SitesBLAST
Comparing AO353_14495 FitnessBrowser__pseudo3_N2E3:AO353_14495 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 14:585/599 of 6denA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ L30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K230 (vs. gap), M266 (= M260), V293 (= V287), V409 (= V397), L434 (= L422), G435 (= G423), M437 (= M425), D462 (≠ E450), N489 (= N477), E491 (≠ V479), Q492 (≠ L480), M494 (= M482), V495 (= V483), W498 (= W486), L520 (= L509), N525 (≠ G514), V526 (≠ H515)
- binding flavin-adenine dinucleotide: R163 (= R153), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ G220), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D304), I320 (= I305), N324 (≠ S309), D338 (≠ P323), V339 (= V324), M414 (= M402), G432 (= G420)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W486)
- binding magnesium ion: D462 (≠ E450), N489 (= N477), E491 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V397), G410 (= G398), Q411 (= Q399), H412 (= H400), G435 (= G423), M437 (= M425), G461 (= G449), D462 (≠ E450), A463 (≠ G451), S464 (= S452), N489 (= N477), E491 (≠ V479), Q492 (≠ L480), G493 (= G481), M494 (= M482), V495 (= V483)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 12:583/597 of 6demA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ L30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (vs. gap), M264 (= M260), V291 (= V287), V407 (= V397), L432 (= L422), G433 (= G423), M435 (= M425), D460 (≠ E450), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), M492 (= M482), V493 (= V483), W496 (= W486), L518 (= L509), N523 (≠ G514), V524 (≠ H515)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M482), W496 (= W486), A567 (≠ K559)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ G220), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ P323), V337 (= V324), M412 (= M402), G430 (= G420)
- binding magnesium ion: D460 (≠ E450), N487 (= N477), E489 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (≠ G451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), G491 (= G481), M492 (= M482), V493 (= V483)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 12:583/597 of 6delA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ L30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (vs. gap), M264 (= M260), V291 (= V287), V407 (= V397), L432 (= L422), G433 (= G423), M435 (= M425), D460 (≠ E450), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), M492 (= M482), V493 (= V483), W496 (= W486), L518 (= L509), N523 (≠ G514), V524 (≠ H515)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W486)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ G220), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ P323), V337 (= V324), M412 (= M402), G430 (= G420)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), G433 (= G423), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (≠ G451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), G491 (= G481), M492 (= M482), V493 (= V483)
- binding magnesium ion: D460 (≠ E450), N487 (= N477), E489 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), G433 (= G423), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (≠ G451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), G491 (= G481), M492 (= M482), V493 (= V483)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 14:587/601 of 6deqA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ L30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K232 (vs. gap), M268 (= M260), V295 (= V287), V411 (= V397), L436 (= L422), G437 (= G423), M439 (= M425), D464 (≠ E450), N491 (= N477), E493 (≠ V479), Q494 (≠ L480), M496 (= M482), V497 (= V483), W500 (= W486), L522 (= L509), N527 (≠ G514), V528 (≠ H515)
- binding flavin-adenine dinucleotide: R163 (= R153), G221 (= G214), A222 (≠ G215), G223 (= G216), N226 (≠ G220), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (= L258), G288 (= G280), A289 (= A281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (= V287), E321 (≠ D304), I322 (= I305), D340 (≠ P323), V341 (= V324), M416 (= M402), G434 (= G420)
- binding magnesium ion: D464 (≠ E450), N491 (= N477), E493 (≠ V479)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M482), V497 (= V483), W500 (= W486), A571 (≠ K559)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V397), G412 (= G398), Q413 (= Q399), H414 (= H400), M439 (= M425), G463 (= G449), D464 (≠ E450), A465 (≠ G451), S466 (= S452), N491 (= N477), E493 (≠ V479), Q494 (≠ L480), G495 (= G481), M496 (= M482), V497 (= V483)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 14:586/600 of 6derA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (= A29), I40 (≠ L30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K231 (vs. gap), M267 (= M260), V294 (= V287), V410 (= V397), L435 (= L422), G436 (= G423), M438 (= M425), D463 (≠ E450), N490 (= N477), E492 (≠ V479), Q493 (≠ L480), M495 (= M482), V496 (= V483), W499 (= W486), L521 (= L509), N526 (≠ G514), V527 (≠ H515)
- binding flavin-adenine dinucleotide: R163 (= R153), G220 (= G214), A221 (≠ G215), G222 (= G216), N225 (≠ G220), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (= L258), H268 (= H261), G287 (= G280), A288 (= A281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (= V287), E320 (≠ D304), I321 (= I305), N325 (≠ S309), G338 (= G322), D339 (≠ P323), V340 (= V324), Q414 (= Q401), M415 (= M402), G433 (= G420)
- binding Metosulam: R293 (= R286), M495 (= M482), W499 (= W486), A570 (≠ K559)
- binding magnesium ion: D463 (≠ E450), N490 (= N477), E492 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V397), G411 (= G398), Q412 (= Q399), H413 (= H400), G436 (= G423), M438 (= M425), G462 (= G449), D463 (≠ E450), A464 (≠ G451), S465 (= S452), N490 (= N477), E492 (≠ V479), Q493 (≠ L480), G494 (= G481), M495 (= M482), V496 (= V483)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V397), G411 (= G398), Q412 (= Q399), H413 (= H400), G436 (= G423), M438 (= M425), G462 (= G449), D463 (≠ E450), A464 (≠ G451), S465 (= S452), M468 (= M455), N490 (= N477), E492 (≠ V479), Q493 (≠ L480), G494 (= G481), V496 (= V483)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 12:584/598 of 6desA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ L30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (vs. gap), M265 (= M260), V292 (= V287), V408 (= V397), L433 (= L422), G434 (= G423), M436 (= M425), D461 (≠ E450), N488 (= N477), E490 (≠ V479), Q491 (≠ L480), M493 (= M482), V494 (= V483), W497 (= W486), L519 (= L509), N524 (≠ G514), V525 (≠ H515)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W486)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ G220), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ P323), V338 (= V324), Q412 (= Q401), M413 (= M402), G431 (= G420)
- binding magnesium ion: D461 (≠ E450), N488 (= N477), E490 (≠ V479)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V397), G409 (= G398), Q410 (= Q399), H411 (= H400), G434 (= G423), M436 (= M425), G460 (= G449), D461 (≠ E450), A462 (≠ G451), S463 (= S452), N488 (= N477), E490 (≠ V479), Q491 (≠ L480), G492 (= G481), M493 (= M482), V494 (= V483)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 12:584/598 of 6depA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ L30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (vs. gap), M265 (= M260), V292 (= V287), V408 (= V397), L433 (= L422), G434 (= G423), M436 (= M425), D461 (≠ E450), N488 (= N477), E490 (≠ V479), Q491 (≠ L480), M493 (= M482), V494 (= V483), W497 (= W486), L519 (= L509), N524 (≠ G514), V525 (≠ H515)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M482), W497 (= W486)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ G220), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G264 (= G259), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ P323), V338 (= V324), M413 (= M402), G431 (= G420)
- binding magnesium ion: D461 (≠ E450), N488 (= N477), E490 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V397), G409 (= G398), Q410 (= Q399), H411 (= H400), G434 (= G423), M436 (= M425), G460 (= G449), D461 (≠ E450), A462 (≠ G451), S463 (= S452), M466 (= M455), N488 (= N477), E490 (≠ V479), Q491 (≠ L480), G492 (= G481), M493 (= M482), V494 (= V483)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V397), G409 (= G398), Q410 (= Q399), H411 (= H400), G434 (= G423), M436 (= M425), G460 (= G449), D461 (≠ E450), A462 (≠ G451), S463 (= S452), M466 (= M455), N488 (= N477), E490 (≠ V479), Q491 (≠ L480), G492 (= G481), M493 (= M482), V494 (= V483)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
43% identity, 99% coverage: 4:573/574 of query aligns to 10:579/593 of 6deoA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (= A29), I36 (≠ L30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), K224 (vs. gap), M260 (= M260), V287 (= V287), V403 (= V397), L428 (= L422), G429 (= G423), M431 (= M425), D456 (≠ E450), N483 (= N477), E485 (≠ V479), Q486 (≠ L480), M488 (= M482), V489 (= V483), W492 (= W486), L514 (= L509), N519 (≠ G514), V520 (≠ H515)
- binding flavin-adenine dinucleotide: R159 (= R153), G213 (= G214), A214 (≠ G215), G215 (= G216), N218 (≠ G220), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (= L258), G280 (= G280), A281 (= A281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (= V287), E313 (≠ D304), I314 (= I305), N318 (≠ S309), D332 (≠ P323), V333 (= V324), M408 (= M402), G426 (= G420)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M482), W492 (= W486)
- binding magnesium ion: D456 (≠ E450), N483 (= N477), E485 (≠ V479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V397), G404 (= G398), Q405 (= Q399), H406 (= H400), G429 (= G423), M431 (= M425), G455 (= G449), D456 (≠ E450), A457 (≠ G451), S458 (= S452), M461 (= M455), N483 (= N477), E485 (≠ V479), Q486 (≠ L480), G487 (= G481), M488 (= M482), V489 (= V483)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 10:578/599 of 1n0hA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (= A29), I36 (≠ L30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), R230 (vs. gap), M266 (= M260), V293 (= V287), V409 (= V397), L434 (= L422), G435 (= G423), M437 (= M425), D462 (≠ E450), N489 (= N477), E491 (≠ V479), Q492 (≠ L480), M494 (= M482), V495 (= V483), W498 (= W486), L520 (= L509), G525 (= G514), L526 (≠ H515), K559 (≠ T549)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V397), G410 (= G398), Q411 (= Q399), H412 (= H400), G435 (= G423), M437 (= M425), G461 (= G449), D462 (≠ E450), A463 (≠ G451), S464 (= S452), M467 (= M455), N489 (= N477), E491 (≠ V479), Q492 (≠ L480), G493 (= G481), V495 (= V483)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G28), A35 (= A29), V109 (= V103), P110 (= P104), F119 (= F113), K169 (= K163), M266 (= M260), D291 (= D285), R292 (= R286), V495 (= V483), W498 (= W486)
- binding flavin-adenine dinucleotide: R159 (= R153), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ G220), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D304), V320 (≠ I305), N324 (≠ S309), G337 (= G322), D338 (≠ P323), A339 (≠ V324), M414 (= M402), G432 (= G420), G433 (= G421)
- binding magnesium ion: D462 (≠ E450), N489 (= N477), E491 (≠ V479)
- binding thiamine diphosphate: Y31 (= Y25), E57 (= E51), P83 (= P77)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 8:575/596 of 1t9cA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ L30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (vs. gap), M263 (= M260), V290 (= V287), V406 (= V397), L431 (= L422), G432 (= G423), M434 (= M425), D459 (≠ E450), N486 (= N477), E488 (≠ V479), Q489 (≠ L480), M491 (= M482), V492 (= V483), W495 (= W486), L517 (= L509), G522 (= G514), L523 (≠ H515), K556 (≠ T549)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), D288 (= D285), R289 (= R286), W495 (= W486)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ G220), T243 (= T240), L244 (= L241), Q245 (≠ M242), L261 (= L258), M263 (= M260), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (≠ P323), A336 (≠ V324), M411 (= M402), G429 (= G420), G430 (= G421)
- binding magnesium ion: D459 (≠ E450), N486 (= N477), E488 (≠ V479)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 8:575/596 of 1t9dA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ L30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R227 (vs. gap), M263 (= M260), V290 (= V287), V406 (= V397), L431 (= L422), G432 (= G423), M434 (= M425), D459 (≠ E450), N486 (= N477), E488 (≠ V479), Q489 (≠ L480), M491 (= M482), V492 (= V483), W495 (= W486), L517 (= L509), G522 (= G514), L523 (≠ H515), K556 (≠ T549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G28), A33 (= A29), V107 (= V103), P108 (= P104), F117 (= F113), K167 (= K163), M263 (= M260), D288 (= D285), R289 (= R286), W495 (= W486)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ G220), T243 (= T240), L244 (= L241), Q245 (≠ M242), M260 (= M257), L261 (= L258), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (≠ P323), A336 (≠ V324), Q410 (= Q401), M411 (= M402), G429 (= G420), G430 (= G421)
- binding magnesium ion: D459 (≠ E450), N486 (= N477), E488 (≠ V479)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E51), P81 (= P77), Q118 (= Q114), G432 (= G423), M434 (= M425), M464 (= M455)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 9:576/597 of 1t9aA
- active site: Y30 (= Y25), G32 (= G27), G33 (= G28), A34 (= A29), I35 (≠ L30), E56 (= E51), T79 (= T74), F118 (= F113), Q119 (= Q114), E120 (= E115), K168 (= K163), R228 (vs. gap), M264 (= M260), V291 (= V287), V407 (= V397), L432 (= L422), G433 (= G423), M435 (= M425), D460 (≠ E450), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), M492 (= M482), V493 (= V483), W496 (= W486), L518 (= L509), G523 (= G514), L524 (≠ H515), K557 (≠ T549)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G28), V108 (= V103), P109 (= P104), F118 (= F113), K168 (= K163), M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M482), V493 (= V483), W496 (= W486)
- binding flavin-adenine dinucleotide: R158 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ G220), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), M264 (= M260), H265 (= H261), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D304), V318 (≠ I305), N322 (≠ S309), G335 (= G322), D336 (≠ P323), A337 (≠ V324), Q411 (= Q401), M412 (= M402), G430 (= G420), G431 (= G421)
- binding magnesium ion: D460 (≠ E450), N487 (= N477), E489 (≠ V479)
- binding propyl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (≠ G451), S462 (= S452), N487 (= N477), E489 (≠ V479), Q490 (≠ L480), G491 (= G481), M492 (= M482)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G423), M435 (= M425), M465 (= M455)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 92:666/687 of P07342
- R241 (= R153) binding
- 355:376 (vs. 261:282, 68% identical) binding
- 407:426 (vs. 304:323, 20% identical) binding
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 12:586/607 of 6u9dB
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), I38 (≠ L30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M274 (= M260), V301 (= V287), V417 (= V397), G443 (= G423), M445 (= M425), D470 (≠ E450), N497 (= N477), E499 (≠ V479), Q500 (≠ L480), M502 (= M482), V503 (= V483), W506 (= W486)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G28), V111 (= V103), P112 (= P104), F121 (= F113), K171 (= K163), D299 (= D285), R300 (= R286), M502 (= M482), W506 (= W486)
- binding flavin-adenine dinucleotide: R161 (= R153), A228 (≠ G215), G229 (= G216), N232 (≠ G220), T254 (= T240), L255 (= L241), Q256 (≠ M242), L272 (= L258), M274 (= M260), G294 (= G280), R296 (= R282), D298 (= D284), R300 (= R286), V301 (= V287), E327 (≠ D304), V328 (≠ I305), N332 (≠ S309), D346 (≠ P323), A347 (≠ V324), M422 (= M402), G440 (= G420), G441 (= G421)
- binding magnesium ion: D470 (≠ E450), N497 (= N477)
- binding thiamine diphosphate: E59 (= E51), P85 (= P77), V417 (= V397), G418 (= G398), Q419 (= Q399), H420 (= H400), G443 (= G423), M445 (= M425), A471 (≠ G451), S472 (= S452), N497 (= N477), E499 (≠ V479), Q500 (≠ L480), G501 (= G481), M502 (= M482), V503 (= V483)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 8:574/595 of 1t9bB
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ L30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R226 (vs. gap), M262 (= M260), V289 (= V287), V405 (= V397), L430 (= L422), G431 (= G423), M433 (= M425), D458 (≠ E450), N485 (= N477), E487 (≠ V479), Q488 (≠ L480), M490 (= M482), V491 (= V483), W494 (= W486), L516 (= L509), G521 (= G514), L522 (≠ H515), K555 (≠ T549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V103), P108 (= P104), D287 (= D285), R288 (= R286), M490 (= M482), W494 (= W486)
- binding flavin-adenine dinucleotide: R157 (= R153), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ G220), T242 (= T240), L243 (= L241), Q244 (≠ M242), M259 (= M257), L260 (= L258), M262 (= M260), H263 (= H261), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (= V287), E315 (≠ D304), V316 (≠ I305), N320 (≠ S309), G333 (= G322), D334 (≠ P323), A335 (≠ V324), Q409 (= Q401), M410 (= M402), G428 (= G420), G429 (= G421)
- binding magnesium ion: D458 (≠ E450), N485 (= N477), E487 (≠ V479)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 7:561/582 of 1t9dB
- active site: Y28 (= Y25), G30 (= G27), G31 (= G28), A32 (= A29), I33 (≠ L30), E54 (= E51), T77 (= T74), F116 (= F113), Q117 (= Q114), E118 (= E115), K166 (= K163), R213 (vs. gap), M249 (= M260), V276 (= V287), V392 (= V397), L417 (= L422), G418 (= G423), M420 (= M425), D445 (≠ E450), N472 (= N477), E474 (≠ V479), Q475 (≠ L480), M477 (= M482), V478 (= V483), W481 (= W486), L503 (= L509), G508 (= G514), L509 (≠ H515), K542 (≠ T549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G28), A32 (= A29), V106 (= V103), P107 (= P104), F116 (= F113), K166 (= K163), M249 (= M260), D274 (= D285), R275 (= R286), W481 (= W486)
- binding flavin-adenine dinucleotide: R156 (= R153), G202 (= G214), A203 (≠ G215), G204 (= G216), N207 (≠ G220), T229 (= T240), L230 (= L241), Q231 (≠ M242), L247 (= L258), M249 (= M260), H250 (= H261), G269 (= G280), A270 (= A281), R271 (= R282), D273 (= D284), R275 (= R286), V276 (= V287), E302 (≠ D304), V303 (≠ I305), N307 (≠ S309), G320 (= G322), D321 (≠ P323), A322 (≠ V324), Q396 (= Q401), M397 (= M402), G415 (= G420), G416 (= G421)
- binding magnesium ion: D445 (≠ E450), N472 (= N477), E474 (≠ V479)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E51), P80 (= P77), G418 (= G423), M420 (= M425), M450 (= M455)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 99% coverage: 4:569/574 of query aligns to 8:562/583 of 1t9bA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ L30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R214 (vs. gap), M250 (= M260), V277 (= V287), V393 (= V397), L418 (= L422), G419 (= G423), M421 (= M425), D446 (≠ E450), N473 (= N477), E475 (≠ V479), Q476 (≠ L480), M478 (= M482), V479 (= V483), W482 (= W486), L504 (= L509), G509 (= G514), L510 (≠ H515), K543 (≠ T549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V103), P108 (= P104), F117 (= F113), D275 (= D285), R276 (= R286), M478 (= M482), W482 (= W486)
- binding flavin-adenine dinucleotide: R157 (= R153), G203 (= G214), A204 (≠ G215), G205 (= G216), N208 (≠ G220), T230 (= T240), L231 (= L241), Q232 (≠ M242), M247 (= M257), L248 (= L258), M250 (= M260), H251 (= H261), G270 (= G280), A271 (= A281), R272 (= R282), D274 (= D284), R276 (= R286), V277 (= V287), E303 (≠ D304), V304 (≠ I305), N308 (≠ S309), D322 (≠ P323), A323 (≠ V324), Q397 (= Q401), M398 (= M402), G416 (= G420), G417 (= G421)
- binding magnesium ion: D446 (≠ E450), N473 (= N477), E475 (≠ V479)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 99% coverage: 4:569/574 of query aligns to 8:570/591 of 5wkcA
- active site: Y29 (= Y25), G31 (= G27), G32 (= G28), A33 (= A29), I34 (≠ L30), E55 (= E51), T78 (= T74), F117 (= F113), Q118 (= Q114), E119 (= E115), K167 (= K163), R222 (vs. gap), M258 (= M260), V285 (= V287), V401 (= V397), L426 (= L422), G427 (= G423), M429 (= M425), D454 (≠ E450), N481 (= N477), E483 (≠ V479), Q484 (≠ L480), M486 (= M482), V487 (= V483), W490 (= W486), L512 (= L509), G517 (= G514), L518 (≠ H515), K551 (≠ T549)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V397), G402 (= G398), Q403 (= Q399), H404 (= H400), G427 (= G423), M429 (= M425), G453 (= G449), D454 (≠ E450), A455 (≠ G451), S456 (= S452), M459 (= M455), N481 (= N477), E483 (≠ V479), Q484 (≠ L480), G485 (= G481), M486 (= M482), V487 (= V483)
- binding ethaneperoxoic acid: G32 (= G28), Q118 (= Q114)
- binding flavin-adenine dinucleotide: R157 (= R153), G211 (= G214), A212 (≠ G215), G213 (= G216), N216 (≠ G220), T238 (= T240), L239 (= L241), Q240 (≠ M242), L256 (= L258), M258 (= M260), G278 (= G280), A279 (= A281), R280 (= R282), R284 (= R286), V285 (= V287), E311 (≠ D304), V312 (≠ I305), N316 (≠ S309), D330 (≠ P323), A331 (≠ V324), M406 (= M402), G424 (= G420)
- binding magnesium ion: D454 (≠ E450), N481 (= N477), E483 (≠ V479)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G28), A33 (= A29), V107 (= V103), F117 (= F113), K167 (= K163), M258 (= M260), R284 (= R286), M486 (= M482), W490 (= W486)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P26), E55 (= E51)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
42% identity, 99% coverage: 4:573/574 of query aligns to 13:581/595 of 6dekA
- active site: Y34 (= Y25), G36 (= G27), G37 (= G28), A38 (= A29), I39 (≠ L30), E60 (= E51), T83 (= T74), Q118 (= Q114), E119 (= E115), K167 (= K163), K226 (vs. gap), M262 (= M260), V289 (= V287), V405 (= V397), L430 (= L422), G431 (= G423), M433 (= M425), D458 (≠ E450), N485 (= N477), E487 (≠ V479), Q488 (≠ L480), M490 (= M482), V491 (= V483), W494 (= W486), L516 (= L509), N521 (≠ G514), V522 (≠ H515)
- binding flavin-adenine dinucleotide: R157 (= R153), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ G220), T242 (= T240), L243 (= L241), Q244 (≠ M242), L260 (= L258), M262 (= M260), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (= V287), E315 (≠ D304), I316 (= I305), N320 (≠ S309), D334 (≠ P323), V335 (= V324), M410 (= M402), G428 (= G420)
- binding magnesium ion: D458 (≠ E450), N485 (= N477), E487 (≠ V479)
- binding thiamine diphosphate: V405 (= V397), G406 (= G398), Q407 (= Q399), H408 (= H400), M433 (= M425), G457 (= G449), D458 (≠ E450), A459 (≠ G451), S460 (= S452), N485 (= N477), E487 (≠ V479), Q488 (≠ L480), G489 (= G481), M490 (= M482), V491 (= V483)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
42% identity, 96% coverage: 4:556/574 of query aligns to 6:528/539 of 6lpiB
- active site: I27 (≠ Y25), G29 (= G27), G30 (= G28), S31 (≠ A29), I32 (≠ L30), E53 (= E51), C76 (≠ T74), F115 (= F113), Q116 (= Q114), E117 (= E115), K165 (= K163), M256 (= M260), A283 (≠ V287), V375 (= V397), G401 (= G423), M403 (= M425), D428 (≠ E450), N455 (= N477), A457 (≠ V479), L458 (= L480), L460 (≠ M482), V461 (= V483), Q464 (≠ W486)
- binding flavin-adenine dinucleotide: R155 (= R153), G212 (= G214), G213 (= G215), G214 (= G216), T236 (= T240), L237 (= L241), M238 (= M242), L254 (= L258), M256 (= M260), H257 (= H261), G276 (= G280), A277 (= A281), R278 (= R282), D280 (= D284), R282 (= R286), A283 (≠ V287), D300 (= D304), I301 (= I305), D319 (≠ P323), V320 (= V324), M380 (= M402), G398 (= G420)
- binding magnesium ion: D428 (≠ E450), N455 (= N477)
- binding thiamine diphosphate: E53 (= E51), C76 (≠ T74), P79 (= P77), G376 (= G398), Q377 (= Q399), H378 (= H400), G401 (= G423), M403 (= M425), G427 (= G449), D428 (≠ E450), G429 (= G451), S430 (= S452), M433 (= M455), N455 (= N477), A457 (≠ V479), L458 (= L480), G459 (= G481), L460 (≠ M482), V461 (= V483)
Query Sequence
>AO353_14495 FitnessBrowser__pseudo3_N2E3:AO353_14495
VELLSGGEMLVRFLRDEGVKYIYGYPGGALLHVYDALFKEPEVTHILVRHEQAATHMADG
YARATGKAGVVLVTSGPGATNAITGIATAYMDSIPMVIISGQVPSTMVGTDAFQETDMIG
ISRPIVKHSFMIKHASEIPEVMKKAFYLAQSGRPGPVVVDIPKDMTNPAEKFEYVFPKKA
KLRSYSPAVRGHSGQIRKAAEMLLAAKRPVLYSGGGVILGGGSAPLTELAQMLNLPVTNT
LMGLGGYPGTDRQFIGMLGMHGSYTANLAMHHADVILAVGARFDDRVINGPAKFCPNAKI
IHIDIDPASISKTIKADVPIVGPVESVLTEMVAILKEIGETPNKESVASWWKQVDEWRGD
RGLFPYEKGDGSVIKPQTVIETLCEVTKGDAFVTSDVGQHQMFAAQYYTFNKPNRWINSG
GLGTMGFGFPAAMGIKLSFPDADVACVTGEGSIQMNIQELSTCLQYGLPVKIVILNNGVL
GMVRQWQDMSYGSRHSHSYMESLPDFVKLAEAYGHVGVRITDSKDLKSKMEEAFAMKDRL
VVLDISVDTSEHVYPMQIKDGSMRDMWLSKTERT
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory