SitesBLAST
Comparing AO353_23135 FitnessBrowser__pseudo3_N2E3:AO353_23135 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
41% identity, 92% coverage: 20:478/498 of query aligns to 20:478/489 of 4cazA
- active site: N152 (= N153), K175 (= K176), E251 (= E251), C285 (= C285), E386 (= E386), E463 (= E463)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I149), G149 (≠ T150), W151 (= W152), N152 (= N153), K175 (= K176), E178 (= E179), G208 (= G209), G212 (= G213), F226 (= F227), T227 (= T228), G228 (= G229), G229 (= G230), T232 (= T233), V236 (≠ I237), E251 (= E251), L252 (= L252), C285 (= C285), E386 (= E386), F388 (= F388)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
41% identity, 92% coverage: 20:478/498 of query aligns to 20:478/489 of 2woxA
- active site: N152 (= N153), K175 (= K176), E251 (= E251), C285 (= C285), E386 (= E386), E463 (= E463)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I149), G149 (≠ T150), W151 (= W152), N152 (= N153), K175 (= K176), S177 (≠ A178), E178 (= E179), G208 (= G209), G212 (= G213), F226 (= F227), T227 (= T228), G228 (= G229), G229 (= G230), T232 (= T233), V236 (≠ I237), E251 (= E251), L252 (= L252), C285 (= C285), E386 (= E386), F388 (= F388)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
41% identity, 92% coverage: 20:478/498 of query aligns to 20:478/489 of 2wmeA
- active site: N152 (= N153), K175 (= K176), E251 (= E251), C285 (= C285), E386 (= E386), E463 (= E463)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ T150), W151 (= W152), K175 (= K176), S177 (≠ A178), E178 (= E179), G208 (= G209), G212 (= G213), F226 (= F227), G228 (= G229), G229 (= G230), T232 (= T233), V236 (≠ I237)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
41% identity, 92% coverage: 20:478/498 of query aligns to 21:479/490 of Q9HTJ1
- GAWN 150:153 (≠ TPWN 150:153) binding
- K162 (= K162) active site, Charge relay system
- KPSE 176:179 (≠ KPAE 176:179) binding
- G209 (= G209) binding
- GTST 230:233 (≠ GTKT 230:233) binding
- E252 (= E251) active site, Proton acceptor
- C286 (= C285) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E386) binding
- E464 (= E463) active site, Charge relay system
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 96% coverage: 3:479/498 of query aligns to 13:487/491 of 5gtlA
- active site: N165 (= N153), K188 (= K176), E263 (= E251), C297 (= C285), E394 (= E386), E471 (= E463)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I149), P163 (= P151), K188 (= K176), A190 (= A178), E191 (= E179), Q192 (≠ I180), G221 (= G209), G225 (= G213), G241 (= G229), S242 (≠ G230), T245 (= T233), L264 (= L252), C297 (= C285), E394 (= E386), F396 (= F388)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 96% coverage: 3:479/498 of query aligns to 13:487/491 of 5gtkA
- active site: N165 (= N153), K188 (= K176), E263 (= E251), C297 (= C285), E394 (= E386), E471 (= E463)
- binding nicotinamide-adenine-dinucleotide: I161 (= I149), I162 (≠ T150), P163 (= P151), W164 (= W152), K188 (= K176), E191 (= E179), G221 (= G209), G225 (= G213), A226 (≠ D214), F239 (= F227), G241 (= G229), S242 (≠ G230), T245 (= T233), Y248 (≠ H236), L264 (= L252), C297 (= C285), Q344 (≠ H332), R347 (≠ S335), E394 (= E386), F396 (= F388)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8vqwC
- binding coenzyme a: I147 (= I149), W150 (= W152), K174 (= K176), S176 (≠ A178), E177 (= E179), G207 (= G209), G211 (= G213), F225 (= F227), G227 (= G229), G228 (= G230), S231 (≠ T233), H331 (= H332), F387 (= F388)
8vj3A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (fad bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8vj3A
8uzoA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (adp bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8uzoA
8uznA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (amp bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8uznA
- binding adenosine monophosphate: I147 (= I149), G148 (≠ T150), K174 (= K176), S176 (≠ A178), E177 (= E179), G207 (= G209), G211 (= G213), F225 (= F227), G228 (= G230), S231 (≠ T233), K234 (≠ H236)
8uzmA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADPH bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8uzmA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G148 (≠ T150), W150 (= W152), K174 (= K176), S176 (≠ A178), E177 (= E179), G207 (= G209), G211 (= G213), F225 (= F227), T226 (= T228), G227 (= G229), G228 (= G230), S231 (≠ T233), E250 (= E251), G252 (= G253), C284 (= C285), E385 (= E386), F387 (= F388)
8uzkA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADP+ bound)
40% identity, 92% coverage: 20:478/498 of query aligns to 19:477/488 of 8uzkA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I147 (= I149), G148 (≠ T150), W150 (= W152), N151 (= N153), K174 (= K176), S176 (≠ A178), E177 (= E179), G207 (= G209), G211 (= G213), F225 (= F227), G227 (= G229), G228 (= G230), S231 (≠ T233), E250 (= E251), F387 (= F388)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
40% identity, 92% coverage: 20:478/498 of query aligns to 28:486/497 of 8skfA
- binding calcium ion: T33 (= T25), I34 (≠ R26), D100 (= D94), V187 (≠ I180)
- binding nicotinamide-adenine-dinucleotide: I156 (= I149), G157 (≠ T150), A158 (≠ P151), W159 (= W152), K183 (= K176), E186 (= E179), G216 (= G209), G220 (= G213), T235 (= T228), G236 (= G229), G237 (= G230), S240 (≠ T233), K243 (≠ H236), E259 (= E251), C293 (= C285), F396 (= F388)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
39% identity, 92% coverage: 28:483/498 of query aligns to 26:480/489 of 4o6rA
- active site: N150 (= N153), K173 (= K176), E248 (= E251), C282 (= C285), E383 (= E386), E460 (= E463)
- binding adenosine monophosphate: I146 (= I149), V147 (≠ T150), K173 (= K176), G206 (= G209), G210 (= G213), Q211 (≠ D214), F224 (= F227), G226 (= G229), S227 (≠ G230), T230 (= T233), R233 (≠ H236)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
37% identity, 96% coverage: 11:489/498 of query aligns to 22:502/505 of 4neaA
- active site: N166 (= N153), K189 (= K176), E264 (= E251), C298 (= C285), E399 (= E386), E476 (= E463)
- binding nicotinamide-adenine-dinucleotide: P164 (= P151), K189 (= K176), E192 (= E179), G222 (= G209), G226 (= G213), G242 (= G229), G243 (= G230), T246 (= T233), H249 (= H236), I250 (= I237), C298 (= C285), E399 (= E386), F401 (= F388)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
42% identity, 94% coverage: 11:478/498 of query aligns to 31:501/515 of 2d4eC
- active site: N173 (= N153), K196 (= K176), E271 (= E251), C305 (= C285), E409 (= E386), E486 (= E463)
- binding nicotinamide-adenine-dinucleotide: I169 (= I149), T170 (= T150), P171 (= P151), W172 (= W152), K196 (= K176), A198 (= A178), G229 (= G209), G233 (= G213), A234 (≠ D214), T248 (= T228), G249 (= G229), E250 (≠ G230), T253 (= T233), E271 (= E251), L272 (= L252), C305 (= C285), E409 (= E386), F411 (= F388), F475 (= F452)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
39% identity, 92% coverage: 28:485/498 of query aligns to 25:480/487 of 4go4A
- active site: N149 (= N153), K172 (= K176), E247 (= E251), C281 (= C285), E381 (= E386), E458 (= E463)
- binding nicotinamide-adenine-dinucleotide: I145 (= I149), V146 (≠ T150), W148 (= W152), N149 (= N153), F154 (≠ S158), K172 (= K176), G205 (= G209), G209 (= G213), Q210 (≠ D214), F223 (= F227), T224 (= T228), G225 (= G229), S226 (≠ G230), T229 (= T233), E247 (= E251), G249 (= G253), C281 (= C285), E381 (= E386), F383 (= F388)
Query Sequence
>AO353_23135 FitnessBrowser__pseudo3_N2E3:AO353_23135
MTLEQTLPICIAGEWRLGRGERYATRYPATGEAVAWLNAASVEDVEDAVHGAHQAFLHSG
WAQRKPHERASVLYRIAELIRQRSEELAQLQRQDNGKPINETRALVASAAGTFQFFAAAC
ETLEETITPSRGDFVSMSVYEPMGVIAAITPWNSPIASEAQKVAPALAAGNAVVIKPAEI
TPLMALQLARICEDAGLPKGLLSVLPGKGSLLGDALTRHPLVKRVSFTGGTKTGKHIAHI
AADKMMPVSLELGGKSPTIVLDDADLDHAVAGVLYGIFSSSGEACIAGSRLFVARALYEP
FMARLVAAAAELRVGDPADERTQMGPLISAGHRESVERYVALGLAEGGRLLLGGQRPSGG
VYDQGYYYPPTILEGLNNSQQVCQEEIFGPVLVAMPFDDEAQLIEQANDSLYALAAGIWT
RDYKRAWALGRKIQAGTVWINTYKQFSISTPFGGWRDSGLGREKGRLGILQYMEQKSLYW
GMNEQPLAWAGVQQEVGL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory