L

G

G

S

G

I

L

D

K

S

P

L

I

K

Q

S

T

A

A

V

I

L

A

T

G

S

G

L

C

P

P

binding 5-cyclohexyl-1-pentyl-beta-d-maltoside: F72 (≠ L65), F76 (= F69), R78 (≠ G77)

2wsxA Crystal structure of carnitine transporter from escherichia coli (see paper)
28% identity, 66% coverage: 46:486/667 of query aligns to 35:475/496 of 2wsxA

query
sites
2wsxA

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

V

M

M

T

L

L

F

-

G

-

W

-

F

Y

W

L

L

V

V

F

F

V

-

T

-

A

-

L

-

S

G

G

P

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

-

H

E

D

E

E

P

P

P

E

E

F

F

S

S

Y

T

L

A

S

S

W

W

A

I

G

F

M

M

L

M

F

F

A

A

A

S

G

C

I

T

S

S

I

A

T

A

L

V

F

L

F

F

F

W

C

G

V

S

S

I

E

E

P

I

L

Y

T

Y

H

Y

M

I

L

S

Q

T

P

P

Q

F

G

G

-

L

E

E

A

P

G

N

T

S

A

T

D

G

A

A

A

K

R

E

Q

L

A

G

M

L

Q

A

V

Y

L

S

F

L

L

F

H

H

W
|
W

G

G

L

P

H

L

G

P

W

W

G

A

V

T

F

Y

A

S

F

F

V

L

G

S

M

V

A

A

L

F

A

A

Y

Y

F

F

A

F

Y

F

R

V

H

R

N

K

L

M

P

E

L

V

A

I

L

R

-

P

R

S

S

S

A

T

L

L

Y

V

P

P

L

L

I

V

G

G

-

E

K

K

R

H

I

A

N

K

G

G

P

L

I

F

G

G

Y

T

A

I

V

V

D

D

G

N

F

F

G

Y

I

L

I

V

A

A

T

L

V

I

F

F

G

A

L

M

G

G

A

T

D

S

M

L

G

G

F

L

G

A

V

T

L

P

H

L

L

V

N

T

S

E

G

C

L

M

D

Q

Y

W

L

L

F

F

G

G

I

I

A

P

H

H

T

T

Q

L

W

Q

I

L

Q

D

V

A

G

I

L

I

I

I

T

T

L

C

M

W

M

I

G

I

A

L

A

N

I

A

I

I

V

C

A

V

V

A

A

C

G

G

V

L

D

Q

K

K

G

A

V

V

R

R

V

I

M

A

S

S

D

D

I

V

N

R

M

S

L

Y

L

L

A

S

C

F

A

L

L

M

L

L

L

G

F

W

V

V

L

F

F

I

A

V

G

S

P

G

T

A

Q

S

H

F

L

I

L

M

N

N

T

Y

L

F

I

T

Q

D

N

S

L

V

G

G

D

M

Y

L

L

L

G

M

A

Y

L

L

P

P

M

R

K

M

S

L

F

F

D

-

L

-

Y

-

A

-

Y

Y

D

T

K

D

P

P

S

I

D

A

W

K

L

G

G
|
G

-

F

-

P

-

Q

G
|
G

W

W

T

T

V

V

F

F

Y

Y

W

W

A

A

W
|
W

W

W

I

V

A

I

W
x
Y

S

A

P

I

F

Q

V
x
M

G

S

L

I

F

F

I

L

A

A

R

R

I

I

S

S

R

R

G

G

R

R

T

T

I

V

R

R

E

E

F

L

V

C

F

F

G

G

V

M

L

V

L

L

I

G

P

L

L

T

G

A

F

S

T

T

L

W

A

I

W

L

M

W

S

T

I

V

F

L

G

G

N

S

S

N

A

T

I

L

D

L

Q

L

V

I

L

D

N

K

H

N

G

I

M

L

S

N

A

I

L

P

G

N

L

L

S

-

A

-

I

I

E

E

N

Q

P

Y

S

G

M

V

T

A

L

-

Y

R

L

A

L

I

E

E

T

T

Y

W

-

A

-

L

P

P

W

L

S

S

K

T

T

A

V

T

I

M

A

W

V

G

T

F

V

F

F

I

I

L

S

C

F

F

V

I

F

A

F

T

V

V

T

T

S

L

A

V

D

N

S

A

G

C

T

S

V

Y

V

T

L

L

S

A

T

M

L

S

S

T

A

C

K

R

G

E

G

V

N

R

A

D

D

G

E

E

D

D

G

P

P

P

K

L

W

L

L

V

R

R

V

I

F

G

W

W

G

S

A

I

M

L

T

V

A

G

L

I

V

I

T

G

S

I

A

V

L

L

F

A

A

L

G

G

S

G

I

L

D

K

S

P

L

I

K
x
Q

S

T

A

A

V

I

L

A

T

G

S

G

L

C

P

P

binding 3-carboxy-n,n,n-trimethylpropan-1-aminium: W135 (= W147), G304 (= G318), G308 (= G319), W316 (= W327), Y320 (≠ W331), M324 (≠ V335), Q466 (≠ K477)

4m8jA Crystal structure of cait r262e bound to gamma-butyrobetaine (see paper)
28% identity, 66% coverage: 46:486/667 of query aligns to 34:474/495 of 4m8jA

query
sites
4m8jA

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

I

M

M

T

F

-

G

-

W

L

F

Y

W

L

L

V

V

F

F

V

-

T

-

A

-

L

-

S

G

G

R

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

-

H

D

D

E

E

K

P

P

E

E

F

F

S

S

Y

T

L

A

S

S

W

W

A

I

G

F

M

M

L

M

F

F

A

A

A

S

G

C

I

T

S

S

I

A

T

A

L

V

F

L

F

F

F

W

C

G

V

S

S

I

E

E

P

I

L

Y

T

Y

H

Y

M

I

L

S

Q

S

P

P

Q

F

G

G

E

M

A

E

G

G

T

Y

A

S

D

A

A

P

A

A

R

K

Q

E

-

I

A

G

M

L

Q

A

V

Y

L

S

F

L

L

F

H

H

W

W

G

G

L

P

H

L

G

P

W
|
W

G

A

V

T

F

Y

A

S

F

F

V

L

G

S

M

V

A

A

L

F

A

A

Y

Y

F

F

A

F

Y

F

R

V

H

R

N

K

L

M

P

E

L

V

A

I

L

R

-

P

R

S

S

S

A

T

L

L

Y

V

P

P

L

L

I

V

G

G

-

E

K

K

R

H

I

V

N

N

G

G

P

L

I

F

G

G

Y

T

A

V

V

V

D

D

G

N

F

F

G

Y

I

L

I

V

A

A

T

L

V

I

F

L

G

A

L

M

G

G

A

T

D

S

M

L

G

G

F

L

G

A

V

T

L

P

H

L

L

V

N

T

S

E

G

C

L

I

D

Q

Y

Y

L

L

F

F

G

G

I

I

A

P

H

H

T

T

Q

L

W

Q

I

L

Q

D

V

A

G

I

L

I

I

I

T

S

L

C

M

W

M

I

G

L

A

L

A

N

I

A

I

I

V

C

A

V

V

A

A

F

G

G

V

L

D

Q

K

K

G

G

V

V

R

K

V

I

M

A

S

S

D

D

I

V

N

E

M

T

L

Y

L

L

A

S

C

F

A

L

L

M

L

L

L

G

F

W

V

V

L

F

F

I

A

V

G

G

P

G

T

A

Q

S

H

F

L

I

L

V

N

N

T

Y

L

F

I

T

Q

D

N

S

L

V

G

G

D

T

Y

L

L

L

G

M

A

Y

L

M

P

P

M

R

K

M

S

L

F

F

D

-

L

-

Y

-

A

-

Y

Y

D

T

K

D

P

P

S

I

D

G

W

K

L

G

G

G

-

F

-

P

-

Q

G

A

W

W

T

T

V

V

F

F

Y

Y

W

W

A

A

W
|
W

I

V

A

I

W

Y

S

A

P

I

F

Q

V

M

G

S

L

I

F

F

I

L

A

A

R

R

I

I

S

S

R

K

G

G

R

R

T

T

I

V

R

R

E

E

F

L

V

C

F

L

G

G

V

M

L

V

L

S

-

G

I

L

P

T

L

A

G

G

F

T

T

W

L

L

A

I

W

W

M

T

S

I

I

L

F

G

G

G

N

N

S

T

-

L

-

Q

A

L

I

I

D

D

Q

Q

V

-

L

-

N

-

H

-

G

-

M

-

S

N

A

I

L

L

G

N

L

I

S

P

A

Q

I

L

E

I

N

D

P

Q

S

Y

M

G

T

V

L

P

Y

R

L

A

L

I

E

E

T

T

Y

W

-

A

-

L

P

P

W

L

S

S

K

T

T

A

V

T

I

M

A

W

V

G

T

F

V

F

F

I

I

L

S

C

F

F

V

I

F

A

F

T

V

V

T

T

S

L

A

I

D

N

S

A

G

C

T

S

V

Y

V

T

L

L

S

A

T

M

L

S

S

T

A

C

K

R

G

S

G

M

N

K

A

E

D

G

E

A

D

D

G

P

P

P

K

L

W

L

L

V

R

R

V

I

F

G

W

W

G

S

A

V

M

L

T

V

A

G

L

I

V

I

T

G

S

I

A

I

L

L

F

A

A

L

G

G

S

G

I

L

D

K

S

P

L

I

K

Q

S

T

A

A

V

I

L

A

T

G

S

G

L

C

P

P

binding 3-carboxy-n,n,n-trimethylpropan-1-aminium: W139 (= W152), W315 (= W327), W316 (= W328)

B4EY22 L-carnitine/gamma-butyrobetaine antiporter from Proteus mirabilis (strain HI4320) (see 2 papers)
28% identity, 66% coverage: 46:486/667 of query aligns to 42:482/514 of B4EY22

query
sites
B4EY22

A

A

A

V

Q

F

N

S

W

Y

A

V

A

T

N

N

T

V

V

W

G

G

W

W

-

A

-

F

-

E

Y

W

Y

Y

M

M

L

V

A

I

M

M

T

F

-

G

-

W

L

F

Y

W

L

L

V

V

F

F

V

-

T

-

A

-

L

-

S

G

G

R

Y

Y

G

A

K

K

I

K

K

R

L

L

G

G

A

-

D

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E111 (= E117) mutation to A: Abolishes transport activity.
R262 (≠ N265) mutation R->A,E: Strong decrease in L-carnitine transport. Mutant is Na(+)-dependent for substrate binding and transport.
W316 (= W320) mutation to A: 2.5-fold decrease in Vmax.
M331 (≠ V335) mutation to V: 10-fold decrease in Vmax.

Query Sequence

>AO353_11690 FitnessBrowser__pseudo3_N2E3:AO353_11690
MSASFTPPSGQIRMNPPVFYFAATFILLFGLVVIAFPQESGAWLLAAQNWAANTVGWYYM
LAMTLYLVFVVVTALSGYGKIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLT
HMLQPPQGEAGTADAARQAMQVLFLHWGLHGWGVFAFVGMALAYFAYRHNLPLALRSALY
PLIGKRINGPIGYAVDGFGIIATVFGLGADMGFGVLHLNSGLDYLFGIAHTQWIQVGLIT
LMMGAAIIVAVAGVDKGVRVMSDINMLLACALLLFVLFAGPTQHLLNTLIQNLGDYLGAL
PMKSFDLYAYDKPSDWLGGWTVFYWAWWIAWSPFVGLFIARISRGRTIREFVFGVLLIPL
GFTLAWMSIFGNSAIDQVLNHGMSALGLSAIENPSMTLYLLLETYPWSKTVIAVTVFISF
VFFVTSADSGTVVLSTLSAKGGNADEDGPKWLRVFWGAMTALVTSALLFAGSIDSLKSAV
VLTSLPFSLILLLMMWGLHKAFYLESQKQIAQLHSLAPVSASSRRGKGGWRQRLSQAVHF
PSRDEVYRFLDTTVRPAIEEVTAVFAEKGLNVVTQPDPANDSVSLEIGHGEQHPFIYQAQ
MRGYFTPSFARGGMGSKELNNRRYYRAEVHLSEGSQDYDLVGYTKEQIINDILDQYERHM
QFLHLVR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory