SitesBLAST – Find functional sites

 

SitesBLAST

Comparing AO353_24425 FitnessBrowser__pseudo3_N2E3:AO353_24425 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
32% identity, 97% coverage: 1:215/221 of query aligns to 1:214/214 of 4ymwC

query
sites
4ymwC
M
 
M
E
 
T
L
 
V
D
 
D
F
 
F
S
 
L
V
 
S
I
 
M
F
 
V
D
 
K
Y
 
Y
K
 
T
A
 
P
A
 
L
L
 
F
L
 
I
F
 
S
G
 
G
L
 
L
L
 
I
L
 
M
T
 
T
L
 
L
K
 
K
L
 
L
T
 
T
A
 
F
I
 
L
C
 
A
V
 
V
I
 
T
L
 
I
G
 
G
C
 
V
A
 
L
L
 
M
G
 
G
F
 
L
M
 
F
V
 
I
A
 
A
I
 
L
A
 
M
R
 
K
S
 
M
S
 
S
K
 
S
N
 
I
K
 
K
I
 
P
I
 
I
Y
 
K
G
 
L
I
 
V
S
 
A
T
 
S
V
 
S
Y
 
Y
V
 
I
A
 
E
L
 
V
F
 
I
R
 
R
G
 
G
T
 
T
P
 
P
V
 
L
L
 
L
I
 
V
Q
 
Q
L
 
L
F
 
L
W
 
L
M
 
I
F
 
Y
F
 
N
C
 
G
L
 
L
P
 
-
L
 
M
V
 
Q
L
 
F
G
 
G
V
 
M
E
 
N
L
 
I
S
 
P
N
 
A
L
 
F
T
 
T
C
 
A
G
 
G
I
 
V
I
 
S
A
 
A
L
 
L
T
 
A
L
 
I
Y
x
N
M
 
S
A
 
S
A
 
A
I
x
Y
T
 
V
S
 
A
E
 
E
T
 
I
F
 
I
R
 
R
A
 
A
S
 
G
F
 
I
S
 
Q
F
 
A
V
 
V
S
 
D
K
 
P
E
 
G
Q
 
Q
H
 
N
D
 
E
A
 
A
G
 
A
V
 
R
A
 
S
L
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
R
 
A
V
 
M
H
 
A
T
 
M
L
 
R
Y
 
Y
V
 
V
L
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
L
 
I
L
 
K
R
 
N
A
 
I
A
 
L
P
 
P
T
 
A
L
 
L
L
 
G
S
 
N
N
x
E
C
 
F
T
 
I
S
 
V
L
 
M
F
 
L
K
 
K
E
|
E
S
 
S
A
 
A
L
 
I
V
 
V
S
 
S
A
 
V
V
 
I
G
 
G
M
 
F
A
 
A
D
 
D
L
 
L
M
 
T
F
 
R
V
 
Q
S
 
A
Q
 
D
N
 
I
I
 
I
S
 
Q
N
 
S
R
 
V
T
 
T
G
 
Y
H
 
R
P
 
Y
V
 
F
E
 
E
L
 
P
L
 
Y
T
 
I
A
 
I
A
 
I
A
 
A
V
 
A
I
 
I
Y
 
Y
F
 
F
V
 
V
I
 
M
A
 
T
F
 
L
P
 
T
I
 
F
T
 
S
R
 
K
A
 
L
V
 
L
T
 
S
A
 
L
L
 
F
E
 
E
R
 
R
K
 
R
I
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
32% identity, 97% coverage: 1:215/221 of query aligns to 1:214/215 of 4ymtC

query
sites
4ymtC
M
 
M
E
 
T
L
 
V
D
 
D
F
 
F
S
 
L
V
 
S
I
 
M
F
 
V
D
 
K
Y
 
Y
K
 
T
A
 
P
A
 
L
L
 
F
L
 
I
F
 
S
G
 
G
L
 
L
L
 
I
L
 
M
T
 
T
L
 
L
K
 
K
L
 
L
T
 
T
A
 
F
I
 
L
C
 
A
V
 
V
I
 
T
L
 
I
G
 
G
C
 
V
A
 
L
L
 
M
G
 
G
F
 
L
M
 
F
V
 
I
A
 
A
I
 
L
A
 
M
R
 
K
S
 
M
S
 
S
K
 
S
N
 
I
K
 
K
I
 
P
I
 
I
Y
 
K
G
 
L
I
 
V
S
 
A
T
 
S
V
 
S
Y
 
Y
V
 
I
A
 
E
L
 
V
F
 
I
R
 
R
G
 
G
T
 
T
P
|
P
V
x
L
L
 
L
I
 
V
Q
 
Q
L
 
L
F
 
L
W
 
L
M
 
I
F
 
Y
F
 
N
C
 
G
L
 
L
P
 
-
L
 
M
V
 
Q
L
 
F
G
 
G
V
 
M
E
 
N
L
 
I
S
 
P
N
 
A
L
 
F
T
 
T
C
 
A
G
 
G
I
 
V
I
 
S
A
 
A
L
 
L
T
 
A
L
 
I
Y
x
N
M
 
S
A
 
S
A
 
A
I
x
Y
T
 
V
S
 
A
E
 
E
T
 
I
F
 
I
R
 
R
A
 
A
S
 
G
F
 
I
S
 
Q
F
 
A
V
 
V
S
 
D
K
 
P
E
 
G
Q
 
Q
H
 
N
D
 
E
A
 
A
G
 
A
V
 
R
A
 
S
L
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
R
 
A
V
 
M
H
 
A
T
 
M
L
 
R
Y
 
Y
V
 
V
L
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
L
 
I
L
 
K
R
 
N
A
 
I
A
 
L
P
 
P
T
 
A
L
 
L
L
 
G
S
 
N
N
x
E
C
 
F
T
 
I
S
 
V
L
x
M
F
 
L
K
|
K
E
|
E
S
 
S
A
 
A
L
 
I
V
 
V
S
 
S
A
 
V
V
 
I
G
 
G
M
 
F
A
 
A
D
 
D
L
 
L
M
 
T
F
 
R
V
 
Q
S
 
A
Q
 
D
N
 
I
I
 
I
S
 
Q
N
 
S
R
 
V
T
 
T
G
 
Y
H
 
R
P
 
Y
V
 
F
E
 
E
L
 
P
L
 
Y
T
 
I
A
 
I
A
 
I
A
 
A
V
 
A
I
 
I
Y
 
Y
F
 
F
V
 
V
I
 
M
A
 
T
F
 
L
P
 
T
I
 
F
T
 
S
R
 
K
A
 
L
V
 
L
T
 
S
A
 
L
L
 
F
E
 
E
R
 
R
K
 
R
I
 
L

Query Sequence

>AO353_24425 FitnessBrowser__pseudo3_N2E3:AO353_24425
MELDFSVIFDYKAALLFGLLLTLKLTAICVILGCALGFMVAIARSSKNKIIYGISTVYVA
LFRGTPVLIQLFWMFFCLPLVLGVELSNLTCGIIALTLYMAAITSETFRASFSFVSKEQH
DAGVALGLTYRVHTLYVLLPQALLRAAPTLLSNCTSLFKESALVSAVGMADLMFVSQNIS
NRTGHPVELLTAAAVIYFVIAFPITRAVTALERKILHTMAI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory