SitesBLAST
Comparing AO353_13330 FitnessBrowser__pseudo3_N2E3:AO353_13330 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6dbbA Crystal structure of a putative aldehyde dehydrogenase family protein burkholderia cenocepacia j2315 in complex with partially reduced nadh
64% identity, 99% coverage: 5:496/496 of query aligns to 7:503/504 of 6dbbA
- active site: N152 (= N150), E259 (= E252), C293 (= C286), E471 (= E464)
- binding nicotinamide-adenine-dinucleotide: I148 (= I146), S149 (= S147), A150 (= A148), F151 (= F149), N152 (= N150), K175 (= K173), S177 (= S175), R218 (= R211), T236 (= T229), G237 (= G230), S238 (= S231), M241 (= M234), E259 (= E252), L260 (= L253), G261 (= G254), C293 (= C286), E391 (= E384), F393 (= F386)
- binding beta-6-hydroxy-1,4,5,6-tetrhydronicotinamide adenine dinucleotide: I148 (= I146), S149 (= S147), A150 (= A148), F151 (= F149), N152 (= N150), K175 (= K173), S177 (= S175), R218 (= R211), T236 (= T229), G237 (= G230), S238 (= S231), M241 (= M234), E259 (= E252), L260 (= L253), G261 (= G254), C293 (= C286), E391 (= E384), F393 (= F386)
6rtsA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with NAD+ (see paper)
62% identity, 99% coverage: 6:495/496 of query aligns to 18:508/509 of 6rtsA
- active site: N162 (= N150), E263 (= E252), C297 (= C286), E477 (= E464)
- binding nicotinamide-adenine-dinucleotide: I158 (= I146), S159 (= S147), A160 (= A148), F161 (= F149), N162 (= N150), K185 (= K173), S187 (= S175), E188 (= E176), A222 (≠ R211), G225 (= G214), T240 (= T229), G241 (= G230), S242 (= S231), M245 (= M234), E263 (= E252), L264 (= L253), C297 (= C286), E397 (= E384), F399 (= F386)
6rttA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with picolinic acid (see paper)
62% identity, 99% coverage: 6:495/496 of query aligns to 17:507/508 of 6rttA
- active site: N161 (= N150), E262 (= E252), C296 (= C286), E476 (= E464)
- binding pyridine-2-carboxylic acid: A159 (= A148), F162 (= F151), V166 (= V155), W169 (= W158), G240 (= G230), S241 (= S231), R295 (= R285), C296 (= C286), T297 (= T287), E396 (= E384), F398 (= F386), P421 (= P409), K469 (= K457), E470 (= E458)
6rtuA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with alpha-aminoadipic acid (see paper)
61% identity, 99% coverage: 6:495/496 of query aligns to 17:504/505 of 6rtuA
- active site: N161 (= N150), E259 (= E252), C293 (= C286), E473 (= E464)
- binding 2-aminohexanedioic acid: E115 (= E104), F162 (= F151), R292 (= R285), C293 (= C286), T294 (= T287), S454 (= S445), G455 (= G446), A456 (= A447), F462 (= F453)
4zulA Structure aldh7a1 complexed with alpha-aminoadipate (see paper)
51% identity, 95% coverage: 24:495/496 of query aligns to 39:508/509 of 4zulA
- active site: N165 (= N150), K188 (= K173), E266 (= E252), C300 (= C286), E397 (= E384), E477 (= E464)
- binding 2-aminohexanedioic acid: E119 (= E104), F166 (= F151), R299 (= R285), C300 (= C286), T301 (= T287), G459 (= G446), A460 (= A447), F466 (= F453)
4x0tA Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+ (see paper)
51% identity, 95% coverage: 24:495/496 of query aligns to 39:508/509 of 4x0tA
- active site: N165 (= N150), K188 (= K173), E266 (= E252), C300 (= C286), E397 (= E384), E477 (= E464)
- binding 4-(diethylamino)benzaldehyde: F166 (= F151), V170 (= V155), W173 (= W158), C300 (= C286), F466 (= F453)
- binding nicotinamide-adenine-dinucleotide: T162 (≠ S147), A163 (= A148), F164 (= F149), N165 (= N150), K188 (= K173), G189 (≠ P174), A190 (≠ S175), A225 (≠ R211), G228 (= G214), T229 (≠ E215), F242 (≠ A228), T243 (= T229), G244 (= G230), S245 (= S231), V248 (≠ M234), E266 (= E252), L267 (= L253), C300 (= C286), E397 (= E384), F399 (= F386)
P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human) (see 5 papers)
51% identity, 95% coverage: 24:495/496 of query aligns to 69:538/539 of P49419
- TAF 192:194 (≠ SAF 147:149) binding NAD(+)
- A199 (= A154) to V: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912709
- K218 (= K173) binding NAD(+)
- GT 258:259 (≠ GE 214:215) binding NAD(+)
- GS 274:275 (= GS 230:231) binding NAD(+)
- EL 296:297 (= EL 252:253) binding NAD(+)
- C330 (= C286) active site, Nucleophile
- E427 (= E384) binding NAD(+); to Q: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912707
- K439 (= K396) to Q: in dbSNP:rs12514417
Sites not aligning to the query:
- 110:539 natural variant: Missing (in EPEO4; loss of alpha-AASA dehydrogenase activity)
2jg7A Crystal structure of seabream antiquitin and elucidation of its substrate specificity (see paper)
51% identity, 95% coverage: 24:495/496 of query aligns to 40:509/509 of 2jg7A